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science & technology (89) 89
life sciences & biomedicine (87) 87
humans (86) 86
hematology (74) 74
adamts13 protein (51) 51
female (48) 48
adult (44) 44
male (41) 41
middle aged (31) 31
thrombotic thrombocytopenic purpura (30) 30
biological and medical sciences (28) 28
medical sciences (27) 27
abridged index medicus (23) 23
hematologic and hematopoietic diseases (21) 21
hemic and lymphatic diseases (20) 20
purpura, thrombotic thrombocytopenic - diagnosis (20) 20
purpura, thrombotic thrombocytopenic - therapy (20) 20
thrombocytopenic purpura (19) 19
aged (18) 18
plasma exchange (17) 17
platelet diseases and coagulopathies (17) 17
cardiovascular system & cardiology (16) 16
peripheral vascular disease (16) 16
von willebrand factor (16) 16
adolescent (15) 15
purpura, thrombotic thrombocytopenic - genetics (15) 15
adam proteins - deficiency (14) 14
purpura, thrombotic thrombocytopenic - blood (14) 14
recurrence (14) 14
adam proteins - blood (13) 13
adam proteins - genetics (13) 13
adamts13 (13) 13
mutation (13) 13
purpura, thrombotic thrombocytopenic - immunology (13) 13
autoantibodies - immunology (11) 11
pregnancy (11) 11
registries (11) 11
adam proteins - metabolism (10) 10
anemias. hemoglobinopathies (10) 10
diseases of red blood cells (10) 10
purpura, thrombotic thrombocytopenic - complications (10) 10
purpura, thrombotic thrombocytopenic - drug therapy (10) 10
young adult (10) 10
adam proteins - immunology (9) 9
child (9) 9
thrombosis (9) 9
ttp (9) 9
adam proteins (8) 8
case-control studies (8) 8
general & internal medicine (8) 8
medicine, general & internal (8) 8
plasma (8) 8
risk factors (8) 8
610 medicine & health (7) 7
analysis (7) 7
autoantibodies - blood (7) 7
genetic aspects (7) 7
purpura (7) 7
therapeutics (7) 7
von willebrand factor - metabolism (7) 7
follow-up studies (6) 6
fundamental and applied biological sciences. psychology (6) 6
heterocyclic compounds (6) 6
laboratories (6) 6
metalloendopeptidases - deficiency (6) 6
metalloendopeptidases - immunology (6) 6
neoplasms (6) 6
patients (6) 6
purpura, thrombotic thrombocytopenic - enzymology (6) 6
purpura, thrombotic thrombocytopenic - epidemiology (6) 6
purpura, thrombotic thrombocytopenic - etiology (6) 6
respiratory system (6) 6
rituximab (6) 6
adamts13 protein - blood (5) 5
anesthesia. intensive care medicine. transfusions. cell therapy and gene therapy (5) 5
blood coagulation. blood cells (5) 5
immunology (5) 5
molecular and cellular biology (5) 5
purpura, thrombotic thrombocytopenic - mortality (5) 5
retrospective studies (5) 5
acute disease (4) 4
adamts13 activity (4) 4
adamts13 protein - metabolism (4) 4
blood. blood and plasma substitutes. blood products. blood cells. blood typing. plasmapheresis. apheresis (4) 4
care and treatment (4) 4
coagulation factors (4) 4
enzyme-linked immunosorbent assay (4) 4
genetic disorders (4) 4
hemolytic uremic syndrome (4) 4
hemostasis (4) 4
immunoglobulins (4) 4
immunopathology (4) 4
metalloendopeptidases - blood (4) 4
metalloendopeptidases - genetics (4) 4
metalloendopeptidases - metabolism (4) 4
oklahoma - epidemiology (4) 4
prognosis (4) 4
purpura, thrombotic thrombocytopenic - congenital (4) 4
purpura, thrombotic thrombocytopenic - metabolism (4) 4
remission induction (4) 4
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1. Full Text Frequency and Significance of HIV Infection among Patients Diagnosed with Thrombotic Thrombocytopenic Purpura
by Melody Benjamin and Deirdra R. Terrell and Sara K. Vesely and Gene W. Voskuhl and Bruce J. Dezube and Johanna A. Kremer Hovinga and Bernhard Lämmle and James N. George
Clinical infectious diseases, ISSN 1058-4838, 4/2009, Volume 48, Issue 8, pp. 1129 - 1137
