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1. Full Text BH3 Profiling Identifies Three Distinct Classes of Apoptotic Blocks to Predict Response to ABT-737 and Conventional Chemotherapeutic Agents
by Deng, Jing and Carlson, Nicole and Takeyama, Kunihiko and Dal Cin, Paola and Shipp, Margaret and Letai, Anthony
Cancer Cell, ISSN 1535-6108, 2007, Volume 12, Issue 2, pp. 171 - 185
Cancer cells exhibit many abnormal phenotypes that induce apoptotic signaling via the intrinsic, or mitochondrial, pathway. That cancer cells nonetheless... 
CELLCYCLE | MITOCHONDRIAL-MEMBRANE PERMEABILIZATION | B-CELL LYMPHOMA | ONCOLOGY | PROTOTYPE CANCER THERAPEUTICS | CHROMOSOMAL BREAKPOINT | FOLLICULAR LYMPHOMA | INDUCE APOPTOSIS | CYTOCHROME-C RELEASE | BCL-2 FAMILY-MEMBERS | BH3-ONLY PROTEINS | ANTIAPOPTOTIC BCL-2 | Vincristine - pharmacology | Immunoprecipitation | Proto-Oncogene Proteins c-bcl-2 - physiology | Antibiotics, Antineoplastic - pharmacology | Apoptosis - drug effects | Humans | Immunoblotting | Lymphoma, B-Cell - genetics | Bcl-2-Like Protein 11 | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | Lymphoma, B-Cell - drug therapy | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Lymphoma, Large B-Cell, Diffuse - drug therapy | Lymphoma, Large B-Cell, Diffuse - pathology | Membrane Proteins - genetics | Tumor Cells, Cultured - drug effects | Etoposide - pharmacology | Proto-Oncogene Proteins - genetics | Sulfonamides - pharmacology | Piperazines - pharmacology | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | Membrane Proteins - antagonists & inhibitors | Apoptosis Regulatory Proteins - antagonists & inhibitors | Lymphoma, B-Cell - pathology | Apoptosis Regulatory Proteins - physiology | Antineoplastic Agents, Phytogenic - pharmacology | Lymphoma, Large B-Cell, Diffuse - genetics | Doxorubicin - pharmacology
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2. Full Text The AP1-Dependent Secretion of Galectin-1 by Reed-Sternberg Cells Fosters Immune Privilege in Classical Hodgkin Lymphoma
by Przemyslaw Juszczynski and Jing Ouyang and Stefano Monti and Scott J. Rodig and Kunihiko Takeyama and Jeremy Abramson and Wen Chen and Jeffery L. Kutok and Gabriel A. Rabinovich and Margaret A. Shipp
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2007, Volume 104, Issue 32, pp. 13134 - 13139
Classical Hodgkin lymphomas (cHLs) contain small numbers of neoplastic Reed-Sternberg (RS) cells within an extensive inflammatory infiltrate that includes... 
T lymphocytes | Reed Sternberg cells | Tumor cell line | Cytokines | Cell lines | Coculture techniques | Lymphoma | Viability | Application programming interfaces | Tumors | c-Jun | Microenvironment | Immunomodulation | Th2 | TARGET | immunomodulation | APOPTOSIS | MULTIDISCIPLINARY SCIENCES | DEATH | SUPPRESSION | T-reg | microenvironment | FALSE DISCOVERY RATE | DISEASE | REGULATORY T-CELLS | GENE-EXPRESSION | INFLAMMATORY RESPONSE | PROMOTER | Evaluation | Immunology | Physiological aspects | Genetic aspects | Research | T cells | Binding proteins | Hodgkin's disease
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3. Full Text Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma
by Green, Michael R and Monti, Stefano and Rodig, Scott J and Juszczynski, Przemyslaw and Currie, Treeve and O'Donnell, Evan and Chapuy, Bjoern and Takeyama, Kunihiko and Neuberg, Donna and Golub, Todd R and Kutok, Jeffery L and Shipp, Margaret A
Blood, ISSN 0006-4971, 10/2010, Volume 116, Issue 17, pp. 3268 - 3277
Classical Hodgkin lymphoma (cHL) and mediastinal large B-cell lymphoma (MLBCL) are lymphoid malignancies with certain shared clinical, histologic, and... 
