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Biotechnology Advances, ISSN 0734-9750, 11/2018, Volume 36, Issue 6, p. 1709
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit prostanoid formation and represent prevalent therapeutics for treatment of inflammatory disorders.... 
Side effects | Polypharmacy | Inhibitors | Natural products | Lipids | Biosynthesis | Nonsteroidal anti-inflammatory drugs | Lipoxygenase | Product safety | Inflammatory diseases
Journal Article
Biotechnology Advances, ISSN 0734-9750, 11/2018, Volume 36, Issue 6, pp. 1709 - 1723
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit prostanoid formation and represent prevalent therapeutics for treatment of inflammatory disorders.... 
Leukotriene | 5-Lipoxygenase-activating protein | Cyclooxygenase | Prostaglandin | Eicosanoid | 5-Lipoxygenase | Natural product | Microsomal prostaglandin E2 synthase-1 | Polypharmacology | Arachidonic acid
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 11/2015, Volume 98, Issue 1, p. 1
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 08/2009, Volume 8, Issue 8, pp. 2348 - 2355
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2013, Volume 110, Issue 7, pp. 2546 - 2551
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 02/2012, Volume 8, Issue 2, pp. 141 - 143
Until now, a lack of inhibitors with high potency and selectivity in vivo has hampered investigation of the p38 mitogen-activated protein kinase (MAPK)... 
CELLS | ADHESION | SIGNALING PATHWAYS | DESIGN | PLAYS | MAP KINASE | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KAPPA-B | EXPRESSION | Proteins | Biochemistry | Kinases | Molecular biology
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 09/2008, Volume 326, Issue 3, pp. 975 - 982
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2017, Volume 174, Issue 11, pp. 1497 - 1508
BACKGROUND AND PURPOSE The diterpenoids carnosol (CS) and carnosic acid (CA) from Salvia spp. exert prominent anti-inflammatory activities but their molecular... 
HUMAN 5-LIPOXYGENASE | ANTIOXIDANT ACTIVITY | PROSTAGLANDIN E-2 SYNTHASE-1 | ACCURATE DOCKING | NATURAL-PRODUCTS | ESSENTIAL OIL | SALVIA-OFFICINALIS | PHARMACOLOGY & PHARMACY | SMOOTH-MUSCLE-CELLS | MPGES-1 INHIBITORS | NF-KAPPA-B | Analgesics - pharmacology | Inflammation - pathology | Lipoxygenase Inhibitors - isolation & purification | Humans | Male | Monocytes - metabolism | Diterpenes, Abietane - isolation & purification | Diterpenes, Abietane - administration & dosage | Dose-Response Relationship, Drug | Inflammation - drug therapy | Pain - drug therapy | Computer Simulation | Prostaglandin-E Synthases - antagonists & inhibitors | Anti-Inflammatory Agents - administration & dosage | Anti-Inflammatory Agents - isolation & purification | Neutrophils - metabolism | Disease Models, Animal | Analgesics - isolation & purification | Anti-Inflammatory Agents - pharmacology | Neutrophils - drug effects | Analgesics - administration & dosage | Salvia - chemistry | Pain - pathology | Lipoxygenase Inhibitors - administration & dosage | Monocytes - drug effects | Diterpenes, Abietane - pharmacology | Animals | Mice | Molecular Docking Simulation | Lipoxygenase Inhibitors - pharmacology | Physiological aspects | Enzymes | Anti-inflammatory drugs | Analysis | Animal models | Pain perception | Prostaglandin E2 | Leukocytes (neutrophilic) | Inflammation | Biological activity | Prostaglandin-E synthase | Formaldehyde | Monocytes | Molecular modelling | Analgesics | Arachidonate 5-lipoxygenase | Diterpenes | Lipoxygenase | Functional foods & nutraceuticals | Nutraceuticals | Themed Section | Research Papers | Research Paper
Journal Article
British Journal of Cancer, ISSN 0007-0920, 01/2018, Volume 118, Issue 1, pp. 43 - 51
Background: Although altered membrane physiology has been discussed within the context of cancer, targeting membrane characteristics by drugs being an... 
proliferation | metastasis | soraphen A | cancer | metabolism | acetyl-CoA carboxylase | tumour growth | membrane characteristics | CHEMICAL INHIBITION | FATTY-ACID SYNTHESIS | PROTECTS | CELL LUNG-CANCER | ONCOLOGY | GROWTH | MEMBRANE-LIPID THERAPY | MODULATION | Fatty Acid Synthase, Type I - genetics | Neoplasms - metabolism | Cell Proliferation | Humans | Phospholipids - analysis | Molecular Targeted Therapy | Acetyl-CoA Carboxylase - genetics | Gene Knockdown Techniques | Enzyme Inhibitors - administration & dosage | Cerulenin - pharmacology | Macrolides - pharmacology | Acetyl-CoA Carboxylase - antagonists & inhibitors | Cell Membrane - drug effects | Photobleaching | Macrolides - administration & dosage | Neoplasm Invasiveness | Enzyme Inhibitors - pharmacology | Cerulenin - administration & dosage | Fatty Acid Synthase, Type I - antagonists & inhibitors | Membrane Fluidity - drug effects | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Cell Movement - drug effects | Lipogenesis - drug effects | Cell Line, Tumor | Membranes | Deformability | Deformation | Fluorescence | Confocal microscopy | Immunoblotting | Phospholipids | Drug delivery | Confocal | Composition effects | Metastases | Anticancer properties | Receptors | Fluidity | Fluorescence recovery after photobleaching | Acetyl-CoA carboxylase | Cascades | Cerulenin | Lipogenesis | Membrane vesicles | Formability | Phospholipid composition | Fatty acids | Fatty-acid synthase | Signaling | Microscopy | In vivo methods and tests | Scanning microscopy | Cancer | Tumors | Translational Therapeutics
Journal Article
FASEB Journal, ISSN 0892-6638, 10/2017, Volume 31, Issue 10, pp. 4566 - 4577
Journal Article