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1. Full Text Characterization of a novel acetamidobenzoxazolone‐based PET ligand for translocator protein (18 kDa) imaging of neuroinflammation in the brain
by Tiwari, Anjani K and Yui, Joji and Fujinaga, Masayuki and Kumata, Katsushi and Shimoda, Yoko and Yamasaki, Tomoteru and Xie, Lin and Hatori, Akiko and Maeda, Jun and Nengaki, Nobuki and Zhang, Ming‐Rong
Journal of Neurochemistry, ISSN 0022-3042, 05/2014, Volume 129, Issue 4, pp. 712 - 720
We developed the novel positron emission tomography (PET) ligand 2‐[5‐(4‐[ 11 C]methoxyphenyl)‐2‐oxo‐1,3‐benzoxazol‐3( 2H )‐yl]‐ N ‐methyl‐ N ‐phenylacetamide... 
microglia activation | translocator protein (18 kDa) | positron emission tomography | C]MBMP | neuroinflammation | translocator protein (18 kDa) | Microglia - metabolism | Acetanilides - chemical synthesis | Brain - diagnostic imaging | Nerve Tissue Proteins - analysis | Male | Positron-Emission Tomography | Radiopharmaceuticals - chemical synthesis | Tissue Distribution | Infarction, Middle Cerebral Artery - complications | Microglia - diagnostic imaging | Animals, Outbred Strains | Molecular Structure | Imaging, Three-Dimensional | Infarction, Middle Cerebral Artery - diagnostic imaging | Receptors, GABA - analysis | Binding, Competitive | Radiopharmaceuticals - pharmacokinetics | Carbon Radioisotopes - pharmacokinetics | Rats | Inflammation | Brain Ischemia - etiology | Infarction, Middle Cerebral Artery - pathology | Rats, Sprague-Dawley | Benzoxazoles - chemical synthesis | Autoradiography | Animals | Brain Ischemia - pathology | Protein Binding | Ligands | Brain Chemistry | Mice | Acetanilides - pharmacokinetics | Brain Ischemia - diagnostic imaging | Benzoxazoles - pharmacokinetics | Brain | Neurochemistry | Proteins | Medical imaging
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2. Full Text PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation
by Nagai, Yuji and Kikuchi, Erika and Lerchner, Walter and Inoue, Ken-Ichi and Ji, Bin and Eldridge, Mark A. G and Kaneko, Hiroyuki and Kimura, Yasuyuki and Oh-Nishi, Arata and Hori, Yukiko and Kato, Yoko and Hirabayashi, Toshiyuki and Fujimoto, Atsushi and Kumata, Katsushi and Zhang, Ming-Rong and Aoki, Ichio and Suhara, Tetsuya and Higuchi, Makoto and Takada, Masahiko and Richmond, Barry J and Minamimoto, Takafumi
Nature Communications, ISSN 2041-1723, 12/2016, Volume 7, Issue 1, p. 13605
The rostromedial caudate (rmCD) of primates is thought to contribute to reward value processing, but a causal relationship has not been established. Here we... 
RHINAL CORTEX | CIRCUITS | NEURONAL-ACTIVITY | PERFORMANCE | MULTIDISCIPLINARY SCIENCES | CLOZAPINE-N-OXIDE | MOTIVATION | ORBITOFRONTAL CORTEX | PREFERENCE | PREFRONTAL CORTEX | BRAIN
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3. Full Text Radiosynthesis of 6-(2-cyclobutyl-5-[11C]methyl-3H-imidazo[4,5-b]pyridin-3-yl)benzo[d]thiazol-2(3H)-one as a novel PET tracer for imaging of γ-8 dependent transmembrane AMPA receptor regulatory protein
by Qingzhen Yu and Zhen Chen and Katsushi Kumata and Tuo Shao and Hsiao-Ying Wey and Yihan Shao and Lee Josephson and Ming-Rong Zhang and Steven Liang
The Journal of Nuclear Medicine, ISSN 0161-5505, 05/2019, Volume 60
Objectives: AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor is an important protein in humans, the dysfunction of which is often... 
