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The New England Journal of Medicine, ISSN 0028-4793, 04/2019, Volume 380, Issue 15, p. 1476
The article discusses the findings of a study to evaluate the safety and efficacy of verubecestat as a form of treatment for patients with Prodromal... 
Treatment outcome | Care and treatment | Usage | Enzyme inhibitors | Safety and security measures | Analysis | Alzheimer's disease
Journal Article
JAMA Neurology, ISSN 2168-6149, 09/2016, Volume 73, Issue 9, pp. 1051 - 1052
Journal Article
Nature Reviews Neurology, ISSN 1759-4758, 11/2016, Volume 12, Issue 11, pp. 620 - 621
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 04/2019, Volume 380, Issue 15, pp. 1476 - 1478
Some trials fail because the experimental treatment proves to be no different than a control or standard intervention. Others fail because of unacceptable side... 
BACE1 | MEDICINE, GENERAL & INTERNAL | ALZHEIMERS-DISEASE | Enzymes | Cognition & reasoning | Cognitive ability | Clinical trials | β-Amyloid | Mutation | Secretase | Dementia
Journal Article
Neurology, ISSN 0028-3878, 03/2018, Volume 90, Issue 10, pp. 447 - 448
The pathogenesis of Alzheimer disease (AD) remains a work in progress even as we approach the 50-year anniversary of the modern exploration of late-life... 
CLINICAL NEUROLOGY | DISEASE
Journal Article
JAMA Neurology, ISSN 2168-6149, 01/2019, Volume 76, Issue 1, pp. 15 - 16
Knopman expresses insights on the randomized controlled trial by Sha et al which focuses on the novel and unconventional approach to Alzheimer disease (AD)... 
CLINICAL NEUROLOGY | Therapy | Medical research | Brain | Intravenous administration | Neurodegenerative diseases | Neurobiology | Clinical trials | Clinical outcomes | Blood | Parabiosis | Young people | Infusion | Randomization | Blood circulation | Neurodegeneration | Surgery | Mice | Alzheimers disease | Transgenes | Alzheimer's disease
Journal Article
Nature Reviews Neurology, ISSN 1759-4758, 02/2019, Volume 15, Issue 2, pp. 61 - 62
Journal Article
Neurology, ISSN 0028-3878, 06/2017, Volume 88, Issue 24, pp. 2244 - 2245
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 2015, Volume 11, Issue 7, pp. P263 - P263
Journal Article
Neurology, ISSN 0028-3878, 05/2014, Volume 82, Issue 20, pp. 1756 - 1757
Journal Article
Neurology, ISSN 0028-3878, 05/2019, Volume 92, Issue 22, pp. 1053 - 1059
The field of Alzheimer disease (AD) has a nosologic problemThe diagnostic label “Alzheimer disease” has several distinctive meanings. The term probable AD was... 
Journal Article
Cognitive and Behavioral Neurology, ISSN 1543-3633, 09/2018, Volume 31, Issue 3, pp. 158 - 158
Journal Article
by Davies, Gail and Lam, Max and Harris, Sarah E and Trampush, Joey W and Luciano, Michelle and Hill, W. David and Hagenaars, Saskia P and Ritchie, Stuart J and Marioni, Riccardo E and Fawns-Ritchie, Chloe and Liewald, David C. M and Okely, Judith A and Ahola-Olli, Ari V and Barnes, Catriona L. K and Bertram, Lars and Bis, Joshua C and Burdick, Katherine E and Christoforou, Andrea and Derosse, Pamela and Djurovic, Srdjan and Espeseth, Thomas and Giakoumaki, Stella and Giddaluru, Sudheer and Gustavson, Daniel E and Hayward, Caroline and Hofer, Edith and Ikram, M. Arfan and Karlsson, Robert and Knowles, Emma and Lahti, Jari and Leber, Markus and Li, Shuo and Mather, Karen A and Melle, Ingrid and Morris, Derek and Oldmeadow, Christopher and Palviainen, Teemu and Payton, Antony and Pazoki, Raha and Petrovic, Katja and Reynolds, Chandra A and Sargurupremraj, Muralidharan and Scholz, Markus and Smith, Jennifer A and Smith, Albert V and Terzikhan, Natalie and Thalamuthu, Anbupalam and Trompet, Stella and Van Der Lee, Sven J and Ware, Erin B and Windham, B. Gwen and Wright, Margaret J and Yang, Jingyun and Yu, Jin and Ames, David and Amin, Najaf and Amouyel, Philippe and Andreassen, Ole A and Armstrong, Nicola J and Assareh, Amelia A and Attia, John R and Attix, Deborah and Avramopoulos, Dimitrios and Bennett, David A and Böhmer, Anne C and Boyle, Patricia A and Brodaty, Henry and Campbell, Harry and Cannon, Tyrone D and Cirulli, Elizabeth T and Congdon, Eliza and Conley, Emily Drabant and Corley, Janie and Cox, Simon R and Dale, Anders M and Dehghan, Abbas and Dick, Danielle and Dickinson, Dwight and Eriksson, Johan G and Evangelou, Evangelos and Faul, Jessica D and Ford, Ian and Freimer, Nelson A and Gao, He and Giegling, Ina and Gillespie, Nathan A and Gordon, Scott D and Gottesman, Rebecca F and Griswold, Michael E and Gudnason, Vilmundur and Harris, Tamara B and Hartmann, Annette M and Hatzimanolis, Alex and Heiss, Gerardo and Holliday, Elizabeth G and Joshi, Peter K and Kähönen, Mika and Kardia, Sharon L. R and Karlsson, Ida and Kleineidam, Luca and ...
