Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2008, Volume 105, Issue 4, pp. 1303 - 1308
The pandemic influenza of 1918 (Spanish flu) killed 21-50 million people globally, including in Iceland, where the characteristics and spread of the epidemic...
Aggregation | Epidemics | Pandemics | Databases | Mortality | Medical genetics | Death | Viruses | H5N1 subtype influenza A virus | Morbidity | Medical history | Heritability | Host factors | Transmission | IMMUNE | RESPONSES | transmission | medical history | MULTIDISCIPLINARY SCIENCES | mortality | host factors | H5N1 VIRUS-INFECTION | heritability | Iceland - epidemiology | Genetic Predisposition to Disease | History, 20th Century | Humans | Middle Aged | Child, Preschool | Infant | Influenza, Human - epidemiology | Male | Disease Outbreaks | Influenza, Human - genetics | Adolescent | Survival Analysis | Aged, 80 and over | Influenza, Human - mortality | Adult | Family | Female | Aged | Influenza, Human - history | Child | Infant, Newborn | Disease transmission | Genetic susceptibility | Influenza | Distribution | Causes of | Genetic aspects | Heredity | Research | Health aspects | Iceland | Biological Sciences
Aggregation | Epidemics | Pandemics | Databases | Mortality | Medical genetics | Death | Viruses | H5N1 subtype influenza A virus | Morbidity | Medical history | Heritability | Host factors | Transmission | IMMUNE | RESPONSES | transmission | medical history | MULTIDISCIPLINARY SCIENCES | mortality | host factors | H5N1 VIRUS-INFECTION | heritability | Iceland - epidemiology | Genetic Predisposition to Disease | History, 20th Century | Humans | Middle Aged | Child, Preschool | Infant | Influenza, Human - epidemiology | Male | Disease Outbreaks | Influenza, Human - genetics | Adolescent | Survival Analysis | Aged, 80 and over | Influenza, Human - mortality | Adult | Family | Female | Aged | Influenza, Human - history | Child | Infant, Newborn | Disease transmission | Genetic susceptibility | Influenza | Distribution | Causes of | Genetic aspects | Heredity | Research | Health aspects | Iceland | Biological Sciences
Journal Article
European Journal of Human Genetics, ISSN 1018-4813, 2000, Volume 8, Issue 10, pp. 739 - 742
As the new human genetics continues its dramatic expansion into many laboratories and medical institutions, the concern for the protection of the personal...
Ethics | Privacy | Biobank | Database | Genetics | Third-party | Encryption | Sample bank | sample bank | database | genetics | encryption | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | privacy | ethics | biobank | third-party | Genetics - legislation & jurisprudence | Phenotype | Pedigree | Humans | Bioethics | Computer Security - legislation & jurisprudence | Family | Genotype | Confidentiality - legislation & jurisprudence | Computer Communication Networks - legislation & jurisprudence | Iceland | Databases, Factual | Medical research | Laboratories | Computer programs
Ethics | Privacy | Biobank | Database | Genetics | Third-party | Encryption | Sample bank | sample bank | database | genetics | encryption | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | privacy | ethics | biobank | third-party | Genetics - legislation & jurisprudence | Phenotype | Pedigree | Humans | Bioethics | Computer Security - legislation & jurisprudence | Family | Genotype | Confidentiality - legislation & jurisprudence | Computer Communication Networks - legislation & jurisprudence | Iceland | Databases, Factual | Medical research | Laboratories | Computer programs
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 2003, Volume 73, Issue 5, pp. 986 - 993
Migraine is a common form of headache and has a significant genetic component. Here, we report linkage results from a study in Iceland of migraine without aura...