Cerebellum | Neuroimaging | Brain | Cerebral cortex | Mental disorders | Epilepsy | Schizophrenia | Cerebrospinal fluid | α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors | Condensation | Proteins | Ammonium chloride | Chemical reduction | Cesium fluorides | Synthesis | Aromatic compounds | Precursors | α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid | Radiochemistry | Tomography | Oxidation | Solid phases | Compound A | Medical imaging | Health risks | Cortex | Positron emission | Chemical reactions | Liquid chromatography | High-performance liquid chromatography | Ammonium chlorides | Neurological diseases | Reagents | Ligands | Yield | Methylation | Positron emission tomography | Regulatory proteins | Tracers
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4. Full Text Synthesis and evaluation of 4-picolinamide for PET imaging of the metabotropic glutamate receptor 2 in the rat brain
by Kumata, Katsushi and Hatori, Akiko and Yamasaki, Tomoteru and Zhang, Yiding and Mori, Wakana and Fujinaga, Masayuki and Xie, Lin and Nengaki, Nobuki and Zhang, Ming-Rong
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 02/2019, Volume 27, Issue 3, p. 483
Metabotropic glutamate receptor 2 (mGluR2) has been suggested as a therapeutic target for treating schizophrenia-like symptoms arising from increased glutamate... 
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5. Full Text PET Imaging of Lung Inflammation with [18F]FEDAC, a Radioligand for Translocator Protein (18 kDa)
by Hatori, Akiko and Yui, Joji and Yamasaki, Tomoteru and Xie, Lin and Kumata, Katsushi and Fujinaga, Masayuki and Yoshida, Yuichiro and Ogawa, Masanao and Nengaki, Nobuki and Kawamura, Kazunori and Fukumura, Toshimitsu and Zhang, Ming-Rong
PLoS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, p. e45065
Purpose: The translocator protein (18 kDa) (TSPO) is highly expressed on the bronchial and bronchiole epithelium, submucosal glands in intrapulmonary bronchi,... 
RESPONSES | POSITRON-EMISSION-TOMOGRAPHY | LYMPHOID-TISSUE | MACROPHAGES | KINETICS | MULTIDISCIPLINARY SCIENCES | PERIPHERAL BENZODIAZEPINE-RECEPTOR | LIPOPOLYSACCHARIDE | INJURY | RATS | OUTCOMES | Isoquinolines - pharmacokinetics | Area Under Curve | Male | Lung - diagnostic imaging | Fluorine Radioisotopes - pharmacokinetics | Pneumonia - diagnosis | Pulmonary Alveoli - metabolism | Lung - metabolism | Pulmonary Alveoli - diagnostic imaging | Neutrophils - metabolism | Neutrophils - pathology | Lung - pathology | Tissue Distribution - drug effects | Pulmonary Alveoli - pathology | Radiopharmaceuticals - pharmacokinetics | Acetamides - pharmacokinetics | Macrophages - pathology | Carbon Radioisotopes - pharmacokinetics | Neutrophils - drug effects | Purines - pharmacokinetics | Rats | Positron-Emission Tomography - methods | Rats, Sprague-Dawley | Blotting, Western | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Fluorescent Antibody Technique | Lipopolysaccharides - pharmacology | Ligands | Macrophages - drug effects | Receptors, GABA-A - metabolism | Acute respiratory distress syndrome | Inflammation | PET imaging | Macrophages | Mitogens | Disease | Emission analysis | Glands | Bronchi | Lipopolysaccharides | Proteins | Rodents | Imaging | Tomography | Chronic obstructive pulmonary disease | Pretreatment | Alveoli | Trachea | Radioactivity | Medical imaging | Neutrophils | Positron emission | Bronchus | Fluorine isotopes | Leukocytes (neutrophilic) | Epithelium | Pneumocytes | Lungs | Laboratory animals | Positron emission tomography
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6. Full Text Automated Synthesis of (rac)‐, (R)‐, and (S)‐[18F]Epifluorohydrin and Their Application for Developing PET Radiotracers Containing a 3‐[18F]Fluoro‐2‐hydroxypropyl Moiety
by Fujinaga, Masayuki and Ohkubo, Takayuki and Yamasaki, Tomoteru and Zhang, Yiding and Mori, Wakana and Hanyu, Masayuki and Kumata, Katsushi and Hatori, Akiko and Xie, Lin and Nengaki, Nobuki and Zhang, Ming‐Rong
ChemMedChem, ISSN 1860-7179, 08/2018, Volume 13, Issue 16, pp. 1723 - 1731
To introduce the 3‐[ 18 F]fluoro‐2‐hydroxypropyl moiety into positron emission tomography (PET) radiotracers, we performed automated synthesis of ( rac )‐, ( R... 
