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animals (72) 72
science & technology (60) 60
life sciences & biomedicine (53) 53
positron emission tomography (49) 49
rats (48) 48
male (45) 45
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positron-emission tomography (42) 42
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autoradiography (32) 32
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receptors, metabotropic glutamate - metabolism (14) 14
carrier proteins - metabolism (13) 13
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biochemistry & molecular biology (9) 9
chemistry, organic (9) 9
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carbon radioisotopes - pharmacokinetics (8) 8
medical imaging (8) 8
mice, inbred c57bl (8) 8
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11c (7) 7
acetamides - pharmacokinetics (7) 7
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metabotropic glutamate receptor 2 (7) 7
methylation (7) 7
organic chemistry (7) 7
protein binding (7) 7
proteins (7) 7
structure-activity relationship (7) 7
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atp binding cassette transporter, sub-family g, member 2 (6) 6
atp-binding cassette transporters - metabolism (6) 6
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fluorine radioisotopes - pharmacokinetics (5) 5
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1. Full Text Development of the Fibronectin–Mimetic Peptide KSSPHSRN(SG)5RGDSP as a Novel Radioprobe for Molecular Imaging of the Cancer Biomarker α5β1 Integrin
by Jin, Zhao-Hui and Furukawa, Takako and Kumata, Katsushi and Xie, Lin and Yui, Joji and Wakizaka, Hidekatsu and Fujibayashi, Yasuhisa and Zhang, Ming-Rong and Saga, Tsuneo and National Institute of Radiological Sciences and Molecular Imaging Center
Biological & pharmaceutical bulletin, ISSN 0918-6158, 2015, Volume 38, Issue 11, pp. 1722 - 1731
fibronectin–mimetic peptide | fluorine-18 | radioprobe | positron emission tomography | α5β1 integrin | Neoplasms - metabolism | Amino Acid Sequence | Humans | Mice, Inbred C57BL | Rats | Melanoma, Experimental - metabolism | Molecular Imaging - methods | Neoplasms - diagnosis | Positron-Emission Tomography - methods | Fibronectins - metabolism | Molecular Probes - chemistry | Animals | Peptides - metabolism | Biomarkers, Tumor - metabolism | Female | Mice | Mice, Inbred BALB C | Colorectal Neoplasms - metabolism | Integrin alpha5beta1 - metabolism | Disease Models, Animal | Index Medicus
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2. Full Text PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation
by Nagai, Yuji and Kikuchi, Erika and Lerchner, Walter and Inoue, Ken-Ichi and Ji, Bin and Eldridge, Mark A. G and Kaneko, Hiroyuki and Kimura, Yasuyuki and Oh-Nishi, Arata and Hori, Yukiko and Kato, Yoko and Hirabayashi, Toshiyuki and Fujimoto, Atsushi and Kumata, Katsushi and Zhang, Ming-Rong and Aoki, Ichio and Suhara, Tetsuya and Higuchi, Makoto and Takada, Masahiko and Richmond, Barry J and Minamimoto, Takafumi
Nature communications, ISSN 2041-1723, 12/2016, Volume 7, Issue 1, pp. 13605 - 13605
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Index Medicus
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3. Full Text A practical route for synthesizing a PET ligand containing [ 18F]fluorobenzene using reaction of diphenyliodonium salt with [ 18F]F
by Zhang, Ming-Rong and Kumata, Katsushi and Suzuki, Kazutoshi
Tetrahedron letters, ISSN 0040-4039, 2007, Volume 48, Issue 49, pp. 8632 - 8635
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4. Full Text Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys
by Nagai, Yuji and Miyakawa, Naohisa and Takuwa, Hiroyuki and Hori, Yukiko and Oyama, Kei and Ji, Bin and Takahashi, Manami and Huang, Xi-Ping and Slocum, Samuel T and DiBerto, Jeffrey F and Xiong, Yan and Urushihata, Takuya and Hirabayashi, Toshiyuki and Fujimoto, Atsushi and Mimura, Koki and English, Justin G and Liu, Jing and Inoue, Ken-ichi and Kumata, Katsushi and Seki, Chie and Ono, Maiko and Shimojo, Masafumi and Zhang, Ming-Rong and Tomita, Yutaka and Nakahara, Jin and Suhara, Tetsuya and Takada, Masahiko and Higuchi, Makoto and Jin, Jian and Roth, Bryan L and Minamimoto, Takafumi