GALECTIN-1 | RESPONSES | IFN-GAMMA | PANCREATIC-CANCER | COSTIMULATORY MOLECULE | IMBALANCES | B7-H1 | HEMATOLOGY | CARCINOMA | CIRCULAR BINARY SEGMENTATION | CLINICAL-SIGNIFICANCE | Cell Proliferation | B7-H1 Antigen | Hodgkin Disease - genetics | Humans | Programmed Cell Death 1 Ligand 2 Protein | Gene Expression Regulation, Neoplastic | Intercellular Signaling Peptides and Proteins - genetics | Janus Kinase 2 - genetics | Gene Dosage | Gene Expression Profiling | Antigens, CD - genetics | Chromosomes, Human, Pair 9 - genetics | Janus Kinase 2 - metabolism | Cell Line, Tumor | Tumor Cells, Cultured | Lymphoma, Large B-Cell, Diffuse - genetics | Janus Kinase 2 - antagonists & inhibitors | Lymphoid Neoplasia
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4. Full Text B-aggressive Lymphoma Family Proteins Have Unique Domains That Modulate Transcription and Exhibit Poly(ADP-ribose) Polymerase Activity
by Ricardo C. T. Aguiar and Kunihiko Takeyama and Chunyan He and Katherine Kreinbrink and Margaret A. Shipp
Journal of Biological Chemistry, ISSN 0021-9258, 10/2005, Volume 280, Issue 40, pp. 33756 - 33765
BAL1 ( B - a ggressive l ymphoma 1 ) was originally identified as a risk-related gene in diffuse large B-cell lymphoma. BAL1 encodes a nuclear protein with... 
CELLS | HISTONE MACROH2A | COREPRESSOR | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CRYSTAL-STRUCTURES | CORE HISTONE | PARP | IDENTIFICATION | INACTIVE X-CHROMOSOME | BINDING | Protein Structure, Tertiary | Amino Acid Sequence | Chromatin - metabolism | Promoter Regions, Genetic | Humans | Neoplasm Proteins - physiology | Molecular Sequence Data | Structure-Activity Relationship | Lymphoma, B-Cell - genetics | Sequence Analysis, DNA | Poly(ADP-ribose) Polymerases - metabolism | Transcription, Genetic - physiology | Cloning, Molecular | Protein Processing, Post-Translational | Neoplasm Proteins - genetics | DNA, Complementary
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5. Full Text In-hospital mortality associated with the misdiagnosis or unidentified site of infection at admission
by Abe, Toshikazu and Tokuda, Yasuharu and Shiraishi, Atsushi and Fujishima, Seitaro and Mayumi, Toshihiko and Sugiyama, Takehiro and Deshpande, Gautam A and Shiino, Yasukazu and Hifumi, Toru and Otomo, Yasuhiro and Okamoto, Kohji and Kotani, Joji and Sakamoto, Yuichiro and Sasaki, Junichi and Shiraishi, Shin-Ichiro and Takuma, Kiyotsugu and Hagiwara, Akiyoshi and Yamakawa, Kazuma and Takeyama, Naoshi and Gando, Satoshi and Muroya, Takashi and Koike, Kaoru and Anan, Hideaki and Sugita, Manabu and Miki, Yasuo and Yamashita, Hisashi and Kittaka, Hirotada and Maehara, Junichi and Nachi, Sho and Morino, Kazuma and Hoshino, Atsumi and Yamaguchi, Hiroyuki and Harada, Masahiro and Ishikura, Hiroyasu and Kawakami, Masato and Deguchi, Yoshizumi and Yoshihara, Hideaki and Hanaki, Yoshihiro and Okada, Kunihiko and Kaneko, Tadashi and Kiyota, Kazuya and Shimizu, Yoshihiro and JAAM SPICE Study Grp and JAAM SPICE Study Group and for the JAAM SPICE Study Group
Critical Care, ISSN 1364-8535, 06/2019, Volume 23, Issue 1, pp. 202 - 202
Background: Rapid detection, early resuscitation, and appropriate antibiotic use are crucial for sepsis care. Accurate identification of the site of infection... 
Infection | Sepsis | Diagnosis | Source | IMPACT | ANTIBIOTICS | THERAPY | SEPTIC SHOCK | ADULTS | CRITICAL CARE MEDICINE | Usage | Antibiotics | Patient outcomes | Mortality | Diagnostic errors | Evidence-based medicine | Ventilators | Intensive care | Critical care | Infections | Emergency medical care | Vital signs | Patients | Abdomen | Data collection | Urogenital system | Index Medicus
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6. Full Text Integrative Analysis Reveals an Outcome-Associated and Targetable Pattern of p53 and Cell Cycle Deregulation in Diffuse Large B Cell Lymphoma
by Monti, Stefano and Chapuy, Bjoern and Takeyama, Kunihiko and Rodig, Scott J and Hao, Yansheng and Yeda, Kelly T and Inguilizian, Haig and Mermel, Craig and Currie, Treeve and Dogan, Ahmet and Kutok, Jeffery L and Beroukhim, Rameen and Neuberg, Donna and Habermann, Thomas M and Getz, Gad and Kung, Andrew L and Golub, Todd R and Shipp, Margaret A
Cancer Cell, ISSN 1535-6108, 09/2012, Volume 22, Issue 3, pp. 359 - 372
Diffuse large B cell lymphoma (DLBCL) is a clinically and biologically heterogeneous disease with a high proliferation rate. By integrating copy number data... 
