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Nature, ISSN 0028-0836, 07/2007, Volume 448, Issue 7151, pp. 318 - 324
Journal Article
Journal Article
Journal Article
Journal Article
Nature Genetics, ISSN 1061-4036, 2014, Volume 46, Issue 4, pp. 364 - 370
The identification of activating NOTCH1 mutations in T cell acute lymphoblastic leukemia (T-ALL) led to clinical testing of g-secretase inhibitors (GSIs) that... 
NOTCH1 | INHIBITION | CHROMATIN | PATHWAY | GENES | GENETICS & HEREDITY | C-MYC | ACUTE MYELOID-LEUKEMIA | CANCER | LENTIVIRAL RNAI LIBRARY | GENOME | Chromatin - metabolism | Humans | Flow Cytometry | Chromatin Immunoprecipitation | Gene Expression Regulation, Neoplastic - drug effects | Indoles | Nuclear Proteins - genetics | Real-Time Polymerase Chain Reaction | Gene Expression Regulation, Neoplastic - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Enzyme-Linked Immunosorbent Assay | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Signal Transduction - genetics | Transcription Factors - genetics | Enzyme Inhibitors - therapeutic use | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Epigenesis, Genetic - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Histones - metabolism | Receptor, Notch1 - antagonists & inhibitors | Receptor, Notch1 - genetics | Chromatin - genetics | Care and treatment | Pharmacology, Experimental | Acute lymphocytic leukemia | Research | Drug resistance | Proteins | Genotype & phenotype | Leukemia | Epigenetics | Genomes | Kinases | Gene expression | Cancer therapies
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2007, Volume 282, Issue 51, pp. 37244 - 37255
Journal Article