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1. Full Text Improving enzymes by using them in organic solvents
by Klibanov, A.M
Nature, ISSN 0028-0836, 01/2001, Volume 409, Issue 6817, pp. 241 - 246
The technological utility of enzymes can be enhanced greatly by using them in organic solvents rather than their natural aqueous reaction media. Studies over... 
SUBSTRATE-SPECIFICITY | SERINE PROTEASES | RACEMIC AMINES | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | ENZYMATIC CATALYSIS | ALPHA-CHYMOTRYPSIN | MEDIA | SUBTILISIN CARLSBERG | NONAQUEOUS SOLVENTS | RATIONAL CONTROL | Substrate Specificity | Solvents | Catalysis | Enzymes - metabolism | Water - metabolism | Enzymes | Chemistry | Catalysts
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2. Full Text Monitoring Oxygenation Levels Deep in the Tumor Core: Noninvasive Imaging of Hypoxia, Now in Real-Time 3D
by Klibanov, Alexander L and Hu, Song
Cancer research, ISSN 0008-5472, 09/2019, Volume 79, Issue 18, pp. 4577 - 4579
Understanding the way hypoxia influences tumor biology is important; to study tumor hypoxia, simple and robust quantification of tissue oxygenation levels is... 
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3. Full Text Preparation of targeted microbubbles: Ultrasound contrast agents for molecular imaging
by Klibanov, Alexander L
Medical and Biological Engineering and Computing, ISSN 0140-0118, 2009, Volume 47, Issue 8, pp. 875 - 882
Targeted ultrasound contrast agents can be prepared by attaching targeting ligands to the lipid, protein or polymer shell coating of gas-filled microbubbles.... 
Molecular imaging | Microbubbles | Targeted imaging | Targeting | Ultrasound | Ultrasound contrast | GAS-FILLED MICROBUBBLES | MEDICAL INFORMATICS | ENGINEERING, BIOMEDICAL | SHEAR-FLOW | ADHESION | COATED MICROBUBBLES | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | INFLAMMATION | KINETICS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | P-SELECTIN | SURFACE | PERFLUOROBUTANE | ACOUSTIC RADIATION FORCE | Humans | Contrast Media - chemistry | Ligands | Molecular Imaging - methods | Chemistry, Physical | Ultrasonography - methods | Studies | Contrast agents | Medical imaging
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4. Full Text Conjugation to Gold Nanoparticles Enhances Polyethylenimine's Transfer of Plasmid DNA into Mammalian Cells
by Mini Thomas and Alexander M. Klibanov
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2003, Volume 100, Issue 16, pp. 9138 - 9143
Branched polyethylenimine (PEI) chains with an average molecular mass of 2 kDa (PEI2) have been covalently attached to gold nanoparticles (GNPs), and the... 
COS cells | Nanoparticles | Cell culture techniques | Biological Sciences | Ratios | Transfection | Genetic vectors | Plasmids | Teeth | Cytotoxicity | Cell membranes | SALT | COLLOIDAL GOLD | REDUCIBLE POLYCATIONS | THERAPY | MULTIDISCIPLINARY SCIENCES | EFFICIENT GENE DELIVERY | COMPLEXES | LOW-MOLECULAR-WEIGHT | DENDRIMERS | VECTORS | NUCLEIC-ACIDS | Gold - chemistry | Gene Transfer Techniques | Models, Chemical | Humans | DNA - metabolism | Microscopy, Electron | Plasmids - metabolism | Galactosides - pharmacology | Animals | Cell Nucleus - metabolism | Time Factors | Polyethyleneimine - chemistry | Indoles - pharmacology | Genetic Vectors | Spectrophotometry | COS Cells | Nanotechnology | Chromogenic Compounds - pharmacology | DNA | Research
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5. Full Text Microbubble Contrast Agents: Targeted Ultrasound Imaging and Ultrasound-Assisted Drug-Delivery Applications
by Klibanov, Alexander L
Investigative Radiology, ISSN 0020-9996, 03/2006, Volume 41, Issue 3, pp. 354 - 362
The use of microbubble contrast agents for general tissue delineation and perfusion enjoys steady interest in ultrasound imaging. Microbubbles as contrast... 
