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index medicus (28) 28
pregnancy (21) 21
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hypertension (7) 7
placenta (7) 7
pregnant women (7) 7
angiogenesis (6) 6
hemorrhage (6) 6
infertility (6) 6
biochemistry & molecular biology (5) 5
case report (5) 5
pregnancy complications (5) 5
vascular endothelial growth factor receptor-1 - metabolism (5) 5
women (5) 5
analysis (4) 4
biophysics (4) 4
cell proliferation (4) 4
cesarean section (4) 4
health aspects (4) 4
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implantation (4) 4
medical colleges (4) 4
mice, inbred icr (4) 4
mouse model (4) 4
nuclear magnetic resonance--nmr (4) 4
obstetrics (4) 4
placenta previa (4) 4
preparations for medical, dental, or toilet purposes (4) 4
risk (4) 4
specific therapeutic activity of chemical compounds ormedicinal preparations (4) 4
vascular endothelial growth factor (4) 4
bladder (3) 3
case reports (3) 3
cell line, tumor (3) 3
disease models, animal (3) 3
embryonic structures (3) 3
endothelial growth factors (3) 3
endothelial growth-factor (3) 3
gene expression (3) 3
hek293 cells (3) 3
hypopituitarism (3) 3
immunology (3) 3
male (3) 3
management (3) 3
mice, inbred c57bl (3) 3
molecular sequence data (3) 3
multidisciplinary sciences (3) 3
placenta - metabolism (3) 3
placenta percreta (3) 3
postpartum hemorrhage (3) 3
pravastatin (3) 3
pre-eclampsia (3) 3
pre-eclampsia - physiopathology (3) 3
retrospective studies (3) 3
rodents (3) 3
soluble endoglin (3) 3
spermatogenesis (3) 3
subsequent pregnancy (3) 3
t cells (3) 3
uterine receptivity (3) 3
abnormal placentation (2) 2
abridged index medicus (2) 2
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1. Full Text Pathophysiology of preeclampsia: An angiogenic imbalance and long-lasting systemic vascular dysfunction
by Tomimatsu, Takuji and Mimura, Kazuya and Endo, Masayuki and Kumasawa, Keiichi and Kimura, Tadashi
Hypertension Research, ISSN 0916-9636, 04/2017, Volume 40, Issue 4, pp. 305 - 310
Preeclampsia is a systemic vascular disorder characterized by new-onset hypertension and proteinuria after 20 weeks of gestation. This condition targets... 
soluble fms-like tyrosine kinase 1 | angiogenic imbalance | preeclampsia | systemic vascular dysfunction | PREGNANCY-INDUCED HYPERTENSION | PULSE-WAVE VELOCITY | DISEASE RISK-FACTORS | SOLUBLE ENDOGLIN | MATERNAL PLASMA-CONCENTRATIONS | TYROSINE KINASE 1 | BLOOD-PRESSURE | ARTERIAL STIFFNESS | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | ENDOTHELIAL GROWTH-FACTOR | Pregnancy | Humans | Endothelium, Vascular - physiopathology | Female | Neovascularization, Pathologic - physiopathology | Pre-Eclampsia - etiology | Pre-Eclampsia - physiopathology | Kidney - physiopathology
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2. Full Text Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model
by Keiichi Kumasawa and Masahito Ikawa and Hiroyasu Kidoya and Hidetoshi Hasuwa and Tomoko Saito-Fujita and Yuka Morioka and Nobuyuki Takakura and Tadashi Kimura and Masaru Okabe and R. Michael Roberts
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2011, Volume 108, Issue 4, pp. 1451 - 1455
Preeclampsia is a relatively common pregnancy-related disorder. Both maternal and fetal lives will be endangered if it proceeds unabated. Recently, the... 