F]epifluorohydrin | automated synthesis | F-fluoroalkylation | translocator protein | imaging agents | CHEMISTRY, MEDICINAL | HUMAN BRAIN | PERIPHERAL BENZODIAZEPINE-RECEPTORS | NO-CARRIER | BIODISTRIBUTION | TRACERS | [F-18]epifluorohydrin | PROTEIN 18 KDA | F-18 FLUOROMISONIDAZOLE | LIGANDS | RADIOSYNTHESIS | PHARMACOLOGY & PHARMACY | F-18-fluoroalkylation | BINDING | Hydrocarbons, Fluorinated - chemical synthesis | Radiopharmaceuticals - chemistry | Stereoisomerism | Hydrocarbons, Fluorinated - pharmacology | Hydrocarbons, Fluorinated - chemistry | Positron-Emission Tomography - methods | Propanols - pharmacology | Radiopharmaceuticals - chemical synthesis | Propanols - chemical synthesis | Propanols - metabolism | Brain - metabolism | Tissue Distribution | Propanols - chemistry | Radiopharmaceuticals - metabolism | Animals | Epoxy Compounds - chemical synthesis | Bone and Bones - metabolism | Epoxy Compounds - chemistry | Receptors, GABA - metabolism | Hydrocarbons, Fluorinated - metabolism | Mice | Molecular Structure | Fluorine Radioisotopes | Radiopharmaceuticals - pharmacology | Enantiomers | Distillation | Phenylacetamide | Automation | Radiolabelling | Liver | Positron emission | Oxazol | Fluorine isotopes | Radioactive tracers | Proteins | Synthesis | Chirality | Reagents | Phenols | Tomography | Positron emission tomography | Radioactivity
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7. Full Text Comparison between [18F]fluorination and [18F]fluoroethylation reactions for the synthesis of the PDE10A PET radiotracer [18F]MNI-659
by Mori, Wakana and Takei, Makoto and Furutsuka, Kenji and Fujinaga, Masayuki and Kumata, Katsushi and Muto, Masatoshi and Ohkubo, Takayuki and Hashimoto, Hiroki and Tamagnan, Gilles and Higuchi, Makoto and Kawamura, Kazunori and Zhang, Ming-Rong
Nuclear Medicine and Biology, ISSN 0969-8051, 12/2017, Volume 55, pp. 12 - 18
2-(2-(3-(4-(2-[ F]Fluoroethoxy)phenyl)-7-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)-4-isopropoxyisoindoline-1,3-dione ([ F]MNI-659, [ F] ) is a useful PET... 
[18F]MNI-659 | PDE10A | [18F]fluoroethyl bromide | [18F]fluorination | PET | F]fluorination | F]fluoroethyl bromide | F]MNI-659 | [F-18]MNI-659 | EARLY HUNTINGTON DISEASE | RADIOLIGAND | EMISSION-TOMOGRAPHY TRACER | PHOSPHODIESTERASE 10A | [F-18]fluoroethyl bromide | RADIOSYNTHESIS | [F-18]fluorination | PERIPHERAL BENZODIAZEPINE-RECEPTOR | BIOLOGICAL EVALUATION | INHIBITORS | IN-VIVO EVALUATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | BRAIN | Brain - diagnostic imaging | Radioactive Tracers | Chemistry Techniques, Synthetic | Phosphoric Diester Hydrolases - metabolism | Humans | Phthalimides - chemistry | Positron-Emission Tomography | Brain - metabolism | Quinazolinones - chemical synthesis | Phthalimides - chemical synthesis | Halogenation | Radiochemistry | Quinazolinones - chemistry | Pets | Neuroimaging | Enzymes | Brain | Positron emission | Cyclotrons | Studies | Potash | Decay | Phenols | Tomography | Yield | Fluorination | Chemical synthesis | Positron emission tomography | Potassium | Radioactivity | Potassium carbonate | Phosphodiesterase
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8. Full Text Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies
by Ono, Maiko and Sahara, Naruhiko and Kumata, Katsushi and Ji, Bin and Ni, Ruiqing and Koga, Shunsuke and Dickson, Dennis W and Trojanowski, John Q and Lee, Virginia M-Y and Yoshida, Mari and Hozumi, Isao and Yoshiyama, Yasumasa and Van Swieten, John C and Nordberg, Agneta and Suhara, Tetsuya and Zhang, Ming-Rong and Higuchi, Makoto
Brain, ISSN 0006-8950, 03/2017, Volume 140, Issue 3, pp. 764 - 780
Diverse neurodegenerative disorders are characterized by deposition of tau fibrils composed of conformers (i.e. strains) unique to each illness. The... 
