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NATURE, ISSN 0028-0836, 05/2012, Volume 485, Issue 7398, pp. 321 - U170
Opium is one of the world's oldest drugs, and its derivatives morphine and codeine are among the most used clinical drugs to relieve severe pain. These... 
DIPRENORPHINE | ETORPHINE | TOLERANCE | MULTIDISCIPLINARY SCIENCES | LOOP | GPCR | OLIGOMERIZATION | BINDING | RESIDUES
Journal Article
CELL, ISSN 0092-8674, 05/2015, Volume 161, Issue 5, pp. 1101 - 1111
G-protein-coupled receptors (GPCRs) transduce signals from the extracellular environment to intracellular proteins. To gain structural insight into the... 
ADRENOCEPTOR | ACTIVATION | COMPLEX | MECHANISM | PROTEIN-COUPLED RECEPTOR | CRYSTAL-STRUCTURE | KINETICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | EQUILIBRIUM | RHODOPSIN | CONFORMATIONAL STATES | CELL BIOLOGY
Journal Article
Nature, ISSN 0028-0836, 06/2017, Volume 546, Issue 7657, pp. 248 - 253
Journal Article
SCIENCE, ISSN 0036-8075, 11/2007, Volume 318, Issue 5854, pp. 1258 - 1265
Heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors constitute the largest family of eukaryotic signal transduction proteins that... 
MOLECULAR-MECHANISM | CRYSTALLIZATION | ACTIVATION | HUMAN GENOME | LIGAND-BINDING | BETA-ADRENERGIC-RECEPTOR | MEMBRANE | MULTIDISCIPLINARY SCIENCES | RHODOPSIN | HUMAN BETA-2-ADRENERGIC RECEPTOR | AGONIST
Journal Article
SCIENCE, ISSN 0036-8075, 11/2007, Volume 318, Issue 5854, pp. 1266 - 1273
The beta(2)-adrenergic receptor (beta(2)AR) is a well-studied prototype for heterotrimeric guanine nucleotide-binding protein ( G protein)-coupled receptors... 
BETA ADRENERGIC-RECEPTOR | LIGAND-BINDING SPECIFICITY | CONSTITUTIVE ACTIVATION | MULTIDISCIPLINARY SCIENCES | PROTEIN-COUPLED-RECEPTORS | CONSERVED ASPARTIC-ACID | RESONANCE ENERGY-TRANSFER | BETA-2-ADRENERGIC RECEPTORS | IDENTIFICATION | AGONISTS | INDUCED CONFORMATIONAL-CHANGES
Journal Article
NATURE, ISSN 0028-0836, 01/2011, Volume 469, Issue 7329, pp. 175 - 180
Journal Article
NATURE, ISSN 0028-0836, 08/2015, Volume 524, Issue 7565, pp. 315 - 315
Activation of the mu-opioid receptor (mu OR) is responsible for the efficacy of the most effective analgesics. To shed light on the structural basis for mu OR... 
CRYSTALLIZING MEMBRANE-PROTEINS | COMPLEX | LIPIDIC MESOPHASES | PROTEIN-COUPLED RECEPTOR | MULTIDISCIPLINARY SCIENCES | FORCE-FIELD | ADRENERGIC-RECEPTOR | MOLECULAR-DYNAMICS SIMULATIONS | CHARMM | MICE LACKING | MUSCARINIC ACETYLCHOLINE-RECEPTOR
Journal Article
NATURE, ISSN 0028-0836, 09/2011, Volume 477, Issue 7366, pp. 549 - U311
G protein-coupled receptors (GPCRs) are responsible for the majority of cellular responses to hormones and neurotransmitters as well as the senses of sight,... 
CRYSTALLIZATION | LIPIDIC MESOPHASES | ALPHA-SUBUNIT | MULTIDISCIPLINARY SCIENCES | COUPLED RECEPTOR | MEDIATED ACTIVATION | MEMBRANE-PROTEINS | ADENYLATE-CYCLASE | BINDING | BETA-ADRENERGIC RECEPTOR | INSIGHTS
Journal Article
Nature, ISSN 0028-0836, 03/2016, Volume 531, Issue 7594, pp. 335 - 340
Journal Article
NATURE, ISSN 0028-0836, 11/2007, Volume 450, Issue 7168, pp. 383 - U4
Structural analysis of G-protein-coupled receptors (GPCRs) for hormones and neurotransmitters has been hindered by their low natural abundance, inherent... 