Hypertension | Pregnancy | Animal models | Reproduction | Placenta | Fetal growth retardation | Preeclampsia | Blastocyst | Blood pressure | Female animals | Hemolytic anemia, elevated liver enzymes, and low platelet count | Trophoblast | 3-hydroxy-3-methyl-glutaryl-CoA | LOVASTATIN | ANGIOGENESIS | LENTIVIRUS | MULTIDISCIPLINARY SCIENCES | SOLUBLE ENDOGLIN | hemolytic anemia, elevated liver enzymes, and low platelet count | PREGNANCY | GENE-TRANSFER | FETAL | trophoblast | SIMVASTATIN | HYPERTENSION | EXPOSURE | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Pre-Eclampsia - genetics | Humans | Pregnancy Proteins - genetics | Male | Pregnancy Proteins - metabolism | Pre-Eclampsia - prevention & control | HEK293 Cells | Female | Lentivirus - genetics | Pre-Eclampsia - metabolism | Disease Models, Animal | Vascular Endothelial Growth Factor Receptor-1 - genetics | Animals, Newborn | Pravastatin - pharmacology | Cell Line | Transduction, Genetic | Injections, Intraperitoneal | Mice, Transgenic | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Placenta - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Pravastatin - administration & dosage | Placenta Growth Factor | Mice | Development and progression | Models | Dosage and administration | Drug therapy | Pravastatin | Vascular endothelial growth factor | Health aspects | Biological Sciences
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3. Full Text Corrigendum to ‘Soluble FLT-1 rules placental destiny’ [Biochem. Biophys. Res. Commun. 46 (2018) 1243–1249]
by Yamashita, Michiko and Kumasawa, Keiichi and Nakamura, Hitomi and Kimura, Tadashi
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2018, Volume 501, Issue 2, pp. 605 - 606
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4. Full Text Preeclampsia: Maternal Systemic Vascular Disorder Caused by Generalized Endothelial Dysfunction Due to Placental Antiangiogenic Factors
by Tomimatsu, T and Mimura, K and Matsuzaki, S and Endo, M and Kumasawa, K and Kimura, T
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 09/2019, Volume 20, Issue 17, p. 4246
Preeclampsia, a systemic vascular disorder characterized by new-onset hypertension and proteinuria after 20 weeks of gestation, is the leading cause of... 
arterial stiffness | soluble fms-like tyrosine kinase 1 | NORMAL-PREGNANCY | PULSE-WAVE VELOCITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | preeclampsia | endothelial dysfunction | CHEMISTRY, MULTIDISCIPLINARY | TYROSINE KINASE 1 | BLOOD-PRESSURE | placental growth factor | CIRCULATING ANGIOGENIC FACTORS | angiogenic imbalance | LOW-DOSE ASPIRIN | vascular endothelial growth factor | systemic vascular dysfunction | MOLECULAR-WEIGHT HEPARIN | NITRIC-OXIDE | INTRAUTERINE GROWTH RESTRICTION | 11-13 WEEKS GESTATION
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5. Full Text Endothelin-1 profiles in advanced maternal age complicated with hypertensive disorders of pregnancy
by Furuya, Kiichiro and Kumasawa, Keiichi and Nakamura, Hitomi and Kimura, Tadashi
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 08/2019, Volume 516, Issue 3, pp. 941 - 944
Recently, advanced maternal age (AMA) has been increasing due to late marriage and assisted reproductive technology. AMA is high-risk pregnancy associated with... 
Mouse model | HDP | VEGF | Endothelin-1 | Advanced maternal age | BIOCHEMISTRY & MOLECULAR BIOLOGY | RISK | ADVERSE OUTCOMES | PREECLAMPSIA | ANGIOGENIC FACTORS | WOMEN | BIOPHYSICS | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | GROWTH-FACTOR | Hypertension | Pregnancy | Medical colleges | Endothelin | Endothelial growth factors | Pregnant women | Analysis | Obstetrics
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6. Full Text Soluble VEGF receptor 1 (sFLT1) induces non-apoptotic death in ovarian and colorectal cancer cells
by Miyake, Tatsuya and Kumasawa, Keiichi and Sato, Noriko and Takiuchi, Tsuyoshi and Nakamura, Hitomi and Kimura, Tadashi
Scientific Reports, ISSN 2045-2322, 04/2016, Volume 6, Issue 1, p. 24853
Soluble Vascular Endothelial Growth Factor Receptor 1 (sVEGFR1/sFLT1) is an angiogenesis inhibitor that competes with angiogenic factors such as VEGF and... 
