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life sciences & biomedicine (209) 209
science & technology (209) 209
humans (183) 183
female (173) 173
biological and medical sciences (164) 164
medical sciences (163) 163
oncology (147) 147
middle aged (127) 127
adult (119) 119
tumors (110) 110
gynecology. andrology. obstetrics (95) 95
aged (91) 91
mammary gland diseases (88) 88
breast cancer (81) 81
breast neoplasms - genetics (76) 76
breast neoplasms - pathology (57) 57
prognosis (57) 57
pharmacology. drug treatments (55) 55
aged, 80 and over (49) 49
antineoplastic agents (48) 48
breast neoplasms - drug therapy (45) 45
breast neoplasms - mortality (34) 34
chemotherapy (34) 34
mutation (34) 34
survival analysis (34) 34
disease-free survival (31) 31
breast neoplasms - metabolism (29) 29
tamoxifen - therapeutic use (29) 29
risk factors (28) 28
male (26) 26
multivariate analysis (26) 26
genetics & heredity (23) 23
breast neoplasms - diagnosis (22) 22
genes, brca1 (22) 22
genetic aspects (20) 20
ovarian neoplasms - genetics (20) 20
receptors, estrogen - analysis (20) 20
antineoplastic agents, hormonal - therapeutic use (18) 18
breast neoplasms - surgery (18) 18
receptors, progesterone - analysis (18) 18
time factors (18) 18
treatment outcome (18) 18
cancer (17) 17
follow-up studies (17) 17
medicine & public health (17) 17
antineoplastic combined chemotherapy protocols - therapeutic use (16) 16
genes, brca2 (16) 16
lymphatic metastasis (16) 16
predictive value of tests (16) 16
research article (16) 16
breast neoplasms - chemistry (15) 15
genetic predisposition to disease (15) 15
neoplasm proteins - genetics (15) 15
proportional hazards models (15) 15
skin and connective tissue diseases (15) 15
brca1 (14) 14
endocrinology & metabolism (14) 14
neoplasm metastasis (14) 14
abridged index medicus (13) 13
animals (13) 13
breast neoplasms - enzymology (13) 13
research (13) 13
tamoxifen (13) 13
analysis of variance (12) 12
gene expression regulation, neoplastic (12) 12
general & internal medicine (12) 12
genes (12) 12
health aspects (12) 12
mastectomy (12) 12
medicine, general & internal (12) 12
survival rate (12) 12
transcription factors - genetics (12) 12
tumor cells, cultured (12) 12
biochemistry & molecular biology (11) 11
breast neoplasms - epidemiology (11) 11
dna mutational analysis (11) 11
enzyme-linked immunosorbent assay (11) 11
netherlands (11) 11
netherlands - epidemiology (11) 11
prospective studies (11) 11
retrospective studies (11) 11
risk (11) 11
heterozygote (10) 10
immunohistochemistry (10) 10
rats (10) 10
receptors, estrogen - metabolism (10) 10
breast neoplasms - psychology (9) 9
chemotherapy, adjuvant (9) 9
gene expression profiling (9) 9
gene mutations (9) 9
magnetic resonance imaging (9) 9
menopause (9) 9
pedigree (9) 9
receptors (9) 9
receptors, progesterone - metabolism (9) 9
regular (9) 9
regular article (9) 9
age factors (8) 8
brca2 protein (8) 8
breast neoplasms - prevention & control (8) 8
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1. Full Text Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial
by Baum, M and Buzdar, A.U and Cuzick, J and Forbes, J and Houghton, J and Klijn, J.G.M and Sahmoud, T and The ATAC (Arimidex, Tamoxifen Alone or in Combination) Trialists' Group and ATAC Trialists' Grp and ATAC Trialists' Group
The Lancet (British edition), ISSN 0140-6736, 06/2002, Volume 359, Issue 9324, pp. 2131 - 2139