GENOMIC INSTABILITY | INACTIVATION | MESSENGER-RNA TRANSLATION | INHIBITION | ONCOLOGY | R-CHOP | GENE-EXPRESSION | PROGNOSTIC-SIGNIFICANCE | ARGININE METHYLATION | COPY NUMBER VARIATION | CANCER | CELL BIOLOGY | Cell Cycle - genetics | Cell Proliferation | E2F Transcription Factors - biosynthesis | Lymphoma, Large B-Cell, Diffuse - pathology | Humans | Tumor Suppressor Protein p53 - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Molecular Sequence Data | Gene Expression Profiling | Lymphoma, Large B-Cell, Diffuse - metabolism | Genes, p16 | Tumor Suppressor Protein p53 - genetics | DNA Copy Number Variations | Genes, p53 | Ki-67 Antigen - biosynthesis | E2F Transcription Factors - genetics | Lymphoma, Large B-Cell, Diffuse - genetics | Lymphomas | Tumor proteins | Analysis | Genes | Cell cycle
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7. Full Text Successful treatment of ETV6‐NTRK3 fusion gene‐negative infantile fibrosarcoma with metastatic lesion resistant to VAC chemotherapy
by Moriya, Kunihiko and Abe, Sei and Onuma, Masaei and Sato, Atsushi and Takeyama, Junji and Hosaka, Masami and Sasahara, Yoji and Imaizumi, Masue
Pediatrics International, ISSN 1328-8067, 11/2018, Volume 60, Issue 11, pp. 1045 - 1046
Care and treatment | Chemotherapy | Metastasis | Sarcoma | Cancer | Fibrosarcoma | Fusion protein | Metastases
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8. Full Text Viral induction and targeted inhibition of galectin-1 in EBV + posttransplant lymphoproliferative disorders
by Ouyang, Jing and Juszczynski, Przemyslaw and Rodig, Scott J and Green, Michael R and O'Donnell, Evan and Currie, Treeve and Armant, Myriam and Takeyama, Kunihiko and Monti, Stefano and Rabinovich, Gabriel A and Ritz, Jerome and Kutok, Jeffery L and Shipp, Margaret A
Blood, ISSN 0006-4971, 04/2011, Volume 117, Issue 16, pp. 4315 - 4322
Posttransplant lymphoproliferative disorders (PTLDs) are potentially fatal, EBV-driven B-cell malignancies that develop in immunocompromised solid organ or... 
GLYCAN INTERACTIONS | IMMUNE PRIVILEGE | CLASSICAL HODGKIN | HODGKIN LYMPHOMA | C-JUN | HEMATOLOGY | B-CELL-LYMPHOMA | NF-KAPPA-B | EPSTEIN-BARR-VIRUS | STERNBERG CELLS | LATENT MEMBRANE PROTEIN-1 | Up-Regulation | Galectin 1 - immunology | Herpesvirus 4, Human - physiology | Humans | Lymphoproliferative Disorders - virology | Gene Expression Regulation, Neoplastic | Galectin 1 - genetics | Lymphoproliferative Disorders - genetics | Transcription Factor AP-1 - metabolism | Animals | Cell Line, Tumor | Viral Matrix Proteins - metabolism | Mice | T-Lymphocytes, Cytotoxic - cytology | Antibodies, Monoclonal - immunology | Cell Line, Transformed | Cell Transformation, Viral | Apoptosis
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9. Full Text Protein tyrosine phosphatase receptor-type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell-receptor signaling, and cellular proliferation
by Chen, Linfeng and Juszczynski, Przemyslaw and Takeyama, Kunihiko and Aguiar, Ricardo C. T and Shipp, Margaret A
Blood, ISSN 0006-4971, 11/2006, Volume 108, Issue 10, pp. 3428 - 3433
The strength and duration of B-cell-receptor (BCR) signaling depends upon the balance between protein tyrosine kinase (PTK) activation and protein tyrosine... 
