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survival of motor neuron 2 protein - genetics (4) 4
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Journal Article
PLoS ONE, ISSN 1932-6203, 05/2009, Volume 4, Issue 5, pp. e5268 - e5268
Preliminary in vitro and in vivo studies with valproic acid (VPA) in cell lines and patients with spinal muscular atrophy (SMA) demonstrate increased... 
BIOLOGY | Humans | Child, Preschool | Electrophysiology | Valproic Acid - pharmacology | Enzyme Inhibitors - administration & dosage | Young Adult | Muscular Atrophy, Spinal - genetics | Body Composition - drug effects | Survival of Motor Neuron 2 Protein - genetics | Adult | Valproic Acid - therapeutic use | Valproic Acid - adverse effects | Child | Enzyme Inhibitors - adverse effects | Enzyme Inhibitors - pharmacology | Treatment Outcome | Absorptiometry, Photon | Enzyme Inhibitors - therapeutic use | Muscular Atrophy, Spinal - pathology | Bone Density - drug effects | Neurologic Examination | Valproic Acid - administration & dosage | Analysis of Variance | Adolescent | Muscular Atrophy, Spinal - drug therapy | Respiratory Function Tests | Medical research | Divalproex | RNA | Clinical trials | Medicine, Experimental | Bones | Product development | Valproic acid | Health aspects | Density | Spinal muscular atrophy | Carnitine | Pediatrics | Cerebral palsy | Body fat | SMN protein | Innervation | Action potential | mRNA | Body composition | Proteins | Atrophy | Salt | Body composition (biology) | Rodents | Safety engineering | Bone density | Oxidation | Hepatotoxicity | Bone composition | Age | Dual energy X-ray absorptiometry | Departments | Metabolism | Fatty acids | Medicine | Human subjects | Neurology | Pathology | Depletion | Acids | Cell lines | Bone mineral density | In vivo methods and tests | Bone | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 8, pp. e12140 - e12140
Background: Valproic acid (VPA) has demonstrated potential as a therapeutic candidate for spinal muscular atrophy (SMA) in vitro and in vivo. Methods: Two... 
GENE | PROTEIN-LEVEL | BIOLOGY | INCREASES | PHENOTYPE | FUNCTIONAL MOTOR SCALE | RELIABILITY | HAND-HELD DYNAMOMETRY | SMN2 COPY NUMBER | MODEL MICE | CHILDREN | Motor Activity - physiology | Age Factors | Humans | Body Weight - drug effects | Child, Preschool | Motor Activity - drug effects | Infant | Male | RNA, Messenger - metabolism | Valproic Acid - pharmacology | Muscular Atrophy, Spinal - genetics | Body Composition - drug effects | Carnitine - pharmacology | Drug-Related Side Effects and Adverse Reactions | Survival of Motor Neuron 1 Protein - genetics | Female | Valproic Acid - therapeutic use | Valproic Acid - adverse effects | Child | Muscular Atrophy, Spinal - physiopathology | Body Mass Index | Double-Blind Method | RNA, Messenger - genetics | Treatment Outcome | Lung - physiopathology | Gene Expression Regulation - drug effects | Carnitine - adverse effects | Bone Density - drug effects | Lung - drug effects | Carnitine - therapeutic use | Quality of Life | Muscular Atrophy, Spinal - drug therapy | Cohort Studies | Electrophysiological Phenomena - drug effects | Survival of Motor Neuron 1 Protein - blood | Divalproex | RNA | Analysis | Clinical trials | Levocarnitine | Research | Valproic acid | Health aspects | Spinal muscular atrophy | Health care | Pediatrics | Body fat | SMN protein | mRNA | Muscular dystrophy | Body composition | Proteins | Atrophy | Randomization | Motivation | Body composition (biology) | Safety engineering | Rodents | L-Carnitine | Children | Age | Regression analysis | Carnitine | Quality of life | Medicine | Neurology | Acids | In vivo methods and tests | In vitro methods and tests | Index Medicus
Journal Article
Annals of Neurology, ISSN 0364-5134, 12/2017, Volume 82, Issue 6, pp. 883 - 891
Journal Article
Journal Article
Muscle & Nerve, ISSN 0148-639X, 03/2014, Volume 49, Issue 3, pp. 422 - 430
Journal Article
Journal Article
Neuromuscular Disorders, ISSN 0960-8966, 02/2018, Volume 28, Issue 2, pp. 103 - 115
Spinal muscular atrophy (SMA) is a severe neuromuscular disorder due to a defect in the survival motor neuron 1 ( ) gene. Its incidence is approximately 1 in... 
Diagnosis | Nutrition | Orthopedic | Care | Phisotherapy | Spinal muscular atrophy | PHENOTYPIC VARIABILITY | EARLY-ONSET SCOLIOSIS | NEUROSCIENCES | CLINICAL NEUROLOGY | NEUROMUSCULAR SCOLIOSIS | MOTOR-NEURON GENE | GLUCOSE-METABOLISM | CLINICAL-TRIALS | OPERATIVE TREATMENT | CONTROLLED GROWING RODS | CONSENSUS STATEMENT | SMN2 COPY NUMBER | Care and treatment
Journal Article