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Journal of Immunology, ISSN 0022-1767, 02/2017, Volume 198, Issue 3, pp. 1183 - 1201
Journal Article
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 2346 - 2346
Journal Article
Oncotarget, ISSN 1949-2553, 10/2018, Volume 9, Issue 81, pp. 35226 - 35240
Inhibition of cyclin-dependent kinases 4 and 6 (CDK4/6) is associated with robust antitumor activity. Ribociclib (LEE011) is an orally bioavailable CDK4/6... 
LEE011 | Ribociclib | Selectivity | Preclinical | CDK4/6 inhibitor
Journal Article
Molecular cancer therapeutics, ISSN 1535-7163, 08/2019
KRAS, an oncogene mutated in nearly one-third of human cancers, remains a pharmacological challenge for direct inhibition except for recent advances in... 
Journal Article
Journal Article
Journal Article
Journal Article
by Rodgers, Anthony and Ezzati, Majid and Vander Hoorn, Stephen and Lopez, Alan D and Lin, Ruey-Bin and Murray, Christopher J. L and Fishman, Steven and Caulfield, Laura E and de Onis, Mercedes and Blössner, Monika and Hyder, Adnan A and Mullany, Luke and Black, Robert E and Stoltzfus, Rebecca J and Rice, Amy J and West, Keith P and Lawes, Carlene and Law, Malcolm and Elliott, Paul and MacMahon, Stephen and James, W. Philip T and Jackson-Leach, Rachel and Ni Mhurchu, Cliona and Kalamara, Eleni and Shayeghi, Maryam and Rigby, Neville J and Nishida, Chizuru and Lock, Karen and Pomerleau, Joceline and Causer, Louise and McKee, Martin and Bull, Fiona C and Dixon, Tracy and Ham, Sandra and Neiman, Andrea and Pratt, Michael and Rehm, Jürgen and Room, Robin and Monteiro, Maristela and Gmel, Gerhard and Graham, Kathryn and Rehn, Nina and Sempos, Christopher T and Frick, Ulrich and Jernigan, David and Degenhardt, Louisa and Hall, Wayne and Warner-Smith, Matthew and Lynskey, Michael and Slaymaker, Emma and Walker, Neff and Armstrong, Tim and Collumbien, Martine and Gerressu, Makeda and Cleland, John and Prüss-Ustun, Annette and Kay, David and Fewtrell, Lorna and Bartram, Jamie and Cohen, Aaron and Anderson, Ross and Ostro, Bart and Dev Pandey, Kiran and Krzyzanowski, Michal and Künzli, Nino and Gutschmidt, Kersten and Pope, Arden and Romieu, Isabelle and Samet, Jonathan and Smith, Kirk and Smith, Kirk R and Mehta, Sumi and Feuz, Mirjam and Landrigan, Philip and Ayuso, José Luis and McMichael, Anthony and Campbell-Lendrum, Diarmid and Kovats, Sari and Edwards, Sally and Wilkinson, Paul and Tanser, Frank and Le Sueur, David and Schlesinger, Michael and Andronova, Natasha and Nicholls, Robert and Wilson, Theresa and Hales, Simon and Concha, Marisol and Imel Nelson, Deborah and Fingerhut, Marilyn and Leigh, James and Corvalan, Carlos and Driscoll, Tim and Kyle Steenland, N and Punnett, Laura and Tak, SangWoo and Phillips, Sharonne and Hauri, Anja M and Armstrong, Gregory L and Hutin, Yvan J.F and ... and Comparative Risk Assessment and Comparative Risk Assessment Collaborating Group and Group Comparative Risk Assessment Collaborating
PLoS Medicine, ISSN 1549-1277, 2004, Volume 1, Issue 1, pp. 044 - 055
Journal Article
05/2017
Combinación que comprende un primer agente que es un inhibidor de cinasa dependiente de ciclina 4 o de cinasa dependiente de ciclina 6 (CDK4/6) y un segundo... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
02/2017
resumo patente de invenção: "terapia de combinação". a presente invenção refere-se a uma combinação de um inibidor de cdk4/6 e um inibidor de fgfr cinase para... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
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