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American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 02/2012, Volume 302, Issue 4, pp. L363 - L369
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 09/2010, Volume 182, Issue 5, pp. 652 - 660
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 05/2011, Volume 183, Issue 10, pp. 1402 - 1410
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 05/2012, Volume 302, Issue 10, pp. L977 - L991
Journal Article
Journal Article
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 11/2012, Volume 47, Issue 5, pp. 679 - 687
The combination of chronic hypoxia and treatment of rats with the vascular endothelial growth factor (VEGF) receptor blocker, SU5416, induces pulmonary... 
Hypoxia-induced factor-1α | IL-6 | Precursor cell | LUNG | hypoxia-induced factor-1 alpha | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAST-CELLS | precursor cell | RAT MODEL | CELL BIOLOGY | ENDOTHELIAL PROGENITOR CELLS | POEMS SYNDROME | RESPIRATORY SYSTEM | ELEVATED LEVELS | REGULATORY T-CELLS | CLINICAL CLASSIFICATION | GROWTH-FACTOR RECEPTOR-2 | NF-KAPPA-B | Caspase Inhibitors - pharmacology | Cell Proliferation | Ovalbumin - immunology | Apoptosis - drug effects | Male | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Hypertension, Pulmonary - chemically induced | Hypertension, Pulmonary - prevention & control | Dexamethasone - pharmacology | Receptors, Vascular Endothelial Growth Factor - metabolism | Antilymphocyte Serum - pharmacology | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Pyrroles - adverse effects | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Indoles - pharmacology | Interleukin-6 - metabolism | Disease Models, Animal | Asparagine - pharmacology | Immunization | Lung - pathology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Rats | Hypertension, Pulmonary - immunology | Pulmonary Artery - physiopathology | Asparagine - therapeutic use | Pulmonary Artery - drug effects | Rats, Sprague-Dawley | B-Lymphocytes - drug effects | Asparagine - analogs & derivatives | Dexamethasone - therapeutic use | Pyrroles - pharmacology | Animals | B-Lymphocytes - immunology | Indoles - adverse effects | Caspase Inhibitors - therapeutic use | Lung - drug effects | Hemodynamics | Lung - blood supply | Proliferating Cell Nuclear Antigen - metabolism | Lung - immunology | Pulmonary Artery - pathology | hypoxia-induced factor-1α
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2012, Volume 7, Issue 5, p. e38038
Background: Given the relative abundance and toxic potential of acrolein in inhaled cigarette smoke, it is surprising how little is known about the pulmonary... 
OXIDATIVE STRESS | ALPHA,BETA-UNSATURATED ALDEHYDES | BIOLOGY | TOBACCO-SMOKE | LUNG-FUNCTION | NITRIC-OXIDE | CIGARETTE-SMOKE | CELL APOPTOSIS | MASS-SPECTROMETRY | UNFOLDED-PROTEIN-RESPONSE | ENDOTHELIAL GROWTH-FACTOR | Unfolded Protein Response - drug effects | Lung - pathology | Acrolein - administration & dosage | Endoplasmic Reticulum Stress - drug effects | Gene Expression - drug effects | Unfolded Protein Response - genetics | Caspase 3 - metabolism | Pulmonary Emphysema - pathology | Rats | Male | Pulmonary Emphysema - metabolism | Vascular Endothelial Growth Factor A - metabolism | Pulmonary Disease, Chronic Obstructive - pathology | Acrolein - metabolism | Rats, Sprague-Dawley | Pulmonary Emphysema - chemically induced | Animals | Lung - drug effects | Acrolein - toxicity | Protein Binding | Pulmonary Disease, Chronic Obstructive - metabolism | Proteins | Immunohistochemistry | Heat shock proteins | Cigarettes | Gene expression | Vascular endothelial growth factor | Smoking | Apoptosis | Transcription factors | Laboratories | Pathogenesis | Caspase-12 | Lipid peroxidation | Staining | Critical care | Amino acids | Smoke | Caspase-3 | Accumulation | Respiratory tract | Acrolein | Protein adducts | Rodents | Chronic obstructive pulmonary disease | Alveoli | Expansion | Drug dosages | Enlargement | Adducts | Alveolar air | Internal medicine | Lung diseases | GADD34 protein | Caspase | Inflammation | Stress | Medicine | Airspace | Lungs | Morphology | Relative abundance | Protein expression | Light microscopy | Stress proteins | Endoplasmic reticulum | Emphysema | Cigarette smoke | Chronic effects
Journal Article
Circulation, ISSN 0009-7322, 11/2009, Volume 120, Issue 20, pp. 1951 - 1960
Background-The most important determinant of longevity in pulmonary arterial hypertension is right ventricular (RV) function, but in contrast to experimental... 
