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1. Full Text Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals
by Dastani, Zari and Hivert, Marie-France and Timpson, Nicholas and Perry, John R. B and Yuan, Xin and Scott, Robert A and Henneman, Peter and Heid, Iris M and Kizer, Jorge R and Lyytikäinen, Leo-Pekka and Fuchsberger, Christian and Tanaka, Toshiko and Morris, Anew P and Small, Kerrin and Isaacs, Aaron and Beekman, Marian and Coassin, Stefan and Lohman, Kurt and Qi, Lu and Kanoni, Stavroula and Pankow, James S and Uh, Hae-Won and Wu, Ying and Bidulescu, Aurelian and Rasmussen-Torvik, Laura J and Greenwood, Celia M. T and Ladouceur, Martin and Grimsby, Jonna and Manning, Alisa K and Liu, Ching-Ti and Kooner, Jaspal and Mooser, Vincent E and Vollenweider, Peter and Kapur, Karen A and Chambers, John and Wareham, Nicholas J and Langenberg, Claudia and Frants, Rune and Willems-Vandijk, Ko and Oostra, Ben A and Willems, Sara M and Lamina, Claudia and Winkler, Thomas W and Psaty, Bruce M and Tracy, Russell P and Brody, Jennifer and Chen, Ida and Viikari, Jorma and Kähönen, Mika and Pramstaller, Peter P and Evans, David M and St Pourcain, Beate and Sattar, Naveed and Wood, Anew R and Bandinelli, Stefania and Carlson, Olga D and Egan, Josephine M and Böhringer, Stefan and van Heemst, Diana and Kedenko, Lyudmyla and Kristiansson, Kati and Nuotio, Marja-Liisa and Loo, Britt-Marie and Harris, Tamara and Garcia, Melissa and Kanaya, Alka and Haun, Margot and Klopp, Norman and Wichmann, H.-Erich and Deloukas, Panos and Katsareli, Efi and Couper, David J and Duncan, Bruce B and Kloppenburg, Margreet and Adair, Linda S and Borja, Judith B and Wilson, James G and Musani, Solomon and Guo, Xiuqing and Johnson, Toby and Semple, Robert and Teslovich, Tanya M and Allison, Matthew A and Redline, Susan and Buxbaum, Sarah G and Mohlke, Karen L and Meulenbelt, Ingrid and Ballantyne, Christie M and Dedoussis, George V and Hu, Frank B and Liu, Yongmei and Paulweber, Bernhard and Spector, Timothy D and Slagboom, P. Eline and Ferrucci, Luigi and Jula, Antti and Perola, Markus and Raitakari, Olli and Florez, Jose C and Salomaa, Veikko and ... and GLGC Investigators and DIAGRAM Consortium and MAGIC Consortium and MuTHER Consortium and Global B Pgen Consortium and MAGIC investigators and Procardis Consortium and DIAGRAM+ Consortium and GLGC Consortium and GIANT Consortium
PLoS genetics, ISSN 1553-7390, 2012, Volume 8, Issue 3, p. e1002607
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes... 
POPULATION | GENETIC-BASIS | VARIANTS | INSULIN-RESISTANCE | LIPID CONCENTRATIONS | GENETICS & HEREDITY | RISK | RECEPTOR | CORONARY-ARTERY-DISEASE | GENOME-WIDE ASSOCIATION | ADIPOSE-TISSUE | Gene Expression | Genetic Predisposition to Disease | Genome-Wide Association Study | Glucose Tolerance Test | Diabetes Mellitus, Type 2 - genetics | Humans | African Americans | European Continental Ancestry Group | Male | Cholesterol, HDL - genetics | Adiponectin - blood | Asian Continental Ancestry Group | Metabolic Networks and Pathways | Adiponectin - genetics | Insulin Resistance - genetics | Female | Polymorphism, Single Nucleotide | Waist-Hip Ratio | Type 2 diabetes | Physiological aspects | Development and progression | Genetic aspects | Research | Metabolism | Health aspects | Blood proteins | Meta-analysis | Medical research | Cardiovascular disease | Drug therapy | Insulin | Metabolic disorders | Medical and Health Sciences | Medicin och hälsovetenskap