TYPICAL MIGRAINE | MAPS | HEADACHES | 19P13 | GENETICS & HEREDITY | CLINICAL CHARACTERISTICS | SUSCEPTIBILITY LOCUS | PREVALENCE | MUTATIONS | LINKAGE | FAMILIAL HEMIPLEGIC MIGRAINE | Migraine without Aura - genetics | Humans | Alleles | Finland | Female | Male | Chromosome Mapping | Chromosomes, Human, Pair 4 - genetics | Iceland | Lod Score | Migraine | Research
TYPICAL MIGRAINE | MAPS | HEADACHES | 19P13 | GENETICS & HEREDITY | CLINICAL CHARACTERISTICS | SUSCEPTIBILITY LOCUS | PREVALENCE | MUTATIONS | LINKAGE | FAMILIAL HEMIPLEGIC MIGRAINE | Migraine without Aura - genetics | Humans | Alleles | Finland | Female | Male | Chromosome Mapping | Chromosomes, Human, Pair 4 - genetics | Iceland | Lod Score | Migraine | Research
Journal Article
Nature, ISSN 0028-0836, 03/2008, Volume 452, Issue 7186, pp. 423 - 428
Common human diseases result from the interplay of many genes and environmental factors. Therefore, a more integrative biology approach is needed to unravel...
YEAST | SEGREGATING MOUSE-POPULATION | OBESITY | PEDIGREES | INTEGRATIVE GENOMICS APPROACH | MULTIDISCIPLINARY SCIENCES | LINKAGE ANALYSIS | NETWORKS | ASSOCIATION | DISCOVERY | ADIPOSE-TISSUE | Humans | Middle Aged | Male | Gene Expression Profiling | Blood - metabolism | Obesity - genetics | Iceland | Lod Score | Adipose Tissue - metabolism | Aged, 80 and over | Adult | Female | Waist-Hip Ratio | Body Mass Index | European Continental Ancestry Group - genetics | Gene Expression Regulation - genetics | Sample Size | Animals | Adolescent | Polymorphism, Single Nucleotide - genetics | Aged | Mice | Genome, Human | Cohort Studies | Quantitative Trait Loci - genetics
YEAST | SEGREGATING MOUSE-POPULATION | OBESITY | PEDIGREES | INTEGRATIVE GENOMICS APPROACH | MULTIDISCIPLINARY SCIENCES | LINKAGE ANALYSIS | NETWORKS | ASSOCIATION | DISCOVERY | ADIPOSE-TISSUE | Humans | Middle Aged | Male | Gene Expression Profiling | Blood - metabolism | Obesity - genetics | Iceland | Lod Score | Adipose Tissue - metabolism | Aged, 80 and over | Adult | Female | Waist-Hip Ratio | Body Mass Index | European Continental Ancestry Group - genetics | Gene Expression Regulation - genetics | Sample Size | Animals | Adolescent | Polymorphism, Single Nucleotide - genetics | Aged | Mice | Genome, Human | Cohort Studies | Quantitative Trait Loci - genetics
Journal Article
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Full Text
A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
Nature, ISSN 0028-0836, 2008, Volume 452, Issue 7187, pp. 638 - 642
Smoking is a leading cause of preventable death, causing about 5 million premature deaths worldwide each year. Evidence for genetic influence on smoking...
LOWER-EXTREMITY | RISK-FACTORS | FAGERSTROM TEST | STATISTICS | SMOKERS | MULTIDISCIPLINARY SCIENCES | ISCHEMIA | SMOKING | CARCINOMA | GENETIC INFLUENCE | ADDICTION | Lung Neoplasms - genetics | Multigene Family - genetics | Smoking - adverse effects | Genetic Predisposition to Disease - genetics | Peripheral Vascular Diseases - genetics | Europe | Humans | Genotype | Male | Smoking - genetics | Chromosomes, Human, Pair 15 - genetics | New Zealand | Polymorphism, Single Nucleotide - genetics | Female | Tobacco Use Disorder - genetics | Odds Ratio | Receptors, Nicotinic - genetics | Addictions | Lung cancer | Genomics | Risk factors | Smoking | Nicotine | Index Medicus
LOWER-EXTREMITY | RISK-FACTORS | FAGERSTROM TEST | STATISTICS | SMOKERS | MULTIDISCIPLINARY SCIENCES | ISCHEMIA | SMOKING | CARCINOMA | GENETIC INFLUENCE | ADDICTION | Lung Neoplasms - genetics | Multigene Family - genetics | Smoking - adverse effects | Genetic Predisposition to Disease - genetics | Peripheral Vascular Diseases - genetics | Europe | Humans | Genotype | Male | Smoking - genetics | Chromosomes, Human, Pair 15 - genetics | New Zealand | Polymorphism, Single Nucleotide - genetics | Female | Tobacco Use Disorder - genetics | Odds Ratio | Receptors, Nicotinic - genetics | Addictions | Lung cancer | Genomics | Risk factors | Smoking | Nicotine | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 07/2007, Volume 448, Issue 7151, pp. 353 - 357
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans and is characterized by chaotic electrical activity of the atria. It affects...
