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Cancer Letters, ISSN 0304-3835, 2015, Volume 360, Issue 2, pp. 219 - 226
Abstract Standard chemotherapeutic protocols, based on maximum tolerated doses, do not prevent nor overcome chemoresistance caused by the efflux transporter... 
Hematology, Oncology and Palliative Medicine | P-glycoprotein | Mitochondria | Reactive oxygen species | Doxorubicin | CELLS | IRINOTECAN-RESISTANT | OXALIPLATIN | DRUG-RESISTANCE | COMBINATION | CANCER | CHEMOTHERAPY | ZOLEDRONIC ACID | METRONOMIC CYCLOPHOSPHAMIDE | ONCOLOGY | ENCAPSULATED DOXORUBICIN | Lung Neoplasms - drug therapy | Caspase 9 - metabolism | Colonic Neoplasms - drug therapy | Humans | Lung Neoplasms - metabolism | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Caspase 3 - metabolism | Drug Resistance, Neoplasm | Colonic Neoplasms - metabolism | Dose-Response Relationship, Drug | Female | Antibiotics, Antineoplastic - pharmacokinetics | Doxorubicin - administration & dosage | Drug Administration Schedule | Cytochromes c - metabolism | Mitochondria - metabolism | ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis | Mitochondria - drug effects | Random Allocation | Doxorubicin - pharmacokinetics | Antibiotics, Antineoplastic - administration & dosage | HT29 Cells | Xenograft Model Antitumor Assays | Animals | Mice | Mice, Inbred BALB C | Oxidative Stress - drug effects | Chemotherapy | Anthracyclines | Cytochrome b | Drug resistance | Cancer | Tumors | Medical research | Colleges & universities | Cell cycle | Cytotoxicity | Metabolism | Drug dosages | Cancer therapies | DNA repair
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 12/2017, Volume 18, Issue 12, p. 2770
Journal Article
Molecular Cancer, ISSN 1476-4598, 05/2017, Volume 16, Issue 1, pp. 91 - 13
Background: Nutrient deprivation, hypoxia, radiotherapy and chemotherapy induce endoplasmic reticulum (ER) stress, which activates the so-called unfolded... 
Eukaryotic translation initiation factor-2α kinase 3/protein kinase RNA-like endoplasmic reticulum kinase | Multidrug resistance related protein 1 | Chemoresistance | Endoplasmic reticulum stress | Unfolded protein response | INDUCED APOPTOSIS | ER STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | Eukaryotic translation initiation factor-2 alpha kinase 3/protein kinase RNA-like endoplasmic reticulum kinase | DOWN-REGULATION | COLON-CANCER CELLS | NRF2 | METABOLISM | ONCOLOGY | ANTICANCER DRUGS | MULTIDRUG-RESISTANCE | EXPRESSION | Colonic Neoplasms - genetics | Endoplasmic Reticulum Stress - drug effects | Unfolded Protein Response - genetics | Apoptosis - drug effects | Colonic Neoplasms - drug therapy | Humans | eIF-2 Kinase - antagonists & inhibitors | HT29 Cells | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Cell Death - genetics | Signal Transduction - drug effects | Colonic Neoplasms - pathology | Multidrug Resistance-Associated Proteins - genetics | NF-E2-Related Factor 2 - genetics | Mice | Cell Death - drug effects | Doxorubicin - administration & dosage | eIF-2 Kinase - genetics | Drugs | Cell culture | Transcription factors | Profiling | Transcription | Colorectal cancer | Homeostasis | Activation | Drug resistance | Drug development | Kinases | Cancer therapies | Proteins | Antioxidants | Cell growth | Pathways | Protein folding | Penicillin | Xenografts | Nutrients | Stress response | Protein transport | Adaptation | Stresses | Enzymes | Deprivation | Cell survival | Tumor cells | Mortality | Multidrug resistance | Cloning | Radiation therapy | Gene expression | Stressing | Ribonucleic acid--RNA | Survival | Stress | Membrane proteins | Chemotherapy | Protein kinase | Cell death | Hypoxia | Disruption | Endoplasmic reticulum | Transporter | Tumors | Cancer | Apoptosis
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 05/2019, Volume 20, Issue 10, p. 2505
The extracellular signal-related kinases (ERKs) act as pleiotropic molecules in tumors, where they activate pro-survival pathways leading to cell proliferation... 
