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ubiquitin thiolesterase - genetics (9) 9
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Journal Article
Nature Genetics, ISSN 1061-4036, 12/2014, Volume 47, Issue 1, pp. 31 - 38
Cushing's disease is caused by corticotroph adenomas of the pituitary. To explore the molecular mechanisms of endocrine autonomy in these tumors, we performed... 
UBPY | ENDOSOMES | DOMAIN | PROTEIN | EPIDERMAL-GROWTH-FACTOR | GENETICS & HEREDITY | UBIQUITYLATION | DEGRADATION | RECEPTOR DOWN-REGULATION | ENDOCYTIC TRAFFICKING | PITUITARY-ADENOMAS | Adenoma - genetics | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Cercopithecus aethiops | Endosomal Sorting Complexes Required for Transport - genetics | Molecular Sequence Data | Pituitary Neoplasms - complications | ACTH-Secreting Pituitary Adenoma - complications | Pituitary ACTH Hypersecretion - genetics | ACTH-Secreting Pituitary Adenoma - genetics | Receptor, Epidermal Growth Factor - metabolism | Pituitary Neoplasms - secretion | Neoplasm Proteins - genetics | Pro-Opiomelanocortin - genetics | Amino Acid Sequence | ACTH-Secreting Pituitary Adenoma - metabolism | Pituitary Neoplasms - genetics | Ubiquitin Thiolesterase - physiology | Pituitary Neoplasms - metabolism | Ubiquitin Thiolesterase - genetics | 14-3-3 Proteins - metabolism | Adrenocorticotropic Hormone - secretion | Sequence Homology, Amino Acid | Exome - genetics | Sequence Alignment | Animals | Endopeptidases - genetics | ACTH-Secreting Pituitary Adenoma - secretion | Pro-Opiomelanocortin - biosynthesis | Mutation | COS Cells | Endosomal Sorting Complexes Required for Transport - physiology | Endopeptidases - physiology | Gene mutations | Cushing syndrome | Physiological aspects | Genetic aspects | Research | Ubiquitin-proteasome system | Health aspects | Risk factors | Pituitary gland | Kinases | Rodents | Genes | Tumors | Index Medicus
Journal Article
Journal Article
Journal of Neuropathology and Experimental Neurology, ISSN 0022-3069, 10/2010, Volume 69, Issue 10, pp. 1017 - 1033
The complex manifestations of chronic multiple sclerosis (MS)are due in part to widespread axonal abnormalities that affect lesional and nonlesional areas in... 
Neurofascin | Node of Ranvier | Neuroinflammation | Multiple sclerosis | Sodium channel | Demyelination | CHANNEL EXPRESSION | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | SODIUM-CHANNELS | PATHOLOGY | NEUROSCIENCES | CLINICAL NEUROLOGY | MYELINATED AXONS | APPEARING WHITE-MATTER | JUNCTIONS | CENTRAL-NERVOUS-SYSTEM | GLUTAMATE EXCITOTOXICITY | PARKINSONS-DISEASE | Peptide Fragments | Minocycline - pharmacology | Humans | Middle Aged | Encephalomyelitis, Autoimmune, Experimental - immunology | Caspase 1 - metabolism | Male | Ranvier's Nodes - metabolism | Brain - metabolism | DNA-Binding Proteins - metabolism | Anti-Bacterial Agents - therapeutic use | Microglia - immunology | Microglia - physiology | NAV1.6 Voltage-Gated Sodium Channel | Encephalomyelitis, Autoimmune, Experimental - chemically induced | Minocycline - therapeutic use | Sodium Channels - metabolism | Microglia - pathology | Adult | Female | Indoles | HLA-DR Antigens - metabolism | Encephalomyelitis, Autoimmune, Experimental - pathology | Gene Expression Regulation - immunology | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Mice, Inbred C57BL | Myelin-Oligodendrocyte Glycoprotein | Glycoproteins | Ranvier's Nodes - drug effects | CD3 Complex - metabolism | Toll-Like Receptor 4 - metabolism | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Microscopy, Confocal | Animals | Analysis of Variance | Kv1.2 Potassium Channel - metabolism | Axons - pathology | Brain - pathology | Multiple Sclerosis - pathology | Aged | Anti-Bacterial Agents - pharmacology | Mice | Ranvier's Nodes - pathology | Neurofilament Proteins - metabolism | Postmortem Changes | Nitric Oxide Synthase Type II - metabolism | Index Medicus
Journal Article
Journal Article
Journal of Cell Science, ISSN 0021-9533, 04/2018, Volume 131, Issue 8, pp. jcs210856 - jcs210856
Stress granules are transient cytoplasmic foci induced by various stresses that contain translation-stalled mRNAs and RNA-binding proteins. They are proposed... 