N279K/G272V FTDP-17-MAPT mutation | PBB3/AV-1451 | Progressive supranuclear palsy/corticobasal degeneration/Pick’s disease | Tau PET ligand | Alzheimer’s disease | HUMAN BRAIN | DEMENTIA | SUPRANUCLEAR PALSY | ALZHEIMERS-DISEASE | NEUROFIBRILLARY PATHOLOGY | COGNITIVE IMPAIRMENT | EMISSION-TOMOGRAPHY TRACER | NEUROSCIENCES | CLINICAL NEUROLOGY | progressive supranuclear palsy/corticobasal degeneration/Pick's disease | MUTATION | tau PET ligand | PAIRED HELICAL FILAMENTS | Alzheimer's disease | CORTICOBASAL DEGENERATION | Neurofibrillary Tangles - pathology | Brain - diagnostic imaging | Radiopharmaceuticals - pharmacokinetics | Humans | Butadienes - pharmacokinetics | Fluorescence | Phenazopyridine - pharmacokinetics | Tauopathies - pathology | tau Proteins - metabolism | Male | Positron-Emission Tomography | Benzothiazoles - pharmacokinetics | Brain - drug effects | Autoradiography | Tauopathies - metabolism | Tauopathies - diagnostic imaging | Benzothiazoles - chemistry | Brain - pathology | Thiadiazoles - pharmacokinetics | Female | Carbolines - pharmacokinetics | Diagnosis | Radioligand Assay | AV-1451 | corticobasal degeneration | PBB3 | N279K | G272V FTDP-17-MAPT mutation | Original | Pick’s disease | progressive supranuclear palsy
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9. Full Text Synthesis and Preliminary Evaluation of 11C‐Labeled VU0467485/AZ13713945 and Its Analogues for Imaging Muscarinic Acetylcholine Receptor Subtype 4
by Deng, Xiaoyun and Hatori, Akiko and Chen, Zhen and Kumata, Katsushi and Shao, Tuo and Zhang, Xiaofei and Yamasaki, Tomoteru and Hu, Kuan and Yu, Qingzhen and Ma, Longle and Wang, Gangqiang and Wang, Lu and Shao, Yihan and Josephson, Lee and Sun, Shaofa and Zhang, Ming‐Rong and Liang, Steven
ChemMedChem, ISSN 1860-7179, 02/2019, Volume 14, Issue 3, pp. 303 - 309
Muscarinic acetylcholine receptors (mAChRs) have five distinct subunits (M 1 –M 5 ) and are involved in the action of the neurotransmitter acetylcholine in the... 
carbon-11 | muscarinic acetylcholine receptor subtype 4 | positron emission tomography | positive allosteric modulator | VU0467485/AZ13713945 | Neuroimaging | Brain | Acetylcholine receptors (muscarinic) | Mental disorders | Emission analysis | Schizophrenia | Nervous system | Neuromodulation | Modulators | Optimization | Receptors | Allosteric properties | Synthesis | Radiochemistry | Tomography | Physiochemistry | Alzheimer's disease | Peripheral nervous system | Evaluation | Neurodegenerative diseases | Positron emission | Permeability | Autoradiography | Ligands | Acetylcholine | Drug discovery | Alzheimers disease | Positron emission tomography
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10. Full Text Visualization of acute liver damage induced by cycloheximide in rats using PET with [18F]FEDAC, a radiotracer for translocator protein (18 kDa)
by Hatori, Akiko and Yui, Joji and Xie, Lin and Yamasaki, Tomoteru and Kumata, Katsushi and Fujinaga, Masayuki and Wakizaka, Hidekatsu and Ogawa, Masanao and Nengaki, Nobuki and Kawamura, Kazunori and Zhang, Ming-Rong
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, pp. e86625 - e86625
Liver damage induced by drug toxicity is an important concern for both medical doctors and patients. The aim of this study was to noninvasively visualize acute... 
