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1. Full Text Genome-Wide Association Scan for Diabetic Nephropathy Susceptibility Genes in Type 1 Diabetes
by Marcus G. Pezzolesi and G. David Poznik and Josyf C. Mychaleckyj and Andrew D. Paterson and Michelle T. Barati and Jon B. Klein and Daniel P.K. Ng and Grzegorz Placha and Luis H. Canani and Jacek Bochenski and Daryl Waggott and Michael L. Merchant and Bozena Krolewski and Lucia Mirea and Krzysztof Wanic and Pisut Katavetin and Masahiko Kure and Pawel Wolkow and Jonathon S. Dunn and Adam Smiles and William H. Walker and Andrew P. Boright and Shelley B. Bull and the DCCT/EDIC Research Group and Alessandro Doria and John J. Rogus and Stephen S. Rich and James H. Warram and Andrzej S. Krolewski and DCCT EDIC Res Grp and DCCT/EDIC Research Group and the DCCT/EDIC Research Group
Diabetes, ISSN 0012-1797, 06/2009, Volume 58, Issue 6, pp. 1403 - 1410
Genome-Wide Association Scan for Diabetic Nephropathy Susceptibility Genes in Type 1 Diabetes Marcus G. Pezzolesi 1 , G. David Poznik 1 , Josyf C. Mychaleckyj... 
POPULATION | FERM DOMAIN | GENETICS | MEMBRANE | MICROALBUMINURIA | ENDOCRINOLOGY & METABOLISM | FOLLOW-UP | COMPLICATIONS | STAGE RENAL-DISEASE | PROGRESSION | FAMILY | Genetic Predisposition to Disease | Genome-Wide Association Study | Cytoskeletal Proteins - genetics | Membrane Proteins - genetics | Humans | Diabetes Mellitus, Type 1 - genetics | Diabetic Nephropathies - genetics | Chromosome Mapping | Diabetes Mellitus, Type 1 - complications | Proteinuria - genetics | Kidney Failure, Chronic - genetics | Polymorphism, Single Nucleotide | Genome, Human | Microfilament Proteins - genetics | Kidney - physiopathology | Type 1 diabetes | Diabetic nephropathies | Genetic aspects | Diagnosis | Kidney diseases | Diabetes | Research | Risk factors | Original
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2. Full Text Paternal lineage early onset hereditary ovarian cancers: A Familial Ovarian Cancer Registry study
by Eng, Kevin H and Szender, J. Brian and Etter, John Lewis and Kaur, Jasmine and Poblete, Samantha and Huang, Ruea-Yea and Zhu, Qianqian and Grzesik, Katherine A and Battaglia, Sebastiano and Cannioto, Rikki and Krolewski, John J and Zsiros, Emese and Frederick, Peter J and Lele, Shashikant B and Moysich, Kirsten B and Odunsi, Kunle O
PLoS Genetics, ISSN 1553-7390, 02/2018, Volume 14, Issue 2, p. e1007194
Given prior evidence that an affected woman conveys a higher risk of ovarian cancer to her sister than to her mother, we hypothesized that there exists an... 
X-CHROMOSOME | XIST RNA | SUSCEPTIBILITY | GENETICS & HEREDITY | INACTIVE-X | BRCA1 | MAGE-A | RISK-ASSESSMENT | HETEROZYGOSITY | ASSOCIATION | BREAST | Genetic Predisposition to Disease | Humans | Middle Aged | Male | Heredity | Paternal Inheritance - genetics | Ovarian Neoplasms - complications | Ovarian Neoplasms - epidemiology | Ovarian Neoplasms - genetics | Breast Neoplasms - complications | Breast Neoplasms - genetics | Genes, X-Linked | Pedigree | Age of Onset | Adult | Family | Female | Registries | Models, Genetic | Breast Neoplasms - epidemiology | Epigenetic inheritance | Genetic aspects | Health aspects | Ovarian cancer | Women | Haplotypes | BRCA1 protein | Funding | Genomics | Genes | Families & family life | Oncology | Breast cancer | Genomes | Disease prevention | Genetics | Software | Health risk assessment | Bioinformatics | Prostate cancer | Chromosomes | Prostate | Supervision | Age
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3. Full Text MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes
by Liu, Can and Liu, Ruifang and Zhang, Dingxiao and Deng, Qu and Liu, Bigang and Chao, Hsueh-Ping and Rycaj, Kiera and Takata, Yoko and Lin, Kevin and Lu, Yue and Zhong, Yi and Krolewski, John and Shen, Jianjun and Tang, Dean G
Nature Communications, ISSN 2041-1723, 01/2017, Volume 8, Issue 1, pp. 14270 - 14270
MicroRNAs play important roles in regulating tumour development, progression and metastasis. Here we show that one of the miR-200 family members, miR-141, is... 