HIV/AIDS | Plasma exchange | Highly active antiretroviral therapy | HIV infections | Thrombotic thrombocytopenic purpura | HIV | Hemolytic uremic syndrome | Thrombotic microangiopathies | Disorders | AIDS | Infections | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Hematologic and hematopoietic diseases | Immunopathology | Infectious diseases | Viral diseases | Viral diseases of the lymphoid tissue and the blood. Aids | Biological and medical sciences | Medical sciences | Human viral diseases | Immunodeficiencies. Immunoglobulinopathies | Immunodeficiencies | Platelet diseases and coagulopathies | HIV Infections - epidemiology | Humans | Middle Aged | Male | Purpura, Thrombotic Thrombocytopenic - complications | Purpura, Thrombotic Thrombocytopenic - diagnosis | ADAMTS13 Protein | Purpura, Thrombotic Thrombocytopenic - epidemiology | ADAM Proteins - metabolism | Purpura, Thrombotic Thrombocytopenic - pathology | HIV Infections - pathology | HIV Infections - complications | Adult | Female | Registries | Retrospective Studies | Clinical medicine | Hematology | Blood diseases | Patients | Human immunodeficiency virus--HIV | Index Medicus
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2. Full Text Hereditary Thrombotic Thrombocytopenic Purpura
by Kremer Hovinga, Johanna A and George, James N
The New England journal of medicine, ISSN 0028-4793, 10/2019, Volume 381, Issue 17, pp. 1653 - 1662
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Purpura, Thrombotic Thrombocytopenic - history | Plasma | Diagnosis, Differential | Prevalence | History, 20th Century | Humans | Male | Plasma Exchange | Purpura, Thrombotic Thrombocytopenic - diagnosis | Genes, Recessive | ADAMTS13 Protein - metabolism | Blood Component Transfusion | ADAMTS13 Protein - genetics | ADAMTS13 Protein - deficiency | Female | Purpura, Thrombotic Thrombocytopenic - therapy | Mutation | Purpura, Thrombotic Thrombocytopenic - genetics | Thrombocytopenic purpura | Outcome and process assessment (Health Care) | Care and treatment | Analysis | Risk factors | Blood transfusions | Health care | Pathogenesis | Thrombosis | Clotting | Hereditary diseases | Proteins | Thrombotic thrombocytopenic purpura | Hospitals | Blood platelets | Purpura | Von Willebrand factor | Health risk assessment | Binding sites | Index Medicus | Abridged Index Medicus
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3. Full Text Survival and relapse in patients with thrombotic thrombocytopenic purpura
by Kremer Hovinga, Johanna A and Vesely, Sara K and Terrell, Deirdra R and Lämmle, Bernhard and George, James N
Blood, ISSN 0006-4971, 02/2010, Volume 115, Issue 8, pp. 1500 - 1511
Life Sciences & Biomedicine | Hematology | Science & Technology | Hematologic and hematopoietic diseases | Anemias. Hemoglobinopathies | Biological and medical sciences | Medical sciences | Diseases of red blood cells | Platelet diseases and coagulopathies | Recurrence | Follow-Up Studies | Humans | Oklahoma | Male | Survival Rate | Plasma Exchange | ADAMTS13 Protein | Purpura, Thrombotic Thrombocytopenic - mortality | ADAM Proteins - blood | Disease-Free Survival | Protease Inhibitors - blood | Female | Registries | Purpura, Thrombotic Thrombocytopenic - therapy | Retrospective Studies | Purpura, Thrombotic Thrombocytopenic - blood | Index Medicus | Abridged Index Medicus
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4. Full Text Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura
by Scully, Marie and Cataland, Spero R and Peyvandi, Flora and Coppo, Paul and Knöbl, Paul and Kremer Hovinga, Johanna A and Metjian, Ara and de la Rubia, Javier and Pavenski, Katerina and Callewaert, Filip and Biswas, Debjit and De Winter, Hilde and Zeldin, Robert K and HERCULES Investigators
The New England journal of medicine, ISSN 0028-4793, 01/2019, Volume 380, Issue 4, pp. 335 - 346