Nature neuroscience, ISSN 1097-6256, 09/2020, Volume 23, Issue 9, pp. 1157 - 1167
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Clinical neuropsychology | Biochemical genetics | Clozapine | Testing | Actuators | Acetylcholine receptors (muscarinic) | Positron emission | Monkeys | Prefrontal cortex | Remote control | Emissions | Liabilities | Tomography | Primates | Agonists | Short term memory | Positron emission tomography | Spatial memory | Index Medicus
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5. Full Text Characterization of a novel acetamidobenzoxazolone‐based PET ligand for translocator protein (18 kDa) imaging of neuroinflammation in the brain
by Tiwari, Anjani K and Yui, Joji and Fujinaga, Masayuki and Kumata, Katsushi and Shimoda, Yoko and Yamasaki, Tomoteru and Xie, Lin and Hatori, Akiko and Maeda, Jun and Nengaki, Nobuki and Zhang, Ming‐Rong
Journal of neurochemistry, ISSN 0022-3042, 05/2014, Volume 129, Issue 4, pp. 712 - 720
[11C]MBMP | microglia activation | translocator protein (18 kDa) | positron emission tomography | neuroinflammation | translocator protein (18 kDa) | Microglia - metabolism | Acetanilides - chemical synthesis | Brain - diagnostic imaging | Nerve Tissue Proteins - analysis | Male | Positron-Emission Tomography | Radiopharmaceuticals - chemical synthesis | Tissue Distribution | Infarction, Middle Cerebral Artery - complications | Microglia - diagnostic imaging | Animals, Outbred Strains | Molecular Structure | Imaging, Three-Dimensional | Infarction, Middle Cerebral Artery - diagnostic imaging | Receptors, GABA - analysis | Binding, Competitive | Radiopharmaceuticals - pharmacokinetics | Carbon Radioisotopes - pharmacokinetics | Rats | Inflammation | Brain Ischemia - etiology | Infarction, Middle Cerebral Artery - pathology | Rats, Sprague-Dawley | Benzoxazoles - chemical synthesis | Autoradiography | Animals | Brain Ischemia - pathology | Protein Binding | Ligands | Brain Chemistry | Mice | Acetanilides - pharmacokinetics | Brain Ischemia - diagnostic imaging | Benzoxazoles - pharmacokinetics | Brain | Neurochemistry | Proteins | Medical imaging | Index Medicus
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6. Full Text Radiosynthesis of 6-(2-cyclobutyl-5-[11C]methyl-3H-imidazo[4,5-b]pyridin-3-yl)benzo[d]thiazol-2(3H)-one as a novel PET tracer for imaging of γ-8 dependent transmembrane AMPA receptor regulatory protein
by Qingzhen Yu and Zhen Chen and Katsushi Kumata and Tuo Shao and Hsiao-Ying Wey and Yihan Shao and Lee Josephson and Ming-Rong Zhang and Steven Liang
The Journal of nuclear medicine (1978), ISSN 0161-5505, 05/2019, Volume 60
Cerebellum | Neuroimaging | Brain | Cerebral cortex | Mental disorders | Epilepsy | Schizophrenia | Cerebrospinal fluid | α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors | Condensation | Proteins | Ammonium chloride | Chemical reduction | Cesium fluorides | Synthesis | Aromatic compounds | Precursors | α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid | Radiochemistry | Tomography | Oxidation | Solid phases | Compound A | Medical imaging | Health risks | Positron emission | Chemical reactions | Liquid chromatography | High-performance liquid chromatography | Neurological diseases | Reagents | Ligands | Yield | Methylation | Positron emission tomography | Regulatory proteins | Tracers
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7. Full Text Developing new PET tracers to image the growth hormone secretagogue receptor 1a (GHS-R1a)
by Kawamura, Kazunori and Fujinaga, Masayuki and Shimoda, Yoko and Yamasaki, Tomoteru and Zhang, Yiding and Hatori, Akiko and Xie, Lin and Wakizaka, Hidekatsu and Kumata, Katsushi and Ohkubo, Takayuki and Kurihara, Yusuke and Ogawa, Masanao and Nengaki, Nobuki and Zhang, Ming-Rong
Nuclear medicine and biology, ISSN 0969-8051, 2017, Volume 52, pp. 49 - 56
