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Molecular Neurodegeneration, ISSN 1750-1326, 2013, Volume 8, Issue Suppl 1, pp. O26 - O26
Journal Article
Molecular Neurodegeneration, ISSN 1750-1326, 2011, Volume 6, Issue 1, pp. 27 - 27
Journal Article
BBA - Biomembranes, ISSN 0005-2736, 12/2013, Volume 1828, Issue 12, p. 2898
[gamma]-Secretase is a fascinating, multi-subunit, intramembrane cleaving protease that is now being considered as a therapeutic target for a number of... 
Peptides | Proteases | Amyloid beta-protein | Alzheimer's disease
Journal Article
BioEssays, ISSN 0265-9247, 10/2013, Volume 35, Issue 10, pp. 844 - 844
Journal Article
Nature, ISSN 0028-0836, 02/2012, Volume 482, Issue 7384, pp. 216 - U107
Our understanding of Alzheimer's disease pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model... 
AMYLOID BETA-PROTEIN | APP | MICROTUBULE-BINDING | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | DOWN-SYNDROME | MOUSE MODEL | TAU | DYSFUNCTION | FIBROBLASTS | SENILE PLAQUES | Neurons - pathology | Coculture Techniques | Humans | Middle Aged | Amyloid beta-Peptides - secretion | tau Proteins - metabolism | Male | Phosphoproteins - metabolism | Endosomes - metabolism | Synapsins - metabolism | Alzheimer Disease - pathology | Cellular Reprogramming | Protease Inhibitors - pharmacology | Amyloid beta-Protein Precursor - secretion | Proteolysis | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Aged, 80 and over | Female | Neurons - metabolism | Phosphorylation - drug effects | Neurons - drug effects | Fibroblasts - metabolism | Induced Pluripotent Stem Cells - metabolism | Astrocytes - cytology | Biomarkers - metabolism | Induced Pluripotent Stem Cells - pathology | Peptide Fragments - metabolism | Cells, Cultured | Peptide Fragments - secretion | Glycogen Synthase Kinase 3 - metabolism | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - genetics | Models, Biological | Alzheimer Disease - metabolism | Fibroblasts - cytology | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Enzyme Activation | Messenger RNA | Synthesis | Glycogen | Stem cells | Physiological aspects | Research | Alzheimer's disease | Proteins | Phosphorylation | Neurons | Efficiency | Genomes | Mutation | Alzheimers disease | Index Medicus
Journal Article
Neuron, ISSN 0896-6273, 08/2013, Volume 79, Issue 3, pp. 447 - 460
The convergence of APP (substrate) and BACE-1 (enzyme) is a rate-limiting, obligatory event triggering the amyloidogenic pathway—a key step in Alzheimer’s... 
RECYCLING ENDOSOMES | SYNAPTIC FUNCTION | AMPA RECEPTORS | ALZHEIMERS-DISEASE | IN-VIVO | TRAFFICKING | AXONAL-TRANSPORT | AMYLOID PRECURSOR PROTEIN | NEUROSCIENCES | CULTURED HIPPOCAMPAL-NEURONS | BETA | Amyloid Precursor Protein Secretases - genetics | Membrane Microdomains - metabolism | Protein Transport - physiology | Aspartic Acid Endopeptidases - genetics | rab5 GTP-Binding Proteins - metabolism | Case-Control Studies | Alzheimer Disease - pathology | Brain - metabolism | Neurons - ultrastructure | Amyloid beta-Protein Precursor - metabolism | Organ Culture Techniques | Animals, Newborn | Enzyme Inhibitors - pharmacology | Clathrin - genetics | Clathrin-Coated Vesicles - drug effects | Excitatory Amino Acid Antagonists - pharmacology | Hippocampus - cytology | Nerve Tissue Proteins - genetics | Clathrin - metabolism | Endocytosis - physiology | GABA Antagonists - pharmacology | Nerve Tissue Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Animals | Glycine - pharmacology | Aspartic Acid Endopeptidases - metabolism | Brain - pathology | Picrotoxin - pharmacology | Signal Transduction - physiology | Mice | Clathrin-Coated Vesicles - physiology | Hydrogen-Ion Concentration | Enzymes | Clathrin | Neurosciences | Amyloidosis | Alzheimer's disease | Amyloid beta-protein | Proteins | Brain research | Sucrose | Neurons | Colleges & universities | Biosynthesis | Alzheimers disease | Convergence | Index Medicus | recycling endosomes | β-site APP cleaving enzyme (BACE-1) | amyloid precursor protein (APP) | neuronal activity | vesicle trafficking
