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The New England Journal of Medicine, ISSN 0028-4793, 09/2014, Volume 371, Issue 11, pp. 1005 - 1015
About 25% of young adults with ALL have Ph-like genotypes, which are associated with poor outcomes with conventional treatment. In this gene-expression study,... 
MEDICINE, GENERAL & INTERNAL | MODELS | B-CELL PRECURSOR | INHIBITOR THERAPY | IMATINIB | PEDIATRIC ACUTE LEUKEMIAS | GENE FUSION | EXPRESSION | ETV6-NTRK3 FUSION TRANSCRIPTS | CRLF2 | DELETION | Oligonucleotide Array Sequence Analysis | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Humans | Child, Preschool | Infant | Male | Young Adult | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Heterografts | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality | Adult | Female | DNA, Neoplasm - analysis | Receptors, Cytokine - metabolism | Child | Philadelphia Chromosome | Receptors, Cytokine - genetics | Signal Transduction - genetics | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | Protein Kinase Inhibitors - therapeutic use | Adolescent | Survival Analysis | Mice | Polymorphism, Single Nucleotide | Genome, Human | Protein-Tyrosine Kinases - antagonists & inhibitors | Development and progression | Care and treatment | Genetic aspects | Research | Lymphocytic leukemia | Tyrosine metabolism | Cell proliferation | Tyk2 protein | Leukemia | Genes | Clinical trials | Oncology | Genomes | Kinases | Cell activation | Janus kinase 2 | Xenografts | Teenagers | Children | Adolescents | Protein-tyrosine kinase | Age | Tyrosine | Young adults | Genomic analysis | Acute lymphatic leukemia | Stat5 protein | Lymphatic leukemia | Gene expression | Philadelphia chromosome | Interleukin 7 receptors | Thymic stromal lymphopoietin | Lymphocytes B
Journal Article
by Townsend, Elizabeth C and Murakami, Mark A and Christodoulou, Alexandra and Christie, Amanda L and Köster, Johannes and DeSouza, Tiffany A and Morgan, Elizabeth A and Kallgren, Scott P and Liu, Huiyun and Wu, Shuo-Chieh and Plana, Olivia and Montero, Joan and Stevenson, Kristen E and Rao, Prakash and Vadhi, Raga and Andreeff, Michael and Armand, Philippe and Ballen, Karen K and Barzaghi-Rinaudo, Patrizia and Cahill, Sarah and Clark, Rachael A and Cooke, Vesselina G and Davids, Matthew S and DeAngelo, Daniel J and Dorfman, David M and Eaton, Hilary and Ebert, Benjamin L and Etchin, Julia and Firestone, Brant and Fisher, David C and Freedman, Arnold S and Galinsky, Ilene A and Gao, Hui and Garcia, Jacqueline S and Garnache-Ottou, Francine and Graubert, Timothy A and Gutierrez, Alejandro and Halilovic, Ensar and Harris, Marian H and Herbert, Zachary T and Horwitz, Steven M and Inghirami, Giorgio and Intlekofer, Andrew M and Ito, Moriko and Izraeli, Shai and Jacobsen, Eric D and Jacobson, Caron A and Jeay, Sébastien and Jeremias, Irmela and Kelliher, Michelle A and Koch, Raphael and Konopleva, Marina and Kopp, Nadja and Kornblau, Steven M and Kung, Andrew L and Kupper, Thomas S and LeBoeuf, Nicole R and LaCasce, Ann S and Lees, Emma and Li, Loretta S and Look, A. Thomas and Murakami, Masato and Muschen, Markus and Neuberg, Donna and Ng, Samuel Y and Odejide, Oreofe O and Orkin, Stuart H and Paquette, Rachel R and Place, Andrew E and Roderick, Justine E and Ryan, Jeremy A and Sallan, Stephen E and Shoji, Brent and Silverman, Lewis B and Soiffer, Robert J and Steensma, David P and Stegmaier, Kimberly and Stone, Richard M and Tamburini, Jerome and Thorner, Aaron R and van Hummelen, Paul and Wadleigh, Martha and Wiesmann, Marion and Weng, Andrew P and Wuerthner, Jens U and Williams, David A and Wollison, Bruce M and Lane, Andrew A and Letai, Anthony and Bertagnolli, Monica M and Ritz, Jerome and Brown, Myles and Long, Henry and Aster, Jon C and Shipp, Margaret A and Griffin, James D and Weinstock, David M
Cancer Cell, ISSN 1535-6108, 07/2016, Volume 30, Issue 1, pp. 183 - 183
Journal Article
Cancer Cell, ISSN 1535-6108, 09/2014, Volume 26, Issue 3, pp. 428 - 442
Journal Article
Cancer Science, ISSN 1347-9032, 12/2015, Volume 106, Issue 12, pp. 1705 - 1713
Journal Article
Cancer Cell, ISSN 1535-6108, 06/2015, Volume 27, Issue 6, pp. 864 - 876
Journal Article
Cell Reports, ISSN 2211-1247, 12/2015, Volume 13, Issue 12, pp. 2715 - 2727
Journal Article
Nature, ISSN 0028-0836, 02/2017, Volume 542, Issue 7642, pp. 479 - 483
B-lymphoid transcription factors, such as PAX5 and IKZF1, are critical for early B-cell development(1,2), yet lesions of the genes encoding these transcription... 
ENERGY STRESS | ACTIVATION | GENE | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | ACUTE LYMPHOBLASTIC-LEUKEMIA | HEMATOPOIETIC STEM-CELLS | REGULATORY NETWORK | DIFFERENTIATION | MINIMAL RESIDUAL DISEASE | EXPRESSION | Glucocorticoids - therapeutic use | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Receptor, Cannabinoid, CB2 - agonists | Humans | Gene Expression Regulation, Neoplastic | Receptors, Glucocorticoid - metabolism | PAX5 Transcription Factor - deficiency | Carrier Proteins - agonists | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Chromatin Immunoprecipitation | Adenosine Triphosphate - metabolism | Cell Death | Pyruvic Acid - metabolism | Female | Ikaros Transcription Factor - metabolism | Energy Metabolism - genetics | B-Lymphocytes - metabolism | PAX5 Transcription Factor - metabolism | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | AMP-Activated Protein Kinases - antagonists & inhibitors | Carcinogenesis - genetics | PAX5 Transcription Factor - genetics | Mice, Transgenic | Citric Acid Cycle | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Transcription Factors - metabolism | B-Lymphocytes - drug effects | Receptor, Cannabinoid, CB2 - metabolism | Animals | Carrier Proteins - metabolism | Sequence Analysis, RNA | Glucocorticoids - pharmacology | Glucose - metabolism | Mice | Physiological aspects | Transcription factors | B cells | Proteins | Metabolites | Rodents | Cloning | Leukemia | Glucose | Kinases | Metabolism | Gene expression | Apoptosis
Journal Article
Nature Medicine, ISSN 1078-8956, 04/2016, Volume 22, Issue 4, pp. 379 - 387
Journal Article