PD-L1 EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | CELL-PROLIFERATION | CHEMISTRY, MULTIDISCIPLINARY | immune-escape | LIGAND 1 EXPRESSION | P-GLYCOPROTEIN | LUNG-CANCER | chemoresistance | UNFOLDED PROTEIN RESPONSE | SELF-ASSEMBLING NANOPARTICLES | immune-resistance | SIGNAL-REGULATED KINASE | ERK | CHEMOTHERAPY RESISTANCE
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 2/2019, Volume 76, Issue 3, pp. 609 - 625
Doxorubicin is one of the most effective drugs for the first-line treatment of high-grade osteosarcoma. Several studies have demonstrated that the major cause... 
Life Sciences | Biomedicine, general | Biochemistry, general | P-glycoprotein | Life Sciences, general | Osteosarcoma | H 2 S-releasing doxorubicin | Endoplasmic reticulum-associated protein degradation | Cell Biology | Endoplasmic reticulum stress | S-releasing doxorubicin | CANCER CELLS | HYDROGEN-SULFIDE H2S | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-DEATH | CELL BIOLOGY | INDUCED CARDIOTOXICITY | INHIBITION | CYSTATHIONINE-BETA-SYNTHASE | HIGH-GRADE OSTEOSARCOMA | MULTIDRUG-RESISTANCE | STRESS | H2S-releasing doxorubicin | Osteosarcoma - drug therapy | Cell Survival - drug effects | Doxorubicin - therapeutic use | Humans | Immunoblotting | Drug Delivery Systems | Antibiotics, Antineoplastic - therapeutic use | Endoplasmic Reticulum - drug effects | Polymerase Chain Reaction | Inhibitory Concentration 50 | DNA Damage | Apoptosis | Drug Resistance, Neoplasm - drug effects | Ubiquitin | Pharmacogenetics | Anthracyclines | Proteolysis | Toxicity | Genes | Gene regulation | Three axis | CCAAT/enhancer-binding protein | Doxorubicin | Degradation | Hydrogen sulfide | Proteins | Biomedical materials | Ubiquitination | Protein folding | Biocompatibility | P-Glycoprotein | Efflux | Glycoprotein | Osteosarcoma cells | Gene expression | Bone cancer | Molecular modelling | Anthracycline | Quality control | Endoplasmic reticulum | Transporter | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, p. e60975
Durable tumor cell eradication by chemotherapy is challenged by the development of multidrug-resistance (MDR) and the failure to induce immunogenic cell death.... 
ADAPTIVE IMMUNITY | BISPHOSPHONATES | ACTIVATION | MEDIATED DRUG-RESISTANCE | MULTIDISCIPLINARY SCIENCES | NITRIC-OXIDE | ANTITUMOR-ACTIVITY | EXPRESSION | CHEMOTHERAPY | MODULATION | P-GLYCOPROTEIN | Prenylation - drug effects | Drug Resistance, Multiple - drug effects | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Cell Death - immunology | ras Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Terpenes - metabolism | rho-Associated Kinases - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | CD8-Positive T-Lymphocytes - metabolism | Dendritic Cells - drug effects | Cell Death - drug effects | Dendritic Cells - metabolism | Phagocytosis - drug effects | Imidazoles - pharmacology | Down-Regulation - drug effects | Mevalonic Acid - metabolism | Signal Transduction - drug effects | Models, Biological | CD8-Positive T-Lymphocytes - drug effects | Cell Line, Tumor | ATP Binding Cassette Transporter, Sub-Family B | Protein Kinase Inhibitors - pharmacology | Cholesterol - biosynthesis | Diphosphonates - pharmacology | Doxorubicin - pharmacology | Drug Resistance, Neoplasm - drug effects | Drug Screening Assays, Antitumor | Drug resistance in microorganisms | Anthracyclines | Immune response | Dendritic cells | Biochemistry | T cells | Investigations | Prevention | Chemotherapy | Cell death | Cancer cells | Health aspects | Cancer | Drugs | Toxicity | CD8 antigen | Lung cancer | Cytotoxicity | Oncology | Lymphocytes T | Drug resistance | Kinases | Doxorubicin | Recruitment | Proteins | Signal transduction | Mevalonic acid | Lymphocytes | Zoledronic acid | P-Glycoprotein | Medical research | Hematology | Mortality | Glycoprotein | RhoA protein | Breast cancer | Cholesterol | Studies | Signaling | Acids | Immunogenicity | Hypoxia | Apoptosis
Journal Article
Molecular Cancer, ISSN 1476-4598, 11/2013, Volume 12, Issue 1, pp. 137 - 137
Background: The activity of P-glycoprotein (Pgp) and multidrug resistance related protein 1 (MRP1), two membrane transporters involved in multidrug resistance... 