ANDROGEN RECEPTOR | POPULATION | ZEB1 | REPRESSION | MULTIDISCIPLINARY SCIENCES | GROUP PROTEIN EZH2 | E-CADHERIN | EXPRESSION PROFILES | MESENCHYMAL TRANSITION | IDENTIFICATION | MIR-200 FAMILY | Prostatic Neoplasms - metabolism | Enhancer of Zeste Homolog 2 Protein - genetics | Enhancer of Zeste Homolog 2 Protein - metabolism | Neoplasm Invasiveness | rho GTP-Binding Proteins - genetics | Humans | Male | MicroRNAs - metabolism | Mice, SCID | Hyaluronan Receptors - genetics | Cell Movement - physiology | Animals | Neoplastic Stem Cells - metabolism | rho GTP-Binding Proteins - metabolism | Hyaluronan Receptors - metabolism | Cell Line, Tumor | Neoplasms, Experimental | Mice | MicroRNAs - genetics | Gene Expression Regulation, Neoplastic - physiology | Index Medicus
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4. Full Text Opportunities and challenges in combination gene cancer therapy
by Nastiuk, Kent L and Krolewski, John J
Advanced Drug Delivery Reviews, ISSN 0169-409X, 03/2016, Volume 98, pp. 35 - 40
Treatment for solid tumor malignancies, which constitute the majority of human cancers, is still dominated by surgery and radiotherapies. This is especially... 
Chemotherapy | Targeted therapy | Therapeutics | Gene therapy | Death receptors | c-FLIP | Cancer | Hormonal therapy | CHEMOKINE LIGAND 2 | ANDROGEN RECEPTOR | HUMAN MONOCLONAL-ANTIBODY | ACQUIRED-RESISTANCE | TUMOR-REGRESSION | INHIBITORY PROTEIN GENE | LUNG-CANCER | PHARMACOLOGY & PHARMACY | INCREASED SURVIVAL | RESISTANT PROSTATE-CANCER | CARLUMAB CNTO 888 | Genetic Therapy | Neoplasms - therapy | Animals | Humans | Antineoplastic Agents - therapeutic use | Combined Modality Therapy | Antineoplastic Agents - administration & dosage | Apoptosis | Antimitotic agents | Genes | Genetic aspects | Metastasis | Antineoplastic agents | Health aspects | hormonal therapy | targeted therapy | therapeutics | gene therapy | chemotherapy | death receptors
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5. Full Text Serum concentration of cystatin C and risk of end-stage renal disease in diabetes
by Krolewski, Andrzej S and Warram, James H and Forsblom, Carol and Smiles, Adam M and Thorn, Lena and Skupien, Jan and Harjutsalo, Valma and Stanton, Robert and Eckfeldt, John H and Inker, Lesley A and Groop, Per-Henrik
Diabetes Care, ISSN 0149-5992, 11/2012, Volume 35, Issue 11, pp. 2311 - 2316
OBJECTIVE-Patients with diabetes have a high risk of end-stage renal disease (ESRD). We examined whether prediction of this outcome, according to chronic... 