OF-FUNCTION MUTATION | GENE | KCNQ1 | MULTIDISCIPLINARY SCIENCES | FAMILIAL AGGREGATION | PREVALENCE | ISCHEMIC-STROKE | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease - genetics | Age Distribution | Hong Kong | United States | Gene Frequency | Humans | Middle Aged | Asian Continental Ancestry Group - genetics | Male | Atrial Fibrillation - genetics | Chromosomes, Human, Pair 4 - genetics | Genome, Human - genetics | Iceland | Haplotypes - genetics | Sweden | Aged, 80 and over | Polymorphism, Single Nucleotide - genetics | Female | Aged | Genetic Variation - genetics | Atrial Fibrillation - diagnosis | Prognosis | Atrial fibrillation | Physiological aspects | Research | Chromosomes | Genetic polymorphisms | Risk factors | Cardiac arrhythmia | Electricity | Genomics | Mortality | Cardiovascular disease | Whites | Mutation | Asians | Reproduction | Vibration | Fibrillation | Populations | Risk | Atria | Descent
OF-FUNCTION MUTATION | GENE | KCNQ1 | MULTIDISCIPLINARY SCIENCES | FAMILIAL AGGREGATION | PREVALENCE | ISCHEMIC-STROKE | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease - genetics | Age Distribution | Hong Kong | United States | Gene Frequency | Humans | Middle Aged | Asian Continental Ancestry Group - genetics | Male | Atrial Fibrillation - genetics | Chromosomes, Human, Pair 4 - genetics | Genome, Human - genetics | Iceland | Haplotypes - genetics | Sweden | Aged, 80 and over | Polymorphism, Single Nucleotide - genetics | Female | Aged | Genetic Variation - genetics | Atrial Fibrillation - diagnosis | Prognosis | Atrial fibrillation | Physiological aspects | Research | Chromosomes | Genetic polymorphisms | Risk factors | Cardiac arrhythmia | Electricity | Genomics | Mortality | Cardiovascular disease | Whites | Mutation | Asians | Reproduction | Vibration | Fibrillation | Populations | Risk | Atria | Descent
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 08/2007, Volume 357, Issue 7, pp. 639 - 647
Genetic analyses of Icelandic and North American subjects with periodic leg movements and restless legs syndrome implicate a genetic susceptibility variant...
MEDICINE, GENERAL & INTERNAL | GENERAL-POPULATION | RESTLESS LEGS SYNDROME | ANTICIPATION | DISORDER | RLS | VALIDATION | SYMPTOMS | PREVALENCE | ASSOCIATION | EPIDEMIOLOGY | Genetic Predisposition to Disease | Humans | Risk Factors | Genotype | Male | Genetic Markers | Transcription Factors - genetics | Chromosomes, Human, Pair 6 | Case-Control Studies | Restless Legs Syndrome - genetics | Linkage Disequilibrium | Nocturnal Myoclonus Syndrome - blood | Restless Legs Syndrome - blood | Ferritins - blood | Iron - deficiency | Female | Nocturnal Myoclonus Syndrome - genetics | Polymorphism, Single Nucleotide | Genome, Human | Restless legs syndrome | Genetic aspects | Risk factors | Anemia | Sleep
MEDICINE, GENERAL & INTERNAL | GENERAL-POPULATION | RESTLESS LEGS SYNDROME | ANTICIPATION | DISORDER | RLS | VALIDATION | SYMPTOMS | PREVALENCE | ASSOCIATION | EPIDEMIOLOGY | Genetic Predisposition to Disease | Humans | Risk Factors | Genotype | Male | Genetic Markers | Transcription Factors - genetics | Chromosomes, Human, Pair 6 | Case-Control Studies | Restless Legs Syndrome - genetics | Linkage Disequilibrium | Nocturnal Myoclonus Syndrome - blood | Restless Legs Syndrome - blood | Ferritins - blood | Iron - deficiency | Female | Nocturnal Myoclonus Syndrome - genetics | Polymorphism, Single Nucleotide | Genome, Human | Restless legs syndrome | Genetic aspects | Risk factors | Anemia | Sleep
Journal Article
Nature Genetics, ISSN 1061-4036, 1997, Volume 17, Issue 1, pp. 84 - 87
Essential tremor (ET), the most common movement disorder in humans, appears to be inherited as an autosomal dominant trait in many families(1,2). The familial...
