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Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 7770 - 11
Journal Article
Proteins: Structure, Function and Bioinformatics, ISSN 0887-3585, 04/2009, Volume 75, Issue 1, pp. 139 - 146
Antibody modeling is widely used for the analysis of antibody-antigen interactions and for the design of potent antibody drugs. The antibody combining site is... 
Antibody modeling | Canonical structures | CDR-L3 | Complementarity determining regions | DOMAIN | FAB FRAGMENT | complementarity determining regions | BIOCHEMISTRY & MOLECULAR BIOLOGY | antibody modeling | IMMUNOGLOBULINS | HYPERVARIABLE REGION | canonical structures | CONFORMATIONS | BIOPHYSICS | DATABASE | STRUCTURAL CLASSIFICATION | PROTEINS | RESHAPING HUMAN-ANTIBODIES
Journal Article
Journal Article
BIOTECHNOLOGY AND BIOENGINEERING, ISSN 0006-3592, 01/2012, Volume 109, Issue 1, pp. 53 - 62
A novel thermostable NAD(P)H oxidase from the hyperthermophilic archaeon Thermococcus kodakarensis KOD1 (TkNOX) catalyzes oxidation of NADH and NADPH with... 
ENZYME-CATALYZED SYNTHESIS | alcohol dehydrogenase | cofactor regeneration | NAD(P)H oxidase | hyperthermophile | high temperature | FORMATE DEHYDROGENASE | KETONES | REDUCTION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ALCOHOL-DEHYDROGENASE | LACTOBACILLUS-BREVIS | THERMOCOCCUS-KODAKARAENSIS KOD1 | GLYCEROL DEHYDROGENASE | WATER
Journal Article
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, ISSN 0387-5911, 11/2016, Volume 90, Issue 6, pp. 792 - 797
Journal Article
Journal of Pharmacological Sciences, ISSN 1347-8613, 2013, Volume 122, Issue 3, pp. 176 - 183
A growing body of evidence suggests that podocyte apoptosis is a major cause of decreased podocyte number, which leads to albuminuria and glomerular injury.... 
Journal Article
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, ISSN 0387-5911, 11/2016, Volume 90, Issue 6, p. 792
In 2013, two outbreaks of enterohemorrhagic Escherichia coli (EHEC) occurred in Saitama city. According to reports from each of the medical institutions that... 
Escherichia coli Infections - epidemiology | Escherichia coli O157 - genetics | Disease Outbreaks | Humans | Japan | Bacterial Proteins - genetics | Escherichia coli Infections - microbiology | Female | Male | Shiga Toxin 2 - genetics
Journal Article
Biotechnology and Bioengineering, ISSN 0006-3592, 01/2012, Volume 109, Issue 1, p. 53
  A novel thermostable NAD(P)H oxidase from the hyperthermophilic archaeon Thermococcus kodakarensis KOD1 (TkNOX) catalyzes oxidation of NADH and NADPH with... 
Enzymes | Catalytic oxidation | Gram-positive bacteria | High temperature | Chemical compounds
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2017, Volume 12, Issue 1, p. e0169258
textabstractAim: The combination of weight excess and hypertension significantly contributes to cardiovascular risk and progressive kidney damage. An... 
GLOMERULAR-FILTRATION-RATE | DOUBLE-BLIND TRIAL | COLLECTING DUCT RENIN | MULTIDISCIPLINARY SCIENCES | BODY-MASS INDEX | SMOOTH-MUSCLE-CELLS | ANGIOTENSIN-II | (PRO)RENIN RECEPTOR | BLOOD-PRESSURE | INHIBITOR ALISKIREN | URINARY RENIN | Antihypertensive Agents - pharmacology | Overweight - complications | Humans | Middle Aged | Hypertension - drug therapy | Male | Glomerular Filtration Rate - drug effects | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Renal Circulation - drug effects | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Ramipril - pharmacology | Ramipril - therapeutic use | Amides - pharmacology | Albuminuria - etiology | Double-Blind Method | Fumarates - therapeutic use | Kidney Diseases - prevention & control | Renin-Angiotensin System - physiology | Amides - therapeutic use | Overweight - physiopathology | Albuminuria - prevention & control | Antihypertensive Agents - therapeutic use | Hypertension - physiopathology | Cross-Over Studies | Renin - antagonists & inhibitors | Fumarates - pharmacology | Hypertension - complications | Renin-Angiotensin System - drug effects | Hemodynamics - drug effects | Kidney Diseases - etiology | Blood Pressure Monitoring, Ambulatory | Hypertension | Renin inhibitors | Care and treatment | Analysis | Dosage and administration | Hemodynamics | Research | Renin-angiotensin system | Nephrology | Clinical trials | Randomization | Renin | Peptidyl-dipeptidase A | Rodents | Blood pressure | Inhibition | Drug dosages | Obesity | Filtration | Kidneys | Health risks | Pharmacology | Metabolism | Angina pectoris | Glomerular filtration rate | Medicine | Direct reduced iron | Weight reduction | Angiotensin | Diabetes | Circulatory system | Cardiovascular diseases