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2. Full Text New genetic loci link adipose and insulin biology to body fat distribution
by Shungin, Dmitry and Winkler, Thomas W and Croteau-Chonka, Damien C and Ferreira, Teresa and Locke, Adam E and Mägi, Reedik and Strawbridge, Rona J and Pers, Tune H and Fischer, Krista and Justice, Anne E and Workalemahu, Tsegaselassie and Wu, Joseph M. W and Buchkovich, Martin L and Heard-Costa, Nancy L and Roman, Tamara S and ng, Alexander W and Song, Ci and Gustafsson, Stefan and Day, Felix R and Esko, Tonu and Fall, Tove and Kutalik, Zoltán and Luan, Jian'an and Randall, Joshua C and Scherag, Ané and Vedantam, Sailaja and Wood, Anew R and Chen, Jin and Fehrmann, Rudolf and Karjalainen, Juha and Kahali, Bratati and Liu, Ching-Ti and Schmidt, Ellen M and Absher, Devin and Amin, Najaf and Anderson, Denise and Beekman, Marian and Bragg-Gresham, Jennifer L and Buyske, Steven and Demirkan, Ayse and Ehret, Georg B and Feitosa, Mary F and Goel, Anuj and Jackson, Anne U and Johnson, Toby and Kleber, Marcus E and Kristiansson, Kati and Mangino, Massimo and Mateo Leach, Irene and Medina-Gomez, Carolina and Palmer, Cameron D and Pasko, Dorota and Pechlivanis, Sonali and Peters, Marjolein J and Prokopenko, Inga and Stančáková, Alena and Ju Sung, Yun and Tanaka, Toshiko and Teumer, Alexander and van Vliet-Ostaptchouk, Jana V and Yengo, Loïc and Zhang, Weihua and Albrecht, Eva and Ärnlöv, Johan and Arscott, Gillian M and Bandinelli, Stefania and Barrett, Amy and Bellis, Claire and Bennett, Amanda J and Berne, Christian and Blüher, Matthias and Böhringer, Stefan and Bonnet, Fabrice and Böttcher, Yvonne and Bruinenberg, Marcel and Carba, Delia B and Caspersen, Ida H and Clarke, Robert and Daw, E. Warwick and Deelen, Joris and Deelman, Ewa and Delgado, Graciela and Doney, Alex S. F and Eklund, Niina and Erdos, Michael R and Estrada, Karol and Eury, Elodie and Frieich, Nele and Garcia, Melissa E and Gieaitis, Vilmantas and Gigante, Bruna and Go, Alan S and Golay, Alain and Grallert, Harald and Grammer, Tanja B and Gräßler, Jürgen and Grewal, Jagvir and Groves, Christopher J and Haller, Toomas and Hallmans, Goran and ... and PAGE Consortium and LifeLines Cohort Study and CARDIOGRAMplusC4D Consortium and MuTHER Consortium and ICBP and ADIPOGEN Consortium and CKDGen Consortium and GEFOS Consortium and Int Endogene Consortium and GENIE Consortium and MAGIC Investigators and ReproGen Consortium and GLGC and ADIPOGen Consortium and International Endogene Consortium and The PAGE Consortium and The International Endogene Consortium and The MAGIC Investigators and The ReproGen Consortium and The CKDGen Consortium and The ADIPOGen Consortium and The ICBP and The CARDIOGRAMplusC4D Consortium and The GENIE Consortium and The GLGC and The GEFOS Consortium and The MuTHER Consortium and The LifeLines Cohort Study and Högskolan Dalarna and Akademin Utbildning, hälsa och samhälle and Medicinsk vetenskap
Nature, ISSN 0028-0836, 2015, Volume 518, Issue 7538, pp. 187 - U378
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our... 