Microbubbles | Drug delivery | Echo contrast | Targeted contrast | Ultrasound | Ultrasound contrast | ultrasound contrast | drug delivery | GAS-FILLED MICROPARTICLES | DIAGNOSTIC ULTRASOUND | TUMOR ANGIOGENESIS | MYOCARDIAL CONTRAST | ultrasound | DESTRUCTION | microbubbles | echo contrast | ALBUMIN MICROSPHERES | IN-VIVO | ACCELERATED THROMBOLYSIS | ENHANCEMENT | P-SELECTIN | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | targeted contrast | Animals | Plasmids | Contrast Media - administration & dosage | Humans | Ultrasonography | Contrast Media - pharmacokinetics | Clinical Trials as Topic | Vascular Diseases - drug therapy | Vascular Diseases - diagnostic imaging | Drug Delivery Systems
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6. Full Text Analysis of in vitro Transfection by Sonoporation Using Cationic and Neutral Microbubbles
by Tlaxca, Jose L and Anderson, Christopher R and Klibanov, Alexander L and Lowrey, Bryce and Hossack, John A and Alexander, J. Steven and Lawrence, Michael B and Rychak, Joshua J
Ultrasound in Medicine & Biology, ISSN 0301-5629, 2010, Volume 36, Issue 11, pp. 1907 - 1918
Abstract The objective of the study was to examine the role of acoustic power intensity and microbubble and plasmid concentrations on transfection efficiency... 
Radiology | Gene delivery | Cationic microbubbles | Microbubble | Ultrasound | Transfection efficiency | Sonoporation | CONTRAST AGENTS | PLASMID | CULTURED-CELLS | ENHANCED ULTRASOUND | ACOUSTICS | DESTRUCTION | THERAPY | MEDIATED GENE DELIVERY | Cationic micro bubbles | ACOUSTIC RADIATION FORCE | EXPRESSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | TARGETED DELIVERY | Cell Line | Gene Transfer Techniques | Transducers | Cell Survival | Cells, Cultured | Gene Expression Regulation | Green Fluorescent Proteins - genetics | Ultrasonics | Flow Cytometry | Transfection | Plasmids | Microbubbles | Cations | In Vitro Techniques | Microscopy, Fluorescence | Fluorescence | Analysis | Universities and colleges | Cell survival | Green fluorescent protein | Lipids | Acoustics | Conjugation
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7. Full Text Surpassing nature: rational design of sterile-surface materials
by Lewis, Kim and Klibanov, Alexander M
Trends in Biotechnology, ISSN 0167-7799, 2005, Volume 23, Issue 7, pp. 343 - 348
The rise of multidrug-resistant pathogens and recalcitrance of biofilm infections present a formidable challenge to combating infectious diseases. There are... 
CELLS | MECHANISM | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PSEUDOMONAS-AERUGINOSA | DRUG DISCOVERY | BERBERINE | RESISTANCE | BACTERIAL BIOFILMS | MULTIDRUG PUMP | Drug Resistance, Microbial | Biomedical Engineering - methods | Surface Properties | Biomedical Engineering - trends | Sterilization | Drug resistance in microorganisms | Bacteria | Antimicrobial agents | Microorganisms | Nosocomial infections | Polymers | Technological change
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8. Full Text Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli
by Cronk, James C and Derecki, Noël C and Ji, Emily and Xu, Yang and Lampano, Aaron E and Smirnov, Igor and Baker, Wendy and Norris, Geoffrey T and Marin, Ioana and Coddington, Nathan and Wolf, Yochai and Turner, Stephen D and Aderem, Alan and Klibanov, Alexander L and Harris, Tajie H and Jung, Steffen and Litvak, Vladimir and Kipnis, Jonathan
Immunity, ISSN 1074-7613, 04/2015, Volume 42, Issue 4, pp. 679 - 691
Mutations in encoding the epigenetic regulator methyl-CpG-binding protein 2, are the predominant cause of Rett syndrome, a disease characterized by both... 