FLT-1 GENE | FACTOR-A | INHIBITION | BEVACIZUMAB | MULTIDISCIPLINARY SCIENCES | GENE-THERAPY | PREECLAMPSIA | DYSFUNCTION | HYPERTENSION | CARCINOMA | ENDOTHELIAL GROWTH-FACTOR | Colorectal carcinoma | Cytology | Colorectal cancer | Cytotoxicity | Pre-eclampsia | Ovarian cancer | Angiogenesis | Transfection | Placenta | Rodents | Vascular endothelial growth factor | Apoptosis | Tumors
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7. Full Text Novel biomarker profiles in experimental aged maternal mice with hypertensive disorders of pregnancy
by Furuya, Kiichiro and Kumasawa, Keiichi and Nakamura, Hitomi and Nishimori, Katsuhiko and Kimura, Tadashi
Hypertension Research, ISSN 0916-9636, 01/2019, Volume 42, Issue 1, pp. 29 - 39
Recently, advanced maternal age (AMA) has increased in Western countries because of late marriage and advances in assisted reproductive technology. One major... 
PATHOGENESIS | TYROSINE KINASE-1 | H2O2-INDUCED PREMATURE SENESCENCE | ATHEROSCLEROSIS | CELL SENESCENCE | RISK | PERIPHERAL VASCULAR DISEASE | ADVERSE OUTCOMES | PREECLAMPSIA | UTERINE PERFUSION-PRESSURE | FIBROBLASTS
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8. Full Text Obstetric outcome in patients with a unicornuate uterus after laparoscopic resection of a rudimentary horn
by Sawada, Masaaki and Kakigano, Aiko and Matsuzaki, Shinya and Takiuchi, Tsuyoshi and Mimura, Kazuya and Kumasawa, Keiichi and Endo, Masayuki and Ueda, Yutaka and Yoshino, Kiyoshi and Kimura, Tadashi
Journal of Obstetrics and Gynaecology Research, ISSN 1341-8076, 06/2018, Volume 44, Issue 6, pp. 1080 - 1086
Aim Previous studies have shown adverse obstetric outcomes of the laparoscopic resection of a rudimentary horn. Our study aimed to investigate the obstetric... 
preterm birth | rudimentary horn | small for gestational age | vaginal delivery | unicornuate uterus | MANAGEMENT | MYOMECTOMY | BIRTH | OBSTETRICS & GYNECOLOGY | Hypertension | Care and treatment | Analysis | Patient outcomes | Laparoscopic surgery | Laparoscopy | Cesarean section | Uterus | Premature birth | Pregnancy complications | Data processing | Obstetrics | Gestational age
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9. Full Text Successful conservative management of placenta percreta: Investigation by serial magnetic resonance imaging of the clinical course and a literature review
by Sawada, Masaaki and Matsuzaki, Shinya and Mimura, Kazuya and Kumasawa, Keiichi and Endo, Masayuki and Kimura, Tadashi
Journal of Obstetrics and Gynaecology Research, ISSN 1341-8076, 12/2016, Volume 42, Issue 12, pp. 1858 - 1863
Placenta percreta is a rare condition that presents a risk of massive intraoperative hemorrhage. To decrease maternal morbidity in such cases, conservative... 
magnetic resonance imaging | placenta percreta | conservative management | placenta previa | Placenta percreta | Placenta previa | Magnetic resonance imaging | Conservative management | ACCRETA | OBSTETRICS & GYNECOLOGY | Placenta Accreta - surgery | Humans | Conservative Treatment | Gadolinium | Treatment Outcome | Gestational Age | Placenta Previa - surgery | Pregnancy | Magnetic Resonance Imaging | Placenta Accreta - diagnostic imaging | Contrast Media | Ultrasonography, Prenatal | Adult | Female | Investigations | Literature reviews | Placenta | Nuclear magnetic resonance--NMR | Hemorrhage | Morbidity
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10. Full Text Soluble FLT-1 rules placental destiny
by Yamashita, Michiko and Kumasawa, Keiichi and Nakamura, Hitomi and Kimura, Tadashi
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 02/2018, Volume 496, Issue 4, pp. 1243 - 1249
Placenta previa is an abnormality in which the placenta covers the internal uterine os, and it can cause serious morbidity and mortality in both mother and... 