BCR | LOCALIZATION | MACROPHAGES | ACUTE LYMPHOBLASTIC-LEUKEMIA | ANTIGEN-RECEPTOR | KINASE | TUMOR-SUPPRESSOR GENE | MOLECULAR-CLONING | IDENTIFICATION | HEMATOLOGY | EXPRESSION | Phosphorylation | Cell Proliferation | Signal Transduction | Protein-Tyrosine Kinases - metabolism | Humans | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Receptors, Antigen, B-Cell | Intracellular Signaling Peptides and Proteins - metabolism | Receptor-Like Protein Tyrosine Phosphatases, Class 2 | Protein Tyrosine Phosphatases - genetics | Cell Line, Tumor | Lymphoma - pathology | Receptors, Cell Surface - physiology | Syk Kinase | Apoptosis | Protein Tyrosine Phosphatases - physiology | Protein-Tyrosine Kinases - antagonists & inhibitors | Receptors, Cell Surface - genetics
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10. Full Text Union for International Cancer Control International Session: Healthcare Economics: The significance of the UN summit non‐communicable diseases political declaration in Asia
by Akaza, Hideyuki and Kawahara, Norie and Masui, Tohru and Takeyama, Kunihiko and Nogimori, Masafumi and Roh, Jae Kyung
Cancer Science, ISSN 1347-9032, 06/2013, Volume 104, Issue 6, pp. 773 - 778
The Japan National Committee for the Union for International Cancer Control (UICC) and UICC‐Asia Regional Office (ARO) organized an international session as... 
ONCOLOGY | Delivery of Health Care - economics | Neoplasms - economics | Asia | Humans | United Nations | Health care industry | Cancer
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11. Full Text Optimization of region of interest drawing for quantitative analysis: Differentiation between benign and malignant breast lesions on contrast-enhanced sonography
by Nakata, Norio and Ohta, Tomoyuki and Nishioka, Makiko and Takeyama, Hiroshi and Toriumi, Yasuo and Kato, Kumiko and Nogi, Hiroko and Kamio, Makiko and Fukuda, Kunihiko
Journal of Ultrasound in Medicine, ISSN 0278-4297, 11/2015, Volume 34, Issue 11, pp. 1969 - 1976
Objectives-This study was performed to evaluate the diagnostic utility of quantitative analysis of benign and malignant breast lesions using contrast-enhanced... 
Contrast-enhanced sonography | Breast lesions | Kinetic parameters | Receiver operating characteristic curve | Breast ultrasound | Quantitative analysis | breast ultrasound | receiver operating characteristic curve | TUMORS | kinetic parameters | AGENT | ACOUSTICS | THERAPY | ULTRASOUND | breast lesions | contrast-enhanced sonography | COLOR DOPPLER US | EXPERIENCE | quantitative analysis | ULTRASONOGRAPHY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Diagnosis, Differential | Reproducibility of Results | Ultrasonography, Mammary - methods | Humans | Image Interpretation, Computer-Assisted - methods | Middle Aged | Male | Oxides | Iron | Ferric Compounds | Algorithms | Contrast Media | Sensitivity and Specificity | Adult | Female | Aged | Image Enhancement - methods | Breast Neoplasms - diagnostic imaging | Observer Variation | Pattern Recognition, Automated - methods
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12. Full Text Successful treatment of ETV 6‐ NTRK 3 fusion gene‐negative infantile fibrosarcoma with metastatic lesion resistant to VAC chemotherapy
by Moriya, Kunihiko and Abe, Sei and Onuma, Masaei and Sato, Atsushi and Takeyama, Junji and Hosaka, Masami and Sasahara, Yoji and Imaizumi, Masue
Pediatrics International, ISSN 1328-8067, 11/2018, Volume 60, Issue 11, pp. 1045 - 1046
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13. Full Text Analysis of Genetic Polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese Patients with Therapy-related Leukemia/Myelodysplastic Syndrome and de novo Acute Myeloid Leukemia
by Tomoki Naoe and Kunihiko Takeyama and Toshiya Yokozawa and Hitoshi Kiyoi and Masao Seto and Naokuni Uike and Teruo Ino and Atae Utsunomiya and Atsuo Maruta and Itsuro Jin-nai and Nanao Kamada and Yoshitsugu Kubota and Hiroyuki Nakamura and Chihiro Shimazaki and Shigeo Horiike and Yoshihisa Kodera and Hidehiko Saito and Ryuzo Ueda and Joseph Wiemels and Ryuzo Ohno
Clinical Cancer Research, ISSN 1078-0432, 10/2000, Volume 6, Issue 10, pp. 4091 - 4095
Several genetic polymorphisms in metabolic activation or detoxification enzymes have been associated with susceptibility to therapy-related leukemia and... 
