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Animal Technology and Welfare, ISSN 1742-0385, 04/2018, Volume 17, Issue 1, pp. 29 - 31
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2016, Volume 11, Issue 2, pp. e0149099 - e0149099
Activating KRAS mutations are found in approximately 20% of human cancers but no RAS-directed therapies are currently available. Here we describe a novel,... 
CYCLIN-DEPENDENT KINASES | BREAST-CANCER | THERAPY | COLORECTAL-CANCER | LUNG-CARCINOMA | MULTIDISCIPLINARY SCIENCES | K-RAS ONCOGENES | CELL-CYCLE | PATIENT | SMALL-MOLECULE INHIBITOR | REVEALS | CDC2 Protein Kinase | RNA, Small Interfering - genetics | Cyclin-Dependent Kinases - metabolism | Pancreatic Neoplasms - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Colorectal Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Quinolines - pharmacology | Dose-Response Relationship, Drug | Genes, Lethal | Pancreatic Neoplasms - drug therapy | Colorectal Neoplasms - drug therapy | Female | Antineoplastic Agents - pharmacology | Pancreatic Neoplasms - mortality | Cyclin-Dependent Kinases - antagonists & inhibitors | Cyclin-Dependent Kinases - genetics | Colorectal Neoplasms - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Colorectal Neoplasms - mortality | Signal Transduction | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - genetics | Imidazoles - pharmacology | Pyrimidines - pharmacology | Xenograft Model Antitumor Assays | Animals | High-Throughput Screening Assays | Mice, Nude | Survival Analysis | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Mutation | Colorectal Neoplasms - pathology | G1 Phase Cell Cycle Checkpoints - drug effects | RNA, Small Interfering - metabolism | Ras genes | Gene mutations | Causes of | Physiological aspects | Genetic aspects | Research | Tumors | Cell culture | Medical research | Research parks | Laboratories | Genes | Cyclin-dependent kinases | Amino acids | Breast cancer | Lethality | siRNA | Kinases | Screens | K-Ras protein | Signal transduction | Acids | Cell cycle | Xenografts | Pancreas | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 2018, Volume 13, Issue 10, pp. e0206729 - e0206729
[This corrects the article DOI: 10.1371/journal.pone.0176578.]. 
Tumors
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 09/2017, Volume 16, Issue 9, pp. 2022 - 2034
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 03/2019, Volume 129, Issue 3, pp. 1211 - 1228
Journal Article
PloS one, ISSN 1932-6203, 2017, Volume 12, Issue 4, pp. e0176578 - e0176578
[This corrects the article DOI: 10.1371/journal.pone.0149099.]. 
Medical research | Cancer | K-Ras protein | Tumors
Journal Article
Cancer Research, ISSN 0008-5472, 2017, Volume 77, Issue 24, pp. 7014 - 7026
Synovial sarcoma (SS) is an aggressive soft-tissue malignancy characterized by expression of SS18-SSX fusions, where treatment options are limited. To identify... 
CANCER-CELLS | ACTIVATION | FUSION | ONCOLOGY | KINASE | INHIBITORS | LETHAL | MUTATIONS | IDENTIFICATION | TUMORS | DEFICIENCY | Humans | Recombinant Fusion Proteins - therapeutic use | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Cell Death - genetics | Ataxia Telangiectasia Mutated Proteins - antagonists & inhibitors | Female | Cell Death - drug effects | Tumor Cells, Cultured | RNA Interference - physiology | Molecular Targeted Therapy - methods | Recombinant Fusion Proteins - administration & dosage | Cell Proliferation - genetics | Mice, SCID | Ataxia Telangiectasia Mutated Proteins - physiology | Xenograft Model Antitumor Assays | Animals | Sarcoma, Synovial - genetics | Mice, Nude | RNA, Small Interfering - therapeutic use | Sarcoma, Synovial - drug therapy | Recombinant Fusion Proteins - genetics | Mice, Inbred NOD | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | RNA, Small Interfering - administration & dosage | Therapy | DNA damage | Malignancy | Kinases | Anticancer properties | Proteins | Clonal deletion | Xenografts | Deletion | Cyclin E | Bioindicators | Deoxyribonucleic acid--DNA | Sarcoma | Threonine | Synovial sarcoma | Tumor cells | Poly(ADP-ribose) polymerase | siRNA | Tumor cell lines | Ribonucleic acid--RNA | Screens | Cisplatin | Chromatin remodeling | Signaling | Sensitivity | Inhibitors | Protein kinase | Biomarkers | Tumor suppressor genes | Replication | Antitumor activity | Protein-serine/threonine kinase | R-loops | Ejection | Cancer | Apoptosis | Index Medicus | targeted therapy | replication fork stress | ATR inhibitor | Synovial Sarcoma | synthetic lethality
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2016, Volume 11, Issue 4, pp. e0154007 - e0154007
Journal Article
Cancer Research, ISSN 0008-5472, 01/2014, Volume 74, Issue 1, pp. 287 - 297
Journal Article
JOURNAL OF CLINICAL ONCOLOGY, ISSN 0732-183X, 05/2014, Volume 32, Issue 15, pp. 4039 - 4039
Conference Proceeding
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