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Cytokine, ISSN 1043-4666, 11/2015, Volume 76, Issue 1, p. 61
The Inhibitor of Apoptosis (IAP) family members are important oncogenes overexpressed in many solid and blood cancers. We have recently found that innate... 
Journal Article
Cytokine, ISSN 1043-4666, 11/2015, Volume 76, Issue 1, pp. 61 - 61
Journal Article
Science, ISSN 0036-8075, 9/1998, Volume 281, Issue 5383, pp. 1680 - 1683
Tumor necrosis factor α (TNF-α) binding to the TNF receptor (TNFR) potentially initiates apoptosis and activates the transcription factor nuclear factor kappa... 
Mitochondria | Transcription factors | RNA | Cell death | Cell lines | Fibroblasts | Monoclonal antibodies | Antibodies | Cytochromes | Reports | Apoptosis | INDUCED CELL-DEATH | RECEPTOR-1 SIGNALING COMPLEX | CYTOCHROME-C | POLY(ADP-RIBOSE) POLYMERASE | KINASE COMPLEX | ALPHA PROTEOLYSIS | CAENORHABDITIS-ELEGANS | PROTEIN | INDUCED APOPTOSIS | MULTIDISCIPLINARY SCIENCES | CD95 FAS/APO-1 | Prevention
Journal Article
2005, ISBN 0521529565, ix, 249
The process of programmed cell death or apoptosis has, in the decade preceding the publication of this 2005 book, been shown to be centrally involved in the... 
physiology | drug effects | Pathology, Cellular | Apoptosis
Book
Molecular & Cellular Oncology, ISSN 2372-3556, 07/2019, Volume 6, Issue 4, p. 1607456
A genome-wide small-interfering RNA-based screen identified the transcription factor Specificity Protein 3 (SP3) as a critical factor for Second... 
RNAi | inflammation | IAP antagonist | inhibitor of apoptosis | SP3 | cIAP2 | cIAP1 | Specificity Protein 3 | Smac mimetic | RIPK1 | cancer | MDA-MB-231
Journal Article
Apoptosis, ISSN 1360-8185, 9/2007, Volume 12, Issue 9, pp. 1543 - 1568
Apoptosis has been accepted as a fundamental component in the pathogenesis of cancer, in addition to other human diseases including neurodegeneration, coronary... 
Biochemistry, general | TNFR | TRAF | Oncology | NFkB | Virology | Cell Biology | Biomedicine | Cancer Research | IAPs | Caspases | Smac | Knock out mice | Apoptosis | Cancer | NEURONAL APOPTOSIS | X-LINKED INHIBITOR | SERINE-PROTEASE OMI/HTRA2 | MITOCHONDRIA-DERIVED ACTIVATOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | knock out mice | INDUCED PROXIMITY MODEL | apoptosis | CELL BIOLOGY | CELL LUNG-CANCER | SPINAL MUSCULAR-ATROPHY | IN-VIVO | cancer | CYTOCHROME-C RELEASE | caspases | CASPASE ACTIVATION | Caspases - physiology | Proto-Oncogene Proteins c-bcl-2 - physiology | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Humans | Neoplasm Proteins - physiology | Serine Endopeptidases - physiology | Neoplasm Proteins - antagonists & inhibitors | Inhibitor of Apoptosis Proteins - physiology | X-Linked Inhibitor of Apoptosis Protein - antagonists & inhibitors | Neoplasms - genetics | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | Oligonucleotides, Antisense - therapeutic use | Intracellular Signaling Peptides and Proteins - therapeutic use | Mitochondrial Proteins - therapeutic use | Peptide Termination Factors - physiology | Mitochondrial Proteins - physiology | Neoplasm Proteins - therapeutic use | Microtubule-Associated Proteins - antagonists & inhibitors | Caspase Inhibitors | High-Temperature Requirement A Serine Peptidase 2 | Neoplasms - drug therapy | Animals | Protein Kinases - physiology | Checkpoint Kinase 1 | Enzyme Activation | Genetic Vectors | Intracellular Signaling Peptides and Proteins - physiology | Proteins | Cancer therapies
Journal Article
Immunity, ISSN 1074-7613, 06/2009, Volume 30, Issue 6, pp. 789 - 801
Cellular inhibitor of apoptosis proteins (cIAPs) block apoptosis, but their physiological functions are still under investigation. Here, we report that cIAP1... 