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Body Mass Index | Single-Domain Antibodies - therapeutic use | Double-Blind Method | Single-Domain Antibodies - adverse effects | Humans | Middle Aged | Male | Gingival Diseases - chemically induced | Plasma Exchange | Purpura, Thrombotic Thrombocytopenic - mortality | ADAMTS13 Protein - metabolism | Young Adult | Fibrinolytic Agents - adverse effects | Platelet Count | von Willebrand Factor - antagonists & inhibitors | Fibrinolytic Agents - therapeutic use | Adolescent | Intention to Treat Analysis | Purpura, Thrombotic Thrombocytopenic - drug therapy | Adult | Female | Aged | Purpura, Thrombotic Thrombocytopenic - therapy | Hemorrhage - chemically induced | Thrombocytopenic purpura | Placebos | Clinical trials | Usage | Drug therapy | Analysis | Fees & charges | Thrombocytopenia | Plasma | Intravenous administration | Anemia | Thrombosis | Patients | Thrombotic thrombocytopenic purpura | Hemolytic anemia | Ischemia | Purpura | Von Willebrand factor | Autoimmune diseases | Thromboembolism | Health risk assessment | Platelets | Index Medicus | Abridged Index Medicus
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5. Full Text Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura
by Peyvandi, Flora and Scully, Marie and Kremer Hovinga, Johanna A and Cataland, Spero and Knöbl, Paul and Wu, Haifeng and Artoni, Andrea and Westwood, John-Paul and Mansouri Taleghani, Magnus and Jilma, Bernd and Callewaert, Filip and Ulrichts, Hans and Duby, Christian and Tersago, Dominique and TITAN Investigators
The New England journal of medicine, ISSN 0028-4793, 02/2016, Volume 374, Issue 6, pp. 511 - 522
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Single-Blind Method | Recurrence | Single-Domain Antibodies - therapeutic use | Single-Domain Antibodies - adverse effects | Humans | Middle Aged | Male | ADAMTS13 Protein | Remission Induction | Young Adult | Fibrinolytic Agents - adverse effects | ADAM Proteins - metabolism | von Willebrand Factor - antagonists & inhibitors | Fibrinolytic Agents - therapeutic use | Purpura, Thrombotic Thrombocytopenic - drug therapy | Adult | Female | Aged | Hemorrhage - chemically induced | Purpura, Thrombotic Thrombocytopenic - metabolism | Plasma | Immunoglobulins | Thrombosis | Patients | Bleeding | Morbidity | Immunosuppressive agents | Thrombocytopenic purpura | Thrombotic thrombocytopenic purpura | Ischemia | Blood platelets | Purpura | Von Willebrand factor | Remission | Microvasculature | Blood diseases | Health risk assessment | Platelets | Drug therapy | Index Medicus | Abridged Index Medicus
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6. Full Text Impaired DNase1‐mediated degradation of neutrophil extracellular traps is associated with acute thrombotic microangiopathies
by Jiménez‐Alcázar, M and Napirei, M and Panda, R and Köhler, E. C and Kremer Hovinga, J. A and Mannherz, H. G and Peine, S and Renné, T and Lämmle, B and Fuchs, T. A
Journal of thrombosis and haemostasis, ISSN 1538-7933, 05/2015, Volume 13, Issue 5, pp. 732 - 742
neutrophil extracellular traps | thrombosis | thrombotic microangiopathies | neutrophils | deoxyribonuclease I | Deoxyribonuclease I | Thrombosis | Neutrophil extracellular traps | Thrombotic microangiopathies | Neutrophils | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Hydrolysis | Deoxyribonuclease I - metabolism | Thrombotic Microangiopathies - blood | Extracellular Traps - metabolism | Neutrophils - metabolism | Humans | Enzymes | Plasma | Index Medicus | Medicin och hälsovetenskap
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7. Full Text Children and adults with thrombotic thrombocytopenic purpura associated with severe, acquired Adamts13 deficiency: Comparison of incidence, demographic and clinical features
by Reese, Jessica A and Muthurajah, Darrshini S and Hovinga, Johanna A. Kremer and Vesely, Sara K and Terrell, Deirdra R and George, James N
Pediatric blood & cancer, ISSN 1545-5009, 10/2013, Volume 60, Issue 10, pp. 1676 - 1682