CEREBELLAR | HEREDITARY ESSENTIAL TREMOR | PRIMIDONE | GENETICS & HEREDITY | POSITRON EMISSION TOMOGRAPHY | LINKAGE ANALYSIS | PREVALENCE | Chromosomes, Human, Pair 3 | Humans | Tremor - genetics | Female | Genotype | Male | Chromosome Mapping | Genetic Markers | Genome, Human | Iceland | Lod Score | Genetic Linkage
CEREBELLAR | HEREDITARY ESSENTIAL TREMOR | PRIMIDONE | GENETICS & HEREDITY | POSITRON EMISSION TOMOGRAPHY | LINKAGE ANALYSIS | PREVALENCE | Chromosomes, Human, Pair 3 | Humans | Tremor - genetics | Female | Genotype | Male | Chromosome Mapping | Genetic Markers | Genome, Human | Iceland | Lod Score | Genetic Linkage
Journal Article
Nature Genetics, ISSN 1061-4036, 04/2009, Volume 41, Issue 4, pp. 460 - 464
In order to search for sequence variants conferring risk of thyroid cancer we conducted a genome-wide association study in 192 and 37,196 Icelandic cases and...
CLEFT-PALATE | GENETICS | NEOPLASIA | SUSCEPTIBILITY | GENETICS & HEREDITY | SEQUENCE VARIANTS | RISK | CARCINOMA | ASSOCIATION | EXPRESSION | ICELAND | Genetic Predisposition to Disease - genetics | Humans | Thyroid Neoplasms - epidemiology | Europe - epidemiology | Thyroxine - blood | Chromosome Mapping | Chromosomes, Human, Pair 9 | DNA-Binding Proteins - genetics | Forkhead Transcription Factors - genetics | Chromosomes, Human, Pair 4 | Genetic Variation | Triiodothyronine - blood | Thyroid Neoplasms - genetics | Transcription Factors | Thyrotropin - blood | Genetic aspects | Thyroid cancer | Research | Genetic variation | Risk factors | Sample size | Population | Thyroid gland | Multivariate analysis | Females | Statistics
CLEFT-PALATE | GENETICS | NEOPLASIA | SUSCEPTIBILITY | GENETICS & HEREDITY | SEQUENCE VARIANTS | RISK | CARCINOMA | ASSOCIATION | EXPRESSION | ICELAND | Genetic Predisposition to Disease - genetics | Humans | Thyroid Neoplasms - epidemiology | Europe - epidemiology | Thyroxine - blood | Chromosome Mapping | Chromosomes, Human, Pair 9 | DNA-Binding Proteins - genetics | Forkhead Transcription Factors - genetics | Chromosomes, Human, Pair 4 | Genetic Variation | Triiodothyronine - blood | Thyroid Neoplasms - genetics | Transcription Factors | Thyrotropin - blood | Genetic aspects | Thyroid cancer | Research | Genetic variation | Risk factors | Sample size | Population | Thyroid gland | Multivariate analysis | Females | Statistics
Journal Article
Nature Genetics, ISSN 1061-4036, 2009, Volume 41, Issue 10, pp. 1122 - 1126
We report a prostate cancer genome-wide association follow-on study. We discovered four variants associated with susceptibility to prostate cancer in several...
