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1. Full Text Distinguishing Coevolution from Covicariance in an Obligate Pollination Mutualism: Asynchronous Divergence in Joshua Tree and its Pollinators
by Christopher Irwin Smith and William K. W. Godsoe and Shantel Tank and Jeremy B. Yoder and Olle Pellmyr
Evolution, ISSN 0014-3820, 2008, Volume 62, Issue 10, pp. 2676 - 2687
Bouse Embayment | IM | pollination | coevolution | cospeciation | yucca moth | Biogeography | yucca | vicariance | Pollinating insects | Gene flow | Chloroplasts | Phylogenetics | Evolution | Moths | Coevolution | Genetic mutation | Mutualism | Pollination | Yucca | Yucca moth | Vicariance | Cospeciation | Environmental Sciences & Ecology | Ecology | Genetics & Heredity | Life Sciences & Biomedicine | Evolutionary Biology | Science & Technology | Geography | DNA, Chloroplast - chemistry | Yucca - physiology | Phylogeny | Sequence Analysis, DNA | Moths - genetics | Animals | Genetic Speciation | Bayes Theorem | Moths - physiology | Mutation | Yucca - genetics | Evolution, Molecular | Usage | Cladistic analysis | Analysis | Mutualism (Biology) | Research | Pollination by insects | Studies | Butterflies & moths | Plant reproduction | Flowers & plants | Evolutionary biology | Index Medicus
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2. Full Text Genetic evidence for a normal-weight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes
by Yaghootkar, Hanieh and Scott, Robert A and White, Charles C and Zhang, Weihua and Speliotes, Elizabeth and Munroe, Patricia B and Ehret, Georg B and Bis, Joshua C and Fox, Caroline S and Walker, Mark and Borecki, Ingrid B and Knowles, Joshua W and Yerges-Armstrong, Laura and Ohlsson, Claes and Perry, John R. B and Chambers, John C and Kooner, Jaspal S and Franceschini, Nora and Langenberg, Claudia and Hivert, Marie-France and Dastani, Zari and Richards, J. Brent and Semple, Robert K and Frayling, Timothy M and Göteborgs universitet and Gothenburg University and Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition and Sahlgrenska Academy and Centre for Bone and Arthritis Research and Sahlgrenska akademin and Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Diabetes (New York, N.Y.), ISSN 0012-1797, 12/2014, Volume 63, Issue 12, pp. 4369 - 4377
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Body Mass Index | Genetic Predisposition to Disease | Intra-Abdominal Fat | Diabetes Mellitus, Type 2 - genetics | Humans | Obesity - genetics | Lipodystrophy - genetics | Phenotype | Metabolic Syndrome - genetics | Coronary Artery Disease - genetics | Insulin Resistance - genetics | Subcutaneous Fat | Hypertension - genetics | Odds Ratio | Hypertension | Type 2 diabetes | Analysis | Insulin resistance | Genetic aspects | Coronary heart disease | Risk factors | Cardiovascular disease | Diabetes | Risk assessment | Index Medicus | Abridged Index Medicus | Metabolomics | Genetics | Genomes | Proteomics | Endokrinologi och diabetes | Endocrinology and Diabetes
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3. Cascade screening for familial hypercholesterolemia and the use of genetic testing
by Knowles, Joshua W and Rader, Daniel J and Khoury, Muin J
JAMA : the journal of the American Medical Association, ISSN 0098-7484, 07/2017, Volume 318, Issue 4, pp. 381 - 382
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Pedigree | Humans | Female | Hyperlipoproteinemia Type II - diagnosis | Male | Genetic Testing - methods | Hyperlipoproteinemia Type II - genetics | Screening | Genetic disorders | Hypercholesterolemia | Medical treatment | Arteriosclerosis | Atherosclerosis | Cardiovascular disease | Medical diagnosis | Medical screening | Cardiovascular diseases | Cholesterol | Genetic screening
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4. Full Text Statins in Familial Hypercholesterolemia: Translating Evidence to Action
by Knowles, Joshua W
Journal of the American College of Cardiology, ISSN 0735-1097, 07/2016, Volume 68, Issue 3, pp. 261 - 264
