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Nature Medicine, ISSN 1078-8956, 01/2016, Volume 22, Issue 1, pp. 78 - 83
Journal Article
Journal Article
Cell, ISSN 0092-8674, 01/2013, Volume 152, Issue 1-2, pp. 340 - 351
Monitoring cancer and aging in vivo remains experimentally challenging. Here, we describe a luciferase knockin mouse (p16 ), which faithfully reports... 
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 2014, Volume 106, Issue 4, p. dju057
Journal Article
American Journal of Cardiology, The, ISSN 0002-9149, 2013, Volume 111, Issue 7, pp. 32B - 32B
  Description Values Observed Code 1 Amount of Contrast Used Numerical Value Value in "ml" 2 Diabetes with Micro angiopathy Yes 1 No 0 3 Hypotension Yes 1 No 0... 
Cardiovascular | CARDIAC & CARDIOVASCULAR SYSTEMS | Disease prevention | Mortality | Diabetes
Journal Article
Cell Stem Cell, ISSN 1934-5909, 2007, Volume 1, Issue 1, pp. 9 - 11
The “rate-of-living theory” is an ancient explanation of longevity which holds that aging occurs due to the exhaustion of some finite substance—breaths,... 
Stem Cells - cytology | Cellular Senescence | Cell Division | Humans
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 11/2004, Volume 114, Issue 9, pp. 1299 - 1307
The Ink4a/Arflocus encodes 2 tumor suppressor molecules, p16(INK4a) and Arf, which are principal mediators of cellular senescence. To study the links between... 
TRANSCRIPTION FACTORS | MEDICINE, RESEARCH & EXPERIMENTAL | LIFE-SPAN | P16(INK4A) EXPRESSION | HEMATOPOIETIC STEM-CELLS | BONE-MARROW | IN-VIVO | TELOMERASE ACTIVITY | TUMOR-SUPPRESSOR | SIRT1 DEACETYLASE | CELLULAR SENESCENCE
Journal Article
Aging Cell, ISSN 1474-9718, 10/2012, Volume 11, Issue 5, pp. 916 - 918
The p16 INK4a tumor suppressor gene is a mediator of cellular senescence and has been suggested to be a biomarker of ‘molecular’ age in several tissues... 
immunosenescence | p16 | CDKN2a | human | T cell | INK4/ARF | Human | Immunosenescence | P16 | ARF | INK4 | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | Highly active antiretroviral therapy | Antiviral agents | Medical colleges | Care and treatment | Genes | Aged patients | HIV patients | HIV (Viruses) | T cells | HIV infection | Emergency medical services | Public health | Aging | Biomarkers | Human immunodeficiency virus--HIV
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2019, Volume 116, Issue 7, pp. 2603 - 2611
The activation of cellular senescence throughout the lifespan promotes tumor suppression, whereas the persistence of senescent cells contributes to aspects of... 
cdkn2a | Aging | Senescence
Journal Article
Blood, ISSN 0006-4971, 03/2011, Volume 117, Issue 12, pp. 3257 - 3267
Previous authors have suggested that tumor suppressor expression promotes aging while preventing cancer, but direct experimental support for this cancer-aging... 
Plenary Paper
Journal Article
Proceedings of the National Academy of Sciences of the United States, ISSN 0027-8424, 02/2019, Volume 116, Issue 7, p. 2603
The activation of cellular senescence throughout the lifespan promotes tumor suppression, whereas the persistence of senescent cells contributes to aspects of... 
Chemical inhibitors | Cell research | Cell cycle | Physiological aspects | Aging | Research | Cells
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2019, Volume 116, Issue 7, p. 2603
The activation of cellular senescence throughout the lifespan promotes tumor suppression, whereas the persistence of senescent cells contributes to aspects of... 
Phenotypes | Senescence | Enumeration | Transcription | INK4a protein | p16 Protein | Galactosidase | Radioactive half-life | Activation | INK4 protein | Embryo fibroblasts | Macrophages | Gene expression | Embryos | Cell activation | Life span | Aging | Fibroblasts | Mice | Dimers | Tomatoes | Cyclin-dependent kinase inhibitors | Peritoneum
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 02/2019, Volume 116, Issue 7, pp. 2603 - 2611
The accumulation of senescent cells over a lifetime causes age-related pathologies; however, the inability to reliably identify senescent cells in vivo has... 
senescence | cdkn2a | Biological Sciences | aging | PNAS Plus
Journal Article