Nature, ISSN 0028-0836, 10/2017, Volume 550, Issue 7677, pp. 534 - 538
The ubiquitin system regulates essential cellular processes in eukaryotes. Ubiquitin is ligated to substrate proteins as monomers or chains and the topology of...
DEUBIQUITINATING ENZYME | MULTIDISCIPLINARY SCIENCES | LINKED UBIQUITIN | Pyridines - chemistry | Ubiquitin-Specific Peptidase 7 - chemistry | Humans | Ubiquitin - metabolism | Substrate Specificity | Tumor Suppressor Protein p53 - genetics | Aminopyridines - chemistry | Ubiquitin-Specific Peptidase 7 - deficiency | Proto-Oncogene Proteins c-pim-1 - antagonists & inhibitors | Female | Proto-Oncogene Proteins c-mdm2 - metabolism | Phenols - pharmacology | Binding, Competitive | Indazoles - chemistry | Tumor Suppressor Protein p53 - metabolism | Ubiquitin - chemistry | Models, Molecular | Neoplasms - enzymology | Ubiquitin-Specific Peptidase 7 - antagonists & inhibitors | Ubiquitin-Specific Peptidase 7 - metabolism | Mice, SCID | Tumor Suppressor Protein p53 - deficiency | Neoplasms - drug therapy | Drug Synergism | Indazoles - pharmacology | Animals | Aminopyridines - pharmacology | Cell Line, Tumor | Protein Binding | Phenols - chemistry | Mice | Pyridines - pharmacology | Neoplasms - pathology | Biological research | Physiological aspects | Chemical inhibitors | Research | Ubiquitin-proteasome system | Biology, Experimental | Ubiquitin | Nuclear magnetic resonance--NMR | Toxicity | Hydrogen | p53 Protein | Cytotoxicity | Chains | Kinases | Monomers | Proteins | Depolymerization | Eukaryotes | Ubiquitination | Cell cycle | Reaction kinetics | Catalysis | Crystal structure | Binding | Enzymes | Magnetic resonance | Topology | Substrates | Chemotherapy | Inhibitors | Cell death | Proteasomes | Resonance | Mutation | Kinetics | Cancer | Tumors
DEUBIQUITINATING ENZYME | MULTIDISCIPLINARY SCIENCES | LINKED UBIQUITIN | Pyridines - chemistry | Ubiquitin-Specific Peptidase 7 - chemistry | Humans | Ubiquitin - metabolism | Substrate Specificity | Tumor Suppressor Protein p53 - genetics | Aminopyridines - chemistry | Ubiquitin-Specific Peptidase 7 - deficiency | Proto-Oncogene Proteins c-pim-1 - antagonists & inhibitors | Female | Proto-Oncogene Proteins c-mdm2 - metabolism | Phenols - pharmacology | Binding, Competitive | Indazoles - chemistry | Tumor Suppressor Protein p53 - metabolism | Ubiquitin - chemistry | Models, Molecular | Neoplasms - enzymology | Ubiquitin-Specific Peptidase 7 - antagonists & inhibitors | Ubiquitin-Specific Peptidase 7 - metabolism | Mice, SCID | Tumor Suppressor Protein p53 - deficiency | Neoplasms - drug therapy | Drug Synergism | Indazoles - pharmacology | Animals | Aminopyridines - pharmacology | Cell Line, Tumor | Protein Binding | Phenols - chemistry | Mice | Pyridines - pharmacology | Neoplasms - pathology | Biological research | Physiological aspects | Chemical inhibitors | Research | Ubiquitin-proteasome system | Biology, Experimental | Ubiquitin | Nuclear magnetic resonance--NMR | Toxicity | Hydrogen | p53 Protein | Cytotoxicity | Chains | Kinases | Monomers | Proteins | Depolymerization | Eukaryotes | Ubiquitination | Cell cycle | Reaction kinetics | Catalysis | Crystal structure | Binding | Enzymes | Magnetic resonance | Topology | Substrates | Chemotherapy | Inhibitors | Cell death | Proteasomes | Resonance | Mutation | Kinetics | Cancer | Tumors
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2009, Volume 284, Issue 47, pp. 32670 - 32679
P 4 -ATPases comprise a relatively new subfamily of P-type ATPases implicated in the energy-dependent translocation of aminophospholipids across cell...