Journal Article
by Naj, Adam C and Jun, Gyungah and Beecham, Gary W and Wang, Li-San and Vardarajan, Badri Narayan and Buros, Jacqueline and Gallins, Paul J and Buxbaum, Joseph D and Jarvik, Gail P and Crane, Paul K and Larson, Eric B and Bird, Thomas D and Boeve, Bradley F and Graff-Radford, Neill R and De Jager, Philip L and Evans, Denis and Schneider, Julie A and Carrasquillo, Minerva M and Ertekin-Taner, Nilufer and Younkin, Steven G and Cruchaga, Carlos and Kauwe, John S. K and Nowotny, Petra and Kramer, Patricia and Hardy, John and Huentelman, Matthew J and Myers, Amanda J and Barmada, Michael M and Demirci, F Yesim and Baldwin, Clinton T and Green, Robert C and Rogaeva, Ekaterina and George-Hyslop, Peter St and Arnold, Steven E and Barber, Robert and Beach, Thomas and Bigio, Eileen H and Bowen, James D and Boxer, Adam and Burke, James R and Cairns, Nigel J and Carlson, Chris S and Carney, Regina M and Carroll, Steven L and Chui, Helena C and Clark, David G and Corneveaux, Jason and Cotman, Carl W and Cummings, Jeffrey L and Decarli, Charles and Dekosky, Steven T and Diaz-Arrastia, Ramon and Dick, Malcolm and Dickson, Dennis W and Ellis, William G and Faber, Kelley M and Fallon, Kenneth B and Farlow, Martin R and Ferris, Steven and Frosch, Matthew P and Galasko, Douglas R and Ganguli, Mary and Gearing, Marla and Geschwind, Daniel H and Ghetti, Bernardino and Gilbert, John R and Gilman, Sid and Giordani, Bruno and Glass, Jonathan D and Growdon, John H and Hamilton, Ronald L and Harrell, Lindy E and Head, Elizabeth and Honig, Lawrence S and Hulette, Christine M and Hyman, Bradley T and Jicha, Gregory A and Jin, Lee-Way and Johnson, Nancy and Karlawish, Jason and Karydas, Anna and Kaye, Jeffrey A and Kim, Ronald and Koo, Edward H and Kowall, Neil W and Lah, James J and Levey, Allan I and Lieberman, Andrew P and Lopez, Oscar L and MacK, Wendy J and Marson, Daniel C and Martiniuk, Frank and Mash, Deborah C and Masliah, Eliezer and McCormick, Wayne C and McCurry, Susan M and McDavid, Andrew N and McKee, Ann C and Mesulam, Marsel and Miller, Bruce L and ...
Nature Genetics, ISSN 1061-4036, 05/2011, Volume 43, Issue 5, pp. 436 - 443
Journal Article
Frontiers in Behavioral Neuroscience, ISSN 1662-5153, 12/2015, Volume 9
People with Down syndrome (DS) virtually all develop intellectual disability (ID) of varying degree of severity, and also have a high risk of early Alzheimer’s... 
Amyloid beta-peptides | Neuron activity-dependent | Vascular dementia | Amyloidbeta-proteinprecursor | Down syndrome | Cognitive dysfunction | Down Syndrome | Vascular Dementia | cognitive dysfunction | Amyloid beta-Protein Precursor | Amyloid beta-Peptides | neuron activity-dependent
Journal Article
Neuron, ISSN 0896-6273, 01/2011, Volume 69, Issue 2, p. 203
  Most current Alzheimer's disease (AD) therapies in advanced phases of development target amyloid β-peptide (Aβ) production, aggregation, or accumulation.... 
Studies | Proteins | Design | Hypotheses | Brain research | Cognitive ability | Clinical trials | Pharmaceutical industry | Alzheimers disease | Females | Age
Journal Article