X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (18) 18
animals (12) 12
male (11) 11
mice (8) 8
obesity (8) 8
rats (8) 8
5-ht (6) 6
humans (6) 6
neurosciences (6) 6
piperazine derivatives (6) 6
rats, wistar (6) 6
hypertension (5) 5
metabolic stability (5) 5
molecular docking (5) 5
pharmacology & pharmacy (5) 5
piperazines - pharmacology (5) 5
rodents (5) 5
analysis (4) 4
antagonists (4) 4
anxiety (4) 4
biochemistry & molecular biology (4) 4
biomedicine (4) 4
body weight (4) 4
chemistry, medicinal (4) 4
docking (4) 4
endothelium (4) 4
histamine (4) 4
idalopirdine (4) 4
ligands (4) 4
molecular structure (4) 4
nitric oxide (4) 4
non-imidazole histamine h3r ligands (4) 4
original (4) 4
original article (4) 4
pharmacy (4) 4
receptor antagonist (4) 4
serotonin receptors (4) 4
1,3,5-triazine (3) 3
adrenergic alpha-1 receptor antagonists - pharmacology (3) 3
agonist (3) 3
antagonist (3) 3
anti-obesity agents (3) 3
blood pressure - drug effects (3) 3
body weight - drug effects (3) 3
cd-1 mice (3) 3
chemistry, multidisciplinary (3) 3
corticosterone (3) 3
derivatives (3) 3
diet (3) 3
dose-response relationship, drug (3) 3
drugs (3) 3
glucose (3) 3
histamine h3 receptor (3) 3
histamine h3 receptor ligands (3) 3
liver (3) 3
metabolism (3) 3
obesity - drug therapy (3) 3
organic chemistry (3) 3
pharmacokinetics (3) 3
pharmacology (3) 3
phenyl ethers - pharmacology (3) 3
physiological aspects (3) 3
piperazines - chemistry (3) 3
pitolisant (3) 3
receptor (3) 3
structure-activity relationship (3) 3
triglycerides (3) 3
5-ht1a receptor antagonist (2) 2
5-ht6 ligands (2) 2
5-ht7 receptor antagonist (2) 2
admet in vitro (2) 2
adrenergic alpha-1 receptor antagonists - chemistry (2) 2
adrenoceptors (2) 2
animal-models (2) 2
anorectic activity (2) 2
anti-obesity agents - therapeutic use (2) 2
antidepressant-like activity (2) 2
antidepressants (2) 2
antidepressive (2) 2
antioxidants (2) 2
anxiolytics (2) 2
benign prostatic hyperplasia (2) 2
blood pressure (2) 2
blood–brain barrier (2) 2
brain (2) 2
carbohydrates (2) 2
cgmp (2) 2
chemistry (2) 2
cholesterol (2) 2
college teachers (2) 2
corticosterone-induced model of depression (2) 2
decreased messenger-rna (2) 2
dextrose (2) 2
disease (2) 2
disease models, animal (2) 2
dopamine (2) 2
drug-likeness (2) 2
drugstores (2) 2
endocrinology & metabolism (2) 2
evaluation (2) 2
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2016, Volume 11, Issue 10, p. e0165495
Older and even new antidepressants cause adverse effects, such as orthostatic hypotension, hyper-or hypoglycemia, liver injury or lipid disorders. In our... 
DEPRESSION | ANTIDEPRESSANTS | HOMEOSTASIS | METAANALYSIS | CHOLESTEROL | METABOLISM | MULTIDISCIPLINARY SCIENCES | DOUBLE-BLIND | WEIGHT | DERIVATIVES | FLUOXETINE | Guinea Pigs | Liver - enzymology | Histamine - pharmacology | Humans | Rats | Male | Phenyl Ethers - pharmacology | Piperazines - pharmacology | Hep G2 Cells | Ileum - drug effects | Animals | Liver - drug effects | Time Factors | Muscle Contraction - drug effects | Lipids - blood | Blood Pressure - drug effects | Ileum - physiology | Blood Glucose - metabolism | Measurement | Animal experimentation | Enzymes | Low density lipoproteins | Measuring instruments | Aspartate | Triglycerides | Glucose | Blood | Dextrose | Analysis and chemistry | Piperazine | Antidepressants | Blood pressure | Blood lipids | Lipoproteins (low density) | Plasma | Dehydrogenases | Thiols | Toxicity | Liver | Disorders | Cytotoxicity | Lipids | Antagonists | Mental depression | Experiments | Antioxidants | Receptors | Fluorescence recovery after photobleaching | Older people | Rodents | Anxiety | Lipoproteins (high density) | Drug dosages | Alanine | Liver diseases | Free radicals | Hypoglycemia | Ileum | Hypotension | Cholesterol | Anxiolytics | Organic chemistry | Properties (attributes) | Lipoproteins | Pharmacy | Histamine H1 receptors | Alanine transaminase | Aspartate aminotransferase | Diabetes | Pressure measurement | Laboratory animals | Psychiatry | Protein thiols
Journal Article
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 8/2018, Volume 391, Issue 8, pp. 875 - 881
The pharmacological profile of pitolisant, a histamine H3 receptor antagonist/inverse agonist, indicates that this compound might reduce body weight and... 
