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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2015, Volume 112, Issue 52, pp. E7230 - E7238
The aggressive activated B cell-like subtype of diffuse large B-cell lymphoma is characterized by aberrant B-cell receptor (BCR) signaling and constitutive... 
NF-κB | Mouse model | JNK | CARD11 | Diffuse large B-cell lymphoma | SURVIVAL | mouse model | MULTIDISCIPLINARY SCIENCES | KINASE | PKC-BETA | diffuse large B-cell lymphoma | T-CELL | HODGKIN-LYMPHOMA | MALT1 | NF-kappa B | ONCOGENIC CARD11 MUTATIONS | C-JUN | INHIBITOR | EXPRESSION | Humans | JNK Mitogen-Activated Protein Kinases - metabolism | NF-kappa B - metabolism | Lymphoma, Large B-Cell, Diffuse - metabolism | Neoplasm Proteins - metabolism | CARD Signaling Adaptor Proteins - genetics | CARD Signaling Adaptor Proteins - metabolism | Caspases - metabolism | Flow Cytometry | B-Lymphocytes - pathology | Neoplasm Proteins - genetics | B-Lymphocytes - metabolism | Cell Line | Cell Proliferation - genetics | Lymphoma, Large B-Cell, Diffuse - pathology | Caspases - genetics | Cells, Cultured | Guanylate Cyclase - metabolism | Mice, Transgenic | Signal Transduction - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Knockout | Animals | B-Cell CLL-Lymphoma 10 Protein | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Guanylate Cyclase - genetics | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein | Enzyme Activation | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Lymphoma, Large B-Cell, Diffuse - genetics | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
by Dastani, Zari and Hivert, Marie-France and Timpson, Nicholas and Perry, John R. B and Yuan, Xin and Scott, Robert A and Henneman, Peter and Heid, Iris M and Kizer, Jorge R and Lyytikäinen, Leo-Pekka and Fuchsberger, Christian and Tanaka, Toshiko and Morris, Anew P and Small, Kerrin and Isaacs, Aaron and Beekman, Marian and Coassin, Stefan and Lohman, Kurt and Qi, Lu and Kanoni, Stavroula and Pankow, James S and Uh, Hae-Won and Wu, Ying and Bidulescu, Aurelian and Rasmussen-Torvik, Laura J and Greenwood, Celia M. T and Ladouceur, Martin and Grimsby, Jonna and Manning, Alisa K and Liu, Ching-Ti and Kooner, Jaspal and Mooser, Vincent E and Vollenweider, Peter and Kapur, Karen A and Chambers, John and Wareham, Nicholas J and Langenberg, Claudia and Frants, Rune and Willems-Vandijk, Ko and Oostra, Ben A and Willems, Sara M and Lamina, Claudia and Winkler, Thomas W and Psaty, Bruce M and Tracy, Russell P and Brody, Jennifer and Chen, Ida and Viikari, Jorma and Kähönen, Mika and Pramstaller, Peter P and Evans, David M and St Pourcain, Beate and Sattar, Naveed and Wood, Anew R and Bandinelli, Stefania and Carlson, Olga D and Egan, Josephine M and Böhringer, Stefan and van Heemst, Diana and Kedenko, Lyudmyla and Kristiansson, Kati and Nuotio, Marja-Liisa and Loo, Britt-Marie and Harris, Tamara and Garcia, Melissa and Kanaya, Alka and Haun, Margot and Klopp, Norman and Wichmann, H.-Erich and Deloukas, Panos and Katsareli, Efi and Couper, David J and Duncan, Bruce B and Kloppenburg, Margreet and Adair, Linda S and Borja, Judith B and Wilson, James G and Musani, Solomon and Guo, Xiuqing and Johnson, Toby and Semple, Robert and Teslovich, Tanya M and Allison, Matthew A and Redline, Susan and Buxbaum, Sarah G and Mohlke, Karen L and Meulenbelt, Ingrid and Ballantyne, Christie M and Dedoussis, George V and Hu, Frank B and Liu, Yongmei and Paulweber, Bernhard and Spector, Timothy D and Slagboom, P. Eline and Ferrucci, Luigi and Jula, Antti and Perola, Markus and Raitakari, Olli and Florez, Jose C and Salomaa, Veikko and ... and GLGC Investigators and DIAGRAM Consortium and MAGIC Consortium and MuTHER Consortium and Global B Pgen Consortium and MAGIC investigators and Procardis Consortium and DIAGRAM+ Consortium and GLGC Consortium and GIANT Consortium
PLoS genetics, ISSN 1553-7390, 2012, Volume 8, Issue 3, pp. e1002607 - e1002607
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2012, Volume 7, Issue 8, pp. e42465 - e42465
Journal Article
Circulation Research, ISSN 0009-7330, 01/2017, Volume 120, Issue 1, pp. 120 - 132
RATIONALE:Phosphodiesterase 2 is a dual substrate esterase, which has the unique property to be stimulated by cGMP, but primarily hydrolyzes cAMP. Myocardial... 
