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1. Full Text Drugs and hepatic transporters: A review
by Jetter, Alexander and Kullak-Ublick, Gerd A
Pharmacological research, ISSN 1043-6618, 04/2019, p. 104234
The liver is the primary organ for the metabolic degradation of xenobiotics. Transmembrane transport proteins from the ABC and the SLC families mediate the... 
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2. Full Text Molecular Mechanisms of Colistin-Induced Nephrotoxicity
by Gai, Zhibo and Samodelov, Sophia L and Kullak-Ublick, Gerd A and Visentin, Michele
Molecules (Basel, Switzerland), ISSN 1420-3049, 02/2019, Volume 24, Issue 3, p. 653
The emergence of multidrug resistant (MDR) infections and the shortage of new therapeutic options have made colistin, a polymyxin antibiotic, the main option... 
acute kidney injury | nephrotoxicity | proximal tubule | mitochondria | colistin | polymyxins | RESPIRATORY-CHAIN | CARNITINE | PROTEIN | VENTILATOR-ASSOCIATED PNEUMONIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | OXIDOREDUCTASE | ACUTE-RENAL-FAILURE | ASCORBIC-ACID | CHEMISTRY, MULTIDISCIPLINARY | INTRAVENOUS COLISTIN | CRITICALLY-ILL PATIENTS | Animals | Colistin - pharmacology | Kidney - drug effects | Humans | Gram-Negative Bacterial Infections - drug therapy | Acute Kidney Injury - chemically induced | Anti-Bacterial Agents - pharmacology | Antioxidants - pharmacology | Drug Resistance, Multiple, Bacterial - drug effects | Cell Membrane - drug effects | Index Medicus
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3. Full Text Lipid accumulation and chronic kidney disease
by Gai, Zhibo and Wang, Tianqi and Visentin, Michele and Kullak-Ublick, Gerd A and Fu, Xianjun and Wang, Zhenguo
Nutrients, ISSN 2072-6643, 04/2019, Volume 11, Issue 4, p. 722
Obesity and hyperlipidemia are the most prevalent independent risk factors of chronic kidney disease (CKD), suggesting that lipid accumulation in the renal... 
Metabolic disease | Potential therapeutic strategy | Lipid accumulation | Chronic kidney disease | Blood lipids | PPAR-ALPHA | chronic kidney disease | FATTY-ACID TRANSPORT | PROLIFERATOR-ACTIVATED RECEPTORS | BINDING-PROTEIN | FOLLOW-UP | MITOTIC CLONAL EXPANSION | metabolic disease | LOW-PROTEIN-DIET | blood lipids | potential therapeutic strategy | NUTRITION & DIETETICS | OBESITY-RELATED GLOMERULOPATHY | BODY-MASS INDEX | FISH-OIL | lipid accumulation | Renal Insufficiency, Chronic - metabolism | Kidney - metabolism | Animals | Kidney - pathology | Humans | Lipid Metabolism - drug effects | Biological Transport - physiology | Carrier Proteins | Renal Insufficiency, Chronic - drug therapy | Wnt protein | Transplants & implants | Polyunsaturated fatty acids | Lipids | Superoxide dismutase | Systematic review | Activation | Accumulation | Antioxidants | Body mass index | Chinese medicine | Intestine | Patient safety | Peroxidase | Lipid metabolism | Growth factors | Statins | Glutathione | Glutathione peroxidase | Obesity | Kidneys | Cytokines | Fish oils | Superoxide | Inflammation | Metabolism | Insulin | Fatty acids | Cholesterol | Fibrosis | Agonists | Kidney diseases | Diabetes | Metabolic disorders | Proteinuria
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4. Full Text Renal Glycosuria as a Novel Early Sign of Colistin-Induced Kidney Damage in Mice
by Samodelov, Sophia L and Visentin, Michele and Gai, Zhibo and Häusler, Stephanie and Kullak-Ublick, Gerd A
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 10/2019, Volume 63, Issue 12
ABSTRACT The polymyxin colistin represents a last-resort antibiotic for multidrug-resistant infections, but its use is limited by the frequent onset of acute... 
