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1. Full Text FcγRs Modulate the Anti-tumor Activity of Antibodies Targeting the PD-1/PD-L1 Axis
by Dahan, Rony and Sega, Emanuela and Engelhardt, John and Selby, Mark and Korman, Alan J and Ravetch, Jeffrey V
Cancer cell, ISSN 1535-6108, 09/2015, Volume 28, Issue 3, pp. 285 - 295
Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Tumor Microenvironment - immunology | Animals | Neoplasms - immunology | Antibodies - immunology | Cell Line, Tumor | Ligands | Mice | Programmed Cell Death 1 Receptor - immunology | Receptors, IgG - immunology | B7-H1 Antigen - immunology | Index Medicus
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2. Full Text Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens
by Gubin, Matthew M and Zhang, Xiuli and Schuster, Heiko and Caron, Etienne and Ward, Jeffrey P and Noguchi, Takuro and Ivanova, Yulia and Hundal, Jasreet and Arthur, Cora D and Krebber, Willem-Jan and Mulder, Gwenn E and Toebes, Mireille and Vesely, Matthew D and Lam, Samuel S.K and Korman, Alan J and Allison, James P and Freeman, Gordon J and Sharpe, Arlene H and Pearce, Erika L and Schumacher, Ton N and Aebersold, Ruedi and Rammensee, Hans-Georg and Melief, Cornelis J.M and Mardis, Elaine R and Gillanders, William E and Artyomov, Maxim N and Schreiber, Robert D
Nature (London), ISSN 0028-0836, 11/2014, Volume 515, Issue 7528, pp. 577 - 581
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Antigens, Neoplasm - genetics | Sarcoma - immunology | Antigens, Neoplasm - immunology | Antibodies, Monoclonal - therapeutic use | Male | Vaccines, Synthetic - therapeutic use | Epitopes - genetics | Sarcoma - therapy | Cancer Vaccines - therapeutic use | Animals | Immunotherapy | Mice | CD8-Positive T-Lymphocytes - immunology | Cell Cycle Checkpoints - immunology | Care and treatment | Sarcoma | Analysis | Development and progression | Drug therapy | Health aspects | Antigenic determinants | Cancer | Antigens | Peptides | Lymphocytes | Mutation | Tumors | Index Medicus
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3. Full Text Evolving synergistic combinations of targeted immunotherapies to combat cancer
by Melero, Ignacio and Berman, David M and Aznar, M. Angela and Korman, Alan J and Gracia, José Luis Pérez and Haanen, John
Nature reviews. Cancer, ISSN 1474-175X, 08/2015, Volume 15, Issue 8, pp. 457 - 472
Life Sciences & Biomedicine | Oncology | Science & Technology | Tumor Microenvironment - immunology | Neoplasms - therapy | Animals | Neoplasms - immunology | Humans | Immunotherapy | Biomarkers, Tumor - metabolism | Antineoplastic Agents - pharmacology | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | Combined Modality Therapy | Molecular Targeted Therapy | Care and treatment | Pharmacology, Experimental | Oncology, Experimental | Innovations | Drug targeting | Research | Methods | Drug synergism | Cancer | Index Medicus
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4. Full Text Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape
by Woo, Seng-Ryong and Turnis, Meghan E and Goldberg, Monica V and Bankoti, Jaishree and Selby, Mark and Nirschl, Christopher J and Bettini, Matthew L and Gravano, David M and Vogel, Peter and Liu, Chih Long and Tangsombatvisit, Stephanie and Grosso, Joseph F and Netto, George and Smeltzer, Matthew P and Chaux, Alcides and Utz, Paul J and Workman, Creg J and Pardoll, Drew M and Korman, Alan J and Drake, Charles G and Vignali, Dario A. A
Cancer research (Chicago, Ill.), ISSN 0008-5472, 02/2012, Volume 72, Issue 4, pp. 917 - 927
Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Tumors | Antibodies - therapeutic use | Antigens, CD - immunology | Neoplasm Transplantation | Mice, Inbred C57BL | Neoplasms, Experimental - therapy | Programmed Cell Death 1 Receptor - physiology | CD4-Positive T-Lymphocytes - immunology | Drug Synergism | Neoplasms, Experimental - pathology | Animals | Immune Tolerance - immunology | Neoplasms, Experimental - immunology | Cell Line, Tumor | Antigens, CD - physiology | Mice | Programmed Cell Death 1 Receptor - immunology | Tumor Escape - immunology | Index Medicus | T cells | LAG-3 | PD-1 | tumor | immunotherapy