MECP2 | PATHWAYS | CELLS | RETT-SYNDROME | MOUSE MODEL | MONOCYTES | TISSUE-RESIDENT MACROPHAGES | SYMPTOMS | MUTATIONS | IMMUNOLOGY | MATURATION | Epigenesis, Genetic | Humans | Macrophages, Peritoneal - pathology | Longevity - immunology | Male | Gene Expression Profiling | Methyl-CpG-Binding Protein 2 - immunology | Rett Syndrome - immunology | Methyl-CpG-Binding Protein 2 - deficiency | Methyl-CpG-Binding Protein 2 - genetics | DNA Methylation | Microglia - immunology | Microglia - pathology | Female | Receptors, Chemokine - genetics | Macrophages, Peritoneal - drug effects | Disease Models, Animal | CpG Islands - immunology | Microglia - drug effects | Signal Transduction | Mice, Inbred C57BL | Homeostasis - immunology | Macrophages, Peritoneal - immunology | Receptors, Chemokine - immunology | Mice, Knockout | Tumor Necrosis Factor-alpha - pharmacology | Animals | Rett Syndrome - pathology | High-Throughput Nucleotide Sequencing | Mice | Integrases - immunology | Rett Syndrome - genetics | CX3C Chemokine Receptor 1 | Integrases - genetics | Epigenetic inheritance | Neurosciences | Corticosteroids | RNA | Genes | Macrophages | Gene expression | Protein binding | Flow cytometry | Brain research | Disease | Rodents | Mutation | Experiments
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9. Full Text Enhancing Polyethylenimine's Delivery of Plasmid DNA into Mammalian Cells
by Mini Thomas and Alexander M. Klibanov
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2002, Volume 99, Issue 23, pp. 14640 - 14645
The effect of various chemical modifications of nitrogen atoms on the efficiency of polyethylenimines (PEIs) as synthetic vectors for the delivery of plasmid... 
COS cells | Protons | Solvents | Biological Sciences | Transfection | Amines | Plasmids | Bromides | Cytotoxicity | Kidney cells | Alkylation | POLYPLEXES | MOLECULAR-WEIGHT | GENE DELIVERY | TRANSFECTION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | COMPLEXES | POLY(ETHYLENIMINE) | DERIVATIVES | EFFICIENCY | VECTOR | Polyethyleneimine | Cell Line | Animals | Transfection - methods | Genes, Synthetic | Cercopithecus aethiops | Indicators and Reagents | Genetic Vectors | Mammals | COS Cells | Physiological aspects | Cells | Physical Sciences
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10. Full Text Exploring polyethylenimine‐mediated DNA transfection and the proton sponge hypothesis
by Akinc, Akin and Thomas, Mini and Klibanov, Alexander M and Langer, Robert
The Journal of Gene Medicine, ISSN 1099-498X, 05/2005, Volume 7, Issue 5, pp. 657 - 663
Background The relatively high transfection efficiency of polyethylenimine (PEI) vectors has been hypothesized to be due to their ability to avoid trafficking... 
gene delivery | proton sponge | lysosome | polyethylenimine (PEI) | transfection | Polyethylenimine (PEI) | Gene delivery | Proton sponge | Transfection | Lysosome | MEDICINE, RESEARCH & EXPERIMENTAL | DESIGN | COMPLEXES | TRAFFICKING | FUSOGENIC PEPTIDES | MAMMALIAN-CELLS | VECTOR | CHLORIDE ACCUMULATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IN-VIVO | ENHANCEMENT | GENETICS & HEREDITY | Gene Transfer Techniques | Luciferases - metabolism | Proton Pump Inhibitors | Cercopithecus aethiops | DNA - administration & dosage | Genetic Vectors - metabolism | Cytoplasm - metabolism | Polyethyleneimine - pharmacology | Endosomes - metabolism | Polylysine - metabolism | Chloroquine - pharmacology | Polyethyleneimine - analogs & derivatives | Animals | Macrolides - pharmacology | Anti-Bacterial Agents - pharmacology | COS Cells | Polymers - metabolism | Hydrogen-Ion Concentration
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11. Full Text BMP7 Gene Transfer via Gold Nanoparticles into Stroma Inhibits Corneal Fibrosis In Vivo
by Tandon, A and Sharma, A and Rodier, JT and Klibanov, AM and Rieger, FG and Mohan, RR
PLOS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6, p. e66434
This study examined the effects of BMP7 gene transfer on corneal wound healing and fibrosis inhibition in vivo using a rabbit model. Corneal haze in rabbits... 
