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by Mok, Tony and Mok, Tony S K and Wu, Yilong and Wu, Yi-Long and Kudaba, Iveta and Kowalski, Dariusz M and Kowalski, Dariusz and Cho, Byoung Chul and Turna, Hande and Turna, Hande Z and Castro, Hugo and Castro, Gilberto and Srimuninnimit, Vichien and Laktionov, Konstantin and Laktionov, Konstantin K and Bondarenko, Igor and Kubota, Kaoru and Lubiniecki, Gregory M and Zhang, Jin and Zhang, Li and Zhang, Xin and Kush, Debra and Lopes, Valeria and Lopes, Gilberto and Adamchuk, Grigory and Ahn, Myung-Ju and Alexandru, Aurelia and Altundag, Ozden and Alyasova, Anna and Andrusenko, Orest and Aoe, Keisuke and Araujo, Antonio and Aren, Osvaldo and Arrieta Rodriguez, Oscar and Ativitavas, Touch and Avendano, Oscar and Barata, Fernando and Barrios, Carlos Henrique and Beato, Carlos and Bergstrom, Per and Betticher, Daniel and Bolotina, Larisa and Botha, Michiel and Buddu, Sayeuri and Caglevic, Christian and Cardona, Andres and Cay Senler, Filiz and Cerny, Carlos Alexandre Sydow and Cesas, Alvydas and Chan, Gee-Chen and Chang, Jianhua and Chen, Xi and Chen, Gongyan and Cheng, Ying and Cheng, Susanna and Cherciu, Nelly and Chiu, Chao-Hua and Cicenas, Saulius and Ciurescu, Daniel and Cohen, Graham and Costa, Marcos Andre and Danchaivijitr, Pongwut and De Angelis, Flavia and de Azevedo, Sergio Jobim and Dediu, Mircea and Deliverski, Tsvetan and De Marchi, Pedro Rafael Martins and de The Bustamante Valles, Flor and Ding, Zhenyu and Doganov, Boyan and Dreosti, Lydia and Duarte, Ricardo and Edusma-Dy, Regina and Emelyanov, Sergey and Erman, Mustafa and Fan, Yun and Fein, Luis and Feng, Jifeng and Fenton, David and Fernandes, Gustavo and Ferreira, Carlos and Franke, Fabio Andre and Freitas, Helano and Fujisaka, Yasuhito and Galindo, Hector and Galvez, Christina and Ganea, Doina and Gil, Nuno and Girotto, Gustavo and Goker, Erdem and Goksel, Tuncay and Gomez Aubin, Gonzalo and Gomez Wolff, Luis and Griph, Hakan and Gumus, Mahmut and Hall, Jacqueline and Hart, Gregory and Havel, Libor and He, Yong and He, Jianxing and ... and KEYNOTE-042 Investigators
The Lancet, ISSN 0140-6736, 05/2019, Volume 393, Issue 10183, pp. 1819 - 1830
First-line pembrolizumab monotherapy improves overall and progression-free survival in patients with untreated metastatic non-small-cell lung cancer with a... 
MEDICINE, GENERAL & INTERNAL | CARBOPLATIN | GEFITINIB | BEVACIZUMAB | CRIZOTINIB | NIVOLUMAB | PACLITAXEL | Genes, erbB-1 - drug effects | Lung Neoplasms - drug therapy | Translocation, Genetic | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Humans | Lung Neoplasms - metabolism | Middle Aged | Far East - epidemiology | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Lung Neoplasms - pathology | Male | Anaplastic Lymphoma Kinase - genetics | Antibodies, Monoclonal, Humanized - administration & dosage | Carcinoma, Non-Small-Cell Lung - secondary | Lung Neoplasms - secondary | Female | Carcinoma, Non-Small-Cell Lung - pathology | Anaplastic Lymphoma Kinase - drug effects | Antibodies, Monoclonal, Humanized - adverse effects | Antibodies, Monoclonal, Humanized - therapeutic use | Drug Administration Schedule | Genes, erbB-1 - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Disease-Free Survival | B7-H1 Antigen - metabolism | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Neoplasm Metastasis - pathology | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Chemotherapy | Metastasis | Lung cancer, Non-small cell | Cancer | Slopes | Lung cancer | Oncology | Kinases | Cancer therapies | Metastases | Pembrolizumab | Randomization | Motivation | Platinum | Risk assessment | Population | Translocation | Cell survival | Life expectancy | Epidermal growth factor receptors | Hyperthyroidism | Histology | Hypothyroidism | Survival | Patients | Medical centres | Life span | Interactive systems | PD-L1 protein | Men | Ligands | Tumors | Apoptosis
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 06/2018, Volume 36, Issue 18_suppl, pp. LBA4 - LBA4
LBA4 Background: In KEYNOTE-024, pembro significantly improved PFS (primary end point) and OS (secondary end-point) over chemo as first-line therapy for... 
