Articles

UofT Libraries is getting a new library services platform in January 2021.
Learn more about the change.

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
human necessities (54) 54
hygiene (42) 42
medical or veterinary science (42) 42
physics (38) 38
diagnosis (29) 29
surgery (29) 29
identification (28) 28
science & technology (23) 23
life sciences & biomedicine (20) 20
optical elements, systems, or apparatus (20) 20
optics (20) 20
agriculture (16) 16
chemistry (16) 16
pharmacology & pharmacy (16) 16
animals (14) 14
humans (14) 14
animal husbandry (13) 13
calculating (13) 13
computing (13) 13
counting (13) 13
fishing (13) 13
forestry (13) 13
hunting (13) 13
trapping (13) 13
cultivation of vegetables, flowers, rice, fruit, vines, hopsor seaweed (12) 12
horticulture (12) 12
watering (12) 12
heterocyclic compounds (11) 11
male (11) 11
metallurgy (11) 11
organic chemistry (11) 11
preparations for medical, dental, or toilet purposes (11) 11
basic electric elements (10) 10
electricity (10) 10
electric digital data processing (8) 8
image data processing or generation, in general (8) 8
pharmacokinetics (8) 8
specific therapeutic activity of chemical compounds ormedicinal preparations (8) 8
arrangement of signalling or lighting devices, the mounting orsupporting thereof or circuits therefor, for vehicles ingeneral (7) 7
performing operations (7) 7
physical sciences (7) 7
rats (7) 7
transporting (7) 7
vehicles in general (7) 7
electric switches (6) 6
emergency protective devices (6) 6
rats, sprague-dawley (6) 6
relays (6) 6
selectors (6) 6
toxicology (6) 6
devices for introducing media into, or onto, the body (5) 5
devices for producing or ending sleep or stupor (5) 5
devices for transducing body media or for taking media fromthe body (5) 5
drug interactions (5) 5
microsomes, liver - metabolism (5) 5
administration, oral (4) 4
cell line (4) 4
chemistry, medicinal (4) 4
chemistry, multidisciplinary (4) 4
crops (4) 4
cytochrome p450 (4) 4
drug design (4) 4
handling record carriers (4) 4
hyperspectral (4) 4
hyperspectral imaging (4) 4
mice (4) 4
pharmacology (4) 4
presentation of data (4) 4
recognition of data (4) 4
record carriers (4) 4
rodents (4) 4
structure-activity relationship (4) 4
agricultural engineering (3) 3
area under curve (3) 3
brain - metabolism (3) 3
cell proliferation - drug effects (3) 3
cho cells (3) 3
cricetulus (3) 3
crystallography, x-ray (3) 3
cyp inhibition (3) 3
disease models, animal (3) 3
drug metabolism (3) 3
drug-drug interaction (3) 3
electric solid state devices not otherwise provided for (3) 3
hyperspectral sensors (3) 3
lighting (3) 3
metabolic stability (3) 3
models, molecular (3) 3
neural networks (3) 3
neuronal activity topography (3) 3
neurosciences (3) 3
neurosciences & neurology (3) 3
plasma protein binding (3) 3
protein binding (3) 3
pyrazines - pharmacology (3) 3
pyrimidines - chemical synthesis (3) 3
satellites (3) 3
semiconductor devices (3) 3
soybean (3) 3
testing (3) 3
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Direct Comparison of Total Clearance Prediction: Computational Machine Learning Model versus Bottom-Up Approach Using In Vitro Assay
by Kosugi, Yohei and Hosea, Natalie
Molecular pharmaceutics, ISSN 1543-8384, 07/2020, Volume 17, Issue 7, pp. 2299 - 2309
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Prediction of Oral Pharmacokinetics Using a Combination of In Silico Descriptors and In Vitro ADME Properties
by Kosugi, Yohei and Hosea, Natalie
Molecular pharmaceutics, 01/2021
Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Impact of P-Glycoprotein on Intestinal Absorption of an Inhibitor of Apoptosis Protein Antagonist in Rats: Mechanisms of Nonlinear Pharmacokinetics and Food Effects
by Yamamoto, Syunsuke and Kosugi, Yohei and Hirabayashi, Hideki and Moriwaki, Toshiya
Pharmaceutical research, ISSN 0724-8741, 10/2018, Volume 35, Issue 10, pp. 1 - 8
Biochemistry, general | Biomedical Engineering | Biomedicine | Absorption | Food effect | Pharmacy | Effulx transporters | Medical Law | Nonlinear pharmacokinetics | Pharmacology/Toxicology | Inhibitor of apoptosis protein | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Femur | Femoral artery | Liver | Oral administration | Rats | Pharmacology | Glycoproteins | Bioavailability | Blood levels | Proteins | Inhibitors | Intestine | Rodents | Portal vein | Intestinal absorption | Pharmacokinetics | P-Glycoprotein | Food | Apoptosis | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text Investigation of MDR1-overexpressing cell lines to derive a quantitative prediction approach for brain disposition using in vitro efflux activities