CRYSTALLIZATION | AGONIST ACTIVATION | DOMAIN | CONFORMATIONAL-CHANGES | LIGAND-BINDING | BOVINE RHODOPSIN | MULTIDISCIPLINARY SCIENCES | INTERMEDIATE | CRYSTALLOGRAPHY | BACTERIORHODOPSIN | BETA-ADRENERGIC RECEPTOR
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 02/2017, Volume 114, Issue 8, pp. 2066 - 2071
The adenosine A(2A) receptor (A(2A)R) has long been implicated in cardiovascular disorders. As more selective A(2A)R ligands are being identified, its roles in... 
allosteric | COMPLEX | Parkinson's disease | MEMBRANE | MULTIDISCIPLINARY SCIENCES | HIGH-AFFINITY | structure | SOFTWARE | FEATURES | A2A adenosine receptor | PROTEIN-COUPLED RECEPTOR | GPCR | ZM241385 | DERIVATIVES | PARKINSONS-DISEASE
Journal Article
Nature, ISSN 0028-0836, 01/2010, Volume 463, Issue 7277, pp. 108 - 112
Journal Article
NATURE, ISSN 0028-0836, 03/2019, Volume 567, Issue 7747, pp. E10 - E10
Journal Article
Journal of The American Society for Mass Spectrometry, ISSN 1044-0305, 5/2015, Volume 26, Issue 5, pp. 808 - 817
G protein-coupled receptors (GPCRs) have important roles in physiology and pathology, and 40% of drugs currently on the market target GPCRs for the treatment... 
Biotechnology | Chemistry | Analytical Chemistry | Detergent | HDX-MS | Proteomics | GPCR | Bicelles | Bioinformatics | Organic Chemistry | Conformation | EX1 | CHEMISTRY, ANALYTICAL | BETA ADRENERGIC-RECEPTOR | H/D EXCHANGE | CRYSTAL-STRUCTURE | DRUG DISCOVERY | BIOCHEMICAL RESEARCH METHODS | CHEMISTRY, PHYSICAL | MEMBRANE-PROTEIN | STRUCTURAL BIOLOGY | SPECTROSCOPY | DEUTERIUM-EXCHANGE | HYDROGEN-EXCHANGE | BETA-ADRENERGIC RECEPTOR | LIPID-BILAYER | Detergents - chemistry | Receptor, PAR-1 - metabolism | Humans | Molecular Sequence Data | Recombinant Fusion Proteins - metabolism | Feasibility Studies | Maltose - chemistry | Receptors, Adrenergic, beta-2 - chemistry | Deuterium Exchange Measurement | Spectrometry, Mass, Electrospray Ionization | Micelles | Protein Structure, Tertiary | Receptor, PAR-1 - chemistry | Amino Acid Sequence | Receptors, Opioid, mu - chemistry | Receptors, Adrenergic, beta-2 - genetics | Receptors, Opioid, mu - metabolism | Solubility | Models, Molecular | Recombinant Fusion Proteins - chemistry | Protein Folding | Receptor, PAR-1 - genetics | Receptors, Adrenergic, beta-2 - metabolism | Maltose - analogs & derivatives | Protein Conformation | Kinetics | Lipid Bilayers - chemistry | Lipid Bilayers - metabolism | Receptors, Opioid, mu - genetics | Proteins | Detergents, Synthetic | Proteases | Conformational analysis | Physiological aspects | G proteins | Mass spectrometry | Protein binding | Deuterium | Spectroscopy | Receptors | Scientific imaging | Detergents | Solubilization | Binding sites
Journal Article
CELL, ISSN 0092-8674, 09/2015, Volume 162, Issue 6, pp. 1431 - 1431
Journal Article
Nature Methods, ISSN 1548-7091, 11/2007, Volume 4, Issue 11, pp. 927 - 929
Journal Article