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1. Full Text Severe acute respiratory syndrome Coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3‐dependent ubiquitination of ASC
by Siu, Kam‐Leung and Yuen, Kit‐San and Castano‐Rodriguez, Carlos and Ye, Zi‐Wei and Yeung, Man‐Lung and Fung, Sin‐Yee and Yuan, Shuofeng and Chan, Chi‐Ping and Yuen, Kwok‐Yung and Enjuanes, Luis and Jin, Dong‐Yan
The FASEB journal, ISSN 0892-6638, 08/2019, Volume 33, Issue 8, pp. 8865 - 8877
SARS Coronavirus | Biochemistry & Molecular Biology | Biology | Life Sciences & Biomedicine - Other Topics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | A549 Cells | Chlorocebus aethiops | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Humans | TNF Receptor-Associated Factor 3 - metabolism | SARS Virus - metabolism | CARD Signaling Adaptor Proteins - metabolism | Ubiquitination | Animals | HEK293 Cells | Viral Structural Proteins - metabolism | Vero Cells | Index Medicus | SARS coronavirus | Research
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2. Full Text Active Replication of Middle East Respiratory Syndrome Coronavirus and Aberrant Induction of Inflammatory Cytokines and Chemokines in Human Macrophages: Implications for Pathogenesis
by Jie Zhou and Hin Chu and Cun Li and Bosco Ho-Yin Wong and Zhong-Shan Cheng and Vincent Kwok-Man Poon and Tianhao Sun and Candy Choi-Yi Lau and Kenneth Kak-Yuen Wong and Jimmy Yu-Wai Chan and Jasper Fuk-Woo Chan and Kelvin Kai-Wang To and Kwok-Hung Chan and Bo-Jian Zheng and Kwok-Yung Yuen
The Journal of infectious diseases, ISSN 0022-1899, 5/2014, Volume 209, Issue 9, pp. 1331 - 1342
T lymphocytes | Coronavirus | Cytokines | Pathogenesis | Epithelial cells | Viruses | Infections | Macrophages | SARS virus | Gene expression | viral replication | pathogenesis | MERS-CoV | cytokine and chemokine response | SARS-CoV | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Miscellaneous | Infectious diseases | Biological and medical sciences | Medical sciences | Virology | Chlorocebus aethiops | Coronavirus - pathogenicity | Humans | Cells, Cultured | Cell Survival - immunology | Coronavirus Infections - immunology | Pneumonia, Viral - immunology | Coronavirus - immunology | Lung - virology | Animals | Macrophages - virology | Antigen Presentation | Coronavirus Infections - virology | Pneumonia, Viral - virology | Vero Cells | Virus Replication - physiology | Coronavirus - physiology | Cytokines - biosynthesis | Macrophages - immunology | Cytokines - immunology | Major histocompatibility complex | Research | Index Medicus | Abridged Index Medicus | Major and Brief Reports
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3. Full Text Middle east respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in the innate antiviral response
by Siu, Kam-Leung and Yeung, Man Lung and Kok, Kin-Hang and Yuen, Kit-San and Kew, Chun and Lui, Pak-Yin and Chan, Chi-Ping and Tse, Herman and Woo, Patrick C.Y and Yuen, Kwok-Yung and Jin, Dong-Yan
Journal of virology, ISSN 0022-538X, 2014, Volume 88, Issue 9, pp. 4866 - 4876
Life Sciences & Biomedicine | Science & Technology | Virology | Cell Line | DEAD Box Protein 58 | Humans | Viral Proteins - metabolism | Coronavirus - immunology | Interferon-Induced Helicase, IFIH1 | Protein Interaction Mapping | Host-Pathogen Interactions | Immune Evasion | DEAD-box RNA Helicases - antagonists & inhibitors | Protein Binding | Interferons - antagonists & inhibitors | RNA-Binding Proteins - metabolism | Index Medicus | Virus-Cell Interactions
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4. Full Text Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2
