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index medicus (16) 16
chemistry, medicinal (13) 13
humans (12) 12
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protein kinase inhibitors - pharmacology (9) 9
janus kinase 1 - antagonists & inhibitors (7) 7
janus kinase 2 - antagonists & inhibitors (7) 7
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janus kinase 1 - chemistry (5) 5
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pyridines - chemistry (5) 5
pyridines - pharmacology (5) 5
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imidazoles - chemistry (4) 4
janus kinase (4) 4
molecular structure (4) 4
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protein kinase inhibitors - chemical synthesis (4) 4
tyk2 kinase - metabolism (4) 4
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jak1 (3) 3
janus kinase 1 - metabolism (3) 3
janus kinase 2 - metabolism (3) 3
janus kinases (3) 3
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pyridines - chemical synthesis (3) 3
pyrroles - chemistry (3) 3
pyrroles - pharmacology (3) 3
tyk2 kinase - antagonists & inhibitors (3) 3
active rheumatoid-arthritis (2) 2
administration, oral (2) 2
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imidazoles - chemical synthesis (2) 2
immunology (2) 2
inflammation (2) 2
interleukin-12 - metabolism (2) 2
jak2 (2) 2
kinase (2) 2
kinases (2) 2
kinetics (2) 2
microsomes, liver - metabolism (2) 2
myeloproliferative disorders (2) 2
physiological aspects (2) 2
prediction (2) 2
protein structure, tertiary (2) 2
protein-serine-threonine kinases - antagonists & inhibitors (2) 2
proteins (2) 2
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selectivity (2) 2
signal transduction - drug effects (2) 2
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structure-based design (2) 2
targeting btk (2) 2
tyk2 (2) 2
4-aminopyridine - analogs & derivatives (1) 1
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4-aminopyridine - pharmacology (1) 1
8-oxo-pyridopyrimidines (1) 1
abridged index medicus (1) 1
active sites (1) 1
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Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 06/2014, Volume 111, Issue 22, p. 8025
  Janus kinases (JAKs) are receptor-associated multidomain tyrosine kinases that act downstream of many cytokines and interferons. JAK kinase activity is... 
Cellular biology | Mutation | Kinases | Cancer
Journal Article
Nature, ISSN 0028-0836, 03/2011, Volume 471, Issue 7336, pp. 110 - 114
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2018, Volume 61, Issue 6, pp. 2227 - 2245
Bruton's tyrosine kinase (Btk) is a nonreceptor cytoplasmic tyrosine kinase involved in B-cell and myeloid cell activation, downstream of B-cell and Fc gamma... 
IRREVERSIBLE INHIBITORS | CHEMISTRY, MEDICINAL | BTK INHIBITOR | INFLAMMATORY DISEASES | B-CELL MALIGNANCIES | MURINE LUPUS | DRUG DESIGN | IBRUTINIB | CHRONIC LYMPHOCYTIC-LEUKEMIA | MEDIATED GLOMERULONEPHRITIS | TARGETING BTK
Journal Article
Nature Communications, ISSN 2041-1723, 01/2018, Volume 9, Issue 1, pp. 179 - 14
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 09/2013, Volume 67, Issue C, pp. 175 - 187
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2018, Volume 61, Issue 6, pp. 2227 - 2245
Bruton’s tyrosine kinase (Btk) is a nonreceptor cytoplasmic tyrosine kinase involved in B-cell and myeloid cell activation, downstream of B-cell and Fcγ... 
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2017, Volume 60, Issue 2, pp. 627 - 640
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2019, Volume 29, Issue 12, pp. 1497 - 1501
Receptor-interacting protein kinase 1 (RIPK1), a key component of the cellular necroptosis pathway, has gained recognition as an important therapeutic target.... 
Metabolic stability | Pentafluoroethyl | RIPK1 | Necroptosis | RIPK1 inhibitor | RIP KINASES | HOMEOSTASIS | CHEMISTRY, MEDICINAL | INFLAMMATION | CHEMISTRY, ORGANIC | HIGHLY POTENT | DISCOVERY | International trade | Protein kinases | Analysis
Journal Article
Science translational medicine, ISSN 1946-6234, 11/2018, Volume 10, Issue 468, p. eaao2151
Preclinical and clinical evidence indicates that a subset of asthma is driven by type 2 cytokines such as interleukin-4 (IL-4), IL-5, IL-9, and IL-13.... 
MEDICINE, RESEARCH & EXPERIMENTAL | TYPE-2 INFLAMMATION | POTENT | INTERLEUKIN-4 | PATENT LITERATURE 2013-2015 | PHOSPHORYLATION | RECEPTOR | JAK-FAMILY KINASES | GUINEA-PIGS | IDENTIFICATION | SELECTIVITY | CELL BIOLOGY
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2019, Volume 29, Issue 12, pp. 1522 - 1531
Disruption of interleukin-13 (IL-13) signaling with large molecule antibody therapies has shown promise in diseases of allergic inflammation. Given that IL-13... 
Janus Kinase | JAK | Atopic dermatitis | Structure-based design | Interleukin-13 | IL-13 | JAK2 | JAK1 | Asthma | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | IDENTIFICATION | Viral antibodies | Antibodies | Mutual fund industry | Interleukins
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2013, Volume 56, Issue 11, pp. 4521 - 4536
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 12/2012, Volume 22, Issue 24, pp. 7627 - 7633
Journal Article