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1. Full Text From structure to disease: the evolving tale of aquaporin biology
by King, Landon S and Kozono, David and Agre, Peter
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 09/2004, Volume 5, Issue 9, pp. 687 - 698
Our understanding of the movement of water through cell membranes has been greatly advanced by the discovery of a family of water-specific, membrane-channel... 
INDUCED DOWN-REGULATION | COLLECTING DUCT | RAT-KIDNEY | LUNG FLUID TRANSPORT | INTRACELLULAR VESICLES | CO2 PERMEABILITY | NEPHROGENIC DIABETES-INSIPIDUS | WATER CHANNEL EXPRESSION | MOLECULAR-BASIS | BRAIN EDEMA | CELL BIOLOGY | Humans | Aquaporins - chemistry | Homeostasis | Phylogeny | Aquaporins - genetics | Tissue Distribution | Aquaporins - classification | Kidney - metabolism | Protein Isoforms - metabolism | Protein Isoforms - classification | Protein Isoforms - chemistry | Cell Membrane - metabolism | Astrocytes - cytology | Eye - metabolism | Eye - anatomy & histology | Water - metabolism | Aquaporins - metabolism | Kidney - anatomy & histology | Permeability | Respiratory System - anatomy & histology | Animals | Respiratory System - metabolism | Protein Conformation | Astrocytes - metabolism | Protein Isoforms - genetics
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2. Full Text Definitive Primary Therapy in Patients Presenting With Oligometastatic Non-Small Cell Lung Cancer
by Parikh, Ravi B., AB and Cronin, Angel M., MS and Kozono, David E., MD, PhD and Oxnard, Geoffrey R., MD and Mak, Raymond H., MD and Jackman, David M., MD and Lo, Peter C., MA and Baldini, Elizabeth H., MD, MPH and Johnson, Bruce E., MD and Chen, Aileen B., MD, MPP
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2014, Volume 89, Issue 4, pp. 880 - 887
Purpose Although palliative chemotherapy is the standard of care for patients with diagnoses of stage IV non-small cell lung cancer (NSCLC), patients with a... 
Radiology | Hematology, Oncology and Palliative Medicine | ADRENAL METASTASES | SURVIVAL | RADICAL TREATMENT | PHASE-II-TRIAL | MANAGEMENT | PROGNOSTIC-FACTORS | BRAIN METASTASIS | ONCOLOGY | RESECTION | SURGICAL-TREATMENT | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | RADIATION-THERAPY | Bone Neoplasms - mortality | Bone Neoplasms - therapy | Lung Neoplasms - mortality | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Bone Neoplasms - secondary | Lung Neoplasms - pathology | Male | Carcinoma, Squamous Cell - diagnostic imaging | Adrenal Gland Neoplasms - mortality | Brain Neoplasms - secondary | Carcinoma, Non-Small-Cell Lung - secondary | Carcinoma, Squamous Cell - mortality | Adrenal Gland Neoplasms - secondary | Female | Retrospective Studies | Brain Neoplasms - mortality | Databases, Factual | Carcinoma, Non-Small-Cell Lung - pathology | Severity of Illness Index | Carcinoma, Squamous Cell - therapy | Lung Neoplasms - therapy | Carcinoma, Non-Small-Cell Lung - mortality | Radiography | Propensity Score | Carcinoma, Non-Small-Cell Lung - therapy | Analysis of Variance | Brain Neoplasms - therapy | Carcinoma, Squamous Cell - secondary | Lung Neoplasms - diagnostic imaging | Aged | Carcinoma, Non-Small-Cell Lung - diagnostic imaging | Neoplasm Staging | Adrenal Gland Neoplasms - therapy | Lung cancer, Small cell | Chemotherapy | Lung cancer, Non-small cell | Cancer | DIAGNOSIS | PATIENTS | NEOPLASMS | LUNGS | METASTASES | RADIOLOGY AND NUCLEAR MEDICINE | HISTOLOGY | CHEMOTHERAPY | HAZARDS
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3. Full Text Low incidence of chest wall pain with a risk-adapted lung stereotactic body radiation therapy approach using three or five fractions based on chest wall dosimetry
by Coroller, Thibaud P and Mak, Raymond H and Lewis, John H and Baldini, Elizabeth H and Chen, Aileen B and Colson, Yolonda L and Hacker, Fred L and Hermann, Gretchen and Kozono, David and Mannarino, Edward and Molodowitch, Christina and Wee, Jon O and Sher, David J and Killoran, Joseph H
PLoS ONE, ISSN 1932-6203, 04/2014, Volume 9, Issue 4, p. e94859
Purpose: To examine the frequency and potential of dose-volume predictors for chest wall (CW) toxicity (pain and/or rib fracture) for patients receiving lung... 
