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Nature Medicine, ISSN 1078-8956, 12/2014, Volume 21, Issue 1, pp. 27 - 36
Journal Article
Diabetes, ISSN 0012-1797, 05/2013, Volume 62, Issue 5, pp. 1453 - 1463
Glucagon, an essential regulator of glucose homeostasis, also modulates lipid metabolism and promotes weight loss, as reflected by the wasting observed in... 
PPAR-ALPHA | BODY-WEIGHT | METABOLISM | FIBROBLAST-GROWTH-FACTOR-21 | PHARMACOLOGY | INCREASES ENERGY-EXPENDITURE | ENDOCRINOLOGY & METABOLISM | DEGRADATION | MICE | INSULIN SENSITIVITY | FGF21 | Obesity - drug therapy | Humans | Peptides - pharmacokinetics | Fibroblast Growth Factors - genetics | Male | Fibroblast Growth Factors - secretion | Obesity - blood | Anti-Obesity Agents - therapeutic use | Glucagon - agonists | Fibroblast Growth Factors - metabolism | Anti-Obesity Agents - pharmacokinetics | Peptides - chemical synthesis | Hepatocytes - secretion | Hypoglycemic Agents - therapeutic use | Receptors, Glucagon - agonists | Receptors, Glucagon - genetics | Hypoglycemic Agents - pharmacokinetics | Peptides - physiology | Rats | Hypoglycemic Agents - pharmacology | Mice, Knockout | Cross-Over Studies | Anti-Obesity Agents - chemical synthesis | Mice | Anti-Obesity Agents - pharmacology | Hepatocytes - pathology | Diabetes Mellitus, Type 2 - metabolism | Hepatocytes - metabolism | Molecular Targeted Therapy | Mice, Mutant Strains | HEK293 Cells | Adult | Female | Hepatocytes - drug effects | Recombinant Proteins - metabolism | Double-Blind Method | Cells, Cultured | Insulin Resistance | Receptors, Glucagon - metabolism | Recombinant Proteins - agonists | Glucagon - pharmacology | Obesity - metabolism | Diabetes Mellitus, Type 2 - blood | Animals | Fibroblast Growth Factors - blood | Hypoglycemic Agents - chemical synthesis | Glucagon - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Peptides - therapeutic use | Physiological aspects | Fibroblast growth factors | Research | Glucagon | Analysis | Original Research
Journal Article
FASEB Journal, ISSN 0892-6638, 01/2015, Volume 29, Issue 1, pp. 286 - 299
Journal Article
Diabetes, ISSN 0012-1797, 05/2018, Volume 67, Issue Supplement 1, p. 1891
Journal Article
Diabetes, ISSN 0012-1797, 05/2018, Volume 67, Issue Supplement 1, p. 1890
Journal Article
Hepatology, ISSN 0270-9139, 03/2017, Volume 65, Issue 3, pp. 950 - 968
Journal Article
Science Translational Medicine, ISSN 1946-6234, 10/2013, Volume 5, Issue 209, pp. 209ra151 - 209ra151
We report the discovery and translational therapeutic efficacy of a peptide with potent, balanced co-agonism at both of the receptors for the incretin hormones... 
MEDICINE, RESEARCH & EXPERIMENTAL | BODY-WEIGHT | GLYCEMIC CONTROL | HIGH-FAT DIET | GLUCOSE-INTOLERANCE | ENTEROINSULAR AXIS | PANCREATIC BETA-CELLS | DEPENDENT INSULINOTROPIC POLYPEPTIDE | GASTRIC-INHIBITORY POLYPEPTIDE | LIPOPROTEIN-LIPASE | PEPTIDE YY3-36 | CELL BIOLOGY | Acylation - drug effects | Glucagon-Like Peptide 1 - administration & dosage | Humans | Middle Aged | Male | Rodentia - metabolism | Weight Loss - drug effects | Hyperglycemia - drug therapy | Young Adult | Incretins - pharmacology | Adult | Female | Gastric Inhibitory Polypeptide - pharmacology | Receptors, Glucagon - agonists | Glucose Tolerance Test | Glucagon-Like Peptide 1 - analogs & derivatives | Glucagon-Like Peptide 1 - pharmacology | Rats | Receptors, Glucagon - metabolism | Treatment Outcome | Haplorhini - metabolism | Gastric Inhibitory Polypeptide - administration & dosage | Peptides - pharmacology | Insulin - metabolism | Animals | Glucagon-Like Peptide-1 Receptor | Adolescent | Aged | Mice | Venoms - pharmacology | Incretins - therapeutic use | Diabetes Mellitus, Type 2 - drug therapy | Receptors, Gastrointestinal Hormone | Incretins - administration & dosage | Liraglutide | Medicin och hälsovetenskap | Medicinsk bioteknologi (inriktn. mot cellbiologi (inkl. stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci) | Medicinsk bioteknologi
Journal Article
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 07/2018, Volume 61, Issue 13, pp. 5580 - 5593
Novel peptidic dual agonists of the glucagon- like peptide 1 (GLP-1) and glucagon receptor are reported to have enhanced efficacy over pure GLP-1 receptor... 
OBESITY | COMPLEX | CHEMISTRY, MEDICINAL | RODENTS | ANALOG | CRYSTAL-STRUCTURE | EXTRACELLULAR DOMAIN | CO-AGONISM | GLP-1 RECEPTOR | CRYO-EM STRUCTURE | PROTEIN-COUPLED-RECEPTOR
Journal Article
Bioconjugate Chemistry, ISSN 1043-1802, 12/2013, Volume 24, Issue 12, p. 2015
  Recombinant human serum albumin (HSA) conjugates of a 15-amino-acid truncated peptide YY (PYY) analogue were prepared using three heterobifunctional linkers... 
Proteins | Peptides | Amino acids | Chemical reactions | Pharmacology | Biochemistry | Biological assays
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 2000, Volume 57, Issue 2, pp. 252 - 258
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2007, Volume 17, Issue 3, pp. 673 - 678
Journal Article