APOPTOSIS | MECHANISM | MULTIDISCIPLINARY SCIENCES | PERIPHERAL BENZODIAZEPINE-RECEPTOR | DISEASE | KUPFFER CELLS | MODEL | EXPRESSION | IL-10 | Cycloheximide - toxicity | Radiopharmaceuticals - pharmacokinetics | Acetamides - pharmacokinetics | Protein Synthesis Inhibitors - toxicity | Purines - pharmacokinetics | RNA, Messenger - genetics | Rats | Male | Positron-Emission Tomography | Reverse Transcriptase Polymerase Chain Reaction | Rats, Sprague-Dawley | Immunoenzyme Techniques | Protein Transport | Tissue Distribution | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Chemical and Drug Induced Liver Injury - metabolism | Receptors, GABA-A - genetics | Receptors, GABA-A - metabolism | Chemical and Drug Induced Liver Injury - pathology | Real-Time Polymerase Chain Reaction | Chemical and Drug Induced Liver Injury - etiology | Liver diseases | PET imaging | RNA | Liver | Cyclohexane | DNA polymerases | Inflammation | Apoptosis | Nuclear magnetic resonance--NMR | RNA-directed DNA polymerase | Toxicity | Emission analysis | Kupffer cells | Kinases | Macrophages | Proteins | Rodents | Hepatology | Tomography | Physiology | Bioindicators | Damage | Radioactivity | Medical personnel | Enzymes | Damage assessment | Medical imaging | Cytokines | Neutrophils | Positron emission | Leukocytes (neutrophilic) | Injection | Gene expression | Doctors | Studies | Polymerase chain reaction | Cycloheximide | Hepatocytes | Biomarkers | Infiltration | Laboratory animals | Positron emission tomography | Index Medicus | Nuclear magnetic resonance | NMR
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11. Full Text Visualization of early infarction in rat brain after ischemia using a translocator protein (18kDa) PET ligand [11C]DAC with ultra-high specific activity
by Yui, Joji and Hatori, Akiko and Kawamura, Kazunori and Yanamoto, Kazuhiko and Yamasaki, Tomoteru and Ogawa, Masanao and Yoshida, Yuichiro and Kumata, Katsushi and Fujinaga, Masayuki and Nengaki, Nobuki and Fukumura, Toshimitsu and Suzuki, Kazutoshi and Zhang, Ming-Rong
NeuroImage, ISSN 1053-8119, 01/2011, Volume 54, Issue 1, pp. 123 - 130
The aim of this study was to visualize early infarction in the rat brain after ischemia using a translocator protein (TSPO) (18 kDa) PET ligand [ C]DAC with... 
Ultra-high specific activity | Autoradiography | Small-animal PET | [11C]DAC | Ischemia | Translocator protein (TSPO) (18 kDa) | Early infarction | Translocator protein (TSPO) (18kDa) | C]DAC | PERIPHERAL BENZODIAZEPINE-RECEPTORS | INDUCTION | FOCAL ISCHEMIA | NEUROSCIENCES | NEUROIMAGING | IN-VITRO | POSITRON-EMISSION-TOMOGRAPHY | MICROGLIA | NEUROINFLAMMATION | INFLAMMATION | [C-11]DAC | BINDING | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | ALZHEIMERS | Brain Ischemia - complications | Brain - diagnostic imaging | Rats | Autoradiography - methods | Positron-Emission Tomography - methods | Cerebral Infarction - diagnostic imaging | Radiography | Purines | Animals | Blood-Brain Barrier - physiology | Brain - pathology | Cerebral Infarction - etiology | Verapamil | Acetamides | Carbon Radioisotopes | Cerebral Infarction - pathology | Brain | Pets | Stroke | Medical imaging | Rodents | Surgery | Mortality | Ligands | Radioactivity
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12. Full Text A useful PET probe [11 C]BU99008 with ultra-high specific radioactivity for small animal PET imaging of I2 -imidazoline receptors in the hypothalamus
by Kawamura, Kazunori and Shimoda, Yoko and Yui, Joji and Zhang, Yiding and Yamasaki, Tomoteru and Wakizaka, Hidekatsu and Hatori, Akiko and Xie, Lin and Kumata, Katsushi and Fujinaga, Masayuki and Ogawa, Masanao and Kurihara, Yusuke and Nengaki, Nobuki and Zhang, Ming-Rong
Nuclear Medicine and Biology, ISSN 0969-8051, 2016, Volume 45, pp. 1 - 7
Abstract Introduction A positron emission tomography (PET) probe with ultra-high specific radioactivity (SA) enables measuring high receptor specific binding... 