IRRADIATION | MULTIDISCIPLINARY SCIENCES | PHASE-II | TOXICITY | RADIOTHERAPY | OUTCOMES | CANCER | Care and treatment | Fractures | Radiotherapy | Health aspects | Analysis | Radiation | Chest | Thoracic surgery | Dosimeters | Toxicity | Lung cancer | Oncology | Risk | Multivariate analysis | Cancer therapies | Medical schools | Optimization | Incidence | Biological effects | Pain | Dosimetry | Fractionation | Rib | Radiation therapy | Regression analysis | Patients | Hospitals | Lungs | Womens health | Tumors
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4. Full Text Updated patterns of failure after multimodality therapy for malignant pleural mesothelioma
by Baldini, Elizabeth H., MD, MPH and Richards, William G., PhD and Gill, Ritu R., MD, MPH and Goodman, Brian M., MD and Winfrey, Olivia K., MPH and Eisen, Hannah M., MS and Mak, Raymond H., MD and Chen, Aileen B., MD, MPP and Kozono, David E., MD, PhD and Bueno, Raphael, MD and Sugarbaker, David J., MD
Journal of Thoracic and Cardiovascular Surgery, The, ISSN 0022-5223, 2015, Volume 149, Issue 5, pp. 1374 - 1381
Abstract Objective We have previously described patterns of failure after extrapleural pneumonectomy and multimodality therapy for malignant pleural... 
Cardiothoracic Surgery | SURGERY | CARDIAC & CARDIOVASCULAR SYSTEMS | MANAGEMENT | INDUCTION CHEMOTHERAPY | INTENSITY-MODULATED RADIOTHERAPY | SURGICAL-TREATMENT | PHASE-II TRIAL | DOSE HEMITHORACIC RADIATION | RESPIRATORY SYSTEM | EXTRAPLEURAL PNEUMONECTOMY | TRIMODALITY THERAPY | HYPERTHERMIC CISPLATIN | CLINICAL-OUTCOMES | Predictive Value of Tests | Pneumonectomy - mortality | Lung Neoplasms - mortality | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Mesothelioma - mortality | Tomography, X-Ray Computed | Positron-Emission Tomography | Multimodal Imaging | Mesothelioma - secondary | Lung Neoplasms - secondary | Time Factors | Treatment Failure | Boston - epidemiology | Adult | Female | Neoadjuvant Therapy | Registries | Retrospective Studies | Chemotherapy, Adjuvant | Radiotherapy, Adjuvant | Pleural Neoplasms - pathology | Radiotherapy Dosage | Pneumonectomy - adverse effects | Mesothelioma - therapy | Risk Factors | Kaplan-Meier Estimate | Neoplasm Recurrence, Local | Proportional Hazards Models | Lung Neoplasms - therapy | Pleural Neoplasms - mortality | Pleural Neoplasms - therapy | Disease Progression | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Mesothelioma | Care and treatment
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5. Full Text Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression
by David Kozono and Jie Li and Masayuki Nitta and Oltea Sampetrean and David Gonda and Deepa S. Kushwaha and Dmitry Merzon and Valya Ramakrishnan and Shan Zhu and Kaya Zhu and Hiroko Matsui and Olivier Harismendy and Wei Hua and Ying Mao and Chang-Hyuk Kwon and Hideyuki Saya and Ichiro Nakano and Donald P. Pizzo and Scott R. VandenBerg and Clark C. Chen
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2015, Volume 112, Issue 30, pp. E4055 - E4064
The available evidence suggests that the lethality of glioblastoma is driven by small subpopulations of cells that self-renew and exhibit tumorigenicity. It... 