Journal Article
by Kodani, Eitaro and Atarashi, Hirotsugu and Inoue, Hiroshi and Okumura, Ken and Yamashita, Takeshi and Otsuka, Toshiaki and Tomita, Hirofumi and Origasa, Hideki and Sakurai, M and Kawamura, Y and Kubota, I and Kaneko, Y and Matsumoto, K and Ogawa, S and Aizawa, Y and Kodama, I and Watanabe, E and Koretsune, Y and Okuyama, Y and Shimizu, A and Igawa, O and Bando, S and Fukatani, M and Saikawa, T and Chishaki, A and Kato, N and Kanda, K and Kato, J and Obata, H and Aoki, M and Honda, H and Konta, Y and Hatayama, T and Abe, Y and Terata, K and Yagi, T and Ishida, A and Komatsu, T and Tachibana, H and Suzuki, H and Kamiyama, Y and Watanabe, T and Oguma, M and Itoh, M and Hirono, O and Tsunoda, Y and Ikeda, K and Kanaya, T and Sakurai, K and Sukekawa, H and Nakada, S and Itoh, T and Tange, S and Manita, M and Ohta, M and Eguma, H and Kato, R and Endo, Y and Ogino, T and Yamazaki, M and Kanki, H and Uchida, M and Miyanaga, S and Shibayama, K and Toratani, N and Kojima, T and Ichikawa, M and Saito, M and Umeda, Y and Sawanobori, T and Sohara, H and Okubo, S and Okubo, T and Tokunaga, T and Kuboyama, O and Ito, H and Kitahara, Y and Sagara, K and Satoh, T and Sugi, K and Kobayashi, Y and Higashi, Y and Katoh, T and Hirayama, Y and Matsumoto, N and Takano, M and Ikeda, T and Yusu, S and Niwano, S and Nakazato, Y and Kawano, Y and Sumiyoshi, M and Hagiwara, N and Murasaki, K and Mitamura, H and Nakagawa, S and Okishige, K and Azegami, K and Aoyagi, H and Sugiyama, K and ... and J-RHYTHM Registry Investigators and J‐RHYTHM Registry Investigators and the J‐RHYTHM Registry Investigators
Journal of the American Heart Association, ISSN 2047-9980, 09/2016, Volume 5, Issue 9, p. n/a
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 03/2017, Volume 22, Issue 3, pp. 430 - 440
Journal Article
Polyhedron, ISSN 0277-5387, 12/2016, Volume 120, pp. 3 - 10
Treatment of [Ru(η -1,5-COD)(η -1,3,5-COT)] ( )/PMe with phenyl vinyl ether in the presence of water gives a tris(μ-hydroxo)diruthenium(II) complex [(Me P)... 
C–O bond activation | Tris(hydroxo)diruthenium(II) | Hydration of nitriles | Phenyl vinyl ether | Mechanism | VINYL-ACETATE | H BOND | C-O bond activation | C-O BOND | STRUCTURAL-CHARACTERIZATION | CRYSTALLOGRAPHY | OXIDATIVE ADDITION | HYDROXO COMPLEXES | HYDRIDE COMPLEXES | CHEMISTRY, INORGANIC & NUCLEAR | LOW-VALENT RUTHENIUM | CARBON-OXYGEN | X-RAY CRYSTAL
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, p. e107853
A growing body of evidence indicates that renal tissue injuries are reversible. We investigated whether dietary salt reduction with the combination therapy of... 
FIBROSIS | OXIDATIVE STRESS | PODOCYTE INJURY | MULTIDISCIPLINARY SCIENCES | KINASE | IGA NEPHROPATHY | KALLIKREIN GENE DELIVERY | INDUCED RENAL INJURY | HYPERTENSION | TYPE-2 DIABETIC-RATS | REVERSAL | Blood Pressure | Tetrazoles - pharmacology | Angiotensin Receptor Antagonists - pharmacology | Calcium Channel Blockers - therapeutic use | NADPH Oxidases - metabolism | Male | Azetidinecarboxylic Acid - analogs & derivatives | Renal Insufficiency - etiology | Receptors, Mineralocorticoid - physiology | Azetidinecarboxylic Acid - therapeutic use | Renal Insufficiency - physiopathology | Diet, Sodium-Restricted | NADPH Oxidases - genetics | Azetidinecarboxylic Acid - pharmacology | Rats, Inbred Dahl | Hypertension - therapy | Imidazoles - therapeutic use | Drug Evaluation, Preclinical | Cytokines - genetics | Gene Expression | Cytokines - metabolism | Gene Expression Regulation | Combined Modality Therapy | Imidazoles - pharmacology | Kidney Glomerulus - pathology | Calcium Channel Blockers - pharmacology | Hypertension - physiopathology | Dihydropyridines - therapeutic use | Renal Insufficiency - therapy | Animals | Dihydropyridines - pharmacology | Hypertension - complications | Tetrazoles - therapeutic use | Angiotensin Receptor Antagonists - therapeutic use | Oxidases | Hypertension | Superoxide | Angiotensin | Therapy | Oxidative stress | Salts | Nephrology | Calcium | Syngeneic grafts | Oxidase | mRNA | Kinases | NAD(P)H oxidase | Sclerosis | Reduction | Rodents | Animal tissues | Gastroenterology | Blood pressure | Angiotensin II | Drug dosages | Injuries | Age | Urine | Medical research | Kidneys | Rats | Pharmacology | Inflammation | Sodium chloride | Medicine | Studies | Injury prevention | Diet | Fibrosis | Infiltration | Diabetes | Hypertrophy | Proteinuria
Journal Article