by Wang, Qihui and Zhang, Yanfang and Wu, Lili and Niu, Sheng and Song, Chunli and Zhang, Zengyuan and Lu, Guangwen and Qiao, Chengpeng and Hu, Yu and Yuen, Kwok-Yung and Wang, Qisheng and Zhou, Huan and Yan, Jinghua and Qi, Jianxun
Cell (Cambridge), ISSN 0092-8674, 05/2020, Volume 181, Issue 4, pp. 894 - 904.e9
receptor binding domain | ACE2 | SARS-CoV-2 | CTD | receptor | crystal structure | immunogenicity | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Amino Acid Sequence | Spike Glycoprotein, Coronavirus - metabolism | Humans | Models, Molecular | Epitopes | Phylogeny | SARS Virus - chemistry | Virus Internalization | Angiotensin-Converting Enzyme 2 | Sequence Alignment | Peptidyl-Dipeptidase A - chemistry | Betacoronavirus - chemistry | Betacoronavirus - physiology | Peptidyl-Dipeptidase A - metabolism | Protein Domains | SARS Virus - physiology | Spike Glycoprotein, Coronavirus - chemistry | Index Medicus
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5. Full Text Infection of bat and human intestinal organoids by SARS-CoV-2
by Zhou Jie and Li Cun and Liu Xiaojuan and Chiu Man Chun and Zhao Xiaoyu and Wang Dong and Wei Yuxuan and Lee, Andrew and Zhang, Anna Jinxia and Chu Hin and Cai Jian-Piao and Yip, Cyril Chik-Yan and Chan, Ivy Hau-Yee and Wong, Kenneth Kak-Yuen and Tsang, Owen Tak-Yin and Chan Kwok-Hung and Chan, Jasper Fuk-Woo and To, Kelvin Kai-Wang and Chen Honglin and Yuen, Kwok Yung
Nature medicine, ISSN 1078-8956, 07/2020, Volume 26, Issue 7, pp. 1077 - 1083
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Betacoronavirus - pathogenicity | Chiroptera - virology | Pandemics | Humans | Child, Preschool | Enterocytes - virology | Infant | Male | COVID-19 | Coronavirus Infections - transmission | Pneumonia, Viral - transmission | SARS-CoV-2 | Intestines - virology | Female | Cell Differentiation | Enterocytes - pathology | Vero Cells | Viral Tropism - physiology | Chlorocebus aethiops | Intestines - pathology | Organoids - pathology | Pneumonia, Viral - pathology | Cells, Cultured | Intestinal Mucosa - virology | Reverse Transcriptase Polymerase Chain Reaction | Viral Load - genetics | Animals | Coronavirus Infections - virology | Coronavirus Infections - pathology | Viral Load - methods | Pneumonia, Viral - virology | Enterocytes - physiology | Intestinal Mucosa - pathology | Organoids - virology | Bats | Intestines | Disease transmission | Physiological aspects | Models | Coronaviruses | Health aspects | Methods | Genomics | Analysis | Severe acute respiratory syndrome | Resveratrol | Genomes | Cell culture | Gastrointestinal symptoms | Nucleotide sequence | Viral diseases | Diarrhea | Viruses | Homology | Infections | Ribonucleic acid--RNA | Epithelium | Severe acute respiratory syndrome coronavirus 2 | Organoids | Intestine | Life cycle analysis | Respiratory diseases | Replication | Robustness | Index Medicus
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6. Full Text Comparative Replication and Immune Activation Profiles of SARS-CoV-2 and SARS-CoV in Human Lungs: An Ex Vivo Study With Implications for the Pathogenesis of COVID-19
by Chu, Hin and Chan, Jasper Fuk-Woo and Wang, Yixin and Yuen, Terrence Tsz-Tai and Chai, Yue and Hou, Yuxin and Shuai, Huiping and Yang, Dong and Hu, Bingjie and Huang, Xiner and Zhang, Xi and Cai, Jian-Piao and Zhou, Jie and Yuan, Shuofeng and Kok, Kin-Hang and To, Kelvin Kai-Wang and Chan, Ivy Hau-Yee and Zhang, Anna Jinxia and Sit, Ko-Yung and Au, Wing-Kuk and Yuen, Kwok-Yung
Clinical infectious diseases, ISSN 1058-4838, 09/2020, Volume 71, Issue 6, pp. 1400 - 1409