Humans | Mice, Inbred C57BL | Phospholipid Transfer Proteins - chemistry | Chromatography - methods | Phospholipids - chemistry | Cytoplasm - metabolism | Gene Expression Regulation, Enzymologic | Phospholipid Transfer Proteins - biosynthesis | Animals | Cattle | Phospholipid Transfer Proteins - physiology | Retina - enzymology | Adenosine Triphosphatases - biosynthesis | Adenosine Triphosphatases - chemistry | Mice | Photoreceptor Cells - enzymology | Lipid Bilayers - metabolism | Adenosine Triphosphatases - physiology | Microscopy, Fluorescence | Membrane Transport, Structure, Function, and Biogenesis
Humans | Mice, Inbred C57BL | Phospholipid Transfer Proteins - chemistry | Chromatography - methods | Phospholipids - chemistry | Cytoplasm - metabolism | Gene Expression Regulation, Enzymologic | Phospholipid Transfer Proteins - biosynthesis | Animals | Cattle | Phospholipid Transfer Proteins - physiology | Retina - enzymology | Adenosine Triphosphatases - biosynthesis | Adenosine Triphosphatases - chemistry | Mice | Photoreceptor Cells - enzymology | Lipid Bilayers - metabolism | Adenosine Triphosphatases - physiology | Microscopy, Fluorescence | Membrane Transport, Structure, Function, and Biogenesis
Journal Article
Molecular & Cellular Proteomics, ISSN 1535-9476, 06/2008, Volume 7, Issue 6, pp. 1053 - 1066
The outer segment is a specialized compartment of vertebrate rod and cone photoreceptor cells where phototransduction takes place. In rod cells it consists of...
ROD PHOTORECEPTORS | IMMUNOCYTOCHEMICAL LOCALIZATION | DISK MORPHOGENESIS | RIM PROTEIN | QUANTITATIVE PROTEOMICS | BIOCHEMICAL RESEARCH METHODS | MOLECULAR-CLONING | CGMP-GATED CHANNEL | PLASMA-MEMBRANE | MASS-SPECTROMETRY | RETINAL-PIGMENT EPITHELIUM | rab GTP-Binding Proteins - metabolism | Retina - metabolism | Munc18 Proteins - metabolism | Rod Cell Outer Segment - chemistry | SNARE Proteins - chemistry | Animals | Cattle | Models, Biological | Qa-SNARE Proteins - metabolism | Cell Membrane - metabolism | Proteomics - methods | Chromatography, Liquid - methods | Vesicle-Associated Membrane Protein 2 - metabolism | Mass Spectrometry - methods | Microscopy, Fluorescence | Rod Cell Outer Segment - physiology
ROD PHOTORECEPTORS | IMMUNOCYTOCHEMICAL LOCALIZATION | DISK MORPHOGENESIS | RIM PROTEIN | QUANTITATIVE PROTEOMICS | BIOCHEMICAL RESEARCH METHODS | MOLECULAR-CLONING | CGMP-GATED CHANNEL | PLASMA-MEMBRANE | MASS-SPECTROMETRY | RETINAL-PIGMENT EPITHELIUM | rab GTP-Binding Proteins - metabolism | Retina - metabolism | Munc18 Proteins - metabolism | Rod Cell Outer Segment - chemistry | SNARE Proteins - chemistry | Animals | Cattle | Models, Biological | Qa-SNARE Proteins - metabolism | Cell Membrane - metabolism | Proteomics - methods | Chromatography, Liquid - methods | Vesicle-Associated Membrane Protein 2 - metabolism | Mass Spectrometry - methods | Microscopy, Fluorescence | Rod Cell Outer Segment - physiology
Journal Article
Internal Medicine Journal, ISSN 1444-0903, 03/2019, Volume 49, Issue S1, pp. 9 - 15
Background/Aim Families, especially in Chinese society, play a crucial role in care provision for relatives with schizophrenia, but the burden of caregiving...
schizophrenia | Hong Kong | family member | caregiver | burden | MEDICINE, GENERAL & INTERNAL | NEEDS | SUPPORT GROUP | Caregivers | Psychiatric hospital care | Clinics | Schizophrenia | Stress (Psychology) | Psychiatric hospitals | Patient compliance | Psychosis | Sleep disorders | Neuroleptics | Social interactions | Mental disorders | Early experience | Anxiety | Stress
schizophrenia | Hong Kong | family member | caregiver | burden | MEDICINE, GENERAL & INTERNAL | NEEDS | SUPPORT GROUP | Caregivers | Psychiatric hospital care | Clinics | Schizophrenia | Stress (Psychology) | Psychiatric hospitals | Patient compliance | Psychosis | Sleep disorders | Neuroleptics | Social interactions | Mental disorders | Early experience | Anxiety | Stress
Journal Article
Psychiatry Research, ISSN 0165-1781, 2007, Volume 165, Issue 3, pp. 241 - 251
Abstract Selective attention biases are believed to be one of the cognitive vulnerabilities to depression. This study examined two types of attention biases,...