HUMAN HEIGHT | ABDOMINAL ADIPOSITY | MULTIDISCIPLINARY SCIENCES | COMMON SNPS | SUSCEPTIBILITY LOCI | GLYCEMIC TRAITS | FALSE DISCOVERY | MESENCHYMAL STEM-CELLS | GENOME-WIDE ASSOCIATION | ADIPOGENIC DIFFERENTIATION | SEXUAL-DIMORPHISM | Body Mass Index | Genome-Wide Association Study | Age Factors | Neovascularization, Physiologic - genetics | Epigenesis, Genetic | Humans | Male | Continental Population Groups - genetics | Sex Characteristics | Obesity - genetics | Europe - ethnology | Genome, Human - genetics | Adipose Tissue - metabolism | Insulin - metabolism | Models, Biological | Adipocytes - metabolism | Insulin Resistance - genetics | Polymorphism, Single Nucleotide - genetics | Female | Body Fat Distribution | Transcription, Genetic - genetics | Adipogenesis - genetics | Waist-Hip Ratio | Quantitative Trait Loci - genetics | Adipose tissues | Quantitative trait loci | Genetic research | Genetic aspects | Research | Metabolism | Health aspects | Studies | Body mass index | Genealogy | Body fat | Insulin resistance | Genetics | Genomes | Abdomen | Meta-analysis | Life Sciences | Adipocytes/metabolism Adipogenesis/genetics Adipose Tissue/metabolism Age Factors Body Fat Distribution Body Mass Index Continental Population Groups/genetics Epigenesis, Genetic Europe/ethnology Female Genome, Human/genetics Genome-Wide Association Study Humans Insulin/metabolism Insulin Resistance/genetics Male Models, Biological Neovascularization, Physiologic/genetics Obesity/genetics Polymorphism, Single Nucleotide/genetics Quantitative Trait Loci/genetics Sex Characteristics Transcription, Genetic/genetics Waist-Hip Ratio | Clinical Medicine | Hälsa och välfärd | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Health and Welfare
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3. Full Text A coherent approach for analysis of the Illumina HumanMethylation450 BeadChip improves data quality and performance in epigenome-wide association studies
by Lehne, Benjamin and Drong, Alexander W and Loh, Marie and Zhang, Weihua and Scott, William R and Tan, Sian-Tsung and Afzal, Uzma and Scott, James and Jarvelin, Marjo-Riitta and Elliott, Paul and McCarthy, Mark I and Kooner, Jaspal S and Chambers, John C
Genome Biology, ISSN 1474-7596, 02/2015, Volume 16, Issue 1, pp. 37 - 37
DNA methylation plays a fundamental role in the regulation of the genome, but the optimal strategy for analysis of genome-wide DNA methylation data remains to... 
SUBSET-QUANTILE | ARRAY | DNA METHYLATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | QUANTILE NORMALIZATION | GENETICS & HEREDITY | GENE-EXPRESSION | PIPELINE | Epigenomics - methods | Oligonucleotide Array Sequence Analysis | Epigenesis, Genetic - genetics | Humans | CpG Islands - genetics | DNA Methylation - genetics | Software | Genome, Human | Genome-Wide Association Study - methods | Quantitative Trait Loci - genetics | Quantitative trait loci | Studies | Quality control | DNA methylation | Epigenetics | Genomes | Methylation | Chromosomes | Method
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4. Full Text Contribution of lower physical activity levels to higher risk of insulin resistance and associated metabolic disturbances in South Asians compared to Europeans
by Afaq, S and Kooner, AS and Loh, M and Kooner, JS and Chambers, JC
PLOS ONE, ISSN 1932-6203, 05/2019, Volume 14, Issue 5, p. e0216354
Background Insulin resistance and related metabolic disturbances are major risk factors for the higher T2D risk and associated morbidity and mortality amongst... 
CARDIORESPIRATORY FITNESS | GLYCEMIC CONTROL | HOMEOSTASIS MODEL ASSESSMENT | DIABETES PREVALENCE | MULTIDISCIPLINARY SCIENCES | CARDIOVASCULAR-DISEASE | SENSITIVITY | INTENSITY | ADULTS | ACTIVITY ENERGY-EXPENDITURE | EXERCISE | Type 2 diabetes | Europeans | Mortality | Glycosylated hemoglobin | Lipids | Glucose | Risk factors | Dextrose | Glucose metabolism | Exercise | Physiological aspects | Insulin resistance | Comparative analysis | Health aspects | Asians | Physical activity | Epidemiology | Questionnaires | Population | Blood pressure | Fitness training programs | Public health | Accelerometers | Fasting | Complications | Metabolism | Risk analysis | Insulin | Minority & ethnic groups | Morbidity | Hip | Studies | Physical fitness | Weight control | Hospitals | Men | Disturbances | Diabetes
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5. Full Text Percutaneous coronary intervention in stable angina (ORBITA): a double-blind, randomised controlled trial
by Al-Lamee, Rasha and Thompson, David and Dehbi, Hakim-Moulay and Sen, Sayan and Tang, Kare and Davies, John and Davies, Justin E and Keeble, Thomas and Mielewczik, Michael and Kaprielian, Raffi and Malik, Iqbal S and Nijjer, Sukhjinder S and Petraco, Ricardo and Cook, Christopher and Ahmad, Yousif and Howard, James and Baker, Christopher and Sharp, Andrew and Gerber, Robert and Talwar, Suneel and Assomull, Ravi and Mayet, Jamil and Wensel, Roland and Collier, David and Shun-Shin, Matthew and Thom, Simon A and Francis, Darrel P and Sethi, Amarjit and Ramrakha, Punit and Foale, Rodney and Khamis, Ramzi and Hadjiloizou, Nearchos and Khan, Masood and Kooner, Jaspal and Bellamy, Michael and Mikhail, Ghada and Clifford, Piers and O'Kane, Peter and Levy, Terry and Swallow, Rosie and ORBITA Investigators and ORBITA investigators
The Lancet, ISSN 0140-6736, 01/2018, Volume 391, Issue 10115, pp. 31 - 40
Symptomatic relief is the primary goal of percutaneous coronary intervention (PCI) in stable angina and is commonly observed clinically. However, there is no... 