Soluble fms-like tyrosine kinase-1 (sFLT-1) | Placental migration | Placenta previa | MIGRATION | WOMEN | BIOPHYSICS | ENDOGLIN | ABNORMAL PLACENTATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PREECLAMPSIA | HYPOXIA | PREVIA | Placenta Previa - mortality | Species Specificity | Placentation | Humans | Middle Aged | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Organ Specificity | Mice, Inbred ICR | Placenta - metabolism | Pregnancy | Tissue Distribution | Animals | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Adult | Female | In Vitro Techniques
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11. Full Text Impact of human cytomegalovirus infection on trophoblast transcriptome
by Mimura, Nobuko and Nagamatsu, Takeshi and Morita, Kazuki and Taguchi, Ayumi and Kumasawa, Keiichi and Iriyama, Takayuki and Osuga, Yutaka and Fujii, Tomoyuki
Placenta, ISSN 0143-4004, 11/2019, Volume 87, pp. 61 - 61
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12. Full Text Role of placental ATX-LPA system and its pathologic relevance to Hypertensive disorders of pregnancy
by Ichikawa, Mayuko and Nagamatsu, Takeshi and Nishimori, Yumiko and Fujii, Tatsuya and Fujii, Tomoyuki and Kumasawa, Keiichi and Iriyama, Takayuki and Osuga, Yutaka
Placenta, ISSN 0143-4004, 11/2019, Volume 87, pp. 64 - 65
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13. Full Text Increasing soluble fms-like tyrosine kinase1(sFlt1) in preeclampsia controls oneself through arginase
by Tanaka, Hiroko and Kumasawa, Keiichi and Kakigano, Aiko and Mimura, Kazuya and Endo, Masayuki and Tomimatsu, Takuji and Kimura, Tadashi
Placenta, ISSN 0143-4004, 11/2019, Volume 87, pp. 72 - 72
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14. Full Text Reliable predictors of neonatal immune thrombocytopenia in pregnant women with idiopathic thrombocytopenic purpura
by Koyama, Shinsuke and Tomimatsu, Takuji and Kanagawa, Takeshi and Kumasawa, Keiichi and Tsutsui, Tateki and Kimura, Tadashi
American Journal of Hematology, ISSN 0361-8609, 01/2012, Volume 87, Issue 1, pp. 15 - 21
Of infants born to women with idiopathic thrombocytopenic purpura (ITP), about 10–15% have transient neonatal immune thrombocytopenic purpura (NITP). Of... 
AUTOIMMUNE THROMBOCYTOPENIA | MANAGEMENT | THERAPY | PLATELET COUNTS | NEWBORN | MATERNAL CHARACTERISTICS | BORN | RISK | HEMATOLOGY | INTRACRANIAL HEMORRHAGE | PRENATAL-DIAGNOSIS | Purpura, Thrombocytopenic, Idiopathic - complications | Prognosis | Humans | Risk Factors | Pregnancy | Young Adult | Platelet Count | Thrombocytopenia, Neonatal Alloimmune - diagnosis | Thrombocytopenia, Neonatal Alloimmune - etiology | Adult | Female | Pregnancy Complications, Hematologic - diagnosis | Pregnancy Complications, Hematologic - etiology | Retrospective Studies | Infant, Newborn
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15. Full Text Placental expression of lysophosphatidic acid receptors in normal pregnancy and preeclampsia
by Fujii, Tatsuya and Nagamatsu, Takeshi and Schust, Danny J and Ichikawa, Mayuko and Kumasawa, Keiichi and Yabe, Shinichiro and Iriyama, Takayuki and Hirota, Yasushi and Osuga, Yutaka and Aoki, Junken and Yatomi, Yutaka and Fujii, Tomoyuki
American Journal of Reproductive Immunology, ISSN 1046-7408, 11/2019, Volume 82, Issue 5, p. n/a
Problem Recent advances in lipid research have revealed that impairments in lipid mediator signaling can be involved in the pathoetiology of a variety of... 