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5. Full Text microRNA-206 modulates the hepatic expression of the organic anion-transporting polypeptide 1B1
by el Saadany, T. mer and van Rosmalen, Belle and Gai, Zhibo and Hiller, Christian and Verheij, Joanne and Stieger, Bruno and van Gulik, Thomas and Visentin, Michele and Kullak-Ublick, Gerd A
Liver international, ISSN 1478-3223, 2019, Volume 39, Issue 12, pp. 2350 - 2359
Background & Aims: The organic anion-transporting polypeptide 1B1 (OATP1B1) is an anion exchanger expressed at the hepatocyte sinusoidal membrane, which... 
liver | microRNA‐206 | epigenetics | OATP1B1 | Index Medicus
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6. Full Text Renal Reabsorption of Folates: Pharmacological and Toxicological Snapshots
by Samodelov, Sophia L and Gai, Zhibo and Kullak-Ublick, Gerd A and Visentin, Michele
Nutrients, ISSN 2072-6643, 10/2019, Volume 11, Issue 10, p. 2353
Folates are water-soluble B9 vitamins that serve as one-carbon donors in the de novo synthesis of thymidylate and purines, and in the conversion of... 
Choroid plexus | Drugs | Drug delivery systems | Cytotoxicity | Arthritis | Proximal tubules | Folic acid | Proteins | Oats | Distal tubules | Food fortification | Vitamin B | DNA methylation | Patient safety | Supplementation | Deoxyribonucleic acid--DNA | Creatinine | Efflux | Kidneys | Polycystic kidney | Tumor cells | Multidrug resistance | Dietary supplements | Tubules | Vitamin deficiency | Reabsorption | Food production | Radiation therapy | Na+/K+-exchanging ATPase | Epithelium | Workload | Urea | Chemotherapy | Placenta | Sodium | Rheumatoid arthritis | Ligands | In vivo methods and tests | Plasma levels | Kidney diseases | Mutation | Homocysteine | folate receptor | folate | renal reabsorption | acute kidney injury | nephrotoxicity | folic acid
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7. Colistin is Substrate of the Carnitine/Organic Cation Transporter 2 (OCTN2, SLC22A5)
by Michele Visentin and Zhibo Gai and Angelo Torozi and Christian Hiller and Gerd A Kullak-Ublick
Drug Metabolism and Disposition, ISSN 0090-9556, 12/2017, Volume 45, Issue 12, p. 1240
Colistin is a polycation antibiotic used for the treatment of multidrug-resistance (MDR) gram-negative infections; nevertheless, its use is often limited by... 
Urine | Organic cation transporter | Renal function | Colistin | Incubation | Toxicity | Reabsorption | Event-related potentials | Tetraethylammonium | Drug resistance | Small intestine | Accumulation | Substrates | Carnitine | Antibiotics | L-Carnitine | Cations | Inhibition | Transport | Carbon 14 | Renal cortex | Transporter
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8. Full Text BSEP and MDR3 haplotype structure in healthy Caucasians, primary biliary cirrhosis and primary sclerosing cholangitis
by Pauli-Magnus, Christiane and Kerb, Reinhold and Fattinger, Karin and Lang, Thomas and Anwald, Birgit and Kullak-Ublick, Gerd A and Beuers, Ulrich and Meier, Peter J
Hepatology (Baltimore, Md.), ISSN 0270-9139, 2004, Volume 39, Issue 3, pp. 779 - 791
Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are characterized by a cholestatic pattern of liver damage, also observed in... 
POPULATION | URSODEOXYCHOLIC ACID | GENE | ADULTHOOD | MUTATION | MECHANISMS | LIVER-DISEASE | GASTROENTEROLOGY & HEPATOLOGY | BILE-SALT TRANSPORTERS | FAMILIAL INTRAHEPATIC CHOLESTASIS | PREGNANCY | Haplotypes | Amino Acid Sequence | European Continental Ancestry Group - genetics | Humans | Cholangitis, Sclerosing - genetics | Molecular Sequence Data | Male | Liver Cirrhosis, Biliary - genetics | Case-Control Studies | Linkage Disequilibrium | Genetic Variation | ATP-Binding Cassette Transporters - genetics | ATP Binding Cassette Subfamily B Member 11 | Recombination, Genetic | Adult | Female | Molecular Structure | ATP Binding Cassette Transporter, Sub-Family B - genetics | Cohort Studies
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9. Full Text Vitamin D.sub.3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor
by Da Silva, Tatiana Claro and Hiller, Christian and Gai, Zhibo and Kullak-Ublick, Gerd A
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 10/2016, Volume 163, p. 77
* Vitamin D.sub.3 induces genes involved in zinc, manganese and iron homeostasis. * Ceruloplasmin and haptoglobin expression is augmented with vitamin D.sub.3... 
