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Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1842, pp. 255 - 264
Rapid generation of conditional knockout models in a diploid system is challenging. Recently, CRISPR-FLIP strategy has been introduced, which facilitates the... 
Gene targeting | CRISPR/Cas9 | Conditional knockouts | Golden Gate assembly | Gene Targeting | Gene Expression | RNA Splicing | Animals | Humans | CRISPR-Cas Systems | Cloning, Molecular | Homologous Recombination | Mice | Gene Knockout Techniques | Gene Order | Genetic Vectors - genetics | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 10/2013, Volume 155, Issue 2, p. 357
Proliferation of the self-renewing epithelium of the gastric corpus occurs almost exclusively in the isthmus of the glands, from where cells migrate... 
Journal Article
Nature, ISSN 0028-0836, 2012, Volume 488, Issue 7413, pp. 665 - 669
LGR5+ stem cells reside at crypt bottoms, intermingled with Paneth cells that provide Wnt, Notch and epidermal growth factor signals. Here we find that the... 
IN-VITRO | INHIBITION | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | UBIQUITYLATION | SMALL-INTESTINE | COLON | BETA-CATENIN | LGR5 | CANCER | NEGATIVE REGULATOR | Oncogene Proteins - genetics | Receptors, Wnt - antagonists & inhibitors | Cell Proliferation | Receptors, G-Protein-Coupled - metabolism | Humans | Ubiquitin - metabolism | Paneth Cells - pathology | Stem Cells - cytology | Receptors, Wnt - metabolism | Stem Cells - metabolism | DNA-Binding Proteins - deficiency | Adenoma - metabolism | DNA-Binding Proteins - metabolism | Endocytosis | Ubiquitination | Lysosomes - metabolism | Stem Cells - enzymology | Tumor Suppressor Proteins - deficiency | Organoids - metabolism | Tumor Suppressor Proteins - genetics | HEK293 Cells | Colorectal Neoplasms - metabolism | Paneth Cells - metabolism | Tumor Suppressor Proteins - metabolism | Organoids - pathology | Oncogene Proteins - metabolism | Organoids - cytology | Ubiquitin-Protein Ligases - metabolism | Frizzled Receptors - metabolism | DNA-Binding Proteins - genetics | beta Catenin - metabolism | Animals | Wnt Signaling Pathway - drug effects | Adenoma - pathology | Ubiquitin-Protein Ligases - deficiency | Oncogene Proteins - deficiency | Mice | Receptors, G-Protein-Coupled - genetics | Colorectal Neoplasms - pathology | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Colorectal cancer | Physiological aspects | Development and progression | Research | Gene expression | Risk factors | Proteins | Epidermal growth factor | Mutation | Kinases | Rodents | Stem cells | Index Medicus
Journal Article
Journal Article
EMBO journal, ISSN 0261-4189, 2012, Volume 31, Issue 14, pp. 3079 - 3091
Journal Article
Nature Medicine, ISSN 1078-8956, 2017, Volume 23, Issue 12, pp. 1424 - 1435
Human liver cancer research currently lacks in vitro models that can faithfully recapitulate the pathophysiology of the original tumor. We recently described a... 
MEDICINE, RESEARCH & EXPERIMENTAL | CHOLANGIOCARCINOMA | STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | ESTABLISHMENT | GENOME | CELL BIOLOGY | HEPATOCELLULAR-CARCINOMA | IN-VITRO EXPANSION | ADULT LIVER | EXPRESSION | INACTIVATING MUTATIONS | Cell Proliferation | Primary Cell Culture - methods | Humans | Gene Expression Regulation, Neoplastic | Transcriptome | Male | Antineoplastic Agents - therapeutic use | Carcinoma, Hepatocellular - drug therapy | Antineoplastic Agents - isolation & purification | Carcinoma, Hepatocellular - genetics | Liver Neoplasms - pathology | Bile Duct Neoplasms - genetics | Tumor Cells, Cultured | Bile Duct Neoplasms - drug therapy | Precision Medicine | Drug Screening Assays, Antitumor - methods | Organoids - pathology | Liver Neoplasms - genetics | Liver Neoplasms - drug therapy | Mice, SCID | Xenograft Model Antitumor Assays | Cholangiocarcinoma - pathology | Animals | Cholangiocarcinoma - drug therapy | Carcinoma, Hepatocellular - pathology | Cholangiocarcinoma - genetics | Mice, Inbred NOD | Mice | Bile Duct Neoplasms - pathology | Cell culture | Liver cancer | Development and progression | Usage | Models | Research | Propagation | Liver | Hepatocellular carcinoma | Tissues | Drug screening | Metastases | Utilities | Biomedical materials | Organoids | Xenografts | Bioindicators | Cholangiocarcinoma | Extracellular signal-regulated kinase | Cultures | Pharmacology | Gene expression | Chemical compounds | Screening | Hepatocytes | Biomarkers | In vivo methods and tests | Tumors | Cancer | Index Medicus
Journal Article
Journal Article
Wiley Interdisciplinary Reviews, ISSN 1759-7684, 03/2017, Volume 6, Issue 2, p. e268
  The front cover image, by Sina Bartfeld and Bon-Kyoung Koo, is based on the Focus Article Adult gastric stem cells and their niches, DOI: 10.1002/wdev.261. 
Layouts | Stem cells
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 06/2015, Volume 112, Issue 24, p. 7548
Rnf43 (RING finger protein 43) and Znrf3 (zinc/RING finger protein 3) (RZ) are two closely related transmembrane E3 ligases, encoded by Wnt target genes, that... 
Journal Article
BMB Reports, ISSN 1976-6696, 2015, Volume 48, Issue 12, p. 655
Lineage tracing is a widely used method for understanding cellular dynamics in multicellular organisms during processes such as development, adult tissue... 
Adult stem cells | Lineage tracing | Tissue clearing | Intravital imaging | Advanced imaging
Journal Article