ATP binding cassette transporters | Detergent resistant membranes | Omega 3 polyunsaturated fatty acids | Multidrug resistance | Cholesterol | ABC TRANSPORTER | ER STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HMG-COA REDUCTASE | P-GLYCOPROTEIN | BREAST-CANCER | ONCOLOGY | DOCOSAHEXAENOIC ACID | COLORECTAL-CANCER | LIPID RAFTS | POLYUNSATURATED FATTY-ACIDS | EICOSAPENTAENOIC ACID | Doxorubicin - therapeutic use | Colonic Neoplasms - genetics | Phosphorylation | Drug Resistance, Multiple | Colonic Neoplasms - drug therapy | Down-Regulation | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Eicosapentaenoic Acid - metabolism | Gene Expression Regulation, Neoplastic | Drug Resistance, Neoplasm | Colonic Neoplasms - metabolism | HT29 Cells | Docosahexaenoic Acids - pharmacology | Ubiquitination | Antibiotics, Antineoplastic - therapeutic use | Eicosapentaenoic Acid - pharmacology | Hydroxymethylglutaryl CoA Reductases - metabolism | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Colonic Neoplasms - immunology | Cell Line, Tumor | Cell Membrane - metabolism | Cholesterol - biosynthesis | Docosahexaenoic Acids - metabolism | Ubiquitin | Prevention | Drug resistance in microorganisms | Unsaturated fatty acids | Colon cancer | Ligases | Cancer cells | Physiological aspects | Biological products industry | Drug resistance | Omega-3 fatty acids | Cancer | Medical research | Membranes | Breast cancer | Fatty acids | Colorectal cancer
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, p. e0126159
Background Multidrug resistant cancer cells are hard to eradicate for the inefficacy of conventional anticancer drugs. Besides escaping the cytotoxic effects... 
TRYPTOPHAN | LUNG-CANCER | INHIBITION | DENDRITIC CELLS | MECHANISM | IDO | MULTIDISCIPLINARY SCIENCES | DISEASE | STAT3 | NITRIC-OXIDE | INDOLEAMINE 2,3-DIOXYGENASE EXPRESSION | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Neoplasms - metabolism | Molecular Chaperones - metabolism | Humans | Drug Resistance, Neoplasm | Protein Inhibitors of Activated STAT - metabolism | Janus Kinase 1 - metabolism | STAT1 Transcription Factor - metabolism | RNA Interference | T-Lymphocytes - metabolism | Female | Kynurenine - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Autocrine Communication | Cytokines - metabolism | Signal Transduction | Down-Regulation | STAT1 Transcription Factor - genetics | STAT1 Transcription Factor - antagonists & inhibitors | HT29 Cells | Animals | T-Lymphocytes - cytology | Mice, Nude | K562 Cells | Cell Line, Tumor | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Neoplasms - pathology | STAT3 Transcription Factor - antagonists & inhibitors | RNA, Small Interfering - metabolism | Chemotherapy | Dendritic cells | Lymphocytes | Analysis | Immunotherapy | Cancer cells | Tryptophan | Drug resistance | Cancer | Cell proliferation | Drugs | Laboratories | Lung cancer | Cytotoxicity | Mesothelioma | Oncology | Tryptophan 2,3-dioxygenase | Lymphocytes T | Metastasis | Immunity | CD40L protein | Immunosuppressive agents | Anticancer properties | Interleukin 6 | Interleukin 4 | Antitumor agents | Janus kinase | Autocrine signalling | Stat1 protein | Inducers | Medical research | Cytokines | Multidrug resistance | Stat3 protein | Breast cancer | Interleukin 13 | Immunosuppression | Immunogenicity | Tumor necrosis factor | Medical prognosis | Tumors
Journal Article
Journal Article
Drug Resistance Updates, ISSN 1368-7646, 03/2020, Volume 49, p. 100670
Lipids, phospholipids and cholesterol in particular, are the predominant components of the plasma membrane, wherein multidrug efflux transporters of the... 
Membranes | Membrane fluidity | Lipid peroxidation | Phospholipids | Drug resistance | MDR reversal | Cholesterol | Isoprenoids
Journal Article