Glucose tolerance | Obesity | Neurosciences | Biomedicine | H 3 histamine ligand | Metabolic disturbance | Pharmacology/Toxicology | Pitolisant | histamine ligand | Sucrose | Body weight | Triglycerides | Pharmacology | Glucose | Metabolism | Insulin | Cholesterol | High fat diet | Histamine | Diet | Rodents | Disturbances | Weight reduction | Mice | Plasma levels | Metformin | Sugar | Sugars | H3 histamine ligand | Original
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1661-6596, 07/2019, Volume 20, Issue 14, p. 3420
Among serotonin receptors, the 5-HT6 subtype is the most controversial and the least known in the field of molecular mechanisms. The 5-HT6R ligands can be... 
MECHANISM | ANXIETY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG-LIKENESS | CHEMISTRY, MULTIDISCIPLINARY | IDALOPIRDINE | MESSENGER-RNA | LIGANDS | ANIMAL-MODELS | 5-HT6 ligands | ADME-Tox parameters | 1,3,5-triazine | pro-cognitive effects | ANTAGONISTS | EXPRESSION | anxiolytic-like activity | AGONIST
Journal Article
Journal Article
Metabolic Brain Disease, ISSN 0885-7490, 6/2018, Volume 33, Issue 3, pp. 733 - 740
Obesity, from early childhood onwards, is a common societal problem. The overconsumption of sweet, salty and high-fat products are the main factors that cause... 
Biochemistry, general | Neurology | Neurosciences | Biomedicine | Idalopirdine | Excessive eating model | Metabolic Diseases | Oncology | 5-HT 6 receptor antagonist | Anorectic activity | LuAE58054 | 5-HT | receptor antagonist | 5-HT6 receptor antagonist | ALZHEIMERS-DISEASE | RATS | NEUROSCIENCES | OBESITY | PICA | ENDOCRINOLOGY & METABOLISM | EMESIS | AGONIST | Obesity | Therapeutic applications | Rodents | Food | Original
Journal Article
Frontiers in Pharmacology, ISSN 1663-9812, 08/2016, Volume 7, p. 229
Studies proved that among all α1-adrenoceptors, cardiac myocytes functionally express only α1A- and α1B-subtype. Scientists indicated that α1A-subtype blockade... 
adrenolytics | adrenoceptor antagonist | 2-methoxyphenylpiperazine | Arrhythmia | Hypotensive | Antiarrhythmic agents | α1A-adrenoceptor antagonist | arrhythmia | α1-adrenolytics
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 10/2019, Volume 168, pp. 193 - 203
Histamine H receptors ligands act anorectic by blocking the H autoreceptors in the CNS, that results in increased synthesis and disinhibition of histamine... 
H3 histamine ligand | KSK19 | Obesity | Histamine | Leptin | Body weight | Physiological aspects | Insulin resistance | Glucose | Dextrose
Journal Article
Hypertension research : official journal of the Japanese Society of Hypertension, ISSN 0916-9636, 08/2019, Volume 42, Issue 8, pp. 1125 - 1141
We investigated the therapeutic effect of MH-76 and MH-79, which are non-quinazoline α1-adrenoceptor antagonists with an additional ability to stimulate the... 
Journal Article
Frontiers in neuroscience, ISSN 1662-4548, 2017, Volume 11, p. 50
Since 5-HT receptors play role in controlling feeding and satiety and dopamine is essential for normal feeding behavior, we evaluated the ability of EMD... 
Journal Article
18.