Radiology | GHS-R1a | Growth hormone secretagogue receptor | Ghrelin | PET | Life Sciences & Biomedicine | Radiology, Nuclear Medicine & Medical Imaging | Science & Technology | Tissue Distribution | Radioactive Tracers | Animals | Chemistry Techniques, Synthetic | Heterocyclic Compounds, 1-Ring - chemistry | Heterocyclic Compounds, 1-Ring - pharmacokinetics | Drug Design | Radiochemistry | Receptors, Ghrelin - metabolism | Mice | Positron-Emission Tomography - methods | Heterocyclic Compounds, 1-Ring - chemical synthesis | Methylation | Pets | Somatotropin | Neuroimaging | Neuroprotection | Brain | G protein-coupled receptors | Liver | Indole | Memory | Homeostasis | Small intestine | Learning | Synthesis | Biphenyl | Tomography | Pretreatment | Pancreas | Radioactivity | Food | Carbonyls | Medical imaging | Positron emission | Injection | Addiction | Growth hormones | Growth hormone | Positron emission tomography | Tracers | Index Medicus
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8. Full Text 3-(Cyclopropylmethyl)-7-((4-(4-[11C]methoxyphenyl)piperidin-1-yl)methyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine: Synthesis and preliminary evaluation for PET imaging of metabotropic glutamate receptor subtype 2
by Kumata, Katsushi and Zhang, Yiding and Ogawa, Masanao and Kurihara, Yusuke and Mori, Wakana and Hu, Kuan and Fujinaga, Masayuki and Nengaki, Nobuki and Zhang, Ming-Rong
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 12/2020, Volume 30, Issue 23, pp. 127555 - 127555
Metabotropic glutamate receptor 2 (mGluR2) | Schizophrenia | Autoradiography | Positron emission tomography (PET) | Carbon-11 | Index Medicus
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9. Full Text Automated Synthesis of (rac)‐, (R)‐, and (S)‐[18F]Epifluorohydrin and Their Application for Developing PET Radiotracers Containing a 3‐[18F]Fluoro‐2‐hydroxypropyl Moiety
by Fujinaga, Masayuki and Ohkubo, Takayuki and Yamasaki, Tomoteru and Zhang, Yiding and Mori, Wakana and Hanyu, Masayuki and Kumata, Katsushi and Hatori, Akiko and Xie, Lin and Nengaki, Nobuki and Zhang, Ming‐Rong
ChemMedChem, ISSN 1860-7179, 08/2018, Volume 13, Issue 16, pp. 1723 - 1731
[18F]epifluorohydrin | automated synthesis | translocator protein | imaging agents | 18F-fluoroalkylation | F]epifluorohydrin | F-fluoroalkylation | Enantiomers | Distillation | Phenylacetamide | Automation | Radiolabelling | Liver | Positron emission | Oxazol | Fluorine isotopes | Radioactive tracers | Proteins | Synthesis | Chirality | Reagents | Phenols | Tomography | Positron emission tomography | Radioactivity
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10. Full Text Radiosynthesis and evaluation of 4-(6-[F-18]Fluoro-4-(5-isopropoxy-1H-indazol-3-yl)pyridin-2-yl)morpholine as a novel radiotracer candidate targeting leucine-rich repeat kinase 2
by Mori, Wakana and Yamasaki, Tomoteru and Hattori, Yasushi and Zhang, Yiding and Kumata, Katsushi and Fujinaga, Masayuki and Hanyu, Masayuki and Nengaki, Nobuki and Zhang, Hong and Zhang, Ming-Rong
RSC MEDICINAL CHEMISTRY, ISSN 2040-2503, 06/2020, Volume 11, Issue 6, pp. 676 - 684
Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Binding | Brain | Pyridines | Parkinson's disease | Neurodegenerative diseases | Radiochemical separation | Fluorine | Positron emission | Fluorine isotopes | Radioactive tracers | Liquid chromatography | Leucine | Lead compounds | Kinases | High-performance liquid chromatography | Rings (mathematics) | Morpholine | Tomography | In vivo methods and tests | Mutation | LRRK2 protein | Positron emission tomography | Movement disorders
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11. Full Text Development of new radioprobes for PET imaging of metabotropic glutamate receptor subtype 2 in rat brain
by Katsushi Kumata and Tomoteru Yamasaki and Yiding Zhang and Akiko Hatori and Wakana Mori and Masayuki Fujinaga and Ming-Rong Zhang
The Journal of nuclear medicine (1978), ISSN 0161-5505, 05/2017, Volume 58, p. 858