genetic | PCSK9 | statin | LDL | prevention | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Health risk assessment | Low density lipoprotein | Mortality | Statins
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5. Full Text Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity
by Burridge, Paul W and Li, Yong Fuga and Matsa, Elena and Wu, Haodi and Ong, Sang-Ging and Sharma, Arun and Holmström, Alexandra and Chang, Alex C and Coronado, Michael J and Ebert, Antje D and Knowles, Joshua W and Telli, Melinda L and Witteles, Ronald M and Blau, Helen M and Bernstein, Daniel and Altman, Russ B and Wu, Joseph C
Nature medicine, ISSN 1078-8956, 05/2016, Volume 22, Issue 5, pp. 547 - 556
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Mitochondria, Heart - metabolism | Reactive Oxygen Species - metabolism | Antibiotics, Antineoplastic - pharmacology | Apoptosis - drug effects | Calcium - metabolism | Humans | Middle Aged | Transcriptome | Antibiotics, Antineoplastic - adverse effects | Mitochondria, Heart - drug effects | Membrane Potential, Mitochondrial - drug effects | Flow Cytometry | Adult | Female | Real-Time Polymerase Chain Reaction | Cardiotoxicity - genetics | DNA Damage - drug effects | Cell Survival - drug effects | Disease Susceptibility | Heart Failure - genetics | Breast Neoplasms - drug therapy | Myocytes, Cardiac - drug effects | Fluorescent Antibody Technique | Myocytes, Cardiac - metabolism | Aged | Polymorphism, Single Nucleotide | Oxidative Stress - drug effects | Induced Pluripotent Stem Cells | Doxorubicin - adverse effects | Doxorubicin - pharmacology | Heart Failure - chemically induced | Complications and side effects | Patient outcomes | Stem cells | Development and progression | Breast cancer | Transplantation | Cardiovascular diseases | Drug therapy | Doxorubicin | Methods | Heart failure | Chemotherapy | Toxicity | Index Medicus
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6. Full Text Clinical assessment incorporating a personal genome
by Ashley, Euan A, Dr and Butte, Atul J, MD and Wheeler, Matthew T, MD and Chen, Rong, PhD and Klein, Teri E, PhD and Dewey, Frederick E, MD and Dudley, Joel T and Ormond, Kelly E, MSc and Pavlovic, Aleksandra, BS and Morgan, Alexander A, MS and Pushkarev, Dmitry and Neff, Norma F, PhD and Hudgins, Louanne, Prof and Gong, Li, PhD and Hodges, Laura M, PhD and Berlin, Dorit S, PhD and Thorn, Caroline F, PhD and Sangkuhl, Katrin, PhD and Hebert, Joan M, MA and Woon, Mark, BSE and Sagreiya, Hersh and Whaley, Ryan, BS and Knowles, Joshua W, MD and Chou, Michael F, PhD and Thakuria, Joseph V, MD and Rosenbaum, Abraham M, PhD and Zaranek, Alexander Wait, PhD and Church, George M, PhD and Greely, Henry T, Prof and Quake, Stephen R, PhD and Altman, Russ B, Prof
The Lancet (British edition), ISSN 0140-6736, 2010, Volume 375, Issue 9725, pp. 1525 - 1535
Internal Medicine | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | General aspects | Medical sciences | Genetic Testing | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Family Health | Male | Death, Sudden, Cardiac | Genetic Counseling | Desmoplakins - genetics | Cytochrome P450 Family 4 | Adult | Genetic Predisposition to Disease - genetics | Pharmacogenetics | Risk Assessment | Membrane Proteins - genetics | Vascular Diseases - genetics | Sequence Analysis, DNA | Vitamin K Epoxide Reductases | Osteoarthritis - genetics | Carrier Proteins - genetics | Cytochrome P-450 CYP2C19 | Pedigree | Cytochrome P-450 Enzyme System - genetics | Environment | Polymorphism, Single Nucleotide | Mutation | Genome, Human | Lipoprotein(a) - genetics | Mixed Function Oxygenases - genetics | Medical research | Medical colleges | Genomics | Medical genetics | Genetic research | Medicine, Experimental | Genetic translation | Cardiovascular disease | Genetics | Decision making | Index Medicus | Abridged Index Medicus
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7. Full Text Is ACS in Young Patients a “Canary in the Coal Mine” for Familial Hypercholesterolemia?