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | Chemotherapy | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Triazoles - adverse effects | Prognosis | Humans | Middle Aged | Endpoint Determination - methods | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Postmenopause | Female | Anticarcinogenic Agents - adverse effects | Chemotherapy, Adjuvant | Anticarcinogenic Agents - therapeutic use | Triazoles - therapeutic use | Enzyme Inhibitors - adverse effects | Anastrozole | Combined Modality Therapy | Breast Neoplasms - drug therapy | Enzyme Inhibitors - therapeutic use | Breast Neoplasms - prevention & control | Aromatase Inhibitors | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Tamoxifen - therapeutic use | Breast Neoplasms - mortality | Aged | Tamoxifen - adverse effects | Nitriles - adverse effects | Nitriles - therapeutic use | Endometrial cancer | Adverse and side effects | Postmenopausal women | Breast cancer | Tamoxifen | Drug therapy | Risk factors | Therapy | Invasiveness | Disorders | Vagina | Patients | Survival | Evidence-based medicine | Subgroups | Bleeding | Post-menopause | Cerebrovascular system | Fractures | Motivation | Womens health | Risk assessment | Hormone replacement therapy | Thromboembolism | Health risk assessment | Endometrium | Cancer | Index Medicus | Abridged Index Medicus
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2. Full Text Definition of Clinically Distinct Molecular Subtypes in Estrogen Receptor–Positive Breast Carcinomas Through Genomic Grade
by Sherene Loi and Benjamin Haibe-Kains and Christine Desmedt and Françoise Lallemand and Andrew M. Tutt and Cheryl Gillet and Paul Ellis and Adrian Harris and Jonas Bergh and John A. Foekens and Jan G.M. Klijn and Denis Larsimont and Marc Buyse and Gianluca Bontempi and Mauro Delorenzi and Martine J. Piccart and Christos Sotiriou
Journal of clinical oncology, ISSN 0732-183X, 04/2007, Volume 25, Issue 10, pp. 1239 - 1246
Life Sciences & Biomedicine | Oncology | Science & Technology | Gynecology. Andrology. Obstetrics | Mammary gland diseases | Biological and medical sciences | Medical sciences | Tumors | Multivariate Analysis | Breast Neoplasms - chemistry | Breast Neoplasms - genetics | Prognosis | Breast Neoplasms - pathology | Humans | Tamoxifen - therapeutic use | Breast Neoplasms - mortality | Female | Gene Expression Profiling | Receptors, Estrogen - analysis | Index Medicus | Medicin och hälsovetenskap
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3. Full Text Strong Time Dependence of the 76-Gene Prognostic Signature for Node-Negative Breast Cancer Patients in the TRANSBIG Multicenter Independent Validation Series
by Christine Desmedt and Fanny Piette and Sherene Loi and Yixin Wang and Françoise Lallemand and Benjamin Haibe-Kains and Giuseppe Viale and Mauro Delorenzi and Yi Zhang and Mahasti Saghatchian d'Assignies and Jonas Bergh and Rosette Lidereau and Paul Ellis and Adrian L. Harris and Jan G.M. Klijn and John A. Foekens and Fatima Cardoso and Martine J. Piccart and Marc Buyse and Christos Sotiriou and TRANSBIG Consortium and on behalf of the TRANSBIG Consortium
Clinical cancer research, ISSN 1078-0432, 06/2007, Volume 13, Issue 11, pp. 3207 - 3214
breast cancer | 76-gene signature | prognosis | time-dependency | gene expression | Gynecology. Andrology. Obstetrics | Mammary gland diseases | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Antineoplastic agents | Tumors | Reproducibility of Results | Prognosis | Genomics | Humans | Middle Aged | Risk | Treatment Outcome | Gene Expression Profiling | Lymphatic Metastasis | Biomarkers, Tumor | Neoplasm Metastasis | Time Factors | Breast Neoplasms - blood | Adult | Breast Neoplasms - mortality | Female | Breast Neoplasms - diagnosis | Index Medicus | Medicin och hälsovetenskap
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4. Full Text Trastuzumab-Associated Cardiac Adverse Effects in the Herceptin Adjuvant Trial
by Thomas M. Suter and Marion Procter and Dirk J. van Veldhuisen and Michael Muscholl and Jonas Bergh and Chiara Carlomagno and Timothy Perren and Rodolfo Passalacqua and Claudia Bighin and Jan G.M. Klijn and Fail T. Ageev and Erika Hitre and Juergen Groetz and Hiroji Iwata and Malgorzata Knap and Michael Gnant and Susanne Muehlbauer and Alison Spence and Richard D. Gelber and Martine J. Piccart-Gebhart
Journal of clinical oncology, ISSN 0732-183X, 09/2007, Volume 25, Issue 25, pp. 3859 - 3865