Psychiatry | Attention biases | Depression | Attention facilitation | Attention disinhibition | Negative priming | Positive priming | TASK | ACTIVATION | ENGLISH | PSYCHIATRY | EMOTION | MECHANISMS | INHIBITION | MOOD | MEMORY | Young Adult | Vocabulary | Humans | Middle Aged | Attention | Depression - psychology | Adult | Female | Male | Reaction Time | Disclosure | Affect | Neurosciences | Depression, Mental
Psychiatry | Attention biases | Depression | Attention facilitation | Attention disinhibition | Negative priming | Positive priming | TASK | ACTIVATION | ENGLISH | PSYCHIATRY | EMOTION | MECHANISMS | INHIBITION | MOOD | MEMORY | Young Adult | Vocabulary | Humans | Middle Aged | Attention | Depression - psychology | Adult | Female | Male | Reaction Time | Disclosure | Affect | Neurosciences | Depression, Mental
Journal Article
Molecular & Cellular Proteomics : MCP, ISSN 1535-9476, 6/2008, Volume 7, Issue 6, pp. 1053 - 1066
The outer segment is a specialized compartment of vertebrate rod and cone photoreceptor cells where phototransduction takes place. In rod cells it consists of...
Research
Research
Journal Article
Journal of Acquired Immune Deficiency Syndromes, ISSN 1525-4135, 06/2017, Volume 75, Issue 2, p. 198
Background: The magnitude and risk factors of progression of atherosclerosis in Asian HIV-infected individuals were unknown. This study aimed to evaluate: (1)...
Lipoproteins (low density) | Particle size | C-reactive protein | Dyslipidemia | Performance prediction | Homeostasis | Risk factors | Body composition | Adiponectin | Body composition (biology) | Human immunodeficiency virus--HIV | Atherosclerosis | Heart diseases | Asians | Hypertension | Diabetes mellitus | Health risks | Inflammation | Risk analysis | Insulin | Cholesterol | Correlation analysis | Arteriosclerosis | Men | Biomarkers | Adults
Lipoproteins (low density) | Particle size | C-reactive protein | Dyslipidemia | Performance prediction | Homeostasis | Risk factors | Body composition | Adiponectin | Body composition (biology) | Human immunodeficiency virus--HIV | Atherosclerosis | Heart diseases | Asians | Hypertension | Diabetes mellitus | Health risks | Inflammation | Risk analysis | Insulin | Cholesterol | Correlation analysis | Arteriosclerosis | Men | Biomarkers | Adults
Journal Article
Electronics Letters, ISSN 0013-5194, 03/2006, Volume 42, Issue 6, pp. 1 - 1
A silica lens pair has been designed to facilitate the free-space optical propagation between opposing planar waveguides. Each lens consists of a graded...
Slopes | Wave propagation | Mathematical analysis | Refractive index | Etching | Slabs | Silicon dioxide | Lenses
Slopes | Wave propagation | Mathematical analysis | Refractive index | Etching | Slabs | Silicon dioxide | Lenses
Journal Article
Molecular and Cellular Proteomics, ISSN 1535-9476, 06/2008, Volume 7, Issue 6, pp. 1053 - 1066
The outer segment is a specialized compartment of vertebrate rod and cone photoreceptor cells where phototransduction takes place. In rod cells it consists of...
Journal Article
Anesthesiology, ISSN 0003-3022, 1997, Volume 87, Issue 1, pp. 168 - 169
Anesthesia: obstetric | Heart: idiopathic subaortic stenosis | Anesthetic technique | Epidural, spinal | heart, idiopathic subaortic stenosis | ANESTHESIOLOGY | anesthesia, obstetric | K BA ANESTHESIOLOGY | anesthetic technique, epidural, spinal | ANALGESIA | Pregnancy | Anesthesia, Epidural | Cardiomyopathy, Hypertrophic | Pregnancy Complications, Cardiovascular | Humans | Adult | Female | Anesthesia, Obstetrical | Anesthesia, Spinal
Journal Article
Survey of Anesthesiology, ISSN 0039-6206, 06/1998, Volume 42, Issue 3, p. 143
Journal Article
Journal of Alzheimer's disease : JAD, 2010, Volume 20, Issue 1, p. 31
X11alpha is a neuronal-specific adaptor protein that binds to the amyloid-beta protein precursor (AbetaPP). Overexpression of X11alpha reduces Abeta production...