Epigenomics | Glioblastoma | Neoplastic stem cells | INITIATING CELLS | CANCER-CELLS | GLIOMA | MULTIDISCIPLINARY SCIENCES | MOLECULAR-ORIGINS | TRANSCRIPTION | epigenomics | EMBRYONIC STEM | EGFR | STOCHASTIC GENE-EXPRESSION | glioblastoma | MODELS | neoplastic stem cells | HISTONE MODIFICATIONS | Neoplasms - metabolism | Neoplasm Transplantation | Epigenesis, Genetic | Humans | Mice, Inbred C57BL | Gene Expression Regulation, Neoplastic | Gene Silencing | Male | Gene Expression Profiling | Proto-Oncogene Proteins c-myc - metabolism | Brain Neoplasms - metabolism | Histone Demethylases - metabolism | Animals | Stochastic Processes | Cell Transformation, Neoplastic | Cell Line, Tumor | Glioblastoma - metabolism | Mice | Epigenetic inheritance | Genetic aspects | Observations | Genetic regulation | Gene expression | Glioblastoma multiforme | Biological Sciences | PNAS Plus
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6. Full Text Maximal regularity of the Stokes operator in an exterior domain with moving boundary and application to the Navier–Stokes equations
by Farwig, Reinhard and Kozono, Hideo and Wegmann, David
Mathematische Annalen, ISSN 0025-5831, 12/2019, Volume 375, Issue 3, pp. 949 - 972
Consider the (Navier–) Stokes system on an exterior domain with moving boundary and Dirichlet boundary conditions. In 2003 Saal proved that the Stokes operator... 
35J65 | Mathematics, general | Mathematics | 76D05 | 35B40 | 35Q30
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7. Full Text Image-guided radiotherapy platform using single nodule conditional lung cancer mouse models
by Herter-Sprie, Grit S and Korideck, Houari and Christensen, Camilla L and Herter, Jan M and Rhee, Kevin and Berbeco, Ross I and Bennett, David G and Akbay, Esra A and Kozono, David and Mak, Raymond H and Mike Makrigiorgos, G and Kimmelman, Alec C and Wong, Kwok-Kin
Nature Communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, p. 5870
Close resemblance of murine and human trials is essential to achieve the best predictive value of animal-based translational cancer research. Kras-driven... 
TRIAL | RESISTANCE | BODY RADIATION-THERAPY | EXPRESSION | MULTIDISCIPLINARY SCIENCES | BIOLOGY | Carcinoma, Non-Small-Cell Lung - radiotherapy | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Lung Neoplasms - metabolism | Radiation Tolerance | Lung Neoplasms - radiotherapy | Lung Neoplasms - pathology | Male | Tumor Suppressor Protein p53 - genetics | Adenoviridae - genetics | Female | Integrases - metabolism | Lentivirus - genetics | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Proto-Oncogene Proteins p21(ras) - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Gene Expression | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | Treatment Outcome | Radiation Dosage | Animals | Radiotherapy, Image-Guided - methods | Mice | Genetic Vectors | Integrases - genetics
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8. Full Text FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair
by Kais, Zeina and Rondinelli, Beatrice and Holmes, Amie and O’Leary, Colin and Kozono, David and D’Andrea, Alan D and Ceccaldi, Raphael
Cell Reports, ISSN 2211-1247, 06/2016, Volume 15, Issue 11, pp. 2488 - 2499
BRCA1/2 proteins function in homologous recombination (HR)-mediated DNA repair and cooperate with Fanconi anemia (FA) proteins to maintain genomic integrity... 