by Sato, Sho and Tohyama, Kimio and Kosugi, Yohei
European journal of pharmaceutical sciences, ISSN 0928-0987, 01/2020, Volume 142, pp. 105119 - 105119
BCRP | MDR1 | MDCK-MDR1 | Kp,uu,brain | Kp,brain ratio | MDCK-BCRP | LLC-PK1-MDR1 | Brain disposition | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Species differences and substrate specificity of CYP3A heteroactivation by efavirenz
by Kosugi, Yohei and Takahashi, Junzo
Xenobiotica, ISSN 0049-8254, 4/2015, Volume 45, Issue 4, pp. 345 - 352
heteroactivation | drug-drug interactions (DDIs) | midazolam | substrate specificity | species differences | CYP3A4 | efavirenz | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Nifedipine - pharmacokinetics | Recombinant Proteins - metabolism | Hydroxylation | Species Specificity | Administration, Oral | Nifedipine - blood | Humans | Microsomes, Liver - metabolism | Rats | Substrate Specificity | Male | Testosterone - pharmacokinetics | Midazolam - pharmacokinetics | Rats, Sprague-Dawley | Haplorhini | Midazolam - analogs & derivatives | Animals | Drug Interactions | Midazolam - blood | Benzoxazines - pharmacokinetics | Cytochrome P-450 CYP3A - metabolism | Microsomes, Liver - drug effects | Benzoxazines - blood | Testosterone - blood | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Risk Assessment Using Cytochrome P450 Time-Dependent Inhibition Assays at Single Time and Concentration in the Early Stage of Drug Discovery
by Kosaka, Mai and Kosugi, Yohei and Hirabayashi, Hideki
Journal of pharmaceutical sciences, ISSN 0022-3549, 09/2017, Volume 106, Issue 9, pp. 2839 - 2846
inhibition | metabolism | drug interactions | cytochrome P450 | protein binding | microsomes | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | Diltiazem - pharmacology | Antihypertensive Agents - pharmacology | Drug Interactions | Cytochrome P-450 CYP3A Inhibitors - pharmacology | Cytochrome P-450 CYP3A - metabolism | Models, Biological | United States | Humans | Microsomes, Liver - metabolism | Drug Discovery - methods | United States Food and Drug Administration | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Non-insulin-dependent Diabetes Mellitus Induced by Immune Checkpoint Inhibitor Therapy in an Insulinoma-associated Antigen-2 Autoantibody-positive Patient with Advanced Gastric Cancer
by Ohara, Nobumasa and Kobayashi, Michi and Ikeda, Yohei and Hoshi, Takahiro and Morita, Shinichi and Kanefuji, Tsutomu and Yagi, Kazuyoshi and Suda, Takeshi and Takada, Toshinori and Hasegawa, Go and Sato, Yo and Hirano, Kenichiro and Kosugi, Shin-ichi
Internal medicine (Tokyo, 1992), ISSN 0918-2918, 01/2020, Volume 59, Issue 4, pp. 551 - 556
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Antigens | Autoantibodies | Insulinoma | Diabetes mellitus (insulin dependent) | Glucose | Insulin | Stomach cancer | Beta cells | Immune checkpoint | Ketoacidosis | Insulin resistance | Diabetes | Diabetes mellitus (non-insulin dependent) | Gastric cancer | Index Medicus | nivolumab | gastric cancer | C-peptide | thyroid peroxidase autoantibody | diabetes mellitus | insulinoma-associated antigen-2 autoantibody | Case Report
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Prenatal diagnosis of congenital thyroid teratoma
by Mori, Teizaburo and Kudo, Yumi and Kanamori, Yutaka and Tahara, Kazunori and Yamada, Yohei and Kutsukake, Mai and Fujita, Takuro and Miyake, Kazue and Fujino, Akihiro and Takahashi, Nozomi and Morimoto, Noriko and Kosugi, Yohei and Uehara, Yoji and Ito, Yushi and Miyazaki, Osamu and Sugibayashi, Rika and Ozawa, Katsusuke and Wada, Seiji and Sago, Haruhiko
Journal of pediatric surgery case reports, ISSN 2213-5766, 06/2020, Volume 57, p. 101459
Thyroid teratoma | Neck mass | Fetal diagnosis
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text Direct Drug Delivery of Low-Permeable Compounds to the Central Nervous System Via Intranasal Administration in Rats and Monkeys
by Iwasaki, Shinji and Yamamoto, Syunsuke and Sano, Noriyasu and Tohyama, Kimio and Kosugi, Yohei and Furuta, Atsutoshi and Hamada, Teruki and Igari, Tomoko and Fujioka, Yasushi and Hirabayashi, Hideki and Amano, Nobuyuki
Pharmaceutical research, ISSN 0724-8741, 5/2019, Volume 36, Issue 5, pp. 1 - 14