Alzheimer Disease - complications | Age Factors | Maze Learning - physiology | Humans | Memory Disorders - metabolism | Mice, Transgenic | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Memory Disorders - prevention & control | Amyloid beta-Protein Precursor - genetics | Animals | Memory Disorders - etiology | Analysis of Variance | Adaptor Proteins, Signal Transducing - genetics | Amyloid beta-Peptides - metabolism | Mice | Adaptor Proteins, Signal Transducing - metabolism | Alzheimer Disease - genetics | Disease Models, Animal
Alzheimer Disease - complications | Age Factors | Maze Learning - physiology | Humans | Memory Disorders - metabolism | Mice, Transgenic | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Memory Disorders - prevention & control | Amyloid beta-Protein Precursor - genetics | Animals | Memory Disorders - etiology | Analysis of Variance | Adaptor Proteins, Signal Transducing - genetics | Amyloid beta-Peptides - metabolism | Mice | Adaptor Proteins, Signal Transducing - metabolism | Alzheimer Disease - genetics | Disease Models, Animal
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 11/2004, Volume 279, Issue 47, p. 49099
Accumulation of cerebral amyloid beta-protein (Abeta) is believed to be part of the pathogenic process in Alzheimer's disease. Abeta is derived by proteolytic...
Immunohistochemistry | Brain - embryology | Humans | Immunoblotting | Male | RNA, Messenger - metabolism | Brain - metabolism | Amyloid beta-Peptides - genetics | Amyloid - biosynthesis | Cloning, Molecular | Female | Cell Membrane - metabolism | Neurons - metabolism | Cadherins - genetics | Carrier Proteins - physiology | Protein Structure, Tertiary | Nerve Tissue Proteins - physiology | Amyloid beta-Peptides - biosynthesis | Mice, Inbred C57BL | Alzheimer Disease - therapy | Mice, Transgenic | Cadherins - physiology | Nerve Tissue Proteins - genetics | Carrier Proteins - genetics | Blotting, Northern | Animals | Mice | Mutation | Crosses, Genetic
Immunohistochemistry | Brain - embryology | Humans | Immunoblotting | Male | RNA, Messenger - metabolism | Brain - metabolism | Amyloid beta-Peptides - genetics | Amyloid - biosynthesis | Cloning, Molecular | Female | Cell Membrane - metabolism | Neurons - metabolism | Cadherins - genetics | Carrier Proteins - physiology | Protein Structure, Tertiary | Nerve Tissue Proteins - physiology | Amyloid beta-Peptides - biosynthesis | Mice, Inbred C57BL | Alzheimer Disease - therapy | Mice, Transgenic | Cadherins - physiology | Nerve Tissue Proteins - genetics | Carrier Proteins - genetics | Blotting, Northern | Animals | Mice | Mutation | Crosses, Genetic
Journal Article
World Allergy Organization Journal, ISSN 1939-4551, 11/2007, p. S30
Journal Article
Neuroreport, 08/2010, Volume 21, Issue 11, p. 761
X11alpha is a neuronal adaptor protein that interacts with the amyloid precursor protein (APP) through a centrally located phosphotyrosine binding domain to...
Cricetulus | Humans | Glycogen Synthase Kinase 3 beta | Multiprotein Complexes - genetics | Brain - metabolism | Multiprotein Complexes - metabolism | Transfection | Transcription, Genetic | CHO Cells | Promoter Regions, Genetic | Cricetinae | Glycogen Synthase Kinase 3 - biosynthesis | Gene Expression Regulation - physiology | Rats | Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Two-Hybrid System Techniques | Blotting, Northern | Animals | Glycogen Synthase Kinase 3 - genetics | Adaptor Proteins, Signal Transducing - genetics | Alzheimer Disease - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Alzheimer Disease - genetics
Cricetulus | Humans | Glycogen Synthase Kinase 3 beta | Multiprotein Complexes - genetics | Brain - metabolism | Multiprotein Complexes - metabolism | Transfection | Transcription, Genetic | CHO Cells | Promoter Regions, Genetic | Cricetinae | Glycogen Synthase Kinase 3 - biosynthesis | Gene Expression Regulation - physiology | Rats | Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Two-Hybrid System Techniques | Blotting, Northern | Animals | Glycogen Synthase Kinase 3 - genetics | Adaptor Proteins, Signal Transducing - genetics | Alzheimer Disease - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Alzheimer Disease - genetics
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 11/2003, Volume 278, Issue 47, p. 47025
Increased production and deposition of the 40-42-amino acid beta-amyloid peptide (Abeta) is believed to be central to the pathogenesis of Alzheimer's disease....
Alzheimer Disease - etiology | Carrier Proteins - physiology | Immunoassay | Nerve Tissue Proteins - physiology | Adaptor Proteins, Vesicular Transport - physiology | Amyloid beta-Peptides - biosynthesis | Humans | Mice, Transgenic | Amyloid beta-Protein Precursor - analysis | Adaptor Proteins, Signal Transducing | Animals | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Amyloid beta-Peptides - analysis | Brain Chemistry | Mice | Protein Processing, Post-Translational
Alzheimer Disease - etiology | Carrier Proteins - physiology | Immunoassay | Nerve Tissue Proteins - physiology | Adaptor Proteins, Vesicular Transport - physiology | Amyloid beta-Peptides - biosynthesis | Humans | Mice, Transgenic | Amyloid beta-Protein Precursor - analysis | Adaptor Proteins, Signal Transducing | Animals | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Amyloid beta-Peptides - analysis | Brain Chemistry | Mice | Protein Processing, Post-Translational
Journal Article
Immunity, ISSN 1074-7613, 04/2018, Volume 48, Issue 4, pp. 812 - 830.e14
We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across...
tumor immunology | immunotherapy | cancer genomics | integrative network analysis | immuno-oncology | tumor microenvironment | immune subtypes | immunomodulatory | Immunology | Infectious Diseases | Immunology and Allergy | GENOMIC ANALYSES | INFORMATION | T-CELL-RECEPTOR | REGULATORY NETWORK | CLASSIFICATION | IMMUNOLOGY | SEQUENCING DATA | SOMATIC MUTATIONS | COMPREHENSIVE ANALYSIS | PREDICTION | REVEALS | Transforming Growth Factor beta - immunology | Prognosis | Humans | Middle Aged | Th1-Th2 Balance - physiology | Male | Neoplasms - classification | Wound Healing - immunology | Young Adult | Transforming Growth Factor beta - genetics | Neoplasms - genetics | Neoplasms - immunology | Interferon-gamma - immunology | Adolescent | Aged, 80 and over | Adult | Female | Aged | Interferon-gamma - genetics | Wound Healing - genetics | Genomics - methods | Child | Macrophages - immunology | Cell proliferation | Cluster analysis | Transcription | Copy number | p53 Protein | Lung cancer | Genomics | Aneuploidy | Lymphocytes T | Genomes | Cell interactions | Macrophages | Immunotherapy | DNA methylation | Deoxyribonucleic acid--DNA | Immune system | Medical research | Wound healing | Immunomodulation | MiRNA | Stockholders | Inflammation | T cell receptors | Communications networks | Gene expression | White blood cells | Inventors | Medical prognosis | γ-Interferon | Mutation | Cancer | Tumors | Immune Subtypes | Integrative Network Analysis | Cancer Genomics | Immuno-oncology | Tumor immunology
tumor immunology | immunotherapy | cancer genomics | integrative network analysis | immuno-oncology | tumor microenvironment | immune subtypes | immunomodulatory | Immunology | Infectious Diseases | Immunology and Allergy | GENOMIC ANALYSES | INFORMATION | T-CELL-RECEPTOR | REGULATORY NETWORK | CLASSIFICATION | IMMUNOLOGY | SEQUENCING DATA | SOMATIC MUTATIONS | COMPREHENSIVE ANALYSIS | PREDICTION | REVEALS | Transforming Growth Factor beta - immunology | Prognosis | Humans | Middle Aged | Th1-Th2 Balance - physiology | Male | Neoplasms - classification | Wound Healing - immunology | Young Adult | Transforming Growth Factor beta - genetics | Neoplasms - genetics | Neoplasms - immunology | Interferon-gamma - immunology | Adolescent | Aged, 80 and over | Adult | Female | Aged | Interferon-gamma - genetics | Wound Healing - genetics | Genomics - methods | Child | Macrophages - immunology | Cell proliferation | Cluster analysis | Transcription | Copy number | p53 Protein | Lung cancer | Genomics | Aneuploidy | Lymphocytes T | Genomes | Cell interactions | Macrophages | Immunotherapy | DNA methylation | Deoxyribonucleic acid--DNA | Immune system | Medical research | Wound healing | Immunomodulation | MiRNA | Stockholders | Inflammation | T cell receptors | Communications networks | Gene expression | White blood cells | Inventors | Medical prognosis | γ-Interferon | Mutation | Cancer | Tumors | Immune Subtypes | Integrative Network Analysis | Cancer Genomics | Immuno-oncology | Tumor immunology
Journal Article