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Oncogenesis, ISSN 2157-9024, 03/2018, Volume 7, Issue 3, pp. 32 - 13
Journal Article
Cancer Research, ISSN 0008-5472, 07/2014, Volume 74, Issue 18, pp. 5057 - 5069
Cancer immunotherapy generally offers limited clinical benefit without coordinated strategies to mitigate the immunosuppressive nature of the tumor... 
ACTIVATION | INHIBITION | MICROENVIRONMENT | ONCOLOGY | ADENOCARCINOMA | INFLAMMATION | KINASE | CSF | POLARIZATION | IPILIMUMAB | PROGRESSION | Receptor, Macrophage Colony-Stimulating Factor - antagonists & inhibitors | Immunotherapy - methods | Receptor, Macrophage Colony-Stimulating Factor - immunology | Adenocarcinoma - pathology | Macrophage Colony-Stimulating Factor - biosynthesis | Mannose-Binding Lectins - biosynthesis | Tissue Array Analysis | Humans | Lectins, C-Type - immunology | Tumor Microenvironment | Deoxycytidine - pharmacology | Lectins, C-Type - biosynthesis | Female | Receptors, Cell Surface - biosynthesis | Carcinoma, Pancreatic Ductal - immunology | Macrophages - immunology | Signal Transduction | Macrophage Colony-Stimulating Factor - antagonists & inhibitors | Adenocarcinoma - immunology | Mice, Inbred C57BL | Pancreatic Neoplasms - pathology | Carcinoma, Pancreatic Ductal - therapy | Random Allocation | Carcinoma, Pancreatic Ductal - pathology | Receptors, Cell Surface - immunology | Macrophage Colony-Stimulating Factor - immunology | Animals | Mannose-Binding Lectins - immunology | Pancreatic Neoplasms - immunology | T-Lymphocytes - immunology | Mice | Deoxycytidine - analogs & derivatives | Cohort Studies | Pancreatic Neoplasms - therapy | macrophage | chemoresistance | pancreatic cancer | cytokines | innate immunity | immune checkpoint
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2016, Volume 22, Issue 8, pp. 851 - 860
Single-agent immunotherapy has achieved limited clinical benefit to date in patients with pancreatic ductal adenocarcinoma (PDAC). This may be a result of the... 
MEDICINE, RESEARCH & EXPERIMENTAL | SKIN WOUND REPAIR | DUCTAL ADENOCARCINOMA | DECREASES GROWTH | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-INFILTRATING MACROPHAGES | 2 KNOCKOUT MICE | ACTIN CYTOSKELETAL REARRANGEMENT | TISSUE STIFFNESS | CELL BIOLOGY | FAK | ANTIGEN RECEPTOR | T-CELLS | Immunohistochemistry | Pancreatic Neoplasms - metabolism | Humans | Carcinoma, Pancreatic Ductal - metabolism | Tumor Microenvironment | Deoxycytidine - pharmacology | Immunoblotting | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Immunotherapy | Antimetabolites, Antineoplastic - pharmacology | Carcinoma, Pancreatic Ductal - immunology | Disease Models, Animal | Tumor Escape - immunology | Immunotherapy, Adoptive - methods | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Pancreatic Neoplasms - pathology | Reverse Transcriptase Polymerase Chain Reaction | Carcinoma, Pancreatic Ductal - pathology | Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors | Disease Progression | Animals | Aminopyridines - pharmacology | Pancreatic Neoplasms - immunology | Fibrosis | Cell Proliferation - drug effects | Mice | CD8-Positive T-Lymphocytes - immunology | Deoxycytidine - analogs & derivatives | Molecular targeted therapy | Care and treatment | Pancreatic cancer | Patient outcomes | Innovations | Genetic aspects | Properties | Phosphotransferases | Methods | Kinases | Cell adhesion & migration | pancreatic cancer | PDAC | CXCL12 | VS-4718 | immunotherapy | fibrosis | tumor microenvironment | PD-1
Journal Article
Cancer Research, ISSN 0008-5472, 02/2013, Volume 73, Issue 3, pp. 1128 - 1141
Journal Article
Immunity, ISSN 1074-7613, 08/2017, Volume 47, Issue 2, pp. 323 - 338.e6
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1250 - 19
Journal Article
Nature Communications, ISSN 2041-1723, 06/2016, Volume 7, Issue 1, p. 11762
Age is a significant risk factor for the development of cancer. However, the mechanisms that drive age-related increases in cancer remain poorly understood. To... 
