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Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 2165 - 11
Epithelial-to-mesenchymal transition (EMT) in cancer cells, represents early stages of metastasis and is a promising target in colorectal cancer (CRC) therapy.... 
SURVIVAL | METASTASIS | MESSENGER-RNA | NONCODING RNAS | COLORECTAL-CANCER | MULTIDISCIPLINARY SCIENCES | TARGETS | MIR-205 | MICRORNA EXPRESSION PROFILES | EMT | PROGRESSION | Adenocarcinoma | Phenotypes | Colon cancer | Mesenchyme | Colorectal carcinoma | Colorectal cancer | MiRNA | Metastasis | Colon | Snail protein | Tumors | Metastases
Journal Article
FRONTIERS IN PHYSIOLOGY, ISSN 1664-042X, 03/2019, Volume 10, p. 326
Platelet factor 4 (PF4) is a pleiotropic inflammatory chemokine, which has been implicated in various inflammatory disorders including liver fibrosis. However,... 
acute liver damage | CELLS | PHYSIOLOGY | ACTIVATED PROTEIN-C | liver | CHEMOKINES | ATHEROSCLEROSIS | RECEPTOR | LIMITS TH17 DIFFERENTIATION | TRANSPLANTATION | macrophages | PLATELETS | IN-VIVO | LIPOPOLYSACCHARIDE | hepatoprotective effects | PF4 | activated protein C | Physiological aspects | Genetic aspects | Research | Blood platelets | Chemokines
Journal Article
Journal of Immunological Methods, ISSN 0022-1759, 01/2020, Volume 476, p. 112675
Monoclonal antibodies ofatumumab (anti-CD20) and alemtuzumab (anti-CD52) which are approved for usage in patients with chronic lymphocytic leukemia (CLL),... 
CLL | Complement system | Ofatumumab | Alemtuzumab
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 271 - 271
Abstract Sepsis is characterized by life-threatening organ dysfunction caused by a dysregulated response to infection. Neutrophils play a crucial role in... 
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 2438 - 2438
Abstract Inherited platelet disorders (IPD) are increasingly recognized as the cause of clinical bleeding. Advances in genomic technologies have identified a... 
Journal Article
Blood, ISSN 0006-4971, 11/2019
Key Points PF4 improves outcome in sepsis by stabilizing NETs and enhancing NET-mediated microbial entrapment. KKO, an Fc-modified HIT-like antibody, further... 
Index Medicus | Abridged Index Medicus
Journal Article
CELLS, ISSN 2073-4409, 08/2019, Volume 8, Issue 8, p. 810
Tumor metastasis, the major problem for clinical oncology in colon cancer treatment, is linked with an epithelial-mesenchymal transition (EMT). The observed... 
colon cancer | SENSITIVITY | vimentin | MECHANISMS | microtubules | BETA-TUBULIN ISOTYPES | MESENCHYMAL TRANSITION | MICROTUBULE DYNAMICS | EMT | BINDING AGENTS | CELL BIOLOGY | ORGANIZATION | migration | III-TUBULIN | INTERMEDIATE-FILAMENTS
Journal Article
CELLS, ISSN 2073-4409, 02/2019, Volume 8, Issue 3, p. 203
During tumor development and ongoing metastasis the acquisition of mesenchymal cell traits by epithelial carcinoma cells is achieved through a programmed... 
MIGRATION | INVADOPODIA | METASTASIS | proteases | Snail | EMT | CANCER | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | MATRIX METALLOPROTEINASES | INVASION | mesenchymal type of migration | PODOSOMES | INHIBITOR | MOTILITY
Journal Article
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 1023 - 1023
In response to infection and inflammation, neutrophils release NETs, histone-decorated nuclear DNA that ensnares bacteria, but also damages host tissues and... 
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 23, pp. 2197 - 2197
Abstract In response to infection and inflammation, neutrophils release neutrophil extracellular traps (NETs), web like structures composed of nuclear DNA... 
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2009, Volume 15, Issue 1, pp. 97 - 103
Journal Article
Blood, ISSN 0006-4971, 12/2014, Volume 124, Issue 21, pp. 98 - 98
Abstract Sepsis is a high-risk clinical setting often resulting in multi-organ failure and death. Release of chromatin NETS (neutrophil extracellular traps)... 
Journal Article
Thrombosis and Haemostasis, ISSN 0340-6245, 05/2007, Volume 97, Issue 5, pp. 722 - 729
Journal Article
Thrombosis and Haemostasis, ISSN 0340-6245, 11/2007, Volume 98, Issue 5, pp. 1108 - 1113
Journal Article
Blood, ISSN 0006-4971, 11/2011, Volume 118, Issue 21, pp. 530 - 530
Abstract Abstract 530 Platelet factor 4 (PF4) increases aPC generation by the thrombin (IIa)/thrombomodulin (TM) complex and may impact outcome in sepsis.... 
Journal Article
Blood, ISSN 0006-4971, 11/2012, Volume 120, Issue 21, pp. 1118 - 1118
Abstract Abstract 1118 There are no currently available tests to rapidly assess and reliably identify both impaired hemostasis and hypercoagulable states, in... 
Journal Article
Journal of Extracellular Vesicles, 01/2018, Volume 7, pp. 233 - 234
Background: Extracellular vesicles (EVs), that include microvesicles (MV) and exosomes, from tumour cells has been considered messengers in intercellular... 
Intercellular signalling | Mesenchyme | Cytokines | CD63 antigen | Secretion | Colorectal carcinoma | Centrifugation | Colorectal cancer | Ultracentrifugation | Inflammation | Electron microscopy | Exosomes | Macrophages | Endothelial cells | Western blotting | Metastases | Cytochrome c | Angiogenesis | Monocytes | Vesicles | Media (differential) | Snail protein | Interleukin 8 | Tumors
Journal Article
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