Ubiquitin | USP13 | Stress granule | Deubiquitylase | USP5 | PRION-LIKE DOMAINS | AGGRESOME | ALS | CELL BIOLOGY | RNA-BINDING PROTEINS | MESSENGER-RNA | DEGRADATION | POLYUBIQUITIN CHAINS | MUTATIONS | UNANCHORED UBIQUITIN | ISOPEPTIDASE-T | Translation | Granule cells | Chains | mRNA | Facilities management | Substrates | Stress | Proteins | Hydrolysis | RNA-binding protein | Heat | Depletion | Ribonucleic acids | Granular materials | Heat tolerance | Heat stress | Dismantling | Assembly
Journal Article
Experimental Cell Research, ISSN 0014-4827, 2007, Volume 313, Issue 16, pp. 3624 - 3634
The deubiquitinating enzyme UBPY, also known as USP8, regulates cargo sorting and membrane traffic at early endosomes. Here we demonstrate the regulatory... 
14-3-3 | Ubiquitin | Deubiquitinating enzyme | Phosphorylation | Deubiquitination | Cell division | Endosome | M phase | MONOUBIQUITINATION | PHOSPHORYLATED NITRATE REDUCTASE | deubiquitinating enzyme | 14-3-3 PROTEINS | cell division | UBIQUITIN ISOPEPTIDASE | RECEPTOR DOWN-REGULATION | IDENTIFICATION | ubiquitin | CELL BIOLOGY | ENDOSOMES | endosome | CYTOKINESIS | ONCOLOGY | EPIDERMAL-GROWTH-FACTOR | deubiquitination | PROTEOMIC ANALYSIS | phosphorylation | Humans | Ubiquitin - metabolism | Cercopithecus aethiops | Molecular Sequence Data | Protein Transport - drug effects | Endopeptidases - chemistry | Protein Binding - drug effects | Phosphorylation - drug effects | Amino Acid Sequence | Endopeptidases - metabolism | Endosomal Sorting Complexes Required for Transport | Mutant Proteins - metabolism | Enzyme Activation - drug effects | Phosphoserine - metabolism | Subcellular Fractions - metabolism | Cell Division - drug effects | Amino Acid Motifs | 14-3-3 Proteins - metabolism | Catalysis - drug effects | Animals | Substrate Specificity - drug effects | Mice | Epidermal Growth Factor - pharmacology | HeLa Cells | COS Cells | Ubiquitin Thiolesterase | Enzymes | Inhibitor drugs | Cellular biology | Molecular biology | Index Medicus | ANTIBODIES | CELL DIVISION | PHOSPHORYLATION | MASS SPECTROSCOPY | IN VIVO | 60 APPLIED LIFE SCIENCES | GROWTH FACTORS | PEPTIDES | ENZYMES | IN VITRO | PHOSPHORUS 32 | MUTATIONS | RECEPTORS
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 03/2019, Volume 9, Issue 1, pp. 3929 - 17
Journal Article
Nature Communications, ISSN 2041-1723, 01/2011, Volume 2, Issue 1, pp. 158 - 158
Activation of the epidermal growth factor receptor (EGFR) not only initiates multiple signal-transduction pathways, including the MAP kinase (MAPK) pathway,... 
CYTOPLASMIC DYNEIN | END-DIRECTED TRANSPORT | MULTIVESICULAR BODIES | UBIQUITIN | MULTIDISCIPLINARY SCIENCES | HRS | ESCRT MACHINERY | ENDOCYTOSIS | PROTEINS | CLATHRIN | PARKINSONS-DISEASE
Journal Article