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2098 - 16
General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and... 
COMMON VARIANTS | METAANALYSIS | REACTION-TIME | PROCESSING SPEED | MULTIDISCIPLINARY SCIENCES | INTELLIGENCE DIFFERENCES | SCHIZOPHRENIA | DCDC2 | DISCOVERY | GENOME-WIDE ASSOCIATION | REVEALS | Multifactorial Inheritance - genetics | Genetic Predisposition to Disease | Humans | Middle Aged | Genetic Loci - genetics | Neurodegenerative Diseases - genetics | Neurodevelopmental Disorders - genetics | Reaction Time - genetics | Young Adult | Mental Disorders - genetics | Adolescent | Aged, 80 and over | Cognition - physiology | Polymorphism, Single Nucleotide - genetics | Adult | Aged | Hypertension | Brain | Cognitive ability | Genomes | Gene expression | Neurodevelopmental disorders | Loci | Consortia | Illnesses | Mathematical analysis | Reaction time | Heritability | Gene loci | Polygenic inheritance | brain cortex | Medical and Health Sciences | Medicin och hälsovetenskap | major clinical study | osteoarthritis | Article | heart infarction | Klinisk medicin | lung cancer | identification method | longevity | grip strength | angina pectoris | genetic correlation | human | major depression | Neurologi | cognition | data set | aged | brain | gene locus | Clinical Medicine | Neurology | genome | vision | genetic analysis | controlled study | response time | adolescent | nervous system disorder | adult | hypertension | gene expression
Journal Article
Nature Reviews Neurology, ISSN 1759-4758, 11/2016, Volume 12, Issue 11, pp. 620 - 621
Studies of preclinical Alzheimer disease (AD) have unexpectedly shown amyloid-beta deposition and/or AD-like neurodegenerative changes in the brains of a high... 
CLINICAL NEUROLOGY | Physiology, Pathological | Research | Biological markers | Epidemiology | Alzheimer's disease | Analysis
Journal Article
by Adams, H.H and Hibar, D.P and Chouraki, V and Stein, J.L and Nyquist, P.A and Renteria, M.E and Trompet, S and Arias-Vasquez, A and Seshai, S and Desrivieres, S and Beecham, A.H and Jahanshad, N and Wittfeld, K and Lee, S.J. van der and Abramovic, L and Alhusaini, S and Amin, N and Andersson, M and Arfanakis, K and Aribisala, B.S and Armstrong, N.J and Athanasiu, L and Axelsson, T and Beiser, A and Bernard, M and Bis, J.C and Blanken, L.M and Blanton, S.H and Bohlken, M.M and Boks, M.P and Bralten, J and Brickman, A.M and Carmichael, O and Chakravarty, M.M and Chauhan, G and Chen, Q and Ching, C.R and Cuellar-Partida, G and Braber, A.D and Doan, N.T and Ehrlich, S and Filippi, I and Ge, T and Giddaluru, S and Goldman, A.L and Gottesman, R.F and Greven, C.U and Grimm, O and Griswold, M.E and Guadalupe, T.M and Hass, J and Haukvik, U.K and Hilal, S and Hofer, E and Hoehn, D and Holmes, A.J and Hoogman, M and Janowitz, D and Jia, T and Kasperaviciute, D and Kim, S and Klein, M and Kraemer, B and Lee, P.H and Liao, J and Liewald, D.C and Lopez, L.M and Luciano, M and Macare, C and Marquand, A and Matarin, M and Mather, K.A and Mattheisen, M and Mazoyer, B and McKay, D.R and McWhirter, R and Milaneschi, Y and Mirza-Schreiber, N and Muetzel, R.L and Maniega, S.M and Nho, K and Nugent, A.C and Loohuis, L.M and Oosterlaan, J and Papmeyer, M and Pappa, I and Pirpamer, L and Pudas, S and Putz, B and Rajan, K.B and Ramasamy, A and Richards, J.S and Risacher, S.L and Roiz-Santianez, R and Rommelse, N and Rose, E.J and Royle, N.A and Rundek, T and Samann, P.G and Satizabal, C.L and ... and EPIGEN and SYS and Alzheimer's Dis Neuroimaging Initi and IMAGEN and Mind Research Network, Albuquerque, NM (United States) and Medicinska fakulteten and Institutionen för integrativ medicinsk biologi (IMB) and Umeå centrum för funktionell hjärnavbildning (UFBI) and Umeå universitet
Nature Neuroscience, ISSN 1097-6256, 2016, Volume 19, Issue 12, pp. 1569 - 1582
Journal Article