heart rate | catecholamine | myocardial contraction | cardiac arrhythmia | cyclic GMP-stimulated phosphodiesterase | CARDIAC & CARDIOVASCULAR SYSTEMS | VENTRICULAR MYOCYTES | FAILURE | SR CA2+ LEAK | HEART-RATE-VARIABILITY | CARDIAC-HYPERTROPHY | CAMP SENSITIVITY | NITRIC-OXIDE | CGMP | PERIPHERAL VASCULAR DISEASE | MICE | PACEMAKER | HEMATOLOGY | Arrhythmias, Cardiac - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 2 - antagonists & inhibitors | Arrhythmias, Cardiac - prevention & control | Isoproterenol - toxicity | Triazines - pharmacology | Arrhythmias, Cardiac - chemically induced | Cardiotonic Agents - metabolism | Myocardial Contraction - physiology | Myocardial Contraction - drug effects | Male | Mice, Transgenic | Catecholamines - toxicity | Imidazoles - pharmacology | Myocardial Infarction - metabolism | Animals | Dogs | Cyclic Nucleotide Phosphodiesterases, Type 2 - biosynthesis | Female | Myocardial Infarction - physiopathology | Mice | EKG | Myocardial infarction | Cardiac arrhythmia | Phenotypes | Phosphorylation | Heart attacks | Arrhythmia | Contractility | Transgenic mice | Cardiomyocytes | Telemetry | Muscle contraction | Contraction | Calcium signalling | Heart rate | Ischemia | Esterase | Cyclic GMP | Rodents | Adrenergic receptors | Ventricle | Heart diseases | Phosphodiesterase | Geriatrics | Index Medicus
Journal Article
Allergy, ISSN 0105-4538, 02/2012, Volume 67, Issue 2, pp. 227 - 234
Background: Glucocorticoids (GC) are potent anti-inflammatory and immunosuppressive steroid hormones, mainly produced by the adrenal glands. However,... 
lung | asthma | 11beta‐Hsd1 | glucocorticoids | inflammation | 11beta-Hsd1 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 | INNATE | IMMUNOLOGY | INTESTINAL EPITHELIAL-CELLS | REGULATOR | TUMOR-NECROSIS-FACTOR | AIRWAY | INTERFACE | ALLERGY | FEEDBACK | METYRAPONE | Tumor Necrosis Factor-alpha - metabolism | Steroid Hydroxylases - metabolism | Lung - pathology | Humans | Mice, Inbred C57BL | Respiratory Hypersensitivity - metabolism | Receptors, Cytoplasmic and Nuclear - genetics | Respiratory Hypersensitivity - immunology | Mice, Knockout | Respiratory Hypersensitivity - genetics | 11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism | Animals | HEK293 Cells | Cell Line, Tumor | Lung - metabolism | Mice | Mice, Inbred BALB C | Glucocorticoids - biosynthesis | In Vitro Techniques | Steroid Hydroxylases - genetics | Lung - immunology | Disease Models, Animal | Receptors, Cytoplasmic and Nuclear - metabolism | Hormones | Lungs | Pathogenesis | Rodents | Allergies | Index Medicus | Enzymes | Ovalbumin | Immune response | Adrenal glands | Glucocorticoids | Corticosterone | Immunoregulation | Hypersensitivity | Lung | Antibodies | Data processing | 11 beta -Hydroxysteroid dehydrogenase | Inflammation | Epithelium | Cholesterol | Lipopolysaccharides | Cell activation | Organ culture | Respiratory tract diseases | Steroidogenesis | Steroid hormones | Tumor necrosis factor- alpha
Journal Article
PLoS ONE, ISSN 1932-6203, 2012, Volume 7, Issue 1, pp. e29202 - e29202
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2017, Volume 12, Issue 9, pp. e0182552 - e0182552
Journal Article
Cell Reports, ISSN 2211-1247, 05/2019, Volume 27, Issue 7, pp. 2199 - 2211.e6
Synaptic dysfunction is associated with many brain disorders, but robust human cell models to study synaptic transmission and plasticity are lacking. Instead,... 
forward programming | iPSC | synaptopathy | NGN2 | synaptic transmission | synapse | synaptic plasticity | synaptic dysfunction | single-cell model | human neuron | PLURIPOTENT STEM-CELLS | SYSTEM | NEUROTRANSMISSION | PROTEIN | MUNC18-1 | GENES | MUTATIONS | SYNAPTOPATHY | CELL BIOLOGY
Journal Article