Radiology | BU99008 | Imidazoline receptors | 11C | Ultra-high specific radioactivity | PET | Neuroimaging | Brain | Syngeneic grafts | Change detection | Hypothalamus | Receptors | Synthesis | Metabolites | Rodents | Imaging | Animal tissues | Tomography | Probes | Radioactivity | Binding | Kidneys | Iodides | Positron emission | Rats | Imidazoline | Ligands | In vivo methods and tests | Methylation | Positron emission tomography
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13. Full Text Developing new PET tracers to image the growth hormone secretagogue receptor 1a (GHS-R1a)
by Kawamura, Kazunori and Fujinaga, Masayuki and Shimoda, Yoko and Yamasaki, Tomoteru and Zhang, Yiding and Hatori, Akiko and Xie, Lin and Wakizaka, Hidekatsu and Kumata, Katsushi and Ohkubo, Takayuki and Kurihara, Yusuke and Ogawa, Masanao and Nengaki, Nobuki and Zhang, Ming-Rong
Nuclear Medicine and Biology, ISSN 0969-8051, 2017, Volume 52, pp. 49 - 56
Abstract Introduction The growth hormone secretagogue receptor 1a (GHS-R1a) is the orphan G-protein-coupled receptor, and its endogenous ligand is ghrelin.... 
Radiology | GHS-R1a | Growth hormone secretagogue receptor | Ghrelin | PET | SYSTEM | GHRELIN RECEPTOR | OBESITY | PITUITARY | MICE | ANTAGONISTS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PEPTIDE | Tissue Distribution | Radioactive Tracers | Animals | Chemistry Techniques, Synthetic | Heterocyclic Compounds, 1-Ring - chemistry | Heterocyclic Compounds, 1-Ring - pharmacokinetics | Drug Design | Radiochemistry | Receptors, Ghrelin - metabolism | Mice | Positron-Emission Tomography - methods | Heterocyclic Compounds, 1-Ring - chemical synthesis | Methylation | Pets | Somatotropin | Neuroimaging | Neuroprotection | Brain | G protein-coupled receptors | Liver | Indole | Memory | Homeostasis | Small intestine | Learning | Synthesis | Biphenyl | Tomography | Pretreatment | Pancreas | Radioactivity | Food | Carbonyls | Medical imaging | Positron emission | Injection | Addiction | Growth hormones | Growth hormone | Positron emission tomography | Tracers
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14. Full Text Noninvasive Quantification of Metabotropic Glutamate Receptor Type 1 with [11C]ITDM: a Small-Animal PET Study
by Yamasaki, Tomoteru and Fujinaga, Masayuki and Yui, Joji and Ikoma, Yoko and Hatori, Akiko and Xie, Lin and Wakizaka, Hidekatsu and Kumata, Katsushi and Nengaki, Nobuki and Kawamura, Kazunori and Zhang, Ming-Rong
Journal of Cerebral Blood Flow & Metabolism, ISSN 0271-678X, 4/2014, Volume 34, Issue 4, pp. 606 - 612
Because of its role in multiple central nervous system (CNS) pathways, metabotropic glutamate receptor type 1 (mGluR1) is a crucial target in the development... 
R6/2 | mGluR1 | Positron emission tomography | Huntington disease | ANTAGONIST | [C-11]ITDM | C-11-ABP688 | NEUROSCIENCES | SIGNAL-TRANSDUCTION | GRAPHICAL ANALYSIS | POSITRON-EMISSION-TOMOGRAPHY | IN-VIVO | DISEASE | ENDOCRINOLOGY & METABOLISM | BPND | RAT-BRAIN | positron emission tomography | BINDING-SITES | HEMATOLOGY | TRANSGENIC MICE | Immunohistochemistry | Brain - diagnostic imaging | Humans | Mice, Inbred C57BL | Rats | Mice, Transgenic | Positron-Emission Tomography | Receptors, Metabotropic Glutamate - metabolism | Nerve Tissue Proteins - genetics | Rats, Sprague-Dawley | Brain - metabolism | Autoradiography | Huntingtin Protein | Pyrimidines | Animals | Protein Binding | Ligands | Mice | Benzamides | Radiopharmaceuticals | Original | [11C]ITDM | BP ND
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