ESRD | ENDOCRINOLOGY & METABOLISM | CREATININE | CHRONIC KIDNEY-DISEASE | ASSOCIATION | EQUATION | ESTIMATING GFR | Glomerular Filtration Rate | Cystatin C - blood | Humans | Child, Preschool | Male | Diabetic Nephropathies - blood | Young Adult | Kidney Failure, Chronic - blood | Kidney Failure, Chronic - epidemiology | Adolescent | Creatinine - blood | Adult | Female | Diabetic Nephropathies - epidemiology | Child | Type 2 diabetes | Diabetics | Chronic kidney failure | Diabetic nephropathies | Development and progression | Research | Diabetes | Risk factors | Kidney diseases | Family medical history | Disease | Logistics | Original Research
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6. Full Text Epidemic of end-stage renal disease in people with diabetes in the United States population: Do we know the cause?
by Jones, Camille A and Krolewski, Andrzej S and Rogus, John and Xue, Jay L and Collins, Allan and Warram, James H
Kidney International, ISSN 0085-2538, 05/2005, Volume 67, Issue 5, pp. 1684 - 1691
Epidemic of end-stage renal disease in people with diabetes in the United States population: Do we know the cause? The number of individuals initiating renal... 
antihypertensive treatments | diabetes mellitus | ACE inhibitors | end-stage renal disease (ESRD) | secular trends | USRDS | Antihypertensive treatments | End-stage renal disease (ESRD) | Secular trends | Diabetes mellitus | PROTEINURIA | PREVALENCE | TRENDS | NEPHROPATHY | BLOOD-PRESSURE | CONVERTING ENZYME-INHIBITION | UROLOGY & NEPHROLOGY | COMPLICATIONS | HYPERTENSION | IRBESARTAN | PROGRESSION | United States - epidemiology | Diabetic Nephropathies - etiology | Humans | Middle Aged | Risk Factors | Renal Replacement Therapy | Male | Diabetic Nephropathies - therapy | Kidney Failure, Chronic - therapy | Kidney Failure, Chronic - epidemiology | Kidney Failure, Chronic - prevention & control | Disease Outbreaks | Adult | Female | Aged | Diabetic Nephropathies - epidemiology | Diabetic Nephropathies - prevention & control | Kidney Failure, Chronic - etiology
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7. Full Text Circulating TNF receptors 1 and 2 predict ESRD in type 2 diabetes
by Niewczas, Monika A and Gohda, Tomohito and Skupien, Jan and Smiles, Adam M and Walker, William H and Rosetti, Florencia and Cullere, Xavier and Eckfeldt, John H and Doria, Alessandro and Mayadas, Tanya N and Warram, James H and Krolewski, Andrzej S
Journal of the American Society of Nephrology, ISSN 1046-6673, 03/2012, Volume 23, Issue 3, pp. 507 - 515
Levels of proinflammatory cytokines associate with risk for developing type 2 diabetes but whether chronic inflammation contributes to the development of... 
TUMOR-NECROSIS-FACTOR | MICROALBUMINURIA | RENAL-FUNCTION | MARKERS | UROLOGY & NEPHROLOGY | RISK | CORONARY-HEART-DISEASE | INFLAMMATORY CYTOKINES | NEPHROPATHY | ASSOCIATION | FACTOR-ALPHA | Predictive Value of Tests | Follow-Up Studies | Diabetic Nephropathies - etiology | Humans | Middle Aged | Male | Incidence | Diabetic Nephropathies - physiopathology | Receptors, Tumor Necrosis Factor, Type II - blood | Adult | Female | Retrospective Studies | Diabetes Mellitus, Type 2 - complications | Kidney Failure, Chronic - physiopathology | Receptors, Tumor Necrosis Factor, Type I - blood | Risk Factors | Proportional Hazards Models | Survival Rate | Biomarkers - blood | Disease Progression | Kidney Failure, Chronic - epidemiology | Signal Transduction - physiology | Aged | Diabetic Nephropathies - epidemiology | Cohort Studies | Kidney Failure, Chronic - etiology | Clinical Research
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8. Full Text Loss of PLZF expression in prostate cancer by immunohistochemistry correlates with tumor aggressiveness and metastasis
by Xiao, Guang-Qian and Unger, Pamela and Yang, Qi and Kinoshita, Yayoi and Singh, Kyra and McMahon, Loralee and Nastiuk, Kent and Sha, Kai and Krolewski, John and Burstein, David
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, p. e0121318
PLZF is a transcription repressor, which plays a critical role in development, spermatogenesis and oncogenesis. Down-regulation of PLZF has been found in... 
