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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2018, Volume 115, Issue 50, pp. E11874 - E11883
Hepatocellular carcinoma (HCC) is one of the most frequent forms of liver cancer, and effective treatment methods are limited due to tumor heterogeneity. There... 
Hepatocellular carcinoma | Biological networks | Genome-scale metabolic models | Personalized medicine | Systems biology | systems biology | SURVIVAL | ACTIVATION | MULTIDISCIPLINARY SCIENCES | CATENIN | CLASSIFICATION | MODEL | biological networks | personalized medicine | PREDICTION | PATHWAY | BIOLOGY | genome-scale metabolic models | GENE-EXPRESSION | hepatocellular carcinoma | Liver Neoplasms - classification | Prognosis | Liver Neoplasms - genetics | Signal Transduction | Humans | Gene Expression Regulation, Neoplastic | Phosphatidylinositol 3-Kinases - metabolism | Gene Regulatory Networks | Hep G2 Cells | Hypoxia - metabolism | Hypoxia - genetics | Metabolic Networks and Pathways | Models, Biological | Carcinoma, Hepatocellular - genetics | Liver Neoplasms - metabolism | Carcinoma, Hepatocellular - classification | Wnt Signaling Pathway | Carcinoma, Hepatocellular - metabolism | Physiological aspects | Hepatoma | TOR protein | Target recognition | Wnt protein | Liver | Genes | Metabolic networks | Lipids | AKT protein | Genomes | Systems analysis | Liver cancer | β-catenin | Heterogeneity | Precision medicine | Controllability | Lipid metabolism | Predictive control | Stability | Therapeutic applications | Chemical reactions | Topology | Metabolism | Gene expression | Patients | Survival | 1-Phosphatidylinositol 3-kinase | Signaling | Predictions | Hypoxia | Tumors | Cancer | Index Medicus | Biological Sciences | PNAS Plus | biology | catenin | survival | gene-expression | classification | genome-scale metabolic | Medicinsk genetik | Medical Genetics | prediction | pathway | model | Cancer and Oncology | activation | Cancer och onkologi
Journal Article
Molecular systems biology, ISSN 1744-4292, 2017, Volume 13, Issue 3, pp. 916 - n/a
To elucidate the molecular mechanisms underlying non-alcoholic fatty liver disease (NAFLD), we recruited 86 subjects with varying degrees of hepatic steatosis... 
serine | NAFLD | personalized genome‐scale metabolic modeling | glutathione | personalized genome-scale metabolic modeling | FATTY LIVER-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUSCLE | DRUG TARGETS | CANCER | AMINO-ACID-METABOLISM | HEPATOCELLULAR-CARCINOMA | INSULIN-RESISTANCE | ADIPOSE-TISSUE | GENOME-SCALE | REVEALS | Glycine - blood | Liver - enzymology | Non-alcoholic Fatty Liver Disease - genetics | Glutathione - metabolism | Serine - blood | Humans | Liver - metabolism | Middle Aged | Male | Non-alcoholic Fatty Liver Disease - metabolism | Patient-Specific Modeling | Metabolomics - methods | Gene Expression Regulation, Enzymologic | Serine - administration & dosage | Animals | Lipoproteins - metabolism | Female | Mice | Non-alcoholic Fatty Liver Disease - diet therapy | Genome | NAD - metabolism | Serine - therapeutic use | Disease Models, Animal | Genomes | Metabolites | Metabolism | Liver | Rodents | Serine | Lipids | Biosynthesis | Glycine | Body mass index | Fatty liver | Precursors | Supplementation | Glutathione | Level (quantity) | Liver diseases | Fasting | Demand analysis | Dietary supplements | Triglycerides | Fluxes | Apolipoproteins | Gene expression | Cholesterol | Steatosis | NAD | Molecular modelling | Insulin resistance | Plasma levels | Laboratory animals | Index Medicus | Life Sciences | Biochemistry, Molecular Biology | Biological Sciences | Naturvetenskap | Biologiska vetenskaper | Natural Sciences
Journal Article
Molecular Systems Biology, ISSN 1744-4292, 08/2017, Volume 13, Issue 8, pp. 938 - n/a
We performed integrative network analyses to identify targets that can be used for effectively treating liver diseases with minimal side effects. We first... 
