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PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 9, pp. 1 - 13
Background: It has long been thought that mammalian cardiomyocytes are terminally-differentiated and unable to proliferate. However, myocytes in more primitive... 
PROGENITORS | ABNORMAL QT PROLONGATION | MULTIPOTENT | FIBROBLAST | MULTIDISCIPLINARY SCIENCES | MOUSE | CARDIAC STEM-CELLS | ZEBRAFISH HEART REGENERATION | EXPRESSION | ADULT | ATRIAL-FIBRILLATION | Cell Proliferation | GATA4 Transcription Factor - metabolism | Myocytes, Cardiac - cytology | Homeodomain Proteins - metabolism | Cells, Cultured | Rats | Rats, Inbred WKY | GATA4 Transcription Factor - genetics | Male | Mice, Transgenic | Transcription Factors - genetics | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Homeobox Protein Nkx-2.5 | Animals | Myocytes, Cardiac - metabolism | Cell Differentiation | Mice | Fluorescence | Genetic engineering | Stem cells | Heart cells | Heart | Cell proliferation | Cell culture | Cardiac arrhythmia | Transcription factors | Physicians | Centrifugation | Myocytes | Kinases | Genotype & phenotype | Cell fate | Transgenic animals | Rodents | Cell cycle | Plasticity | Fibroblasts | Extracellular matrix | Cardiology | Heart diseases | Nkx2.5 protein | Explants | Antigens | Cardiac muscle | Transgenic mice | MiRNA | Zebrafish | Cardiomyocytes | Mammals | Tamoxifen | Gene expression | c-Kit protein | Endothelial cells | Medicine | Studies | Polymerase chain reaction | Microscopy | Striations | Green fluorescent protein | Plastic properties | Diabetes | Gene mapping | Pluripotency | Plastic foam | miRNA
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 42, pp. 18143 - 18148
Effective treatment of brain neurological disorders such as Alzheimer’s disease, multiple sclerosis, or tumors should be possible with drug delivery through... 
Glioma | Antineoplastics | Brain neoplasms | Cell membranes | Drug design | Liposomes | Polymers | Blood brain barrier | Tumors | Endosomes | Glioma treatment | Blood-brain barrier | Laminin-411 | Endosomal escape | Polymalic acid | blood-brain barrier | laminin-411 | GENE DELIVERY | ANGIOGENESIS | PERMEABILITY | MULTIDISCIPLINARY SCIENCES | BARRIER | endosomal escape | glioma treatment | PEPTIDE | CHEMOTHERAPY | LAMININ-8 | polymalic acid | IN-VIVO | MALIGNANT GLIOMAS | HPMA COPOLYMER | Polymers - administration & dosage | Brain Neoplasms - pathology | Brain Neoplasms - drug therapy | Endosomes - metabolism | Nanoparticles | Polymers - therapeutic use | Animals | Mice, Nude | Malates - pharmacokinetics | Polymers - pharmacokinetics | Mice | Infusions, Intravenous | Malates - administration & dosage | Malates - therapeutic use | Blood-Brain Barrier | Hydrogen-Ion Concentration | Drugs | Care and treatment | Drug delivery systems | Brain tumors | Malic acid | Dosage and administration | Research | Vehicles | Multiple sclerosis | Intravenous administration | Neurodegenerative diseases | Biodegradability | Tumor cells | Antisense oligonucleotides | Esters | endosomes | Drug delivery | Leucine | Drug development | pH effects | Neurological diseases | Angiogenesis | Glioma cells | Monoclonal antibodies | nanotechnology | Alzheimer's disease | Cytoplasm | Biological Sciences | Physical Sciences | blood–brain barrier
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 4, p. e10108
Background: Chemotherapeutic drugs and newly developed therapeutic monoclonal antibodies are adequately delivered to most solid and systemic tumors. However,... 