Cerebellum | Neuroimaging | Brain | Nuclear medicine | Cerebral cortex | Amygdala | Mental disorders | Carbon dioxide | Schizophrenia | Feedback inhibition | Caudate-putamen | Analogs | Mental health care | γ-Aminobutyric acid | Synthesis | Precursors | Rodents | Imaging | Radiochemistry | Neostriatum | Tomography | Anxiety | Radioactivity | Binding | Radiolabelling | Incubation | Iodides | Positron emission | Fluorine isotopes | Lead compounds | Putamen | Nucleus accumbens | Autoradiography | Organic chemistry | Addiction | Phenols | In vivo methods and tests | Methylation | Positron emission tomography | Glutamic acid receptors (metabotropic) | Hippocampus
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12. Full Text Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies
by Ono, M and Sahara, N and Kumata, K and Ji, B and Ni, R and Koga, S and Dickson, Dennis and Trojanowski, John and Lee, Virginia and Yoshida, M and Hozumi, I and Yoshiyama, Y and Swieten, John and Nordberg, A and Suhara, T and Zhang, M.-R and Higuchi, M
Brain (London, England : 1878), ISSN 0006-8950, 03/2017, Volume 140, Issue 3, pp. 764 - 780
N279K/G272V FTDP-17-MAPT mutation | PBB3/AV-1451 | Progressive supranuclear palsy/corticobasal degeneration/Pick’s disease | Tau PET ligand | Alzheimer’s disease | Neurosciences | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neurofibrillary Tangles - pathology | Brain - diagnostic imaging | Radiopharmaceuticals - pharmacokinetics | Humans | Butadienes - pharmacokinetics | Fluorescence | Phenazopyridine - pharmacokinetics | Tauopathies - pathology | tau Proteins - metabolism | Male | Positron-Emission Tomography | Benzothiazoles - pharmacokinetics | Brain - drug effects | Autoradiography | Tauopathies - metabolism | Tauopathies - diagnostic imaging | Benzothiazoles - chemistry | Brain - pathology | Thiadiazoles - pharmacokinetics | Female | Carbolines - pharmacokinetics | Diagnosis | Radioligand Assay | Index Medicus | Abridged Index Medicus | AV-1451 | corticobasal degeneration | PBB3 | N279K | tau PET ligand | G272V FTDP-17-MAPT mutation | Original | Pick’s disease | progressive supranuclear palsy | Medicin och hälsovetenskap
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13. Full Text Synthesis and evaluation of 4-picolinamide for PET imaging of the metabotropic glutamate receptor 2 in the rat brain
by Kumata, Katsushi and Hatori, Akiko and Yamasaki, Tomoteru and Zhang, Yiding and Mori, Wakana and Fujinaga, Masayuki and Xie, Lin and Nengaki, Nobuki and Zhang, Ming-Rong
Bioorganic & medicinal chemistry, ISSN 0968-0896, 02/2019, Volume 27, Issue 3, p. 483
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14. Full Text Development of 1-N-11C-Methyl-l-and-d-Tryptophan for pharmacokinetic imaging of the immune checkpoint inhibitor 1-Methyl-Tryptophan
by Xie, Lin and Maeda, Jun and Kumata, Katsushi and Yui, Joji and Zhang, Yiding and Hatori, Akiko and Nengaki, Nobuki and Wakizaka, Hidekatsu and Fujinaga, Masayuki and Yamasaki, Tomoteru and Shimoda, Yoko and Higuchi, Makoto and Suhara, Tetsuya and Wang, Feng and Zhang, Ming-Rong
Scientific reports, ISSN 2045-2322, 11/2015, Volume 5, Issue 1, p. 16417
Stereoisomers | Dioxygenase | Kidneys | Carbon dioxide | Tryptophan | Isomers | Immune checkpoint | Computed tomography | Immunotherapy | Pharmacokinetics | Pancreas | Probes | Radioactivity
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15. Full Text Radiosynthesis and in vivo evaluation of 11C-labeled BMS-193885 and its desmethyl analog as PET tracers for neuropeptide Y1 receptors
by Kawamura, Kazunori and Mori, Wakana and Fujinaga, Masayuki and Yamasaki, Tomoteru and Zhang, Yiding and Wakizaka, Hidekatsu and Hatori, Akiko and Xie, Lin and Kumata, Katsushi and Ohkubo, Takayuki and Kurihara, Yusuke and Ogawa, Masanao and Nengaki, Nobuki and Zhang, Ming-Rong
EJNMMI radiopharmacy and chemistry, ISSN 2365-421X, 12/2019, Volume 4, Issue 1, pp. 1 - 13
Neuropeptide Y1 receptor | Medicine & Public Health | Pharmacotherapy | BMS-193885 | Molecular Medicine | Nuclear Medicine | Carbon-11 | Imaging / Radiology | Positron emission tomography | Nuclear Chemistry | Proteins | Obesity | Chemistry | Peptides | Neuropeptides | Physiology | Glycoproteins | Breast cancer | Sensors | Bioavailability | Laboratory animals
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