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Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1431 - 13
Heat shock protein 27 (HSP27/HSPB1) is a stress-inducible chaperone that facilitates cancer development by its proliferative and anti-apoptotic functions. The... 
EXTRACELLULAR HSP27 | POLYCYTHEMIA-VERA | HSP90 INHIBITOR | ACTIVATION | SHOCK-PROTEIN 27 | MULTIDISCIPLINARY SCIENCES | MYELOPROLIFERATIVE NEOPLASMS | SERUM | MESENCHYMAL TRANSITION | TYROSINE-PHOSPHATASE | BONE-MARROW FIBROSIS | Leukocytes - pathology | Whole-Body Irradiation | Humans | STAT5 Transcription Factor - immunology | Primary Myelofibrosis - pathology | Molecular Targeted Therapy | HSP27 Heat-Shock Proteins - genetics | Leukocytes - immunology | STAT5 Transcription Factor - genetics | Thrombopoietin - immunology | Oligonucleotides - pharmacology | Bone Marrow Cells - immunology | Bone Marrow Transplantation | HEK293 Cells | Female | Disease Models, Animal | Primary Myelofibrosis - drug therapy | Janus Kinase 2 - immunology | Transduction, Genetic | Mice, Inbred C57BL | Primary Myelofibrosis - immunology | Bone Marrow Cells - pathology | Janus Kinase 2 - genetics | Mice, Transgenic | HSP27 Heat-Shock Proteins - immunology | Thrombopoietin - genetics | Primary Myelofibrosis - genetics | Animals | K562 Cells | Cell Line, Tumor | Leukocytes - drug effects | Mice | Mutation | Spleen | CD34 antigen | Cell proliferation | Animal models | Myelofibrosis | Therapeutic applications | Lung diseases | Heat shock proteins | Antisense oligonucleotides | Stat5 protein | Disease control | Patients | Neoplasms | Thrombopoietin | Janus kinase 2 | Hsp27 protein | Fibrosis | Weight reduction | Apoptosis | Cancer | Heat shock | Tumors | Life Sciences
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 07/2016, Volume 213, Issue 8, pp. 1479 - 1496
Myeloproliferative neoplasm (MPN) patients frequently show co-occurrence of JAK2-V617F and mutations in epigenetic regulator genes, including EZH2. In this... 
GROUP GENE EZH2 | MEDICINE, RESEARCH & EXPERIMENTAL | POLYCYTHEMIA-VERA | ACTIVATING MUTATION | HEMATOPOIETIC STEM-CELLS | TYROSINE KINASE JAK2 | IMMUNOLOGY | WORLD-HEALTH-ORGANIZATION | MYELOID METAPLASIA | SOMATIC MUTATIONS | MYELODYSPLASTIC SYNDROMES | REPRESSIVE COMPLEX 2
Journal Article
Cell Stem Cell, ISSN 1934-5909, 12/2014, Volume 15, Issue 6, pp. 791 - 804
Journal Article
Journal Article
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 3842 - 3842
Abstract Background: BM HSC accumulate during aging but are functionally impaired; however, it remains debated whether this aging results from HSC-intrinsic... 
Journal Article
Blood, ISSN 0006-4971, 12/2014, Volume 124, Issue 21, pp. 158 - 158
Abstract Background ;The gain-of-function JAK2 mutation, JAK2V617F, is the most common molecular abnormality in myeloproliferative neoplasms (MPNs) and appears... 
Journal Article
The Journal of Experimental Medicine, ISSN 0022-1007, 10/2014, Volume 211, Issue 11, pp. 2213 - 2230
Journal Article
Blood, ISSN 0006-4971, 11/2011, Volume 118, Issue 21, pp. 615 - 615
Abstract Abstract 615 JAK2-V617F is the most common genetic alteration in myeloproliferative neoplasms (MPN). Forced expression of JAK2-V617F in animal models... 
Journal Article
Alcohol, ISSN 0741-8329, 2005, Volume 37, Issue 3, pp. 157 - 166
Numerous reports document altered drinking behavior following acute stressors but few describe physiological responses to acute stress of chronic ethanol... 
Epinephrine | Norepinephrine | Corticosterone | Prolactin | Catecholamine enzyme mRNA | norepinephrine | prolactin | TYROSINE-HYDROXYLASE | PHENYLETHANOLAMINE-N-METHYLTRANSFERASE | REPEATED IMMOBILIZATION STRESS | epinephrine | PLASMA-CATECHOLAMINES | SUBSTANCE ABUSE | ALCOHOL-CONSUMPTION | BLOOD-PRESSURE | MESSENGER-RNA | PHARMACOLOGY & PHARMACY | TOXICOLOGY | BIOSYNTHETIC-ENZYMES | corticosterone | catecholamine enzyme mRNA | PITUITARY-ADRENAL AXIS | Arousal - genetics | Gene Expression Regulation - genetics | Stress, Psychological - blood | RNA, Messenger - genetics | Rats | Male | Alcohol Drinking - adverse effects | Rats, Sprague-Dawley | Arousal - drug effects | Gene Expression Regulation - drug effects | Prolactin - blood | Tyrosine 3-Monooxygenase - genetics | Arousal - physiology | Norepinephrine - blood | Alcohol Drinking - blood | Animals | Dopamine beta-Hydroxylase - genetics | Epinephrine - blood | Adrenal Medulla - physiopathology | Adrenal Medulla - drug effects | Corticosterone - blood | Stress, Psychological - complications | Phenylethanolamine N-Methyltransferase - genetics | Tyrosine | Enzymes | Messenger RNA | Alcohol, Denatured | Genetic research | Physiological aspects | Alcohol | Peptide hormones | Gene expression | Human subjects | Consumption | Plasma | Hypotheses | Ethanol | Diet | Rodents | Alcoholism | Hormones | Experiments | Stress | Food
Journal Article