BREAST-CANCER | INTRACAROTID INFUSION | LUNG-CANCER | BARRIER PERMEABILITY | MULTIDISCIPLINARY SCIENCES | IN-VIVO | NITRIC-OXIDE | ACTIVATED POTASSIUM CHANNELS | BLOOD-BRAIN | BRADYKININ ANALOG | CHEMOTHERAPY | Neoplasm Transplantation | Sulfones - therapeutic use | Triazines - therapeutic use | Humans | Brain Neoplasms - pathology | Phosphodiesterase 5 Inhibitors | Breast Neoplasms | Sulfones - pharmacology | Lung Neoplasms | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Antibodies, Monoclonal, Humanized | Endocytosis | Biological Transport | Imidazoles - therapeutic use | Triazines - pharmacology | Antibodies, Monoclonal - pharmacology | Antibodies, Monoclonal - pharmacokinetics | Antineoplastic Agents | Phosphodiesterase Inhibitors - pharmacology | Treatment Outcome | Imidazoles - pharmacology | Piperazines - therapeutic use | Brain Neoplasms - drug therapy | Blood-Brain Barrier - drug effects | Piperazines - pharmacology | Phosphodiesterase Inhibitors - administration & dosage | Animals | Antibodies, Monoclonal - administration & dosage | Mice, Nude | Vardenafil Dihydrochloride | Mice | Trastuzumab | Drugs | Drug delivery systems | Biological products | Lung cancer | Brain tumors | Permeability | Metastasis | Vehicles | Dextran | Brain research | Analysis | Monoclonal antibodies | Drug therapy | Health aspects | Cancer | Brain | Drug abuse | Clathrin | Animal models | Physicians | Brain cancer | Nervous system | Drug delivery | Neurosurgery | Molecular weight | Bearing | Metastases | Angiogenesis | Blood-brain barrier | Phosphodiesterase | Caveolae | Oral administration | Breast cancer | Survival | ErbB-2 protein | Endothelial cells | Inhibitors | Acids | Microscopy | Medical prognosis | Coronary vessels | Breast | Transport | Potassium | Tumors
Journal Article
Journal Article
Immunity, ISSN 1074-7613, 04/2015, Volume 42, Issue 4, p. 640
Acute lung injury (ALI) remains a serious health issue with little improvement in our understanding of the pathophysiology and therapeutic approaches. We... 
Acute respiratory distress syndrome | Permeability | Interleukins | Macrophages | Mitogens | Necrosis | Respiratory distress syndrome | Cytokines | Lungs | Microscopy | Rodents | Gangrene | Immune system | Apoptosis | Recruitment | Endothelium
Journal Article
Immunity, ISSN 1074-7613, 04/2015, Volume 42, Issue 4, pp. 640 - 653
Acute lung injury (ALI) remains a serious health issue with little improvement in our understanding of the pathophysiology and therapeutic approaches. We... 
BACTERIAL LIPOPOLYSACCHARIDE | STERILE INFLAMMATION | SIGNALING PATHWAY | P2X RECEPTORS | ALPHA PRODUCTION | ENDOTHELIAL-CELLS | MOUSE MODEL | IN-VIVO | ACUTE LUNG INJURY | IMMUNOLOGY | INFLAMMATORY RESPONSE | Interleukin-1alpha - immunology | Macrophages, Alveolar - pathology | Calcium - metabolism | Humans | Capillary Permeability - immunology | Neutrophil Infiltration | Necrosis - pathology | Receptors, Purinergic P2X7 - genetics | Necrosis - immunology | Cadherins - immunology | Adenosine Triphosphate - metabolism | HEK293 Cells | Interleukin-1alpha - genetics | Cadherins - genetics | Receptors, Purinergic P2X7 - immunology | Macrophages, Alveolar - immunology | Neutrophils - pathology | Lung - pathology | Protein Precursors - genetics | Signal Transduction | Neutrophils - drug effects | Gene Expression Regulation | Neutrophils - immunology | Lipopolysaccharide Receptors - immunology | Mice, Transgenic | Protein Precursors - immunology | Acute Lung Injury - pathology | Necrosis - chemically induced | Endothelial Cells - immunology | Animals | Acute Lung Injury - chemically induced | Macrophages, Alveolar - drug effects | Lung - drug effects | Lipopolysaccharides - pharmacology | Lipopolysaccharide Receptors - genetics | Acute Lung Injury - immunology | Mice | Endothelial Cells - pathology | Intubation, Intratracheal | Lung - immunology | Endothelial Cells - drug effects | endothelial cells | alveolar macrophage | Ca2+ influx | MyD88 | IL-1α | neutrophil | P2X7R | lung injury | necrosis | ARDS | ALI | sepsis | lung inflammation
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 42, p. 18143
  Effective treatment of brain neurological disorders such as Alzheimer's disease, multiple sclerosis, or tumors should be possible with drug delivery through... 
Proteins | Brain | Cell growth | Membranes | Monoclonal antibodies | Alzheimers disease | Cells | Cytoplasm | Tumors
Journal Article
Bioconjugate Chemistry, ISSN 1043-1802, 03/2006, Volume 17, Issue 2, p. 317
A new prototype of nanoconjugate, Polycefin, was synthesized for targeted delivery of antisense oligonucleotides and monoclonal antibodies to brain tumors. The... 
Brain | Amino acids | Biochemistry | Drug therapy | Tumors
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 2007, Volume 122, Issue 3, pp. 356 - 363
Journal Article
Cytometry Part A, ISSN 1552-4922, 07/2009, Volume 75A, Issue 7, pp. 569 - 583
Journal Article