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2010, 1st ed., Current topics in developmental biology, ISBN 0123809142, Volume 92., xvi, 530 p., [24] p. of plates
Notch signaling is an evolutionarily conserved pathway in multicellular organisms that regulates cell-fate determination during development and in stem cells.... 
Notch proteins | Notch genes | Cellular signal transduction | Pre-clinical Medicine: Basic Sciences
Book
2010, 1st ed., Current topics in developmental biology, ISBN 9780123809148, Volume 92.
Web Resource
Cold Spring Harbor Perspectives in Biology, ISSN 1943-0264, 10/2012, Volume 4, Issue 10, pp. a011213 - a011213
When the cell-surface receptor Notch interacts with a ligand (e.g., Delta), its intracellular domain is cleaved and travels to the nucleus to regulate... 
HEAD | SQUAMOUS-CELL CARCINOMA | MUTATIONS | CLEAVAGE | VPS25 | DROSOPHILA | CELL BIOLOGY | Cell Proliferation | Signal Transduction | Models, Biological | Receptors, Notch - metabolism | Cell Death | Receptors, Notch - physiology | Receptors, Notch - genetics | Cell Differentiation | Primer | 063
Journal Article
Journal Article
Structure, ISSN 0969-2126, 2011, Volume 19, Issue 4, pp. 443 - 444
Notch activation requires unfolding of a juxtamembrane negative regulatory domain (NRR). analyzed the dynamics of NRR unfolding in the presence of EGTA. As... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOPHYSICS | CELL BIOLOGY | Structure | Proteases | Analysis | Crystals | Deuterium | Dynamic tests | Protease | Dynamics | Notches | Deletion | Activation | Crystal structure
Journal Article
Journal Article
Cell, ISSN 0092-8674, 2009, Volume 137, Issue 2, pp. 216 - 233
Notch signaling regulates many aspects of metazoan development and tissue renewal. Accordingly, the misregulation or loss of Notch signaling underlies a wide... 
NEURAL STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | GAMMA-SECRETASE CLEAVAGE | C-ELEGANS | TRANSCRIPTION COMPLEXES | AMYLOID PRECURSOR PROTEIN | LIGAND-BINDING DOMAIN | T-CELL DEVELOPMENT | O-FUCOSE | INHIBITS TUMOR-GROWTH | CELL BIOLOGY | Animals | Receptors, Notch - chemistry | Signal Transduction | Receptors, Notch - metabolism | Humans | Proteolysis
Journal Article
Journal Article