by Knowles, Joshua W and Sarraju, Ashish
Journal of the American College of Cardiology, ISSN 0735-1097, 10/2017, Volume 70, Issue 14, pp. 1741 - 1743
cascade screening | early onset coronary artery disease | low-density lipoprotein cholesterol | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Heart | Genes | Coronary artery | Cardiovascular disease | Lipids | Identification | Medical screening | Patients | Low density lipoprotein | Cholesterol | Hypercholesterolemia | Coal mines | Population | Mutation | Coal mining | Acute coronary syndromes | Health risk assessment | Statins
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8. Full Text Genome-wide Characterization of Shared and Distinct Genetic Components that Influence Blood Lipid Levels in Ethnically Diverse Human Populations
by Coram, Marc A and Duan, Qing and Hoffmann, Thomas J and Thornton, Timothy and Knowles, Joshua W and Johnson, Nicholas A and Ochs-Balcom, Heather M and Donlon, Timothy A and Martin, Lisa W and Eaton, Charles B and Robinson, Jennifer G and Risch, Neil J and Zhu, Xiaofeng and Kooperberg, Charles and Li, Yun and Reiner, Alex P and Tang, Hua
American journal of human genetics, ISSN 0002-9297, 06/2013, Volume 92, Issue 6, pp. 904 - 916
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Genome-Wide Association Study | Hispanic Americans - genetics | Humans | Lipids - blood | Middle Aged | African Americans - genetics | Female | Aged | Chromosomes, Human | Models, Genetic | Polymorphism, Single Nucleotide | Genetic Loci | Genotype & phenotype | Atherosclerosis | Lipids | Cardiovascular disease | Multiculturalism & pluralism | Risk factors | Cholesterol | Index Medicus
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9. Full Text The role of registries and genetic databases in familial hypercholesterolemia
by Kindt, Iris and Mata, Pedro and Knowles, Joshua W
Current opinion in lipidology, ISSN 0957-9672, 04/2017, Volume 28, Issue 2, pp. 152 - 160
genetic screening | familial hypercholesterolemia | registries | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Phenotype | Hyperlipoproteinemia Type II - epidemiology | Humans | Databases, Genetic | Genotype | Hyperlipoproteinemia Type II - diagnosis | Registries | Genetic Testing - economics | Hyperlipoproteinemia Type II - genetics | Index Medicus
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10. Full Text Usual Blood Pressure and New-Onset Diabetes Risk: Evidence From 4.1 Million Adults and a Meta-Analysis
by Knowles, Joshua W and Reaven, Gerald
Journal of the American College of Cardiology, ISSN 0735-1097, 04/2016, Volume 67, Issue 13, pp. 1656 - 1657
Blood Pressure | Hypertension | Adult | Diabetes Mellitus, Type 2 | Diabetes Mellitus | Humans | Diuretics | Insulin resistance | Blood pressure | Diabetes | Insulin
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11. Full Text Use of High-Intensity Statins for Patients with Atherosclerotic Cardiovascular Disease in the Veterans Affairs Health System: Practice Impact of the New Cholesterol Guidelines
by Rodriguez, Fatima, MD, MPH and Lin, Shoutzu, MS and Maron, David J., MD and Knowles, Joshua W., MD, PhD and Virani, Salim S., MD, PhD and Heidenreich, Paul A., MD, MS
The American heart journal, ISSN 0002-8703, 2016, Volume 182, pp. 97 - 102
Cardiovascular | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Simvastatin - therapeutic use | United States - epidemiology | Healthcare Disparities - statistics & numerical data | Guideline Adherence - statistics & numerical data | Rosuvastatin Calcium - therapeutic use | Humans | Middle Aged | Male | Coronary Artery Disease - drug therapy | Coronary Artery Disease - blood | Medication Therapy Management - standards | Veterans Health | American Heart Association | Medication Therapy Management - organization & administration | Anticholesteremic Agents - therapeutic use | Cholesterol, LDL - blood | Female | Aged | Coronary Artery Disease - epidemiology | Atorvastatin Calcium - therapeutic use | Care and treatment | Usage | Cardiac patients | Health care industry | Cardiovascular diseases | Hospitals, Veterans | Statins | Cholesterol | Cardiovascular agents | Cardiovascular disease | Health risk assessment | Low density lipoprotein | Index Medicus | Abridged Index Medicus
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