GENOMIC INSTABILITY | MONOUBIQUITINATED FANCD2 | REPLICATION FORKS | FANCONI-ANEMIA PATHWAY | CROSS-LINK REPAIR | S PHASE | CTIP | DOUBLE-STRAND BREAKS | HOMOLOGOUS-RECOMBINATION | BRCA1 | CELL BIOLOGY | Genomic Instability | Cell Survival | DNA End-Joining Repair - genetics | Humans | Nuclear Proteins - metabolism | Up-Regulation - genetics | Mutation - genetics | Poly(ADP-ribose) Polymerases - metabolism | Ubiquitination | Animals | BRCA2 Protein - metabolism | Carrier Proteins - metabolism | Fanconi Anemia Complementation Group D2 Protein - metabolism | Neoplasms - genetics | Mice, Nude | BRCA1 Protein - metabolism | Cell Line, Tumor | DNA Replication - genetics | BRCA2 Protein - deficiency | DNA-Directed DNA Polymerase - metabolism | BRCA1 Protein - deficiency | Neoplasms - pathology
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9. Full Text Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy
by Nitta, Masayuki and Kozono, David and Kennedy, Richard and Stommel, Jayne and Ng, Kimberly and Zinn, Pascal O and Kushwaha, Deepa and Kesari, Santosh and Furnari, Frank and Hoadley, Katherine A and Chin, Lynda and Depinho, Ronald A and Cavenee, Webster K and D'Andrea, Alan and Chen, Clark C
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 5, p. e10767
Despite the critical role of Epidermal Growth Factor Receptor (EGFR) in glioblastoma pathogenesis [1,2], EGFR targeted therapies have achieved limited clinical... 
GROWTH-FACTOR RECEPTOR | CELLS | REPAIR | ACTIVATION | REACTIVE OXYGEN | INSTABILITY | DNA-DAMAGE RESPONSE | MULTIDISCIPLINARY SCIENCES | INTEGRATED GENOMIC ANALYSIS | HUMAN CANCERS | MODULATION | Genomic Instability | Glioblastoma - enzymology | Reactive Oxygen Species - metabolism | Oxidative Stress | Humans | Radiation Tolerance | Gene Expression Regulation, Neoplastic | Treatment Outcome | DNA Repair - genetics | Poly(ADP-ribose) Polymerase Inhibitors | Glioblastoma - therapy | Receptor, Epidermal Growth Factor - metabolism | Glioblastoma - genetics | Survival Analysis | Cell Line, Tumor | DNA Damage | Enzyme Activation | Oxidative stress | Ionizing radiation | Epidermal growth factor | DNA damage | Genes | Gene expression | Health aspects | Glioblastoma multiforme | Sugars | Monosaccharides | Pathogenesis | Glioblastoma | Oncology | Genomes | Kinases | ADP | Cancer therapies | DNA repair | Base excision repair | Genomic instability | Ribose | Tumorigenesis | Inhibition | Repair | Deoxyribonucleic acid--DNA | Medical research | Stability | Epidermal growth factor receptors | Anemia | RNA-mediated interference | Addictions | Polymerase | Poly(ADP-ribose) Polymerase 1 | Overexpression | Addiction | Glioblastoma cells | Mutation | Tumors | Deoxyribonucleic acid | DNA
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10. Full Text A DNA repair pathway-focused score for prediction of outcomes in ovarian cancer treated with platinum-based chemotherapy
by Kang, Josephine and D'Andrea, Alan D and Kozono, David
Journal of the National Cancer Institute, ISSN 0027-8874, 05/2012, Volume 104, Issue 9, pp. 670 - 681
Background New tools are needed to predict outcomes of ovarian cancer patients treated with platinum-based chemotherapy. We hypothesized that a molecular score... 