MAINTENANCE INTENSIFICATION THERAPY | ORTHO-QUINONE | BENZENE | ONCOLOGY | SUSCEPTIBILITY | OXIDOREDUCTASE | C-609->T POLYMORPHISM | GLUTATHIONE-S-TRANSFERASE | ETOPOSIDE VP-16-213 | CANCER | MYELODYSPLASTIC SYNDROMES | NADH, NADPH Oxidoreductases - genetics | Electron Transport Complex I | Cytochrome P-450 CYP3A | Humans | Japan | Middle Aged | Genotype | Male | Risk | Polymorphism, Genetic | Codon | Glutathione Transferase - genetics | Gene Deletion | Myelodysplastic Syndromes - chemically induced | Alleles | Cytochrome P-450 Enzyme System - genetics | Adult | Female | Myelodysplastic Syndromes - genetics | Leukemia - chemically induced | Mixed Function Oxygenases - genetics | Leukemia - genetics | Leukemia, Myeloid, Acute - genetics
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14. Full Text The BAL-binding Protein BBAP and Related Deltex Family Members Exhibit Ubiquitin-Protein Isopeptide Ligase Activity
by Kunihiko Takeyama and Ricardo C. T. Aguiar and Liqun Gu and Chunyan He and Gordon J. Freeman and Jeffery L. Kutok and Jon C. Aster and Margaret A. Shipp
Journal of Biological Chemistry, ISSN 0021-9258, 06/2003, Volume 278, Issue 24, pp. 21930 - 21937
Members of the DTX ( D el t e x ) family act as Notch signaling modifiers and may also regulate transcription through interactions with specific transcription... 
REGULATOR | DOMAIN | GENE | FINGER | RING | BIOCHEMISTRY & MOLECULAR BIOLOGY | BRCA1-BARD1 | MDM2 | Humans | Ubiquitin - metabolism | Molecular Sequence Data | Ligases - chemistry | Cell Nucleus - metabolism | Transfection | Time Factors | Cloning, Molecular | Dimerization | Carrier Proteins | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Amino Acid Sequence | Cell Line | Signal Transduction | Glutathione Transferase - metabolism | Ligases - metabolism | Plasmids - metabolism | Blotting, Western | Precipitin Tests | Sequence Homology, Amino Acid | Ubiquitin-Protein Ligases | Cell Lineage | Two-Hybrid System Techniques | Animals | Proteins - metabolism | Protein Binding | Drosophila melanogaster
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15. Full Text The heat shock protein 90 inhibitor IPI-504 induces apoptosis of AKT-dependent diffuse large B-cell lymphomas
by Abramson, Jeremy S and Chen, Wen and Juszczynski, Przemyslaw and Takahashi, Hidenobu and Neuberg, Donna and Kutok, Jeffery L and Takeyama, Kunihiko and Shipp, Margaret A
British Journal of Haematology, ISSN 0007-1048, 02/2009, Volume 144, Issue 3, pp. 358 - 366
Summary Heat shock protein 90 (HSP90) is a molecular chaperone that stabilizes critical client proteins in multiple cancers. Gene expression profiling was... 
client | AKT | IPI-504 | heat shock protein 90 | lymphoma | IPI‐504 | Client | Lymphoma | Heat shock protein 90 | MULTIPLE-MYELOMA | TARGET | HSP90 INHIBITOR | CYCLE ARREST | ANTITUMOR AGENT | GELDANAMYCIN | LEUKEMIA-CELLS | 17-ALLYLAMINO-17-DEMETHOXYGELDANAMYCIN | HEMATOLOGY | PHASE-I | HEAT-SHOCK-PROTEIN-90 INHIBITOR | Oligonucleotide Array Sequence Analysis | Apoptosis - drug effects | Humans | Antineoplastic Agents - therapeutic use | Gene Expression Profiling | HSP90 Heat-Shock Proteins - analysis | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - genetics | Protein Isoforms - metabolism | Gene Deletion | Antineoplastic Agents - pharmacology | Lactams, Macrocyclic - therapeutic use | Proto-Oncogene Proteins c-akt - metabolism | Lymphoma, Large B-Cell, Diffuse - drug therapy | Lymphoma, Large B-Cell, Diffuse - pathology | RNA, Small Interfering - pharmacology | Protein Isoforms - analysis | Lactams, Macrocyclic - pharmacology | Benzoquinones - pharmacology | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Benzoquinones - therapeutic use | Doxorubicin - pharmacology | Proteins | Heat shock proteins | Lymphomas | Gene expression | Apoptosis
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