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Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2010, Volume 398, Issue 3, pp. 525 - 531
Transforming growth factor-beta 1 (TGF-β1) is secreted as a latent complex, which consists of latency-associated peptide (LAP) and the mature ligand. The... 
Extracellular HSP90β | TGF-β1 | MG63 cell | Osteosarcoma | Latent TGF-β activation
Journal Article
Cancer Letters, ISSN 0304-3835, 05/2013, Volume 331, Issue 2, pp. 230 - 238
Here in, we investigated the mechanism underlying overexpression of miR-135b in the human head and neck squamous cell carcinoma (HNSCC) cell lines and in the... 
Angiogenesis
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 07/2010, Volume 398, Issue 3, pp. 525 - 531
Transforming growth factor-beta 1 (TGF- beta 1) is secreted as a latent complex, which consists of latency-associated peptide (LAP) and the mature ligand. The... 
Cell proliferation
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 07/2010, Volume 398, Issue 3, p. 525
Transforming growth factor-beta 1 (TGF-[beta]1) is secreted as a latent complex, which consists of latency-associated peptide (LAP) and the mature ligand. The... 
Heat shock proteins | Bone morphogenetic proteins | Transforming growth factors | Osteosarcoma | Protein binding | GROWTH FACTORS | HEAT-SHOCK PROTEINS | PEPTIDES | STIMULATION | LIGANDS | CELL PROLIFERATION | CLEAVAGE | OSTEOSARCOMAS | 60 APPLIED LIFE SCIENCES | EXTRACELLULAR SPACE | PH VALUE | CONFORMATIONAL CHANGES
Journal Article
Journal Article
Current Protocols in Cell Biology, ISSN 1934-2500, 2009, Volume Chapter 19, Issue 44, p. 19.12.17
The technique of gene targeting allows for the introduction of engineered genetic mutations into a mouse at a determined genomic locus. The process of... 
Gene knockout | Homologous recombination | Gene targeting | Mice - genetics | Animals | Gene Knockout Techniques - methods | Genetic Vectors - genetics | Mice, Knockout
Journal Article
Journal Article
Current Protocols in Cell Biology, ISSN 1934-2500, 2009, Issue 42, p. 19.11.1.19.11.22
Journal Article
Journal Article
Nature Immunology, ISSN 1529-2908, 04/2011, Volume 12, Issue 4, p. 312
  The molecular mechanisms that direct the development of TCRα[beta]+CD8αα+ intestinal intraepithelial lymphocytes (IELs) are not thoroughly understood. Here... 
Journal Article
Human molecular genetics, ISSN 0964-6906, 06/2019
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor nerve cells in the brain and the spinal cord. Etiological... 
Journal Article
Nature Immunology, ISSN 1529-2908, 04/2011, Volume 12, Issue 4, pp. 312 - 319
Journal Article
Oncogene, ISSN 0950-9232, 07/2012, Volume 31, Issue 28, pp. 3322 - 3332
The molecular mechanisms that contribute to the initiation and progression of head and neck squamous cell carcinoma (HNSCC) have not been completely... 
cancer mouse model | TGF-β | conditional knockout | head and neck squamous cell carcinoma | PI3K/Akt | PATHWAYS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAMMARY-CARCINOMA | FACTOR-KAPPA-B | CELL BIOLOGY | COLON-CANCER | TGF-beta | GROWTH-FACTOR-BETA | GENE | EPITHELIA | ONCOLOGY | GENETICS & HEREDITY | TUMOR-SUPPRESSOR | EXPRESSION | Cell Proliferation | Epithelial Cells - metabolism | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Cell Count | Humans | Transforming Growth Factor beta1 - metabolism | Apoptosis - genetics | Phosphatidylinositol 3-Kinases - metabolism | Inflammation - complications | Neoplastic Stem Cells - metabolism | Neoplastic Stem Cells - pathology | Proto-Oncogene Proteins c-akt - metabolism | Cellular Senescence - genetics | PTEN Phosphohydrolase - genetics | PTEN Phosphohydrolase - deficiency | PTEN Phosphohydrolase - metabolism | Epithelial Cells - pathology | Penetrance | Signal Transduction - genetics | Transforming Growth Factor beta1 - genetics | Gene Knockout Techniques | Head and Neck Neoplasms - pathology | Animals | Carcinoma, Squamous Cell - complications | Cell Line, Tumor | Head and Neck Neoplasms - complications | Head and Neck Neoplasms - genetics | Mice | Myeloid Cells - pathology | Index Medicus | Cell proliferation | Animal models | Senescence | Transformation | biomarkers | AKT protein | Inflammation | Transforming growth factor- beta | Suppressor cells | Carcinogenesis | 1-Phosphatidylinositol 3-kinase | Metastases | Angiogenesis | Signal transduction | Cell activation | Molecular modelling | Stem cells | Head and neck | Head and neck cancer | Microenvironments | PTEN protein | Apoptosis | Tumors | squamous cell carcinoma | Head and Neck Squamous Cell Carcinoma (HNSCC) | Akt | PI3K | Conditional Knockout | Cancer Mouse Model
Journal Article
Molecular Cancer, ISSN 1476-4598, 06/2017, Volume 16, Issue 1, pp. 99 - 15
Background: Cancer immunotherapy offers a promising approach in cancer treatment. The adenosine A2A receptor (A2AR) could protect cancerous tissues from immune... 
Head and neck squamous cell carcinoma | Anti-tumor response | Regulatory T cells | Adenosine A2A receptor | Immunotherapy | ACTIVATION | CD73 | METASTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | IDENTIFICATION | CANCER | CHEMOTHERAPY | ONCOLOGY | GROWTH | SUPPRESSES | TUMOR MICROENVIRONMENT | Immunohistochemistry | Receptor, Transforming Growth Factor-beta Type I | Recurrence | T-Lymphocytes, Regulatory - metabolism | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Induction Chemotherapy | Head and Neck Neoplasms - metabolism | T-Lymphocytes, Regulatory - immunology | Neoplasm Metastasis | Squamous Cell Carcinoma of Head and Neck | Neoplasm Grading | Forkhead Transcription Factors - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | CD8-Positive T-Lymphocytes - metabolism | Adult | Receptor, Adenosine A2A - genetics | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | PTEN Phosphohydrolase - genetics | Gene Expression | Cytokines - metabolism | Immunomodulation | Mice, Transgenic | Receptor, Adenosine A2A - metabolism | Carcinoma, Squamous Cell - immunology | Head and Neck Neoplasms - pathology | Xenograft Model Antitumor Assays | Adenosine A2 Receptor Antagonists - pharmacology | Head and Neck Neoplasms - immunology | Animals | Receptors, Transforming Growth Factor beta - metabolism | Tumor Burden - drug effects | Biomarkers | Lymphocyte Count | Head and Neck Neoplasms - genetics | Aged | Mice | 5'-Nucleotidase - metabolism | CD8-Positive T-Lymphocytes - immunology | Head and neck cancer | Adenosine | Genetic aspects | Research | Gene expression | T cells | CD8 antigen | Immune clearance | Lymphocytes T | Kinases | Tissues | Cancer therapies | Lymph nodes | Human papillomavirus | Lymphocytes | Quality | Rodents | Foxp3 protein | CD73 antigen | Immune system | Antigens | Squamous cell carcinoma | Dysplasia | Cytokines | Immunoregulation | Pharmacology | CD4 antigen | Chemotherapy | Medical prognosis | Hypoxia | Cancer | Apoptosis | Lymph | Tumors
Journal Article
Current Protocols in Cell Biology, ISSN 1934-2500, 2009, Issue 44, p. 19.14.36
Journal Article