Calcifediol | Alfacalcidol | Vitamin D | Haptoglobin | RNA | Multiple sclerosis | Oncology, Experimental | Genes | Research | Gene expression | Osteoporosis | Anopheles | Analysis | Physiological aspects | Cancer
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10. A Mobile App to Stabilize Daily Functional Activity of Breast Cancer Patients in Collaboration With the Physician: A Randomized Controlled Clinical Trial
by Marco Egbring and Elmira Far and Malgorzata Roos and Michael Dietrich and Mathis Brauchbar and Gerd A Kullak-Ublick and Andreas Trojan
Journal of Medical Internet Research, ISSN 1438-8871, 09/2016, Volume 18, Issue 9, p. E238
Background The well-being of breast cancer patients and reporting of adverse events require close monitoring. Mobile apps allow continuous recording of... 
Activities | Drugs | Multimedia computer applications | Terminology | Clinical trials | Critical incidents | Clinical research | Oncology | Well being | Breast cancer | Patients | Chemotherapy | Side effects | Collaboration | Questionnaires | Adverse | Recording | Symptoms
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11. Current concepts of mechanisms in drug-induced hepatotoxicity
by Russmann, Stefan and Kullak-Ublick, Gerd A and Grattagliano, Ignazio
Current Medicinal Chemistry, ISSN 0929-8673, 2009, Volume 16, Issue 23, pp. 3041 - 3053
Drug-induced liver injury (DILI) has become a leading cause of severe liver disease in Western countries and therefore poses a major clinical and regulatory... 
Mitochondrial permeability transition | TNF alpha | Necrosis | Mitochondria | Acetaminophen | Metabonomics | Drug metabolism | Fas | Drug-induced liver injury | Death receptors | Hepatotoxicity | Apoptosis | Glutathione | drug-induced liver injury | metabonomics | ACETAMINOPHEN-INDUCED HEPATOTOXICITY | glutathione | SALT EXPORT PUMP | HEPATIC APOPTOSIS | apoptosis | INDUCED LIVER-INJURY | death receptors | drug metabolism | INTRACELLULAR GLUTATHIONE | PHARMACOLOGY & PHARMACY | S-TRANSFERASE M1 | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | mitochondria | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitochondrial permeability transition | TISSUE-REPAIR | RAT FATTY LIVER | necrosis | hepatotoxicity | Mitochondria, Liver - drug effects | Chemical and Drug Induced Liver Injury - metabolism | Humans | Risk Factors | Chemical and Drug Induced Liver Injury - etiology | Chemical and Drug Induced Liver Injury - immunology | Mitochondria, Liver - physiology
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12. Full Text Chenodeoxycholic acid induced changes in the expression of microRNAs and genes involved in lipid, bile acid and drug metabolism in human hepatocytes
by Kullak-Ublick, Gerd A and Krattinger, Regina and Lee, Serene M and Thasler, Wolfgang E and Mwinyi, Jessica and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Funktionell farmakologi and Uppsala universitet and Institutionen för neurovetenskap
Hepatology, ISSN 0270-9139, 2015, Volume 62, p. 469A
Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Farmakologi och toxikologi | Pharmacology and Toxicology
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13. Full Text Pharmacogenetics of drug‐induced liver injury
by Russmann, Stefan and Jetter, Alexander and Kullak‐Ublick, Gerd A
Hepatology, ISSN 0270-9139, 08/2010, Volume 52, Issue 2, pp. 748 - 761
Recent progress in research on drug‐induced liver injury (DILI) has been determined by key developments in two areas. First, new technologies allow the... 