placenta | lysophosphatidic acid receptor | preeclampsia | human | OXIDATIVE STRESS | INCREASES | IMMUNOLOGY | LYSOPHOSPHOLIPASE-D | WOMEN | REPRODUCTIVE BIOLOGY | PROTEIN-COUPLED RECEPTOR | IMPLANTATION | ROLES | GROWTH | LPA | AUTOTAXIN | Immunohistochemistry | Pregnancy | Lysophosphatidic acid receptors | Placenta | Lysophosphatidic acid | Preeclampsia | Immunoblotting | Pre-eclampsia | Gene expression
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16. Full Text In vivo uterine local gene delivery system using TAT‐displaying bionanocapsules
by Koizumi, Kaori and Nakamura, Hitomi and Iijima, Masumi and Matsuzaki, Takashi and Somiya, Masaharu and Kumasawa, Keiichi and Kimura, Tadashi and Kuroda, Shun’ichi
The Journal of Gene Medicine, ISSN 1099-498X, 11/2019
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17. Full Text Increased LIGHT leading to sFlt-1 elevation underlies the pathogenic link between hydatidiform mole and preeclampsia
by Iriyama, T and Wang, G and MidoriYoshikawa and Mimura, N and Matsui, H and Sayama, S and Kumasawa, K and Nagamatsu, T and Koga, K and Kotani, T and Niimi, K and Yamamoto, E and Kellems, RE and Xia, Y and Osuga, Y and Fujii, T
SCIENTIFIC REPORTS, ISSN 2045-2322, 07/2019, Volume 9, Issue 1, pp. 10107 - 7
Hydatidiform moles are known to pose an extremely high risk of severe early-onset preeclampsia if left untreated. TNF superfamily cytokine, LIGHT has recently... 
PROTEINURIA | ACTIVATION | HYPERTENSION | CONTRIBUTES | EXPRESSION | MULTIDISCIPLINARY SCIENCES | Serum levels | Hydatidiform mole | Tumor necrosis factor | Preeclampsia | Light | Pre-eclampsia | Enzyme-linked immunosorbent assay
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18. Full Text Effect of sustained release of basic fibroblast growth factor using biodegradable gelatin hydrogels on frozen‐thawed human ovarian tissue in a xenograft model
by Tanaka, Ayaka and Nakamura, Hitomi and Tabata, Yasuhiko and Fujimori, Yuka and Kumasawa, Keiichi and Kimura, Tadashi
Journal of Obstetrics and Gynaecology Research, ISSN 1341-8076, 10/2018, Volume 44, Issue 10, pp. 1947 - 1955
Aim Ovarian tissue cryopreservation before cancer treatment is the only option to preserve fertility under some circumstances. However, tissue ischemia after... 
gelatin hydrogel | ovarian tissue cryopreservation | angiogenesis | heterotopic xenograft | basic fibroblast growth factor | SURVIVAL | FERTILITY PRESERVATION | FACTOR BFGF | XENOTRANSPLANTATION | RABBIT MODEL | OBSTETRICS & GYNECOLOGY | INTERNAL THORACIC ARTERIES | PREPUBERTAL GIRLS | MICE | ENHANCED ANGIOGENESIS | FOLLICULOGENESIS | Biodegradation, Environmental | Hydrogels | Humans | Mice, Inbred C57BL | Fibroblast Growth Factor 2 - administration & dosage | Animals | Heterografts | Cryopreservation | Gelatin | Female | Ovary - drug effects | Mice | Delayed-Action Preparations | Neovascularization, Physiologic | Disease Models, Animal | Phosphates | Drugs | Drug delivery systems | Analysis | Fibroblast growth factors | Neovascularization | Vehicles | Cell proliferation | Fibroblast growth factor 2 | Fibroblast growth factor | Cell survival | Biodegradability | Immunodeficiency | Transplantation | Drug delivery | Biological activity | Endothelial cells | Vascularization | Angiogenesis | Ischemia | Fibrosis | Xenografts | Fibroblasts | Growth factors | Controlled release | Cancer
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19. Full Text Prediction of pregnancy after frozen‐thawed embryo transfer via in vivo intrauterine oxidation‐reduction potential measurements: a pilot study
by Nakamura, Hitomi and Hosono, Takayoshi and Taniguchi, Takeshi and Kumasawa, Keiichi and Goa, Satoko and Ono, Masaaki and Kimura, Tadashi
Reproductive Medicine and Biology, ISSN 1445-5781, 07/2018, Volume 17, Issue 3, pp. 255 - 261
Purpose During the implantation period, the uterus goes through many complex, orchestrated changes, including alterations of the glycocalyx that are due to... 
oxidation‐reduction potential | uterine receptivity | implantation | infertility | assisted reproductive technology treatment | oxidation-reduction potential
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