LIVER-CANCER | CRUCIAL ROLE | SECRETORY PHENOTYPE | CANCER-ASSOCIATED FIBROBLASTS | TUMOR SUPPRESSION | MULTIDISCIPLINARY SCIENCES | AGE-RELATED INCREASE | IN-VIVO | GENE-EXPRESSION | SUPPRESSOR-CELLS | CELLULAR SENESCENCE
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 04/2017, Volume 23, Issue 7, pp. 1748 - 1759
Purpose: Aberrant activation of the NF-kB transcription factors underlies the aggressive behavior and poor outcome of pancreatic ductal adenocarcinoma(PDAC).... 
KINASE-ACTIVITY | SIGNALING PATHWAYS | INHIBITION | ONCOLOGY | MACROPHAGES | STELLATE CELLS | CANCER MICROENVIRONMENT | COMBINATION | NF-KAPPA-B | EXPRESSION | PROMOTES | Adenocarcinoma - pathology | Interleukin-1 Receptor-Associated Kinases - genetics | Prognosis | Apoptosis - drug effects | Deoxycytidine - administration & dosage | Humans | Adenocarcinoma - drug therapy | Carcinoma, Pancreatic Ductal - pathology | Carcinoma, Pancreatic Ductal - genetics | Xenograft Model Antitumor Assays | Carcinoma, Pancreatic Ductal - drug therapy | Drug Resistance, Neoplasm - genetics | Animals | Adenocarcinoma - genetics | Cell Proliferation - drug effects | Mice | Gene Expression Regulation, Neoplastic - drug effects | Deoxycytidine - analogs & derivatives | Cell proliferation | Adenocarcinoma | Phosphorylation | Transcription factors | Gemcitabine | Interleukin | Chemoresistance | Staining | Activation | Kinases | Proteins | Receptors | Transcription activation | Surgery | Interleukin 1 | Toll-like receptors | Pancreas | Immune system | IRAK protein | CRISPR | NF-κB protein | Aggressive behavior | Cytokines | Secretion | RNA-mediated interference | Pharmacology | Inflammation | Ribonucleic acid--RNA | Ablation | Signaling | Inhibitors | DNA microarrays | Experimental design | Medical prognosis | Cell lines | Fibrosis | In vivo methods and tests | Aberration | Cancer | Apoptosis
Journal Article
Gut, ISSN 0017-5749, 05/2019, p. gutjnl-2018-317424
We investigated how pancreatic cancer developed resistance to focal adhesion kinase (FAK) inhibition over time. Pancreatic ductal adenocarcinoma (PDAC) tumours... 
Journal Article
Immunity, ISSN 1074-7613, 09/2017, Volume 47, Issue 3, pp. 597 - 597
(Immunity 47, 323-338; August 15, 2017) Main Text The authors omitted the accession number for the microarray data used in Figures 6 and 7 in the originally... 
IMMUNOLOGY | Macrophages | Development and progression | Pancreatic cancer | Adenocarcinoma | Hematopoiesis | Pancreas | Gene expression | Embryos | Hemopoiesis
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 06/2016, Volume 76, Issue 12, pp. 3484 - 3495
Integrin beta 3 is critical for tumor invasion, neoangiogenesis, and inflammation, making it a promising cancer target. However, preclinical and clinical data... 
BETA-3-INTEGRIN | ANGIOGENESIS | ONCOLOGY | RANDOMIZED PHASE-II | NEWLY-DIAGNOSED GLIOBLASTOMA | MACROPHAGES | ALPHA-V-BETA-3 INTEGRIN | INHIBITOR CILENGITIDE | BONE | TUMOR-GROWTH | T-CELLS
Journal Article
Immunity, ISSN 1074-7613, 09/2017, Volume 47, Issue 3, p. 597
(Immunity 47, 323–338; August 15, 2017)Main TextThe authors omitted the accession number for the microarray data used in Figures 6 and 7 in the originally... 
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 12/2015, Volume 14, Issue 12 Supplement 2, pp. B197 - B197
Journal Article
Science translational medicine, ISSN 1946-6234, 07/2019, Volume 11, Issue 499, p. eaau9240
Although checkpoint immunotherapies have revolutionized the treatment of cancer, not all tumor types have seen substantial benefit. Pancreatic ductal... 
MEDICINE, RESEARCH & EXPERIMENTAL | ADHESION | RESPONSES | DENDRITIC CELLS | INTEGRIN | INFLAMMATION | TUMOR-INFILTRATING MACROPHAGES | MAC-1 | IMPROVES | BLOCKADE | EXPRESSION | CELL BIOLOGY
Journal Article
The Journal of surgical research, ISSN 0022-4804, 4/2015, Volume 194, Issue 2, pp. 653 - 658
Journal Article
Cancer research, ISSN 0008-5472, 6/2016, Volume 76, Issue 12, pp. 3484 - 3495
Integrin beta3 is critical for tumor invasion, neoangiogenesis, and inflammation making it a promising cancer target. However, preclinical and clinical data of... 
Journal Article