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 10/2016, Volume 11, Issue 10, pp. S244 - S245
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 10/2016, Volume 11, Issue 10, pp. S244 - S245
Journal Article
JOURNAL OF CLINICAL ONCOLOGY, ISSN 0732-183X, 10/2019, Volume 37, Issue 28, pp. 2518 - 2518
PURPOSE Pembrolizumab monotherapy has demonstrated durable antitumor activity in advanced programmed death ligand 1 (PD-L1)-expressing nonsmall-cell lung... 
ONCOLOGY | THERAPY | IMMUNOHISTOCHEMISTRY | RAPID COMMUNICATION
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 06/2019, Volume 37, Issue 18_suppl, pp. LBA9015 - LBA9015
LBA9015 Background: Pembrolizumab (pembro) monotherapy has demonstrated durable antitumor activity in advanced PD-L1–expressing NSCLC. We present 5-y OS for... 
Journal Article
by Fisher, Charles J and Dhainaut, Jean-Francois A and Opal, Steven M and Pribble, John P and Balk, Robert A and Slotman, Gus J and Iberti, Thomas J and Rackow, Eric C and Shapiro, Marc J and Greenman, Richard L and Reines, H. David and Shelly, Maire P and Thompson, Bruce W and LaBrecque, John F and Catalano, Michael A and Knaus, William A and Sadoff, Jerald C and Astiz, Mark and Carpati, Charles and Bone, Roger C and Friedman, Bruce and Mure, Anthony J and Brathwaite, Collin and Shapiro, Eugenia and Melhorn, Laura and Taylor, Robert and Keegan, Mary and O'Brien, Jacklyn and Schein, Roland and Pena, Maria and Wasserlouf, Monina and Oropello, John and Benjamin, Ernest and DelGuidice, Rosanna and Emmanuel, George and Lie, Thiam and Anderson, Lynn and Marshall, John and De Majo, Wilfred and Rotstein, Ori and Foster, Debra and Abraham, Edward and Middleton, Harold and Perry, Cindy and Levy, Howard and Fry, Donald E and Simpson, Steven Q and Crowell, Richard E and Neidhart, Mary and Stevens, Dennis and Coffman, Thomas and Narasimhan, Nagraj and Merrick, David K and Bergquist, William and Matzel, Klaus E and Huebler, Matthias and Foulke, Garrett E and Albertson, Timothy E and Walby, William F and Allen, Roblee P and Baughman, Robert and Hasselgren, Per-Olof and Fink, Mitchell P and Favorito, Felicia and Thompson, B. Taylor and Corbin, Richard and Shellhorse, G. Yovonne and Frazier, Arnold and White, Sandy and Garrard, Christopher and A'Court, Christine and Storer, Shirley and Gervich, Daniel H and Foshe, Debra and Brase, Rainer and Bagdahn, Andreas and Cooney, Robert and Smith, J. Stanley and Martin, Louis F and Vincent, Jean-Louis and Friedman, Gilberto and Berlot, Giorgio and Fletcher, J. Raymond and Williams, Mark D and Wright, Theresa F and Johnson, Steven and Feild, Carinda and Wolf, Karen and MacIntyre, Neil and Dubin, Howard G and Durkin, Margaret R and Dubin, Penelope K and Staubach, Karl Hermann and Fein, Alan M and Schulman, Debra B and Niederman, Michael S and Chalfin, Donald B and van, Paul A. M and Leeuwen and Boermeester, Marja A and ...
JAMA, ISSN 0098-7484, 06/1994, Volume 271, Issue 23, pp. 1836 - 1843
Objective.—To further define the safety and efficacy of recombinant human interleukin 1 receptor antagonist (rhIL-1ra) in the treatment of sepsis... 
MORTALITY | PATHOGENESIS | MEDICINE, GENERAL & INTERNAL | TUMOR-NECROSIS-FACTOR | RABBITS | BACTEREMIA | CACHECTIN | SEPTIC SHOCK | SUBLETHAL ENDOTOXEMIA | MONOCLONAL-ANTIBODY | IL-1 RECEPTOR | Septic shock | Chemical inhibitors | Bacterial infections | Drug therapy | Septicemia | Health aspects
Journal Article
Journal of Immunotherapy, ISSN 1524-9557, 2017, Volume 40, Issue 9, pp. 334 - 340
KEYNOTE-030 (ClinicalTrials. gov ID, NCT02083484) was a global expanded access program that allowed access to pembrolizumab, an antiprogrammed death 1... 
pembrolizumab | melanoma | PD-1 | immunotherapy | expanded access program | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | RESPONSE CRITERIA | IMMUNOLOGY | CANCER | UNTREATED MELANOMA | METASTATIC UVEAL MELANOMA | ONCOLOGY | ANTITUMOR IMMUNITY | ANTI-PD-1 | NIVOLUMAB | BLOCKADE | IPILIMUMAB | Basic Studies
Journal Article
Journal of Clinical Lipidology, ISSN 1933-2874, 2009, Volume 3, Issue 3, pp. 179 - 186
Background Niacin has proven lipid-modifying efficacy and cardiovascular benefit; however, it is underused because of skin flushing, a process mediated... 
Cardiovascular | Mixed hyperlipidemia | Flushing | Laropiprant | Extended-release niacin | Primary hypercholesterolemia | NICOTINIC-ACID | CHOLESTEROL | SAFETY | TOLERABILITY | PREVENTION | PHARMACOLOGY & PHARMACY | NIACIN
Journal Article
by Ötünçtemur, Alper and Çakır, Süleyman Sami and Dursun, Murat and Polat, Emre Can and Somay, Adnan and Somay, Adnan and Özbay, Nurver and Özbay, Nurver and Çekmen, Mustafa and Lee, Ming Chak and Brooks, Andrew and Drummond, Malcolm and Lau, Howard and Patel, Manish and Wang, Audrey and Woo, Henry and Kim, Hyun Jin and Averch, Timothy D and Averch, Timothy D and Kim, Hyung and Yildirim, Ibrahim and Tapan, Serkan and Aydur, Emin and Tahmaz, Lutfu and Dayanc, Murat and Olweny, Ephrem O and Faddegon, Stephen and Faddegon, Stephen and Best, Sara L and Jackson, Neil and Wehner, Eleanor F and Tan, Yung K and Tan, Yung K and Zuzak, Karel J and Cadeddu, Jeffrey A and Cadeddu, Jeffrey A and Cadeddu, Jeffrey A and Tan, Yung Khan and Olweny, Ephrem O and Liu, Zhou Wei and Kapur, Payal and Faddegon, Steve and Yin, Gang and Cadeddu, Jeffrey and Park, Jane Hyeon and Castillo, Josefino Cortez and Morales Jr, Marcelino Lopeztan and Colli, Janet and Wang, Zijun and Keel, Christopher and Lee, Benjamin R and Dilli, Alper and Zengin, Kürşad and Yalçınkaya, Fatih and Yiğitbaşı, Orhan and Sertçelik, Memduh Nurettin and Arıdoğan, Ibrahim Atilla and Izol, Volkan and Acıkalın, Arbil and Abat, Deniz and Tuli, Abdullah and Bayazıt, Yıldırım and Resorlu, Berkan and Unsal, Ali and Saitz, Theodore and Grossman, Leah and Dorsey, Philip and Pedersen, Ditte and Lund, Martin and Marcussen, Niels and Lund, Lars and Graversen, Joseph A and Wikenheiser, Jamie and Kerkoutian, Susan and Abdelshehid, Corollos and Abdelshehid, Corollos and Alipanah, Reza and Quach, Stephen and Zarraga, Jerome P and Gerbatsch, Isabelle and Huang, Jiaoti and Landman, Jaime and Landman, Jaime and Kyriazis, Iason and Kagadis, George and Loudos, George and Kallidonis, Panagiotis and Kallidonis, Panagiotis and Georgiopoulos, Ioannis and Liourdi, Despoina and Apostolopoulos, Dimitris and Nikiforidis, George and Liatsikos, Evangelos and Liatsikos, Evangelos and Fishman, Andrew and Dorai, Thambi and Dorai, Thambi and Ding, Cheng and Haberle, Ines Batinic and Grasso, Michael and ...