THERAPY | DOXORUBICIN | GROWTH | ERBB2 | CARDIOTOXICITY | VENTRICULAR MYOCYTES | DYSFUNCTION | UMCG Approved | HER2-POSITIVE BREAST-CANCER | CHEMOTHERAPY | NEUREGULIN-1-BETA | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Receptor, ErbB-2 - metabolism | Breast Neoplasms - drug therapy | Antibodies, Monoclonal, Humanized | Disease-Free Survival | Antibodies, Monoclonal - administration & dosage | Antineoplastic Agents - adverse effects | Female | Cardiovascular Diseases - chemically induced | Heart Failure - chemically induced | Trastuzumab | Index Medicus | Medicin och hälsovetenskap
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5. Full Text Efficacy of MRI and Mammography for Breast-Cancer Screening in Women with a Familial or Genetic Predisposition
by Kriege, Mieke and Brekelmans, Cecile T.M and Boetes, Carla and Besnard, Peter E and Zonderland, Harmine M and Obdeijn, Inge Marie and Manoliu, Radu A and Kok, Theo and Peterse, Hans and Tilanus-Linthorst, Madeleine M.A and Muller, Sara H and Meijer, Sybren and Oosterwijk, Jan C and Beex, Louk V.A.M and Tollenaar, Rob A.E.M and de Koning, Harry J and Rutgers, Emiel J.T and Klijn, Jan G.M and Magnetic Resonance Imaging Screeni and Magnetic Resonance Imaging Screening Study Group
The New England journal of medicine, ISSN 0028-4793, 07/2004, Volume 351, Issue 5, pp. 427 - 437
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Gynecology. Andrology. Obstetrics | Mammary gland diseases | Biological and medical sciences | General aspects | Medical sciences | Tumors | Genetic Predisposition to Disease | Prospective Studies | Humans | Middle Aged | Risk | Mammography | Chi-Square Distribution | Mass Screening - methods | Case-Control Studies | Magnetic Resonance Imaging | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Sensitivity and Specificity | Survival Analysis | Germ-Line Mutation | Adult | Female | ROC Curve | Aged | Breast Neoplasms - diagnosis | Breast Neoplasms - diagnostic imaging | Evaluation | Breast cancer | Medical examination | Research | Magnetic resonance imaging | Women | Nuclear magnetic resonance--NMR | Mutation | Index Medicus | Abridged Index Medicus
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6. Full Text Cancer risks in BRCA2 families: estimates for sites other than breast and ovary
by van Asperen, C J and Brohet, R M and Meijers-Heijboer, E J and Hoogerbrugge, N and Verhoef, S and Vasen, H F A and Ausems, M G E M and Menko, F H and Gomez Garcia, E B and Klijn, J G M and Hogervorst, F B L and van Houwelingen, J C and van’t Veer, L J and Rookus, M A and van Leeuwen, F E and Netherlands Collaborative Grp Here and Netherlands Collaborative Group on Hereditary Breast Cancer (HEBON)
Journal of medical genetics, ISSN 0022-2593, 09/2005, Volume 42, Issue 9, pp. 711 - 719
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Cardiology. Vascular system | General aspects. Genetic counseling | Biological and medical sciences | Medical sciences | Medical genetics | Pancreatic Neoplasms - epidemiology | Humans | Middle Aged | Bone Neoplasms - epidemiology | Male | Pancreatic Neoplasms - genetics | Risk | Ovarian Neoplasms - epidemiology | Prostatic Neoplasms - epidemiology | Ovarian Neoplasms - genetics | Netherlands | Pharyngeal Neoplasms - genetics | Breast Neoplasms - genetics | Prostatic Neoplasms - genetics | Pharyngeal Neoplasms - epidemiology | Adult | Female | Aged | Bone Neoplasms - genetics | BRCA2 Protein - genetics | Breast Neoplasms - epidemiology | Cohort Studies | Physiological aspects | Breast cancer | Genetic aspects | BRCA mutations | Risk factors | Ovarian cancer | Mutation | Health risk assessment | Mortality | Genes | Index Medicus | Letter to JMG
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7. Full Text CHEK21100delC and Susceptibility to Breast Cancer: A Collaborative Analysis Involving 10,860 Breast Cancer Cases and 9,065 Controls from 10 Studies