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5. Full Text Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells
by Selby, Mark J and Engelhardt, John J and Quigley, Michael and Henning, Karla A and Chen, Timothy and Srinivasan, Mohan and Korman, Alan J
Cancer immunology research, ISSN 2326-6066, 07/2013, Volume 1, Issue 1, pp. 32 - 42
Oncology | Immunology | Life Sciences & Biomedicine | Science & Technology | Colonic Neoplasms - therapy | Cricetulus | Antibodies, Monoclonal - pharmacology | Mice, Inbred C57BL | Random Allocation | CTLA-4 Antigen - immunology | T-Lymphocytes, Regulatory - immunology | Animals | Colonic Neoplasms - immunology | Immunoglobulin G - immunology | Immunoglobulin G - pharmacology | Female | Mice | Mice, Inbred BALB C | Antibodies, Monoclonal - immunology | CHO Cells | Disease Models, Animal | Index Medicus
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6. Full Text Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer
by Topalian, Suzanne L and Hodi, F. Stephen and Brahmer, Julie R and Gettinger, Scott N and Smith, David C and McDermott, David F and Powderly, John D and Carvajal, Richard D and Sosman, Jeffrey A and Atkins, Michael B and Leming, Philip D and Spigel, David R and Antonia, Scott J and Horn, Leora and Drake, Charles G and Pardoll, Drew M and Chen, Lieping and Sharfman, William H and Anders, Robert A and Taube, Janis M and McMiller, Tracee L and Xu, Haiying and Korman, Alan J and Jure-Kunkel, Maria and Agrawal, Shruti and McDonald, Daniel and Kollia, Georgia D and Gupta, Ashok and Wigginton, Jon M and Sznol, Mario
The New England journal of medicine, ISSN 0028-4793, 06/2012, Volume 366, Issue 26, pp. 2443 - 2454
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | General aspects | Medical sciences | Neoplasms - metabolism | Antibodies, Monoclonal - pharmacology | Humans | Antibodies, Monoclonal - adverse effects | Programmed Cell Death 1 Receptor - metabolism | Antibodies, Monoclonal - therapeutic use | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Neoplasms - drug therapy | Dose-Response Relationship, Drug | Antineoplastic Agents - adverse effects | Colorectal Neoplasms - drug therapy | Melanoma - drug therapy | Adult | Female | Ligands | Antineoplastic Agents - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Programmed Cell Death 1 Receptor - immunology | Carcinoma, Renal Cell - drug therapy | Prostatic Neoplasms - drug therapy | Drugs | Dose-response relationship (Biochemistry) | Immune response | Anti-antibodies | Dosage and administration | Product/Service Evaluations | Regulation | Research | Drug therapy | Cancer | Fees & charges | Kidneys | PD-1 protein | Stock options | Laboratories | Toxicity | Tumor cells | Body weight | Lung cancer | Colorectal carcinoma | Colorectal cancer | Melanoma | Licenses | Lymphocytes T | Patients | Castration | Renal cell carcinoma | PD-L1 protein | Antitumor activity | Prostate cancer | Drug dosages | Prostate | Tumors | Apoptosis | Index Medicus | Abridged Index Medicus
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7. Full Text A conserved intratumoral regulatory T cell signature Identifies 4-1BB as a pan-cancer target
by Freeman, Zachary T and Nirschl, Thomas R and Hovelson, Daniel H and Johnston, Robert J and Engelhardt, John J and Selby, Mark J and Kochel, Christina M and Lan, Ruth Y and Zhai, Jingyi and Ghasemzadeh, Ali and Gupta, Anuj and Skaist, Alyza M and Wheelan, Sarah J and Jiang, Hui and Pearson, Alexander T and Snyder, Linda A and Korman, Alan J and Tomlins, Scott A and Yegnasubramanian, Srinivasan and Drake, Charles G
The Journal of clinical investigation, ISSN 0021-9738, 03/2020, Volume 130, Issue 3, pp. 1405 - 1416
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Animal models | CD137 antigen | PD-1 protein | CD8 antigen | Cytotoxicity | Genomes | Lymphocytes T | Ribonucleic acid--RNA | Proteins | Liver cancer | CTLA-4 protein | Immune checkpoint | Cell death | Lymphocytes | Immunotherapy | PD-L1 protein | Antitumor activity | Ligands | Apoptosis | Tumors | Cancer | Index Medicus | Abridged Index Medicus
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