SURVIVAL | INHIBITION | RECQ HELICASES | CLEAR-CELL | MICROARRAY | ONCOLOGY | ROLES | GENE-EXPRESSION PROFILES | SENSITIVITY PROTEIN MUS308 | HOMOLOGOUS RECOMBINATION | GENOME STABILITY | Predictive Value of Tests | Prognosis | Neoplasms, Glandular and Epithelial - chemistry | Area Under Curve | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Ovarian Neoplasms - pathology | DNA Repair - genetics | Ovarian Neoplasms - genetics | Neoplasms, Glandular and Epithelial - genetics | Adult | Female | Ovarian Neoplasms - drug therapy | DNA Repair - drug effects | Ovarian Neoplasms - chemistry | Biomarkers, Tumor - analysis | Kaplan-Meier Estimate | Proportional Hazards Models | Disease-Free Survival | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Carcinoma, Ovarian Epithelial | Aged | Platinum Compounds - administration & dosage | Neoplasm Staging | Care and treatment | Usage | Platinum compounds | Genetic aspects | Research | Gene expression | DNA repair | Health aspects | Ovarian cancer | Statistical analysis | DNA damage | Data processing | Genomes | Survival | Chemotherapy | DNA microarrays | Databases | Platinum | Models | Age | Atlases | Tumors
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11. Full Text TGF-β Inhibition Rescues Hematopoietic Stem Cell Defects and Bone Marrow Failure in Fanconi Anemia
by Zhang, Haojian and Kozono, David E and O’Connor, Kevin W and Vidal-Cardenas, Sofia and Rousseau, Alix and Hamilton, Abigail and Moreau, Lisa and Gaudiano, Emily F and Greenberger, Joel and Bagby, Grover and Soulier, Jean and Grompe, Markus and Parmar, Kalindi and D’Andrea, Alan D
Cell Stem Cell, ISSN 1934-5909, 05/2016, Volume 18, Issue 5, pp. 668 - 681
Fanconi anemia (FA) is an inherited DNA repair disorder characterized by progressive bone marrow failure (BMF) from hematopoietic stem and progenitor cell... 
DNA End-Joining Repair - drug effects | Hematopoietic Stem Cells - drug effects | Cell Survival - drug effects | Mutagens - toxicity | Acetaldehyde - toxicity | Humans | Mice, Inbred C57BL | Hematopoietic Stem Cells - pathology | Down-Regulation - drug effects | Up-Regulation - drug effects | Animals | Signal Transduction - drug effects | Bone Marrow - pathology | Homologous Recombination - genetics | Transforming Growth Factor beta - antagonists & inhibitors | Fanconi Anemia - pathology | Mice | Stress, Physiological - drug effects | Transforming Growth Factor beta - metabolism
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12. Full Text Radiologic-pathologic correlation of response to chemoradiation in resectable locally advanced NSCLC
by Agrawal, Vishesh, MD and Coroller, Thibaud P., MSc and Hou, Ying, MD and Lee, Stephanie W., BA and Romano, John L., BA and Baldini, Elizabeth H., MD, MPH and Chen, Aileen B., MD, MPP and Jackman, David M., MD and Kozono, David, MD, PhD and Swanson, Scott J., MD and Wee, Jon O., MD and Aerts, Hugo J.W.L., PhD and Mak, Raymond H., MD
Lung Cancer, ISSN 0169-5002, 2016, Volume 102, pp. 1 - 8
Highlights • Early response assessment of chemoradiation can guide clinical-decision making. • Volume change after chemoradiation is associated with... 
Hematology, Oncology and Palliative Medicine | Pulmonary/Respiratory | Recist | Quantitative imaging | Response assessment | Non-small cell lung cancer | GROSS TUMOR VOLUME | RANDOMIZED CONTROLLED-TRIAL | CELL LUNG-CANCER | PHASE-II TRIAL | INDUCTION CHEMORADIATION | PROGNOSTIC-FACTOR | PREOPERATIVE CHEMOTHERAPY | NEOADJUVANT CHEMOTHERAPY | ONCOLOGY | RESPIRATORY SYSTEM | HISTOPATHOLOGIC RESPONSE |