CELLS | GENE | SHOWS | HIGH-RISK | MULTIDISCIPLINARY SCIENCES | FISH ANALYSIS | PROLIFERATION | SUPPRESSOR PLZF | PROGRESSION | PTEN/MMAC1 | PTEN EXPRESSION | Immunohistochemistry | Lymph Node Excision | Prostatic Neoplasms - metabolism | Prostatic Neoplasms - pathology | Adenocarcinoma - pathology | Prostatic Neoplasms - surgery | Humans | Male | Disease Progression | Promyelocytic Leukemia Zinc Finger Protein | Adenocarcinoma - metabolism | Neoplasm Grading | Kruppel-Like Transcription Factors - metabolism | Neoplasm Invasiveness - pathology | Neoplasm Metastasis - pathology | Prostatectomy | Adenocarcinoma - surgery | Development and progression | Metastasis | Prostate cancer | Transcription | Spermatogenesis | Leukemia | Genomics | Genes | Lymph nodes | Metastases | Proteins | Cell growth | Cell cycle | Tumorigenesis | Bioindicators | Chromosomes | Antigens | Lymphatic system | Aggressive behavior | Review boards | Basal cells | Tumor cell lines | Molecular chains | Pathology | Androgens | Biopsy | Biomarkers | Prostate | Cancer | Apoptosis | Tumors | Lymph
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9. Full Text Infiltrating myeloid cells exert protumorigenic actions via neutrophil elastase
by Lerman, Irina and De La Luz Garcia-Hernandez, Maria and Rangel-Moreno, Javier and Chiriboga, Luis and Pan, Chunliu and Nastiuk, Kent L and Krolewski, John J and Sen, Aritro and Hammes, Stephen R
Molecular Cancer Research, ISSN 1541-7786, 09/2017, Volume 15, Issue 9, pp. 1138 - 1152
Tissue infiltration and elevated peripheral circulation of granulocytic myeloid-derived cells is associated with poor outcomes in prostate cancer and other... 
SURVIVAL | ONCOLOGY | PROSTATE-CANCER PATIENTS | GROWTH | TISSUE | GENE-EXPRESSION PROFILES | PERIPHERAL-BLOOD | SUPPRESSOR-CELLS | EXTRACELLULAR TRAPS | TUMOR MICROENVIRONMENT | PROGRESSION | CELL BIOLOGY | Leukocyte Elastase - metabolism | Prostate - pathology | Prostatic Neoplasms - metabolism | Animals | Prostatic Neoplasms - genetics | Mice, Nude | Humans | Cell Line, Tumor | Myeloid Cells - metabolism | Male | Mice | Cell Culture Techniques | Cell proliferation | Transcription | Leukocyte migration | Serine | Lymphocytes T | Suppressor cells | Metastases | Cell activation | Xenografts | Elastase | Immune system | Peripheral circulation | Myeloid cells | Neutrophils | MAP kinase | Signaling | Depletion | Biomarkers | Infiltration | Serine proteinase | Leukocytes (granulocytic) | Prostate cancer | Prostate | Cell migration | PTEN protein | Tumors | Cancer
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10. Full Text A Genome-Wide Linkage Scan for Genes Controlling Variation in Renal Function Estimated by Serum Cystatin C Levels in Extended Families With Type 2 Diabetes
by Grzegorz Placha and G. David Poznik and Jonathon Dunn and Adam Smiles and Bozena Krolewski and Timothy Glew and Sobha Puppala and Jennifer Schneider and John J. Rogus and Stephen S. Rich and Ravindranath Duggirala and James H. Warram and Andrzej S. Krolewski
Diabetes, ISSN 0012-1797, 12/2006, Volume 55, Issue 12, pp. 3358 - 3365
A Genome-Wide Linkage Scan for Genes Controlling Variation in Renal Function Estimated by Serum Cystatin C Levels in Extended Families With Type 2 Diabetes... 
