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Biological Chemistry, ISSN 1431-6730, 04/2019, Volume 400, Issue 4, pp. 555 - 563
Journal Article
Nature, ISSN 0028-0836, 05/2013, Volume 497, Issue 7448, pp. 193 - 194
Intriguingly, the substratebinding region on FRB is also the binding site of the FKBP12-rapamycin complex. [...]the mechanism by which the FKBP12-rapamycin... 
Research | Structure | Protein kinases | Cytology | Crystals | Proteins | Enzymes | Phosphorylation | Cell division | Kinases | Crystal structure | Recruitment
Journal Article
Journal Article
Cell, ISSN 0092-8674, 07/2013, Volume 154, Issue 1, p. 169
Sixteen ovarian tumor (OTU) family deubiquitinases (DUBs) exist in humans, and most members regulate cell-signaling cascades. Several OTU DUBs were reported to... 
Journal Article
The EMBO Journal, ISSN 0261-4189, 05/2008, Volume 27, Issue 9, pp. 1333 - 1344
Upon B‐cell antigen receptor (BCR) activation, the protein tyrosine kinase Syk phosphorylates the adaptor protein SH2 domain‐containing leukocyte protein of 65... 
B‐cell antigen receptor signalling | adaptors | calcium | lymphocyte development | tyrosine kinase | Tyrosine kinase | Lymphocyte development | Calcium | Adaptors | B-cell antigen receptor signalling | CHANNEL FUNCTION | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAST-CELLS | PROTEIN-TYROSINE KINASE | N-TERMINUS | NON-ITAM TYROSINE | CELL BIOLOGY | STRUCTURAL BASIS | LINKER REGION TYROSINES | ANTIGEN RECEPTOR | IG-ALPHA | Phosphorylation | Luciferases - metabolism | Calcium - metabolism | Protein-Tyrosine Kinases - metabolism | Calcium Signaling - physiology | NF-kappa B - metabolism | Green Fluorescent Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | src Homology Domains - genetics | Extracellular Signal-Regulated MAP Kinases - metabolism | Receptors, Antigen, B-Cell - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Recombinant Fusion Proteins - metabolism | Proto-Oncogene Proteins c-akt - genetics | Luciferases - genetics | Protein-Tyrosine Kinases - genetics | Flow Cytometry | Transfection | Cell Differentiation | Proto-Oncogene Proteins c-akt - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Cell Line | Green Fluorescent Proteins - metabolism | Mice, Knockout | Tyrosine - metabolism | Animals | NF-kappa B - genetics | Models, Biological | Adaptor Proteins, Signal Transducing - genetics | Protein Binding | Recombinant Fusion Proteins - genetics | Receptors, Antigen, B-Cell - genetics | Mice | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Calcium Signaling - genetics | Tyrosine - genetics | Antigens | Signal transduction | Immunology | Cellular biology | Lymphocytes
Journal Article
Cell, ISSN 0092-8674, 06/2013, Volume 153, Issue 6, p. 1312
The linear ubiquitin (Ub) chain assembly complex (LUBAC) is an E3 ligase that specifically assembles Met1-linked (also known as linear) Ub chains that regulate... 
Journal Article
Journal Article