MOLIMMUNO | CELLS | ACTIVATION | C-IAP1 | PROTEIN | DROSOPHILA IMD PATHWAY | IN-VIVO | KINASE | IMMUNOLOGY | POLYUBIQUITINATION | NF-KAPPA-B | RIP2 | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Receptors, Pattern Recognition - immunology | Inhibitor of Apoptosis Proteins - genetics | Nod1 Signaling Adaptor Protein - agonists | Colitis - pathology | Baculoviral IAP Repeat-Containing 3 Protein | Nod1 Signaling Adaptor Protein - metabolism | Receptors, Pattern Recognition - metabolism | Signal Transduction - immunology | Receptors, Pattern Recognition - agonists | Nod2 Signaling Adaptor Protein - agonists | Inhibitor of Apoptosis Proteins - metabolism | Colitis - immunology | Receptor-Interacting Protein Serine-Threonine Kinases - immunology | Cytokines - immunology | Cytokines - metabolism | Mice, Inbred C57BL | Nod2 Signaling Adaptor Protein - immunology | Ubiquitination - immunology | Nod1 Signaling Adaptor Protein - immunology | Immunity, Innate | Mice, Knockout | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Ubiquitin-Protein Ligases | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Apoptosis - immunology | Colitis - enzymology | Nod2 Signaling Adaptor Protein - metabolism | Signal Transduction - drug effects | Inhibitor of Apoptosis Proteins - immunology | Mice | Ubiquitin | Oligomers | Ligases | Physiological aspects | Crohn's disease | Colitis | Apoptosis | Medical research | Enzymes | Statistical analysis | Cytokines | Kinases | Proteins | Inflammatory bowel disease | Genotype & phenotype | Insects | Bacteria | Gram-negative bacteria | Chemokines | Immune system
Journal Article
Frontiers in Immunology, 02/2014, Volume 5
Mammalian skeletal muscle maintains a robust regenerative capacity throughout life, due largely to the presence of a stem cell population known as satellite... 
muscle regeneration | Myoblasts, Skeletal | skeletal muscle | myogenesis | TNF receptor family | NF-kB
Journal Article
Nature Immunology, ISSN 1529-2908, 2008, Volume 9, Issue 12, pp. 1371 - 1378
Recent studies suggest that nuclear factor kappa B-inducing kinase (NIK) is suppressed through constitutive proteasome-mediated degradation regulated by TRAF2,... 
MULTIPLE-MYELOMA | TARGETED DISRUPTION | LYMPHOTOXIN-BETA-RECEPTOR | IMMUNE-RESPONSES | ALPHA-DEPENDENT APOPTOSIS | DEGRADATION | DEFICIENT MICE | IMMUNOLOGY | INHIBITOR | TNF | SIGNALING COMPLEX
Journal Article
Nature Communications, ISSN 2041-1723, 02/2017, Volume 8, Issue 1
Small-molecule inhibitor of apoptosis (IAP) antagonists, called Smac mimetic compounds (SMCs), sensitize tumours to TNF-alpha-induced killing while... 
ACTIVATION | VIRUS | INDUCED APOPTOSIS | INDUCE | IMMUNOTHERAPY | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | NF-KAPPA-B | CANCER | CIAP1 | CELL-DEATH | Interferon-alpha - pharmacology | Interferon-beta - immunology | Inhibitor of Apoptosis Proteins - genetics | Antineoplastic Agents - chemical synthesis | Humans | Tumor Necrosis Factor-alpha - genetics | Vesiculovirus - immunology | T-Lymphocytes, Cytotoxic - drug effects | Brain Neoplasms - immunology | Glioblastoma - genetics | Interferon-alpha - genetics | Tumor Necrosis Factor-alpha - immunology | Interferon-beta - genetics | Vesiculovirus - genetics | Female | Antineoplastic Agents - pharmacology | Brain Neoplasms - mortality | T-Lymphocytes, Cytotoxic - immunology | Poly I-C - pharmacology | Genetic Vectors - chemistry | Genetic Vectors - immunology | Immunity, Innate - drug effects | Signal Transduction | Gene Expression Regulation | Brain Neoplasms - genetics | Brain Neoplasms - drug therapy | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Interferon-alpha - immunology | Xenograft Model Antitumor Assays | Tumor Necrosis Factor-alpha - pharmacology | Adaptive Immunity - drug effects | Animals | Glioblastoma - immunology | Interferon-beta - pharmacology | Thiazoles - chemical synthesis | Survival Analysis | Cell Line, Tumor | Immunologic Memory | Inhibitor of Apoptosis Proteins - immunology | Mice | Thiazoles - pharmacology | Glioblastoma - drug therapy | Glioblastoma - mortality
Journal Article