Biochemistry, general | Biomedicine | intranasal administration | Pharmacy | membrane permeability | Medical Law | drug delivery | Pharmacology/Toxicology | Biomedical Engineering and Bioengineering | central nervous system | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Macaca fascicularis | Membranes, Artificial | Rats | Male | Olfactory Bulb - metabolism | Permeability | Administration, Intranasal | Rats, Sprague-Dawley | Blood-Brain Barrier - metabolism | Brain - metabolism | Animals | Pharmaceutical Preparations - administration & dosage | Pharmacokinetics | Drug Delivery Systems - methods | Drugs | Ropinirole | Drug delivery systems | Liability (Law) | Central nervous system | Primates | Methotrexate | Furosemide | Vehicles | Efflux | Intravenous administration | Cimetidine | Intranasal administration | Monkeys | Drug delivery | Atenolol | Monkeys & apes | Sulpiride | Substrates | Liability | Blood-brain barrier | Rodents | Nose | Ranitidine | Metformin | Midazolam | Didanosine | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window
by Kunugi, Akiyoshi and Tanaka, Maiko and Suzuki, Atsushi and Tajima, Yasukazu and Suzuki, Noriko and Suzuki, Motohisa and Nakamura, Shinji and Kuno, Haruhiko and Yokota, Akihiro and Sogabe, Satoshi and Kosugi, Yohei and Awasaki, Yasuyuki and Kaku, Tomohiro and Kimura, Haruhide
Neuropsychopharmacology (New York, N.Y.), ISSN 0893-133X, 04/2019, Volume 44, Issue 5, pp. 961 - 970
Pharmacology & Pharmacy | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Psychiatry | Science & Technology | Cell Line | Mice, Inbred C57BL | Rats, Long-Evans | Neural Stem Cells - drug effects | Excitatory Amino Acid Agents - adverse effects | Cognition - drug effects | Sulfonamides - pharmacology | Rats, Sprague-Dawley | Mice, Inbred ICR | Haplorhini | Seizures - chemically induced | Brain-Derived Neurotrophic Factor - drug effects | Animals | Excitatory Amino Acid Agents - pharmacology | Behavior, Animal - drug effects | Cell Proliferation - drug effects | Primary Cell Culture | Neurons - drug effects | Receptors, AMPA - drug effects | Excitatory Amino Acid Agents - administration & dosage | Seizing | Brain | Dioxides | Neurons | Propionic acid | Cognition | Monkeys | Drug development | Safety margins | Risk factors | Neurological diseases | Brain-derived neurotrophic factor | α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid | Sulfonamides | Rodents | Index Medicus | Depression | Pharmacology
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Full Text Discovery of a Novel and Brain-Penetrant O‑GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead Optimization
by Tawada, Michiko and Fushimi, Makoto and Masuda, Kei and Sun, Huikai and Uchiyama, Noriko and Kosugi, Yohei and Lane, Weston and Tjhen, Richard and Endo, Satoshi and Koike, Tatsuki
Journal of medicinal chemistry, ISSN 0022-2623, 01/2021, Volume 64, Issue 2, pp. 1103 - 1115
Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
12. Full Text Prediction of human pharmacokinetics of long half-life compounds using chimeric mice with humanised liver
by Miyamoto, Maki and Iwasaki, Shinji and Chisaki, Ikumi and Nakagawa, Sayaka and Amano, Nobuyuki and Kosugi, Yohei and Hirabayashi, Hideki
Xenobiotica, ISSN 0049-8254, 12/2019, Volume 49, Issue 12, pp. 1379 - 1387
long half-life | SCID mice | single-species scaling | plasma protein binding | Wajima superposition | PXB mice | Human PK prediction | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Animals | Hepatocytes | Liver - drug effects | Humans | Half-Life | Male | Mice, Transgenic | Mice, SCID | Pharmacokinetics | Chimera | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
13. Full Text Characterization of plasma protein binding in two mouse models of humanized liver, PXB mouse and humanized TK-NOG mouse
by Miyamoto, Maki and Kosugi, Yohei and Iwasaki, Shinji and Chisaki, Ikumi and Nakagawa, Sayaka and Amano, Nobuyuki and Hirabayashi, Hideki
Xenobiotica, ISSN 0049-8254, 01/2021, Volume 51, Issue 1, pp. 51 - 60
chimeric humanized mouse | alpha-1 acid glycoprotein | TK-NOG mouse | unbound fraction | Albumin | plasma protein binding | PXB mouse | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Pharmaceutical Preparations - metabolism | Animals | Humans | Liver - metabolism | Mice | Hepatocytes - metabolism | Mice, SCID | Chimera | Disease Models, Animal | Protein Binding - physiology | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights