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The Keio Journal of Medicine, ISSN 0022-9717, 2017, Volume 67, Issue 1, pp. 1 - 9
The hypoxia response is a fundamental phenomenon mainly regulated by hypoxia-inducible factors (HIFs). For more than a decade, we have investigated and... 
vascular endothelial growth factor (VEGF) | microRNA | hypoxia-inducible factor (HIF) | retina | von Hippel-Lindau protein (PVHL) | Retina | Hypoxia-inducible factor (HIF) | Vascular endothelial growth factor (VEGF) | Von Hippel-Lindau protein (PVHL) | Neurons - pathology | Retinal Pigment Epithelium - metabolism | Vascular Endothelial Growth Factor A - deficiency | Hypoxia - drug therapy | Epithelial Cells - metabolism | MicroRNAs - antagonists & inhibitors | Epithelial Cells - drug effects | Humans | Astrocytes - pathology | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | MicroRNAs - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Vascular Endothelial Growth Factor A - genetics | Hypoxia - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - deficiency | Neovascularization, Pathologic - pathology | Retinal Pigment Epithelium - pathology | Gene Expression Regulation, Developmental | Retinal Pigment Epithelium - blood supply | Neovascularization, Pathologic - prevention & control | Neurons - metabolism | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Neurons - drug effects | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Retinal Pigment Epithelium - drug effects | Astrocytes - drug effects | Signal Transduction | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Angiogenesis Inhibitors - pharmacology | Epithelial Cells - pathology | Mice, Knockout | Hypoxia - genetics | Animals | Hypoxia - pathology | Neovascularization, Pathologic - genetics | Mice | MicroRNAs - genetics | Neovascularization, Pathologic - metabolism | Astrocytes - metabolism
Journal Article
The Keio Journal of Medicine, ISSN 0022-9717, 2017
The hypoxia response is a fundamental phenomenon mainly regulated by hypoxia-inducible factors (HIFs). For more than a decade, we have investigated and... 
hypoxia-inducible factor (HIF) | retina | von Hippel-Lindau protein (PVHL) | vascular endothelial growth factor (VEGF) | microRNA
Journal Article
Japanese Journal of Radiology, ISSN 1867-1071, 09/2019, pp. 1 - 23
On the posterior aspect of the anterior abdominal wall, there are four kinds of “fine” ligaments. They are: the round ligament of the liver, median umbilical... 
Embryology | Liver | Abdominal wall | Umbilical cord | Ligaments | Umbilical vein | Arteries | Umbilicus | Tumors | Abdomen
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 14523 - 8
Myopia is increasing worldwide. Although the exact etiology of myopia is unknown, outdoor activity is one of the most important environmental factors for... 
LONG-TERM | EYE | SCHOOL | INCIDENT MYOPIA | MULTIDISCIPLINARY SCIENCES | TIME OUTDOORS | INTRAOCULAR-LENS IMPLANTATION | PHYSICAL-ACTIVITY | ONSET | EXPOSURE | OUTDOOR ACTIVITY | Environmental factors | Etiology | Elongation | Myopia
Journal Article
PeerJ, ISSN 2167-8359, 10/2019, Volume 7, p. e7849
Purpose The therapeutic approach for retinal ganglion cell (RGC) degeneration has not been fully established. Recently, it has been reported that... 
Hypoxia-inducible factor | Neuroprotection | Topotecan | Ischemia-repufusion | Retinal ganglion cell
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 07/2019, Volume 20, Issue 13, p. 3171
Neurodegeneration caused with retinal ischemia or high intraocular pressure is irreversible in general. We have focused on the role of hypoxia-inducible factor... 
GROWTH-INHIBITION | ACTIVATION | HIF-1 alpha | BIOCHEMISTRY & MOLECULAR BIOLOGY | ischemia-reperfusion | VERSUS-HOST-DISEASE | CHEMISTRY, MULTIDISCIPLINARY | halofuginone | HEPATOCELLULAR-CARCINOMA | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | neuroprotection | NUTRIGENOMICS | MICE | HIF-1α
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 295 - 10
Increased global incidence of myopia necessitates establishment of therapeutic approaches against its progression. To explore agents which may control myopia,... 
ZENK | MESSENGER-RNA | GENE | CROCIN | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | LIGHT | PROLIFERATION | FORM-DEPRIVATION MYOPIA | EXPRESSION | METHYL-D-ASPARTATE | Animal models | EGR-1 protein | Elongation | Myopia
Journal Article
PLOS ONE, ISSN 1932-6203, 01/2016, Volume 11, Issue 1, p. e0146517
Purpose The determination of the molecular mechanism underlying retinal pathogenesis and visual dysfunction during innate inflammation, and the treatment... 
OCULAR INFLAMMATION | MECHANISM | PATHWAY | II TYPE-1 RECEPTOR | MULTIDISCIPLINARY SCIENCES | RHODOPSIN | DEGRADATION | DIABETIC MACULAR EDEMA | ENDOTOXIN-INDUCED UVEITIS | SUPPRESSION | SIROLIMUS | Neuroprotective Agents - therapeutic use | Retina - drug effects | Sirolimus - therapeutic use | Signal Transduction | Uveitis - drug therapy | Mice, Inbred C57BL | Male | NF-kappa B - metabolism | Retina - immunology | Sirolimus - pharmacology | Retinitis - immunology | Animals | Neuroprotective Agents - pharmacology | Retinitis - drug therapy | Inflammation - drug therapy | Uveitis - immunology | Mice | Post-transcription | Diabetic retinopathy | Disease | Pathogenesis | Photopigments | Retina | Immunoblotting | Positive feedback | Proteins | Cell activation | Physiology | Inhibition | Electroretinography | NF-κB protein | Rhodopsin | Cytokines | Rapamycin | Gene expression | Concanavalin A | Protein synthesis | Monocyte chemoattractant protein | Phagocytosis | Monocyte chemoattractant protein 1 | TOR protein | Neuroprotection | Laboratories | Interleukin | Adhesion tests | Clinical trials | Biology | Activation | Feedback loops | Rod outer segment membranes | Kinases | Autophagy | Visual perception | Interleukin 6 | Rodents | Uveitis | Edema | Stat3 protein | Inflammation | Adhesion | Medicine | White blood cells | Signaling | Lymphocytes B | Medical prognosis | Retinitis | Diabetes
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 2026 - 12
Journal Article
Journal Article
Neuroscience Research, ISSN 0168-0102, 09/2011, Volume 71, pp. e336 - e336
Journal Article
Diabetes, ISSN 0012-1797, 08/2008, Volume 57, Issue 8, pp. 2191 - 2198
Angiotensin II Type 1 Receptor Signaling Contributes to Synaptophysin Degradation and Neuronal Dysfunction in the Diabetic Retina Toshihide Kurihara 1 2 3 ,... 
SYSTEM | RENIN | VITREOUS FLUID | PATHWAY | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | RATS | PROXIMAL TUBULAR CELLS | RETINOPATHY | OSCILLATORY POTENTIALS | ENDOTHELIAL GROWTH-FACTOR | Retina - metabolism | Receptor, Angiotensin, Type 1 - physiology | Tetrazoles - pharmacology | Valsartan | Immunoblotting | Neurons - cytology | Extracellular Signal-Regulated MAP Kinases - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacology | Extracellular Signal-Regulated MAP Kinases - genetics | Synaptophysin - genetics | Receptor, Angiotensin, Type 1 - genetics | Ubiquitination - drug effects | RNA Interference | Retina - cytology | Neurons - metabolism | Phosphorylation - drug effects | Diabetes Mellitus, Experimental - metabolism | Oncogene Protein v-akt - metabolism | STAT3 Transcription Factor - metabolism | Diabetes Mellitus, Experimental - physiopathology | Synaptophysin - metabolism | Cell Line | Angiotensin II - metabolism | Mice, Inbred C57BL | Retina - physiopathology | Valine - analogs & derivatives | Reverse Transcriptase Polymerase Chain Reaction | Animals | Signal Transduction - drug effects | Receptor, Angiotensin, Type 1 - metabolism | Benzoates - pharmacology | Benzimidazoles - pharmacology | Signal Transduction - physiology | Mice | Valine - pharmacology | Diabetic retinopathy | Neural transmission | Receptors | Regulation | Research | Angiotensin | Complications
Journal Article