S-TRANSFERASE M1 | ACQUIRED-IMMUNODEFICIENCY-SYNDROME | INDUCED HEPATITIS | GENETIC POLYMORPHISMS | RISK-FACTOR | SALT EXPORT PUMP | METABOLIC-ACTIVATION | GASTROENTEROLOGY & HEPATOLOGY | SINGLE NUCLEOTIDE POLYMORPHISMS | GENOME-WIDE ASSOCIATION | INDUCED HEPATOTOXICITY | HLA Antigens - physiology | Genetic Association Studies | Humans | Risk Factors | Protein Transport - physiology | Chemical and Drug Induced Liver Injury - genetics | Chemical and Drug Induced Liver Injury - etiology | Genes | Risk factors
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14. Full Text Drug-induced liver injury: recent advances in diagnosis and risk assessment
by Kullak-Ublick, Gerd A and Andrade, Raul J and Merz, Michael and End, Peter and Benesic, Andreas and Gerbes, Alexander L and Aithal, Guruprasad P
Gut, ISSN 0017-5749, 06/2017, Volume 66, Issue 6, pp. 1154 - 1164
Idiosyncratic drug-induced liver injury (IDILI) is a rare but potentially severe adverse drug reaction that should be considered in patients who develop... 
Drug Induced Hepatotoxicity | Bile Acid | Pharmacogenetics | Hepatobiliary Disease | Adverse Drug Reactions | ACETAMINOPHEN-INDUCED HEPATOTOXICITY | IDIOPATHIC AUTOIMMUNE | ACID-BINDING PROTEIN | SPANISH REGISTRY | CLINICAL-TRIALS | GENOME-WIDE | ALANINE AMINOTRANSFERASE | CAUSALITY ASSESSMENT | GASTROENTEROLOGY & HEPATOLOGY | GLUTATHIONE S-TRANSFERASE | MECHANISTIC BIOMARKERS | Drugs | Medicine | Complications and side effects | Usage | Liver diseases | Analysis | Practice | Research | Diagnosis | Biological markers | Risk factors | Pathogenesis | Toxicity | Liver | Genomics | Oncology | Identification | Genomes | Kinases | Medical diagnosis | Hepatitis | Mitochondria | Metabolites | Rodents | Risk assessment | Gastroenterology | Colony-stimulating factor | Drug dosages | Antigens | MiRNA | Macrophage colony-stimulating factor | Caspase | Patients | Studies | Monocytes | Surveillance | Hepatocytes | Causality | Physicochemical properties | Bile | Index Medicus | Abridged Index Medicus | ADVERSE DRUG REACTIONS | HEPATOBILIARY DISEASE | 1240 | PHARMACOGENETICS | Recent Advances in Clinical Practice | 1506 | BILE ACID | DRUG INDUCED HEPATOTOXICITY
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15. Full Text Su1680 Effect of Chronic Renal Failure on the Hepatic Expression of Bile Acid Transporters
by Zhibo, Gai and Lei, Chu and Montani, Jean-Pierre and Kullak-Ublick, Gerd A
Gastroenterology, ISSN 0016-5085, 2013, Volume 144, Issue 5, pp. S-996 - S-996
Gastroenterology and Hepatology
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16. Full Text No major effects of vitamin D^sub 3^ (1,25 dihydroxyvitamin D^sub 3^) on absorption and pharmacokinetics of folic acid and fexofenadine in healthy volunteers
by Gerd A Kullak-Ublick and Christoph Gubler and Katharina Spanaus and Manfred G Ismair and Tatiana Claro da Silva and Alexander Jetter
European Journal of Clinical Pharmacology, ISSN 0031-6970, 07/2016, Volume 72, Issue 7, p. 797
  Purpose In Caco-2 cells, folate uptake via the proton-coupled folate transporter (PCFT) increases significantly by a 3-day treatment with... 
Histamine | Vitamin D | Vitamin B | Pharmacology
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17. Full Text Tu1821 The Gene Encoding the Human Organic Anion Transporting Polypeptide Oatp1a2 (Gene Symbol Slco1a2 ) is Transactivated by the Vitamin D Receptor (VDR)
by Eloranta, Jyrki J and Hiller, Christian and Jüttner, Moritz and Kullak-Ublick, Gerd A
Gastroenterology, ISSN 0016-5085, 2012, Volume 142, Issue 5, pp. S-854 - S-854
Gastroenterology and Hepatology
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