CELLS | HAZE | MITOMYCIN-C | MULTIDISCIPLINARY SCIENCES | BONE MORPHOGENETIC PROTEINS | PTERYGIUM SURGERY | PROLIFERATION | CHRONIC KIDNEY-DISEASE | PHOTOREFRACTIVE KERATECTOMY | MYOFIBROBLAST DIFFERENTIATION | EXPRESSION | Corneal Diseases - therapy | Genetic Therapy | Gold | Rabbits | Cornea | Corneal Stroma - metabolism | Signal Transduction | Bone Morphogenetic Protein 7 - genetics | Humans | Cells, Cultured | Treatment Outcome | Gene Dosage | Animals | Transfection | Corneal Stroma - pathology | Fibrosis | Female | Corneal Diseases - pathology | Smad Proteins - metabolism | Bone Morphogenetic Protein 7 - biosynthesis | Fibroblasts - metabolism | Metal Nanoparticles | Infection | Nanoparticles | Fibronectins | Lasers | Analysis | Genes | Bone morphogenetic proteins | Transforming growth factors | Gene therapy | Muscle proteins | Gene expression | Smad protein | Photorefractivity | Immunoblotting | Smooth muscle | Tissues | Alizarin | Western blotting | Fibronectin | Recruitment | Proteins | Biomedical materials | Actin | Fibroblasts | Biocompatibility | Localization | Growth factors | Deoxyribonucleic acid--DNA | CD11b antigen | Osteocalcin | Wound healing | Gene transfer | Haze | Muscles | Stroma | Vectors (Biology) | Medicine | Signaling | Hospitals | Calcification | Healing | In vivo methods and tests | Topical application | Immunofluorescence | Apoptosis | Bone morphogenetic protein 7 | Deoxyribonucleic acid | DNA
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12. Full Text Microbubbles in ultrasound-triggered drug and gene delivery
by Hernot, Sophie and Klibanov, Alexander L
Advanced Drug Delivery Reviews, ISSN 0169-409X, 2008, Volume 60, Issue 10, pp. 1153 - 1166
Ultrasound contrast agents, in the form of gas-filled microbubbles, are becoming popular in perfusion monitoring; they are employed as molecular imaging... 
Molecular imaging | Triggered release | Echo | Acoustic | Ultrasound contrast agent | Microbubbles | Ultrasound | ultrasound contrast agent | INTERCELLULAR-ADHESION MOLECULE-1 | acoustic | echo | MYOCARDIAL CONTRAST ECHOCARDIOGRAPHY | molecular imaging | ALBUMIN MICROBUBBLES | BLOOD-BRAIN-BARRIER | ultrasound | ENHANCED ULTRASOUND | SKELETAL-MUSCLE | IN-VITRO | microbubbles | RADIATION FORCE | triggered release | PHARMACOLOGY & PHARMACY | POLY-DL-LACTIDE-POLY(ETHYLENE GLYCOL) MICROSPHERES | TARGETED DELIVERY | Gene Transfer Techniques | Animals | Humans | Pharmaceutical Preparations - administration & dosage | Drug Delivery Systems - methods | Ultrasonics | Drugs | Medical colleges | Drug delivery systems | Contrast media | Vehicles | Triggered Release | Molecular Imaging
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