8Q24 | GENE | COLORECTAL-CANCER | GENETICS & HEREDITY | SEQUENCE VARIANTS | RISK | MULTIPLE LOCI | SCAN | European Continental Ancestry Group - genetics | Genome-Wide Association Study | Disease Susceptibility | Humans | Risk Factors | DNA Replication | Male | Iceland | Prostatic Neoplasms - epidemiology | DNA - genetics | Prostatic Neoplasms - genetics | Polymorphism, Single Nucleotide | Genome, Human | Disease susceptibility | Genetic aspects | Research | Single nucleotide polymorphisms | Health aspects | Prostate cancer | Risk factors | Studies | Genetic markers | Estimates | Colorectal cancer
8Q24 | GENE | COLORECTAL-CANCER | GENETICS & HEREDITY | SEQUENCE VARIANTS | RISK | MULTIPLE LOCI | SCAN | European Continental Ancestry Group - genetics | Genome-Wide Association Study | Disease Susceptibility | Humans | Risk Factors | DNA Replication | Male | Iceland | Prostatic Neoplasms - epidemiology | DNA - genetics | Prostatic Neoplasms - genetics | Polymorphism, Single Nucleotide | Genome, Human | Disease susceptibility | Genetic aspects | Research | Single nucleotide polymorphisms | Health aspects | Prostate cancer | Risk factors | Studies | Genetic markers | Estimates | Colorectal cancer
Journal Article
Nature Genetics, ISSN 1061-4036, 2009, Volume 41, Issue 2, pp. 221 - 227
The common sequence variants that have recently been associated with cancer risk are particular to a single cancer type or at most two. Following up on our...
BREAST-CANCER | LUNG-CANCER | COMMON VARIANTS | RISK-FACTOR | COLORECTAL-CANCER | BASAL-CELL CARCINOMA | PROSTATE-CANCER | GENETICS & HEREDITY | SUSCEPTIBILITY LOCUS | GENOME-WIDE ASSOCIATION | TELOMERE LENGTH | Genetic Predisposition to Disease | Genome-Wide Association Study | Carcinoma, Basal Cell - genetics | Membrane Proteins - genetics | Gene Frequency | Humans | Middle Aged | Polymorphism, Single Nucleotide - physiology | Male | Case-Control Studies | Linkage Disequilibrium | Telomerase - genetics | Neoplasms - genetics | Skin Neoplasms - genetics | Female | Aged | Neoplasm Proteins - genetics | Quantitative Trait Loci | Gene mutations | Genetic aspects | Research | Single nucleotide polymorphisms | Health aspects | Risk factors | Cancer | Medical research | Sample size | Prostate cancer | Cervical cancer | Colorectal cancer
BREAST-CANCER | LUNG-CANCER | COMMON VARIANTS | RISK-FACTOR | COLORECTAL-CANCER | BASAL-CELL CARCINOMA | PROSTATE-CANCER | GENETICS & HEREDITY | SUSCEPTIBILITY LOCUS | GENOME-WIDE ASSOCIATION | TELOMERE LENGTH | Genetic Predisposition to Disease | Genome-Wide Association Study | Carcinoma, Basal Cell - genetics | Membrane Proteins - genetics | Gene Frequency | Humans | Middle Aged | Polymorphism, Single Nucleotide - physiology | Male | Case-Control Studies | Linkage Disequilibrium | Telomerase - genetics | Neoplasms - genetics | Skin Neoplasms - genetics | Female | Aged | Neoplasm Proteins - genetics | Quantitative Trait Loci | Gene mutations | Genetic aspects | Research | Single nucleotide polymorphisms | Health aspects | Risk factors | Cancer | Medical research | Sample size | Prostate cancer | Cervical cancer | Colorectal cancer
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2008, Volume 105, Issue 4, p. 1303
The pandemic influenza of 1918 (Spanish flu) killed 21-50 million people globally, including in Iceland, where the characteristics and spread of the epidemic...
Disease transmission | Pandemics | Influenza | Mortality | Genetics | Risk factors
Disease transmission | Pandemics | Influenza | Mortality | Genetics | Risk factors
Journal Article