HCC | NAFLD | co‐regulation | metabolism | co‐expression | co-expression | co-regulation | PROTEOME | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTAGONISM | GLUTATHIONE METABOLISM | INSULIN | HEPATIC CB1 RECEPTORS | FATTY-ACID SYNTHASE | EXPRESSION | GENOME-SCALE | SYSTEMS BIOLOGY | REVEALS | Fatty Acid Synthase, Type I - genetics | Liver Neoplasms - genetics | Non-alcoholic Fatty Liver Disease - genetics | Humans | Cells, Cultured | Gene Expression Regulation | Liver Neoplasms - drug therapy | Gene Expression Profiling | Gene Regulatory Networks - drug effects | Molecular Targeted Therapy | Organ Specificity | Liver - chemistry | Hep G2 Cells | Non-alcoholic Fatty Liver Disease - drug therapy | Protein Interaction Maps | Systems Biology - methods | Animals | Carcinoma, Hepatocellular - drug therapy | Sequence Analysis, RNA | Liver - drug effects | Carcinoma, Hepatocellular - genetics | K562 Cells | Mice | Biotechnology | Target recognition | Pathogenesis | Liver | Genes | Central nervous system | Pyruvic acid | Hepatocellular carcinoma | Drug development | Tissues | Human tissues | Liver cancer | Cell growth | Fatty liver | Rodents | Inhibition | Lipogenesis | Liver diseases | Pyruvate kinase | Blood cells | Subtilisin | Tumor cell lines | Gene expression | Fatty acids | Fatty-acid synthase | Diseases | Phospholipase | Side effects | Kexin | Hepatocytes | Predictions | Cancer | Index Medicus | Medical Biotechnology | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinsk bioteknologi
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 05/2019, Volume 9, Issue 1, pp. 6909 - 13
Myocardial dysfunction is commonly associated with accumulation of cardiac lipid droplets (LDs). Perilipin 2 (Plin2) is a LD protein that is involved in LD... 
LIPOTOXICITY | STEATOSIS | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | FATTY-ACID | LIVER | DROPLET-ASSOCIATED PROTEINS | PERILIPIN 5 | MICE | AUTOPHAGY | DYSFUNCTION | Myocardial infarction | Heart | Cerebral infarction | Lipids | Cardiomyocytes | Triglycerides | Heart diseases | Steatosis
Journal Article
International Journal of Mass Spectrometry, ISSN 1387-3806, 03/2019, Volume 437, pp. 77 - 86
Cardiovascular disease (CVD) is largely related to complications from atherosclerotic disease such as myocardial infarction (MI) and ischemic stroke and... 
Myocardial infarction | Lipid accumulation | Mouse heart | ToF-SIMS | Gas cluster ion beams | Imaging | CARDIOLIPIN | BEAMS | QUANTIFICATION | PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | PHOSPHOLIPIDS | IDENTIFICATION | LIPOTOXICITY | ION MASS-SPECTROMETRY | METABOLISM | SPECTROSCOPY | SEPARATION | ELECTROSPRAY-IONIZATION
Journal Article
International Journal of Mass Spectrometry, ISSN 1387-3806, 2017
Cardiovascular disease (CVD) is largely related to complications from atherosclerotic disease such as myocardial infarction (MI) and ischemic stroke and... 
Myocardial infarction | Analytical Chemistry | Mouse heart | ToF-SIMS | Imaging | Lipid accumulation | Analytisk kemi | Gas cluster ion beams
Journal Article
Journal Article
Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, 2017, Volume 95, Issue 8, pp. 920 - 927
Adaptation to chronic intermittent hypoxia (CIH) is associated with reactive oxygen species (ROS) generation implicated in the improved cardiac tolerance... 
Heart | Tempol | Oxidative stress | Chronic intermittent hypoxia | Phospholipases A | Index Medicus
Journal Article
Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, 08/2017, Volume 95, Issue 8, p. 920
Adaptation to chronic intermittent hypoxia (CIH) is associated with reactive oxygen species (ROS) generation implicated in the improved cardiac tolerance... 
Antioxidants | Physiological aspects | Hypoxia | Phospholipases | Health aspects
Journal Article
Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, 2017, Volume 95, Issue 8, pp. 920 - 927
Adaptation to chronic intermittent hypoxia (CIH) is associated with reactive oxygen species (ROS) generation implicated in the improved cardiac tolerance... 
tempol | hypoxie intermittente chronique | chronic intermittent hypoxia | phospholipases A | heart | oxidative stress | stress oxydatif | cœur
Journal Article
Metabolic Engineering, ISSN 1096-7176, 03/2019, Volume 52, pp. 263 - 272
The pathogenesis of non-alcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC) has been associated with altered expression of liver-specific... 
ANALYSIS REVEALS | DATABASE | MODELS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | FATTY LIVER-DISEASE | STRESS | ASSOCIATION | DNA-REPLICATION | TOOLS | DNA replication | Liver | Genes | Development and progression | Triglycerides | DNA binding proteins | Genetic transcription | Fatty acids | Liver cancer | Glucose metabolism | Synthesis | Genetic research | Tumor proteins | Index Medicus
Journal Article
Molecular and Cellular Biochemistry, ISSN 0300-8177, 11/2011, Volume 357, Issue 1, pp. 163 - 169
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2015, Volume 93, pp. 69 - 72
Journal Article
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 10/2017, Volume 91, Issue Pt A, pp. 9 - 13
Journal Article
EBioMedicine, ISSN 2352-3964, 02/2019, Volume 40, pp. 471 - 487
Background: Redox metabolism is often considered a potential target for cancer treatment, but a systematic examination of redox responses in hepatocellular... 
Journal Article
Journal Article