URINARY ALBUMIN EXCRETION | GLOMERULAR-FILTRATION-RATE | GFR | GENOTYPE | DISEASE | ENDOCRINOLOGY & METABOLISM | PROTEINURIA | COMPLICATIONS | CHRONIC KIDNEY | NEPHROPATHY | SUSCEPTIBILITY GENES | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | Reference Values | Kidney Function Tests | Chromosomes, Human, Pair 2 | Genetic Variation | Cystatin C | Adult | Glomerular Filtration Rate | Genotype | Chromosome Mapping | Chromosomes, Human, Pair 7 | Cystatins - blood | DNA - genetics | DNA - isolation & purification | Diabetes Mellitus, Type 2 - blood | Diabetes Mellitus, Type 2 - physiopathology | Cystatins - genetics | Chromosomes, Human, Pair 18 | Age of Onset | Family | Aged | Genome, Human | Chromosomes, Human, Pair 10 | Type 2 diabetes | Complications and side effects | Genetic aspects | Chronic kidney failure | Diabetic nephropathies
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11. Full Text Abstract B043: Cancer stem cell selection drives adverse response to androgen-deprivation therapy
by Sha, Kai and Jiang, Lingxiang and Chang, Chawnshang and Tang, Dean and Nastiuk, Kent L and Krolewski, John J
Cancer Research, ISSN 0008-5472, 08/2018, Volume 78, Issue 16 Supplement, pp. B043 - B043
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12. Full Text High-normal serum uric acid increases risk of early progressive renal function loss in type 1 diabetes: Results of a 6-year follow-up
by Ficociello, Linda H and Rosolowsky, Elizabeth T and Niewczas, Monika A and Maselli, Nicholas J and Weinberg, Janice M and Aschengrau, Ann and Eckfeldt, John H and Stanton, Robert C and Galecki, Andrzej T and Doria, Alessandro and Warram, James H and Krolewski, Andrzej S
Diabetes Care, ISSN 0149-5992, 06/2010, Volume 33, Issue 6, pp. 1337 - 1343
OBJECTIVE - We previously described a cross-sectional association between serum uric acid and reduced glomerular filtration rate (GFR) in nonproteinuric... 
ALLOPURINOL | GLOMERULAR-FILTRATION-RATE | FUNCTION DECLINE | GFR | HYPERURICEMIA | ENDOTHELIAL DYSFUNCTION | SERIAL MEASUREMENTS | DISEASE | ENDOCRINOLOGY & METABOLISM | CYSTATIN-C | CREATININE | Glomerular Filtration Rate | Kidney - pathology | Cystatin C - blood | Albuminuria - blood | Humans | Middle Aged | Male | Diabetes Mellitus, Type 1 - complications | Disease Progression | Kidney Function Tests | Young Adult | Diabetes Mellitus, Type 1 - blood | Adolescent | Creatinine - blood | Adult | Female | Kidney Diseases - blood | Uric Acid - blood | Kidney Diseases - etiology | Albumin | Diabetics | Uric acid | Type 1 diabetes | Risk factors | Original Research
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13. Full Text Risk for ESRD in type 1 diabetes remains high despite renoprotection
by Rosolowsky, Elizabeth T and Skupien, Jan and Smiles, Adam M and Niewczas, Monika and Roshan, Bijan and Stanton, Robert and Eckfeldt, John H and Warram, James H and Krolewski, Andrzej S
Journal of the American Society of Nephrology, ISSN 1046-6673, 03/2011, Volume 22, Issue 3, pp. 545 - 553
Historically, patients with type 1 diabetes and macroalbuminuria had high competing risks: cardiovascular death or renal failure. Here, we assessed these risks... 
IMPROVED GRAFT-SURVIVAL | CONVERTING ENZYME-INHIBITION | MICROALBUMINURIA | TERM ANTIHYPERTENSIVE TREATMENT | UROLOGY & NEPHROLOGY | PROTEINURIA | RENAL-TRANSPLANTATION | MELLITUS | CHRONIC KIDNEY-DISEASE | NEPHROPATHY | PROGRESSION | Albuminuria - epidemiology | Diabetes Mellitus, Type 1 - epidemiology | Kidney Failure, Chronic - mortality | Albuminuria - complications | Follow-Up Studies | Comorbidity | Humans | Middle Aged | Risk Factors | Male | Survival Rate | Diabetes Mellitus, Type 1 - complications | Disease Progression | Diabetic Nephropathies - mortality | Kidney Failure, Chronic - epidemiology | Adult | Female | Diabetic Nephropathies - epidemiology | Retrospective Studies | Longitudinal Studies | Clinical Epidemiology
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