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Trends in Pharmacological Sciences, ISSN 0165-6147, 11/2001, Volume 22, Issue 11, pp. 560 - 564
Identification of natural ligands for orphan G-protein-coupled receptors will help expand the boundaries of physiology and pharmacology. Powerful approaches... 
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 01/2006, Volume 147, Issue S1, pp. S46 - S55
Journal Article
Handbook of Experimental Pharmacology, ISSN 0171-2004, 2017, Volume 238, pp. 339 - 357
Cyclic nucleotide monophosphates (cNMPs) typify the archetype second messenger in living cells and serve as molecular switches with broad functionality. cAMP... 
DMR | Noncanonical cNMP | cUMP | Label-free | cCMP | Nucleotides, Cyclic - metabolism | Animals | Humans | HEK293 Cells | Biological Assay - methods | Kinetics | Second Messenger Systems
Journal Article
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 10/2018, Volume 19, Issue 10, pp. 615 - 616
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 08/2014, Volume 10, Issue 8, pp. 609 - 610
Journal Article
细胞研究:英文版, ISSN 1001-0602, 2011, Volume 21, Issue 10, pp. 1452 - 1469
The directional migration of neutrophils towards inflammatory mediators, such as chemokines and cannabinoids, occurs via the activation of seven transmembrane... 
HEK293 | HL60细胞 | G蛋白偶联受体 | 炎症介质 | 中性粒细胞 | 受体介导 | 炎症反应 | 大麻 | Rac2 | ROS production | GPR55 | Cdc42 | chemotaxis | CB2R | 2-ARACHIDONOYLGLYCEROL | PRIMARY GRANULE EXOCYTOSIS | ENDOGENOUS CANNABINOIDS | PROTEIN | CB2 RECEPTOR | HL-60 CELLS | CELL BIOLOGY | L-ALPHA-LYSOPHOSPHATIDYLINOSITOL | CELL-MIGRATION | IN-VIVO | Cannabinoid Receptor Modulators - pharmacology | Reactive Oxygen Species - metabolism | Receptor, Cannabinoid, CB2 - agonists | Receptors, G-Protein-Coupled - metabolism | Humans | Neutrophil Activation - drug effects | rac GTP-Binding Proteins - metabolism | cdc42 GTP-Binding Protein - metabolism | Receptors, G-Protein-Coupled - agonists | Receptor, Cannabinoid, CB2 - genetics | Cell Movement - physiology | Inflammation - metabolism | rac GTP-Binding Proteins - genetics | HEK293 Cells | Neutrophils - metabolism | Endocannabinoids | Neutrophil Activation - physiology | Arachidonic Acids - pharmacology | Cell Movement - drug effects | Receptor, Cannabinoid, CB2 - metabolism | Glycerides - pharmacology | Signal Transduction - drug effects | cdc42 GTP-Binding Protein - genetics | HL-60 Cells | Inflammation - genetics | Signal Transduction - physiology | Receptors, G-Protein-Coupled - genetics | Cell Degranulation - physiology | Cell Degranulation - drug effects | Original
Journal Article
Nature, ISSN 0028-0836, 09/2017, Volume 549, Issue 7671, pp. 282 - 286
The type 2 cytokines interleukin (IL)-4, IL-5, IL-9 and IL-13 have important roles in stimulating innate and adaptive immune responses that are required for... 
CRTH2 | CYTOKINES | IMMUNE INTERACTIONS | RECEPTORS | MULTIDISCIPLINARY SCIENCES | Inflammation - chemically induced | Inflammation - pathology | Eosinophils - drug effects | Pneumonia - pathology | Interleukin-13 - immunology | Male | Adoptive Transfer | Nippostrongylus - immunology | Receptors, Neurotransmitter - genetics | Eosinophils - immunology | Gastrointestinal Tract - immunology | Lymphocytes - immunology | Pneumonia - chemically induced | Neuropeptides - pharmacology | Interleukin-9 - metabolism | Pneumonia - immunology | Female | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Gastrointestinal Tract - innervation | Cytokines - immunology | Cytokines - metabolism | Immunity, Innate - drug effects | Cholinergic Neurons - metabolism | Interleukin-5 - metabolism | Neuropeptides - metabolism | Inflammation - immunology | Lymphocytes - cytology | Cholinergic Neurons - drug effects | Interleukin-13 - metabolism | Interleukin-5 - immunology | Receptors, Neurotransmitter - deficiency | Animals | Signal Transduction - drug effects | Lymphocytes - drug effects | Gastrointestinal Tract - cytology | Mice | Receptors, Neurotransmitter - metabolism | Eosinophils - cytology | Interleukin-9 - immunology | Genomics | Mucosa | Interleukin | Homeostasis | Nervous system | Neuropeptides | Activation | Small intestine | Antiinfectives and antibacterials | Proteins | Cell activation | Microorganisms | Enteric nervous system | Interleukin 5 | Immune system | Interleukin 9 | Lymphoid cells | Immune response | Cytokines | Secretion | Neurons | Hypersensitivity | Gastrointestinal tract | Inflammation | Interleukin 13 | Signaling | Lungs | Ligands | In vitro methods and tests | Neuromedin
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2018, Volume 13, Issue 8, p. e0203021
The Nociceptin/Orphanin FQ (N/OFQ) peptide NOP receptor is coupled to pertussis toxin (PTX)-sensitive G proteins (G(i/o)) whose activation leads to the... 
LABEL-FREE | IN-VITRO | SELECTIVE ANTAGONIST | BINDING REGION | PROTEIN-COUPLED RECEPTOR | OPIOID RECEPTOR | MULTIDISCIPLINARY SCIENCES | ORL1 RECEPTOR | HIGH-AFFINITY | NOCICEPTIN/ORPHANIN FQ RECEPTOR | LIVING CELLS | Genetically modified animals | Usage | Calcium channels | Pharmacology | Research
Journal Article
Trends in Pharmacological Sciences, ISSN 0165-6147, 12/2017, Volume 38, Issue 12, pp. 1110 - 1124
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 341 - 16
Journal Article