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Journal of Alzheimer's Disease, ISSN 1387-2877, 01/2011, Volume 24, Issue 2, pp. 315 - 325
The field of Alzheimers disease (AD) research eagerly awaits the results of a large number of Phase III clinical trials that are underway to investigate the... 
Journal Article
Journal of Alzheimer's Disease, ISSN 1387-2877, 01/2011, Volume 27, Issue 2, pp. 361 - 376
Transgenic (Tg) mouse models of Alzheimers disease (AD) have been genetically altered with human familial AD genes driven by powerful promoters. However, a Tg... 
Journal Article
Journal of Alzheimer's Disease, ISSN 1387-2877, 02/2016, Volume 50, Issue 3, pp. 645 - 658
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2012, Volume 7, Issue 5, p. e36893
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2011, Volume 6, Issue 11, p. e27291
The amyloid cascade hypothesis provides an economical mechanistic explanation for Alzheimer's disease (AD) dementia and correlated neuropathology. However,... 
EPITHELIUM-DERIVED FACTOR | INSULIN-DEGRADING ENZYME | CEREBROSPINAL-FLUID S100B | FIBRILLARY ACIDIC PROTEIN | MULTIDISCIPLINARY SCIENCES | PAIRED HELICAL FILAMENTS | AMYLOID PRECURSOR PROTEIN | CEREBRAL-BLOOD-FLOW | PIGMENT-EPITHELIUM | ENDOTHELIAL GROWTH-FACTOR | APOLIPOPROTEIN-E | Alzheimer Disease - physiopathology | Enzyme-Linked Immunosorbent Assay | Humans | Male | Amyloid beta-Protein Precursor - analysis | Neurofibrillary Tangles | Case-Control Studies | Aging - pathology | Dementia - etiology | Cognition Disorders - etiology | Aged, 80 and over | Amyloid beta-Peptides - analysis | Female | tau Proteins - analysis | Advertising executives | Endothelial growth factors | Physiological aspects | Biochemistry | Apolipoproteins | Alzheimer's disease | Enzyme-linked immunosorbent assay | Neurophysiology | Brain | Neuroprotection | Peptides | Mental disorders | Laboratories | Neuropathology | Mental health | Cognitive ability | Homeostasis | S100b protein | Protein turnover | Proteins | Angiogenesis | Neurotoxicity | Ischemia | Neurodegeneration | Apolipoprotein E | Dementia disorders | Aging | Pigment epithelium-derived factor | Vascular endothelial growth factor | Plaques | Age | Medical research | Automation | Neurodegenerative diseases | Metabolism | Epithelium | Disease control | Studies | Pathology | Hypotheses | Neurofibrillary tangles | Brain research | Tau protein | Perfusion | Brain damage | Microvasculature | Mutation | Alzheimers disease | Psychiatry | Dementia | Nonagenarian
Journal Article
Neurochemistry International, ISSN 0197-0186, 11/2017, Volume 110, p. 1
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1016/j.neuint.2017.08.007 
Post-translational modification | Peptides | Gene expression | Alzheimer's disease | Analysis | Target marketing
Journal Article
Neurochemistry international, ISSN 0197-0186, 11/2017, Volume 110, pp. 1 - 13
The amyloid cascade hypothesis of Alzheimer’s disease (AD) proposes amyloid-β (Aβ) is a chief pathological element of dementia. AD therapies have targeted... 
Journal Article
Alzheimer's & Dementia, ISSN 1552-5260, 11/2012, Volume 8, Issue 6, pp. 574 - 583
Here, we synthesize several lines of evidence supporting the hypothesis that at least one function of amyloid-[beta] is to serve as a part of the acute... 
Leakage | Brain | Head | Deposits | Neurodegenerative diseases | Diabetes mellitus | Trauma | Adhesives | Dementia disorders | Amyloid | Amyloidosis | Microvasculature | Hemodynamics | Cardiovascular diseases | Alzheimer's disease | Physicochemical properties
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, p. e59735
The characteristic neuropathological changes associated with Alzheimer's disease (AD) and other lines of evidence support the amyloid cascade hypothesis.... 
IMMUNIZATION | CHEMICAL-CHARACTERIZATION | RISK-FACTORS | DEPOSITS | ALZHEIMERS-DISEASE | IMAGING ABNORMALITIES | PASSIVE IMMUNOTHERAPY | MULTIDISCIPLINARY SCIENCES | PEPTIDE REMNANTS | PATHOLOGY | BRAIN-BARRIER BREAKDOWN | Immunotherapy - methods | Enzyme-Linked Immunosorbent Assay | Amyloid beta-Protein Precursor - chemistry | Humans | Alzheimer Disease - therapy | Cognition Disorders - metabolism | Male | Tomography, X-Ray Computed | Cerebral Amyloid Angiopathy - metabolism | tau Proteins - chemistry | Peptide Fragments - chemistry | Antibodies, Monoclonal, Humanized - pharmacology | Alzheimer Disease - metabolism | Aged, 80 and over | Brain - pathology | Female | Aged | Amyloid beta-Peptides - chemistry | Alzheimer Disease - immunology | Antibodies, Monoclonal, Humanized - chemistry | Nuclear magnetic resonance--NMR | Peptides | Laboratories | Neuropathology | Pathogenesis | Cognitive ability | Clinical trials | Biochemistry | Western blotting | Cerebral amyloid angiopathy | Biochemical composition | Immunotherapy | Dementia disorders | Tumor necrosis factor-TNF | Meninges | Species | Alzheimer's disease | Enzyme-linked immunosorbent assay | Medical research | Encephalitis | Temporal lobe | Immunization | Patients | Amyloid precursor protein | Pathology | Neurology | Hypotheses | Brain research | Tau protein | Mutation | Dementia | Nuclear magnetic resonance | NMR
Journal Article
CNS and Neurological Disorders - Drug Targets, ISSN 1871-5273, 2009, Volume 8, Issue 2, pp. 88 - 97
Post mortem examinations of AN-1792-vaccinated humans revealed this therapy produced focal senile plaque disruption. Despite the dispersal of substantial... 
TRANSGENIC MICE EXHIBIT | A-BETA IMMUNIZATION | ALZHEIMERS-DISEASE | MOUSE MODEL | VACCINATION | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | A-BETA-42 IMMUNIZATION | PRECURSOR PROTEIN | UNIFYING HYPOTHESIS | NEUROSCIENCES | MEMORY LOSS
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 2012, Volume 8, Issue 6, pp. 574 - 583
Abstract Here, we synthesize several lines of evidence supporting the hypothesis that at least one function of amyloid-β is to serve as a part of the acute... 
Neurology | Brain microhemorrhages | Alzheimer's disease | Brain microvasculature | Brain hypoperfusion | Amyloid-beta
Journal Article