disparities | TTP | thrombotic thrombocytopenic purpura | children | incidence | Thrombotic thrombocytopenic purpura | Disparities | Children | Incidence | Pediatrics | Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | Japan - epidemiology | Recurrence | Age Factors | Humans | Antibodies, Monoclonal, Murine-Derived - administration & dosage | Child, Preschool | Male | Lupus Erythematosus, Systemic - blood | Renal Insufficiency - epidemiology | ADAM Proteins - blood | Lupus Erythematosus, Systemic - diet therapy | Purpura, Thrombotic Thrombocytopenic - drug therapy | Adult | Female | Registries | Retrospective Studies | Renal Insufficiency - blood | Child | Lupus Erythematosus, Systemic - epidemiology | Immunologic Factors - administration & dosage | ADAM Proteins - deficiency | Rituximab | ADAMTS13 Protein | Purpura, Thrombotic Thrombocytopenic - epidemiology | Renal Insufficiency - therapy | Adolescent | Sex Factors | Purpura, Thrombotic Thrombocytopenic - blood | Thrombocytopenic purpura | Comparative analysis | Von Willebrand factor | Index Medicus
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8. Full Text Von willebrand factor interacts with surface-bound C1q and induces platelet rolling
by Kölm, Robert and Schaller, Monica and Roumenina, Lubka T and Niemiec, Iga and Hovinga, Johanna A. Kremer and Khanicheh, Elham and Kaufmann, Beat A and Hopfer, Helmut and Trendelenburg, Marten
The Journal of immunology (1950), ISSN 0022-1767, 11/2016, Volume 197, Issue 9, pp. 3669 - 3679
Life Sciences & Biomedicine | Immunology | Science & Technology | Autoantibodies - metabolism | Lupus Erythematosus, Systemic - complications | Atherosclerosis - immunology | Blood Platelets - immunology | Collagen Type I - metabolism | Kidney - pathology | Humans | Cells, Cultured | Thrombosis - immunology | Complement C1q - metabolism | Autoantibodies - immunology | Kidney - metabolism | Hemostasis | Platelet Activation | Lupus Erythematosus, Systemic - immunology | Protein Binding | Cell Membrane - metabolism | Antigen-Antibody Complex - metabolism | Apoptosis | von Willebrand Factor - metabolism | Index Medicus | Abridged Index Medicus
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9. Full Text Rituximab reduces risk for relapse in patients with thrombotic thrombocytopenic purpura
by Page, Evaren E and Kremer Hovinga, Johanna A and Terrell, Deirdra R and Vesely, Sara K and George, James N
Blood, ISSN 0006-4971, 06/2016, Volume 127, Issue 24, pp. 3092 - 3094
Life Sciences & Biomedicine | Hematology | Science & Technology | Recurrence | Humans | Middle Aged | ADAMTS13 Protein - analysis | Male | Plasma Exchange | Purpura, Thrombotic Thrombocytopenic - diagnosis | Adrenal Cortex Hormones - therapeutic use | Secondary Prevention - methods | Purpura, Thrombotic Thrombocytopenic - prevention & control | Young Adult | Rituximab - therapeutic use | Purpura, Thrombotic Thrombocytopenic - drug therapy | Adult | Female | Aged | Purpura, Thrombotic Thrombocytopenic - therapy | Immunologic Factors - therapeutic use | Index Medicus | Abridged Index Medicus
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10. Full Text Circulating DNA and myeloperoxidase indicate disease activity in patients with thrombotic microangiopathies
by Fuchs, Tobias A and Kremer Hovinga, Johanna A and Schatzberg, Daphne and Wagner, Denisa D and Lämmle, Bernhard
Blood, ISSN 0006-4971, 08/2012, Volume 120, Issue 6, pp. 1157 - 1164
Life Sciences & Biomedicine | Hematology | Science & Technology | Hematologic and hematopoietic diseases | Biological and medical sciences | Medical sciences | Acute Disease | Prognosis | Humans | Middle Aged | Male | Remission Induction | Case-Control Studies | Disease Progression | DNA - blood | Peroxidase - analysis | DNA - analysis | Adolescent | Thrombotic Microangiopathies - therapy | Adult | Female | Thrombotic Microangiopathies - blood | Thrombotic Microangiopathies - diagnosis | Aged | Nucleosomes - pathology | Peroxidase - blood | Cohort Studies | Index Medicus | Abridged Index Medicus | Thrombosis and Hemostasis | Plenary Paper
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