FRACTIONAL FLOW RESERVE | MEDICINE, GENERAL & INTERNAL | REVASCULARIZATION | METAANALYSIS | OPTIMAL MEDICAL THERAPY | GUIDED PCI | Coronary Stenosis - diagnostic imaging | Coronary Stenosis - complications | Double-Blind Method | Humans | Middle Aged | Male | Treatment Outcome | United Kingdom | Angina, Stable - surgery | Coronary Angiography | Coronary Stenosis - surgery | Exercise Tolerance | Angina, Stable - complications | Female | Aged | Angina, Stable - diagnostic imaging | Percutaneous Coronary Intervention | Transluminal angioplasty | Clinical trials | Angina pectoris | Analysis | Hypertension | Angioplasty | Coronary artery | Cardiovascular disease | Systematic review | Angina | Quality of life | Studies | Medical prognosis | Coronary vessels | Cardiology
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6. Full Text Genetically Determined Height and Coronary Artery Disease
by Nelson, Christopher P and Hamby, Stephen E and Saleheen, Danish and Hopewell, Jenna C and Zeng, Lingyao and Assimes, Themistocles L and Kanoni, Stavroula and Willenborg, Christina and Burgess, Stephen and Amouyel, Phillipe and Anand, Sonia and Blankenberg, Stefan and Boehm, Bernhard O and Clarke, Robert J and Collins, Rory and Dedoussis, George and Farrall, Martin and Franks, Paul W and Groop, Leif and Hall, Alistair S and Hamsten, Anders and Hengstenberg, Christian and Hovingh, G. Kees and Ingelsson, Erik and Kathiresan, Sekar and Kee, Frank and König, Inke R and Kooner, Jaspal and Lehtimäki, Terho and März, Winifred and McPherson, Ruth and Metspalu, Andres and Nieminen, Markku S and O'Donnell, Christopher J and Palmer, Colin N.A and Peters, Annette and Perola, Markus and Reilly, Muredach P and Ripatti, Samuli and Roberts, Robert and Salomaa, Veikko and Shah, Svati H and Schreiber, Stefan and Siegbahn, Agneta and Thorsteinsdottir, Unnur and Veronesi, Giovani and Wareham, Nicholas and Willer, Cristen J and Zalloua, Pierre A and Erdmann, Jeanette and Deloukas, Panos and Watkins, Hugh and Schunkert, Heribert and Danesh, John and Thompson, John R and Samani, Nilesh J and CARDIoGRAM C4D Consortium and CARDIoGRAM+C4D Consortium and Medicinska fakulteten and Institutionen för folkhälsa och klinisk medicin and Enheten för biobanksforskning and Näringsforskning and Umeå universitet and Medicin
The New England Journal of Medicine, ISSN 0028-4793, 04/2015, Volume 372, Issue 17, pp. 1608 - 1618
In this study, there was a relative increase of 13.5% in the risk of coronary artery disease for each 1-SD decrease in genetically determined adult height.... 
MEDICINE, GENERAL & INTERNAL | VARIANTS | ATHEROSCLEROSIS | LOCI | IGF-1 | ASSOCIATION | BLOOD-PRESSURE | Genetic Variation | Coronary Artery Disease - etiology | Humans | Risk Factors | Coronary Artery Disease - genetics | Triglycerides - blood | Adult | Cholesterol, LDL - blood | Odds Ratio | Body Height - genetics | Hyperlipidemias - complications | Coronary artery | Cardiovascular disease | Triglycerides | Risk factors | Cholesterol | Meta-analysis | Studies | Genetic variance | Body height | Arteriosclerosis | Height | Blood pressure | Cardiovascular diseases | Heart diseases | Genotypes | Kardiologi | Clinical Medicine | Cardiac and Cardiovascular Systems | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
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