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Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2009, Volume 418, Issue 3, pp. 625 - 634
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 10/2016, Volume 213, Issue 11, pp. 2503 - 2523
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2006, Volume 394, Issue 1, pp. 365 - 373
ERK8 (extracellular-signal-regulated protein kinase 8) expressed ill Escherichia coli or insect cells was catalytically active and phosphorylated at both... 
Oxidative stress | Protein phosphatase | Extracellular-signal-regulated kinase 8 (ERK8) | Mass spectrometry | Mitogen-activated protein kinase (MAPK) | extracellular-signal-regulated kinase 8 (ERK8) | DOMAIN | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | IDENTIFICATION | MAMMALIAN-CELLS | protein phosphatase | FAMILY | IN-VITRO | SAPK1/JNK | SUBSTRATE | mass spectrometry | INTERMEDIATE | AUTOPHOSPHORYLATION | oxidative stress | Cell Line | Phosphorylation | Humans | Phosphoprotein Phosphatases - metabolism | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Substrate Specificity | Enzyme Activation | Extracellular Signal-Regulated MAP Kinases - metabolism | Recombinant Proteins | Protein Phosphatase 2 | Binding Sites | Extracellular Signal-Regulated MAP Kinases - genetics | Index Medicus | GST, glutathione S-transferase | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PKC, protein kinase C | DYRK, dual tyrosine-regulated phosphorylated kinase | MKP, MAPK phosphatase | GSK3, glycogen synthase kinase 3 | PTPase, protein tyrosine phosphatase | JNK, c-Jun N-terminal kinase | MKK, MAPK kinase | HA, haemagglutinin | IGF-1, insulin-like growth factor 1 | ERK, extracellular-signal-regulated protein kinase | PP2A, protein serine | PTP1B, protein tyrosine phosphatase 1B | MBP, myelin basic protein | threonine phosphatase 2A | MAPK, mitogen-activated protein kinase
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2015, Volume 212, Issue 12, pp. 2057 - 2075
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2015, Volume 195, Issue 1, pp. 265 - 276
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2009, Volume 418, Issue 3, pp. 625 - 634
In Ewing's sarcomas, chromosomal translocations cause the N-terminal domain of the Ewing's sarcoma protein (EWS) to fuse with the DNA-binding domains of the... 
Journal Article
Nature Communications, 11/2014, Volume 5, p. 5232
  Constitutive activation of EGFR- and NF-κB-dependent pathways is a hallmark of cancer, yet signalling proteins that connect both oncogenic cascades are... 
Journal Article
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