Heart failure | Angiogenesis | Microcirculation | Pressure | Pulmonary heart disease | pulmonary heart disease | OVERLOAD | heart failure | CARDIAC & CARDIOVASCULAR SYSTEMS | angiogenesis | pressure | microcirculation | PROGNOSTIC VALUE | MYOSIN HEAVY-CHAIN | ANTIOXIDANT RESPONSE ELEMENT | TRANSCRIPTION FACTOR NRF2 | VENTRICULAR HYPERTROPHY | CARDIAC-HYPERTROPHY | DISEASE | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | HYPERTENSION | HEMATOLOGY | Blood Pressure | Vascular Endothelial Growth Factor A - biosynthesis | Heart Failure - physiopathology | Hypertension, Pulmonary - physiopathology | Male | RNA, Messenger - biosynthesis | Hypertrophy, Right Ventricular - physiopathology | Pulmonary Artery - metabolism | Heme Oxygenase (Decyclizing) - biosynthesis | Hypertrophy, Right Ventricular - pathology | Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis | Hypertrophy, Right Ventricular - metabolism | Disease Models, Animal | Gene Expression Regulation | Rats | Heart Failure - metabolism | Hypertension, Pulmonary - metabolism | Pulmonary Artery - physiopathology | Heart Failure - pathology | Rats, Sprague-Dawley | Animals | Fibrosis | Hypertension, Pulmonary - pathology | Pulmonary Artery - pathology | Ventricular Function, Right | Apoptosis | Usage | Animal models in research | Heart ventricle, Left | Physiological aspects | Diagnosis | Pulmonary hypertension
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 07/2012, Volume 303, Issue 1, pp. L20 - L32
Fisher BJ, Kraskauskas D, Martin EJ, Farkas D, Wegelin JA, Brophy D, Ward KR, Voelkel NF, Fowler AA 3rd, Natarajan R. Mechanisms of attenuation of abdominal... 
Epithelial ion channels | Coagulopathy | Barrier integrity | VITAMIN-C | OXIDATIVE STRESS | PHYSIOLOGY | NITRIC-OXIDE SYNTHASE | epithelial ion channels | coagulopathy | MULTIPLE ORGAN FAILURE | PULMONARY-EDEMA | TIGHT JUNCTIONS | RESPIRATORY SYSTEM | DISSEMINATED INTRAVASCULAR COAGULATION | ENDOTHELIAL-CELLS | SEPTIC SHOCK | barrier integrity | FACTOR PATHWAY INHIBITOR | Respiratory Mucosa - drug effects | Humans | Male | Bronchoalveolar Lavage - methods | Inflammation - blood | Sepsis - drug therapy | Inflammation - metabolism | Peritonitis - microbiology | Sepsis - metabolism | Pulmonary Alveoli - metabolism | Pulmonary Alveoli - drug effects | Cytoskeletal Proteins - metabolism | Ion Transport - drug effects | Respiratory Mucosa - physiopathology | Acute Lung Injury - drug therapy | Acute Lung Injury - metabolism | Lung - metabolism | Pulmonary Alveoli - physiopathology | Neutrophils - metabolism | Cell Line | Acute Lung Injury - physiopathology | Permeability - drug effects | Abdomen - microbiology | Mice, Inbred C57BL | Neutrophils - drug effects | Peritonitis - metabolism | Neutrophils - physiology | Lung - physiopathology | Biomarkers - blood | Sepsis - physiopathology | Sodium-Potassium-Exchanging ATPase - metabolism | Acute Lung Injury - microbiology | Animals | Blood Coagulation - drug effects | Ion Channels - metabolism | Lung - drug effects | Abdomen - pathology | Ascorbic Acid - pharmacology | Peritonitis - physiopathology | Mice | Sepsis - blood | Peritonitis - drug therapy | Respiratory Mucosa - metabolism | Inflammation - physiopathology | Complications and side effects | Bacterial infections | Lung diseases | Vitamin C | Research | Health aspects | Risk factors
Journal Article
Physiological Genomics, ISSN 1094-8341, 06/2013, Volume 45, Issue 12, pp. 449 - 461
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 03/2011, Volume 300, Issue 3, pp. 402 - 413
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, p. e0120157
Inflammation and altered immunity are recognized components of severe pulmonary arterial hypertension in human patients and in animal models of PAH. While... 
CELLS | CYCLOOXYGENASE-2 | INHIBITION | THROMBOXANE | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | ARTERIAL-HYPERTENSION | PROSTAGLANDIN | EXPRESSION | RAT LUNG | VASOCONSTRICTION | Hypoxia - drug therapy | Arachidonate 5-Lipoxygenase - genetics | Dinoprostone - biosynthesis | Leukotriene D4 - biosynthesis | Humans | Arterioles - enzymology | Prostaglandins F - antagonists & inhibitors | Male | Thromboxane B2 - antagonists & inhibitors | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Lung - enzymology | Dinoprost - biosynthesis | Cyclooxygenase 2 - genetics | Prostaglandins F - biosynthesis | Hypertension, Pulmonary - drug therapy | Ventricular Function, Right - drug effects | Leukotriene D4 - antagonists & inhibitors | Hypertension, Pulmonary - enzymology | Pyrazoles - pharmacology | Lung - pathology | Hypoxia - enzymology | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Diethylcarbamazine - pharmacology | Rats | Hypertension, Pulmonary - genetics | Inflammation | Pulmonary Artery - drug effects | Thromboxane B2 - biosynthesis | Arterioles - drug effects | Rats, Sprague-Dawley | Pulmonary Artery - enzymology | Arterioles - pathology | Hypoxia - genetics | Animals | Hypoxia - pathology | Lung - drug effects | Cyclooxygenase 2 - metabolism | Dinoprost - antagonists & inhibitors | Dinoprostone - antagonists & inhibitors | Lipoxygenase Inhibitors - pharmacology | Pulmonary Artery - pathology | COX-2 inhibitors | Research | Metabolites | Analysis | Pulmonary hypertension | Heart | Oxidative stress | Animal models | Pathogenesis | Arterioles | Critical care | Biochemistry | Kinases | Immunity | Prostaglandin endoperoxide synthase | Antioxidants | Vascular diseases | Rodents | Arachidonate 5-lipoxygenase | Cardiology | Heart failure | Hypertension | Medical research | Pulmonary arteries | Lung diseases | Blood vessels | Medicine | Lungs | Hypoxia | Ventricle | Cyclooxygenase-2 | Lipoxygenase | Molecular biology | Cancer
Journal Article