COVID-19 | coronavirus | SARS-CoV-2 | ex vivo | interferon | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Pandemics | Humans | Virus Replication - immunology | Interferons - immunology | Coronavirus Infections - immunology | Pneumonia, Viral - immunology | Immunity, Innate - immunology | Lung - virology | Coronavirus Infections - virology | Betacoronavirus - physiology | SARS Virus - physiology | Pneumonia, Viral - virology | Lung - immunology | Chemokines - immunology | Cytokines - immunology | Index Medicus
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7. Full Text Discovery of Seven Novel Mammalian and Avian Coronaviruses in the Genus Deltacoronavirus Supports Bat Coronaviruses as the Gene Source of Alphacoronavirus and Betacoronavirus and Avian Coronaviruses as the Gene Source of Gammacoronavirus and Deltacoronavirus
by Patrick C. Y. Woo and Susanna K. P. Lau and Carol S. F. Lam and Candy C. Y. Lau and Alan K. L. Tsang and John H. N. Lau and Ru Bai and Jade L. L. Teng and Chris C. C. Tsang and Ming Wang and Bo-Jian Zheng and Kwok-Hung Chan and Kwok-Yung Yuen
Journal of Virology, ISSN 0022-538X, 04/2012, Volume 86, Issue 7, pp. 3995 - 4008
Life Sciences & Biomedicine | Science & Technology | Virology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Miscellaneous | Microbiology | Bird Diseases - virology | Chiroptera - virology | Coronavirus - classification | Mammals - virology | Humans | Coronaviridae Infections - virology | Molecular Sequence Data | Phylogeny | Coronaviridae - isolation & purification | Coronaviridae Infections - veterinary | Swine | Base Sequence | Coronaviridae - genetics | Coronavirus - isolation & purification | Genome, Viral | Cats | Rodentia | Viral Proteins - genetics | Birds | Haplorhini | Coronaviridae - classification | Animals | Dogs | Coronavirus - genetics | Evolution, Molecular | Index Medicus | Genetic Diversity and Evolution
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8. Full Text Dissemination of the mcr-1 colistin resistance gene
by Tse, Herman and Yuen, Kwok-Yung
The Lancet infectious diseases, ISSN 1473-3099, 2016, Volume 16, Issue 2, pp. 145 - 146
Infectious Disease | Life Sciences & Biomedicine | Infectious Diseases | Science & Technology | Enterobacteriaceae Infections - immunology | Swine Diseases - drug therapy | Animals | Polymyxins - therapeutic use | Humans | Plasmids - immunology | Enterobacteriaceae - drug effects | Colistin - therapeutic use | Enterobacteriaceae Infections - drug therapy | Antibacterial agents | Salmonella | Plasmids | Genes | Bacteriology | Index Medicus
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9. Full Text Suppression of SARS‐CoV‐2 infection in ex‐vivo human lung tissues by targeting class III phosphoinositide 3‐kinase
by Yuen, Chun‐Kit and Wong, Wan‐Man and Mak, Long‐Fung and Wang, Xiaohui and Chu, Hin and Yuen, Kwok‐Yung and Kok, Kin‐Hang
Journal of medical virology, ISSN 0146-6615, 04/2021, Volume 93, Issue 4, pp. 2076 - 2083
Vps34 | COVID‐19 | SARS‐CoV‐2 | class III PI3‐K | ex vivo human lung tissues | Life Sciences & Biomedicine | Science & Technology | Virology | Pandemics | Nucleation | Severe acute respiratory syndrome | Viral diseases | Acidification | Infections | Coronaviruses | Bioavailability | Kinases | Autophagy | Severe acute respiratory syndrome coronavirus 2 | COVID-19 | Immunosuppression | Inhibitors | Lungs | Respiratory diseases | Phagocytosis | Index Medicus
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10. Full Text Coronaviruses-drug discovery and therapeutic options
by Zumla, Alimuddin and Chan, Jasper F. W and Azhar, Esam I and Hui, David S. C and Yuen, Kwok-Yung
Nature reviews. Drug discovery, ISSN 1474-1776, 05/2016, Volum