by Easton, D and McGuffog, L and Thompson, D and Dunning, A and tee, L and Baynes, C and Healey, C and Pharoah, P and Ponder, B and Seal, S and Barfoot, R and Sodha, N and Eeles, R and Stratton, M and Rahman, N and Peto, J and Spurdle, A. B and Chen, X. Q and Chenevix-Trench, G and Hopper, J. L and Giles, G. G and McCredie, M. R. E and Syrjakoski, K and Holli, K and Kallioniemi, O and Eerola, H and Vahteristo, P and Blomqvist, C and Nevanlinna, H and Kataja, V and Mannermaa, A and Dork, T and Bremer, M and Devilee, P and de Bock, G. H and Krol-Warmerdam, E. M. M and Kroese-Jansema, K and Wijers-Koster, P and Cornelisse, C. J and Tollenaar, R. A. E. M and Meijers-Heijboer, H and Berns, E and Nagel, J and Foekens, J and Klijn, J. G. M and Schutte, M and CHEK2 Breast Cancer Case-Control Consortium and CHEK2 Breast Canc Case-Control Cons
American journal of human genetics, ISSN 0002-9297, 2004, Volume 74, Issue 6, pp. 1175 - 1182
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Gynecology. Andrology. Obstetrics | Mammary gland diseases | Biological and medical sciences | Medical sciences | Tumors | Genetics, Population | Sequence Deletion | Genetic Predisposition to Disease | Humans | Middle Aged | Risk Factors | Gene Expression Regulation, Neoplastic | Protein-Serine-Threonine Kinases - genetics | Genotype | Case-Control Studies | Breast Neoplasms - genetics | Checkpoint Kinase 2 | Adult | Female | Aged | Breast Neoplasms - diagnosis | Odds Ratio | Breast Neoplasms - epidemiology | Human genetics | Research | Index Medicus
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8. Full Text RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response
by Burger, Herman and Foekens, John and Look, Maxime and Meijer van Gelder, Marion and Klijn, Jan and Wiemer, Erik and Stoter, Gerrit and Nooter, Kees
Clinical cancer research, ISSN 1078-0432, 01/2003, Volume 9, Issue 2, pp. 827 - 836
P-Glycoprotein/genetics | Predictive Value of Tests | Recurrence | Multidrug Resistance-Associated Proteins/genetics | RNA | Transcription | Humans | Neoplasm/genetics | Multiple/genetics | Time Factors | Middle aged | Base Sequence | Neoplasm Proteins/genetics | Adult | Female | Retrospective Studies | Drug Resistance | Genetic/genetics | Gene Expression Regulation | Lymphatic Metastasis | DNA Primers | Antineoplastic Combined Chemotherapy Protocols/therapeutic use | Vault Ribonucleoprotein Particles/genetics | Membrane Transport Proteins | Survival Analysis | Breast Neoplasms/drug therapy/genetics/mortality/pathology/surgery | ATP-Binding Cassette Transporters/genetics | Aged | Messenger/genetics | Neoplastic | Life Sciences & Biomedicine | Oncology | Science & Technology | Gynecology. Andrology. Obstetrics | Mammary gland diseases | Biological and medical sciences | Medical sciences | Tumors | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Breast Neoplasms - surgery | Middle Aged | Gene Expression Regulation, Neoplastic | Vault Ribonucleoprotein Particles - genetics | ATP-Binding Cassette Transporters - genetics | Multidrug Resistance-Associated Proteins - genetics | Neoplasm Proteins - genetics | Drug Resistance, Multiple - genetics | RNA, Messenger - genetics | Breast Neoplasms - drug therapy | Breast Neoplasms - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | RNA, Neoplasm - genetics | Breast Neoplasms - mortality | Transcription, Genetic - genetics | Index Medicus
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9. Full Text Breast Cancer after Prophylactic Bilateral Mastectomy in Women with a BRCA1 or BRCA2 Mutation
by Meijers-Heijboer, Hanne and van Geel, Bert and van Putten, Wim L.J and Henzen-Logmans, Sonja C and Seynaeve, Caroline and Menke-Pluymers, Marian B.E and Bartels, Carina C.M and Verhoog, Leon C and van den Ouweland, Ans M.W and Niermeijer, Martinus F and Brekelmans, Cecile T.M and Klijn, Jan G.M
The New England journal of medicine, ISSN 0028-4793, 07/2001, Volume 345, Issue 3, pp. 159 - 164