Journal of Endourology, ISSN 0892-7790, 09/2012, Volume 26, Issue S1, pp. P1 - A572
Journal Article
by Chris J, Allender and Jenna L, Bowen and Widatella, Awadalla and Iason, Kyriazis and Nikolaos, Tsopanoglou and Panagiotis, Kallidonis and Odysseas, Andrikopoulos and Despoina, Liourdi and Helen, Papadaki and Konstantina, Geronatsiou and Nicolas, Haseke and Sebastian, Walther and Christan, Gratzke and Christain G, Stief and Ronald, Sroka and Ephrem O, Olweny and Stephen, Faddegon and Stacey, McLeroy and Raul, Fernandez and Bruce E, Gnade and Heather E, Beardsley and Margaret S, Pearle and Jeffrey A, Cadeddu and Jeffrey A, Cadeddu and Tatsuo, Igarashi and Takuro, Ishii and Satoki, Zenbutsu and Yukio, Naya and Nuzhath, Khan and Deirdre, Anderson and Jonathan, Watkiss and Ben, Challacombe and Mohammed Shamim, Khan and Prokar, Dasgupta and Declan, Cahill and Nuzhath, Khan and Deirdre, Anderson and Faria, Khan and Jonathan, Watkiss and Ben, Challacombe and Mohammed Shamim, Khan and Prokar, Dasgupta and Declan, Cahill and Nieroshan, Rajarubendra and Ping Han, Chia and Aasheen, Munshey and Shomik, Sengupta and Damien, Bolton and Oneel, Patel and Lin, Xiao and Joseph, Ischia and Graham, Baldwin and Arthur, Schulkes and Payal, Kapur and Yung K, Tan and Samuel K, Park and Mehrad, Adibi and Sara L, Best and Jeffrey A, Cadeddu and Daniel M, de Bruin and Dirk J, Faber and Ton G, van Leeuwen and Jean J, de la Rosette and Pilar, Laguna and Shubha, De and Leah, Grossman and Niels, Johnsen and Greg, Mitchell and Ted, Klein and Benjamin, Lee and Panagiotis, Kitrou and Dimitrios, Karnabatidis and Christina, Kalogeropoulou and Athanasios, Tsamandas and Theofanis, Vrettos and Ioannis, Georgiopoulos and Aarond D, Benson and Bradley F, Schwartz and Kristina L, Penniston and Lauren, Iwicki and Ibrahim, Saeed and Thomas D, Crenshaw and Stephen Y, Nakada and Vivek, Joshi and Sushil, Karia and Sudhir, Sheth and Jitendra, Amlani and Sunil, Moteria and Mohammad Reza, Darabi mahboub and Eugene, Fuchs and Michael, Conlin and Hassan, Razvi and John D, Denstedt and Linda, Nott and Ad, Hendrikx and Michael, Luke and S.K, Pal and Jean, de la Rosette and Sunil, M and Maria Chiara, Sighinolfi and ...
Journal of Endourology, ISSN 0892-7790, 11/2011, Volume 25, Issue S1, pp. P1 - A373
Journal Article