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Nature Medicine, ISSN 1078-8956, 12/2016, Volume 22, Issue 12, pp. 1428 - 1438
Aging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the natural polyamine spermidine... 
MEDICINE, RESEARCH & EXPERIMENTAL | PRESSURE-OVERLOAD | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIAL AUTOPHAGY | PRESERVED EJECTION FRACTION | TANDEM MASS-SPECTROMETRY | DIASTOLIC HEART-FAILURE | ROBUST QUANTIFICATION | ARGININE BIOAVAILABILITY | CELL BIOLOGY | SALT-SENSITIVE RATS | AMINO-ACIDS | MYOCARDIAL HYPERTROPHY | Mitochondria, Heart - metabolism | Prospective Studies | Diastole | Gene Expression - drug effects | Longevity - drug effects | Humans | Middle Aged | Aging - drug effects | Immunoblotting | Male | Autophagy-Related Protein 5 - genetics | Chromatography, High Pressure Liquid | Mitochondria, Heart - drug effects | Autophagy - drug effects | Aging - immunology | Mass Spectrometry | Cardiovascular Diseases - epidemiology | Heart Failure | Adult | Female | Surveys and Questionnaires | Blood Pressure - drug effects | Rats, Inbred Dahl | Phosphorylation - drug effects | Cytokines - immunology | Glucose Tolerance Test | Echocardiography | Diet - statistics & numerical data | Connectin - drug effects | Cardiomegaly - diagnostic imaging | Rats | Inflammation | Cardiotonic Agents - pharmacology | Heart - diagnostic imaging | Animals | Myocytes, Cardiac - drug effects | Connectin - metabolism | Cytokines - drug effects | Mitochondrial Degradation - drug effects | Spermidine - pharmacology | Heart - drug effects | Aged | Mice | Aging - metabolism | Cardiovascular diseases | Polyamines | Research | Aging | Cardiomyocytes | Mitochondria | Kardiologi | Biological Sciences | Clinical Medicine | Cardiac and Cardiovascular Systems | Naturvetenskap | Medical and Health Sciences | Medicin och hälsovetenskap | Biologiska vetenskaper | Natural Sciences | Klinisk medicin
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2017, Volume 1619, pp. 203 - 212
Clinical lipidomics is an emerging biomarker discovery approach that compares lipid profiles under pathologically and physiologically normal conditions. Here... 
Shotgun lipidomics | Lipids | LipidXplorer | Mass spectrometry | Blood plasma | Mass Spectrometry - standards | Reproducibility of Results | Humans | Metabolome | Workflow | Statistics as Topic | Metabolomics - methods | Lipids - isolation & purification | Metabolomics - standards | Reference Standards | Lipids - blood | Software | Mass Spectrometry - methods
Journal Article
Journal Article
Developmental Cell, ISSN 1534-5807, 06/2014, Volume 29, Issue 6, pp. 729 - 739
Journal Article
Cold Spring Harbor Protocols, ISSN 1940-3402, 05/2017, Volume 2017, Issue 5, pp. 412 - 415
Thin-layer chromatography (TLC) is a versatile technique for the separation of lipid classes. It provides excellent resolution, can be used for both... 
Lipids - isolation & purification | Staining and Labeling - methods | Solvents | Phospholipids - isolation & purification | Chromatography, Thin Layer - methods | Yeasts - chemistry | Saccharomyces cerevisiae - chemistry
Journal Article
Cold Spring Harbor Protocols, ISSN 1940-3402, 05/2017, Volume 2017, Issue 5, pp. 408 - 411
Journal Article
Cold Spring Harbor Protocols, ISSN 1940-3402, 05/2017, Volume 2017, Issue 5, pp. 416 - 419
Analysis of fatty acids by gas chromatography (GC) is facilitated by the generation of volatile fatty acid methyl ester (FAME) derivatives. Here we describe... 
Fatty Acids - analysis | Chromatography, Gas - methods | Yeasts - chemistry | Methylation | Esterification | Fatty Acids, Volatile - isolation & purification
Journal Article
Analytical Chemistry, ISSN 0003-2700, 08/2018, Volume 90, Issue 16, p. 9868
Shotgun analysis provides a quantitative snapshot of the lipidome composition of cells, tissues, or model organisms; however, it does not elucidate the spatial... 
Composition | Liver | Glycerol | Lipids | Abundance | Esters | Histology | Stitching | Cholesterol | Personal computers | Proteins | Commonality | Tissue | Spatial distribution | Extraction processes | Proteomics | Ablative materials | Dissection
Journal Article
TrAC - Trends in Analytical Chemistry, ISSN 0165-9936, 2018
Human plasma lipidome has been extensively studied in many pathophysiological contexts with the hope of identifying biomarkers for early diagnostics and... 
Biomarker discovery | Lipid quantification | Human blood plasma | Lipidomics | Molecular diagnostics
Journal Article
Journal Article
Journal of Chromatography B, ISSN 1570-0232, 03/2014, Volume 951-952, Issue 1, pp. 119 - 128
Journal Article
eLife, ISSN 2050-084X, 01/2019, Volume 8
Kleiber’s law, or the 3/4 -power law scaling of the metabolic rate with body mass, is considered one of the few quantitative laws in biology, yet its... 
Metabolic rate | Life history | Laboratories | Metabolism | Allometry | Proteins | Energy balance | Hypotheses | Body mass | Animal behavior | Body size | Scaling | Physiology | Software | Energy storage
Journal Article
Analytical Chemistry, ISSN 0003-2700, 08/2018, Volume 90, Issue 16, pp. 9868 - 9878
Shotgun analysis provides a quantitative snapshot of the lipidome composition of cells, tissues, or model organisms; however, it does not elucidate the spatial... 
IMAGING MASS-SPECTROMETRY | CHEMISTRY, ANALYTICAL | HIGH-THROUGHPUT | FATTY LIVER-DISEASE | ACID-METABOLISM | BLOOD-PLASMA | PROTEIN QUANTIFICATION | ZONAL GENE-EXPRESSION | EXTRACTION SURFACE-ANALYSIS | MEMBRANE LIPIDOME | SENILE PLAQUES
Journal Article
Journal Article