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | Surgery of the genital tract and mammary gland | Medical sciences | Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases | Breast Neoplasms - surgery | Prospective Studies | Humans | Middle Aged | Proportional Hazards Models | Transcription Factors - genetics | Breast Neoplasms - prevention & control | Breast Neoplasms - genetics | BRCA2 Protein | Adult | Female | Genes, BRCA1 | Mastectomy, Simple | Mutation | Neoplasm Proteins - genetics | Breast Neoplasms - epidemiology | Prevention | Mastectomy | Evaluation | Breast cancer | Gene mutations | Health aspects | Women | BRCA2 gene | BRCA1 gene | mastectomy | Index Medicus | Abridged Index Medicus
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10. Full Text Combined Tamoxifen and Luteinizing Hormone-Releasing Hormone (LHRH) Agonist Versus LHRH Agonist Alone in Premenopausal Advanced Breast Cancer: A Meta-Analysis of Four Randomized Trials
by J. G.M. Klijn and R.W. Blamey and F. Boccardo and T. Tominaga and L. Duchateau and R. Sylvester and for the Combined Hormone Agents Trialists’ Group and the European Organization for Research and Treatment of Cancer and Combined Hormone Agents Trialists and European Org Res Treatment Canc and Combined Hormone Agents Trialists' Group and the European Organization for Research and Treatment of Cancer
Journal of clinical oncology, ISSN 0732-183X, 01/2001, Volume 19, Issue 2, pp. 343 - 353
Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Chemotherapy | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Goserelin - administration & dosage | Premenopause | Antineoplastic Agents, Hormonal - administration & dosage | Buserelin - therapeutic use | Humans | Breast Neoplasms - drug therapy | Tamoxifen - administration & dosage | Randomized Controlled Trials as Topic | Buserelin - administration & dosage | Neoplasm Metastasis | Breast Neoplasms - pathology | Antineoplastic Agents, Hormonal - therapeutic use | Tamoxifen - therapeutic use | Survival Analysis | Female | Neoplasms, Hormone-Dependent - drug therapy | Drug Therapy, Combination | Goserelin - therapeutic use | Gonadotropin-Releasing Hormone - agonists | Index Medicus
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11. Full Text Family system characteristics and psychological adjustment to cancer susceptibility genetic testing: a prospective study
by van Oostrom and Meijers-Heijboer and Duivenvoorden and Brocker-Vriends and van Asperen and Sijmons and Seynaeve and Van Gool and Klijn and Tibben
Clinical genetics, ISSN 0009-9163, 01/2007, Volume 71, Issue 1, pp. 35 - 42
family functioning | BRCA1/2 | HNPCC | family communication | psychological adjustment | genetic testing | Family communication | Genetic testing | Family functioning | Psychological adjustment | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Fundamental and applied biological sciences. Psychology | General aspects. Genetic counseling | Medical genetics | Biological and medical sciences | Molecular and cellular biology | Genetics of eukaryotes. Biological and molecular evolution | Medical sciences | Family - psychology | Genetic Predisposition to Disease - genetics | Prospective Studies | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Humans | Middle Aged | Colorectal Neoplasms, Hereditary Nonpolyposis - psychology | Social Support | Genetic Counseling - methods | Male | Stress, Psychological - psychology | Genetic Testing - psychology | Netherlands | Breast Neoplasms - genetics | Breast Neoplasms - psychology | Genes, BRCA2 | Adult | Female | Surveys and Questionnaires | Genes, BRCA1 | Communication | Psychotherapy | Disease susceptibility | Research | Oncology, Experimental | Genetic screening | Cancer | Psychological aspects | Families & family life | Genetic disorders | Genetic counseling | Index Medicus
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